Publikationen
Dr. rer. nat. Bernhard Singer

 

Orginalpublikationen:

 

Slevogt H, Zabel S, Opitz B, Hocke A, Eitel J, N'guessan PD, Lucka L, Riesbeck K, Zimmermann W, Zweigner J, Temmesfeld-Wollbrueck B, Suttorp N, Singer BB.
CEACAM1 inhibits Toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells. Nature Immunologie 2008 Nov;9(11):1270-8. Epub 2008 Oct 5.

Ergün S, Hohn HP, Kilic N, Singer BB, Tilki D.:
Endothelial and hematopoietic progenitor cells (EPCs and HPCs): hand in hand fate determining partners for cancer cells.
Stem Cell Rev. 2008 Sep;4(3):169-77. Epub 2008 Jul 8. Review.

Harvey DJ, Crispin M, Scanlan C, Singer BB, Lucka L, Chang VT, Radcliffe CM, Thobhani S, Yuen CT, Rudd PM. Differentiation between isomeric triantennary N-linked glycans by negative ion tandem mass spectrometry and confirmation of glycans containing galactose attached to the bisecting (beta1-4-GlcNAc) residue in N-glycans from IgG.
Rapid Commun Mass Spectrom. 2008 Apr;22(7):1047-52.

Kammerer R, Popp T, Hartle S, Singer BB, Zimmermann W.
Species-specific evolution of immune receptor tyrosine based activation motif-containing CEACAM1-related immune receptors in the dog.
BMC Evol Biol. 2007 Oct 18;7(1):196.

Kilic N, Oliveira-Ferrer L, Neshat-Vahid S, Irmak S, Obst-Pernberg K, Wurmbach JH, Loges S, Kilic E, Weil J, Lauke H, Tilki D, Singer BB, Ergun S.:
Lymphatic reprogramming of micro vascular endothelial cells by CEA-related Cell Adhesion Molecule-1 via interaction with VEGFR-3 and Prox1.
Blood. 2007 Dec 15;110(13):4223-33.

Scanlan CN, Ritchie GE, Baruah K, Crispin M, Harvey DJ, Singer BB, Lucka L, Wormald MR, Wentworth P Jr, Zitzmann N, Rudd PM, Burton DR, Dwek RA.
Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.
J Mol Biol. 2007 Sep 7;372(1):16-22.

Tilki D, Singer BB, Seitz M, Stief CG, Ergün S.
Molecular imaging of tumor blood vessels.
Urologe A. 2007 Sep;46(9):1266-1271.

Klaile E, Müller MM, Kannicht C, Otto W, Singer BB, Reutter W, Obrink B, Lucka L.
The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38.
J Biol Chem. 2007 Sep 7;282(36):26629-40.

N'Guessan PD, Vigelahn M, Bachmann S, Zabel S, Opitz B, Schmeck B, Hippenstiel S, Zweigner J, Riesbeck K, Singer BB, Suttorp N, Slevogt H.
The UspA1 protein of Moraxella catarrhalis induces CEACAM-1-dependent apoptosis in alveolar epithelial cells.
J Infect Dis. 2007 Jun 1;195(11):1651-60.

Slevogt H, Seybold J, Tiwari KN, Hocke AC, Jonatat C, Dietel S, Hippenstiel S, Singer BB, Bachmann S, Suttorp N, Opitz B.
Moraxella catarrhalis is internalized in respiratory epithelial cells by a trigger-like mechanism and initiates a TLR2- and partly NOD1-dependent inflammatory immune response.
Cell Microbiol. 2007 Mar;9(3):694-707.

Klaile E, Müller MM, Kannicht C, Singer BB, Lucka L.
CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration.
J Cell Sci. 2005 Dec 1;118(Pt 23):5513-24.

Scheffrahn I, Singer BB, Sigmundsson K, Lucka L, Obrink B.
Control of density-dependent, cell state-specific signal transduction by the cell adhesion molecule CEACAM1, and its influence on cell cycle regulation.
Exp Cell Res. 2005 Jul 15;307(2):427-35.

Singer BB, Klaile E, Scheffrahn I, Müller MM, Kammerer R, Reutter W, Obrink B, Lucka L.
CEACAM1 (CD66a) mediates delay of spontaneous and Fas ligand-induced apoptosis in granulocytes.
Eur J Immunol. 2005 Jun;35(6):1949-59.

Müller MM, Singer BB, Klaile E, Obrink B, Lucka L.
Transmembrane CEACAM1 affects integrin-dependent signaling and regulates extracellular matrix protein-specific morphology and migration of endothelial cells.
Blood. 2005 May 15;105(10):3925-34. Epub 2005 Feb 1. Erratum in: Blood. 2005 Jul 15;106(2):407.

Kammerer R, Popp T, Singer BB, Schlender J, Zimmermann W.
Identification of allelic variants of the bovine immune regulatory molecule CEACAM1 implies a pathogen-driven evolution.
Gene. 2004 Sep 15;339:99-109.

Greicius G, Severinson E, Beauchemin N, Obrink B, Singer BB.
CEACAM1 is a potent regulator of B cell receptor complex-induced activation.
J Leukoc Biol. 2003 Jul;74(1):126-34.

Obrink B, Sawa H, Scheffrahn I, Singer BB, Sigmundsson K, Sundberg U, Heymann R, Beauchemin N, Weng G, Ram P, Iyengar R.
Computational analysis of isoform-specific signal regulation by CEACAM1-A cell adhesion molecule expressed in PC12 cells.
Ann N Y Acad Sci. 2002 Oct;971:597-607.

Singer BB, Scheffrahn I, Heymann R, Sigmundsson K, Kammerer R, Obrink B.:
Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes.
J Immunol. 2002 May 15;168(10):5139-46.

Kammerer R, Stober D, Singer BB, Obrink B, Reimann J.:
Carcinoembryonic antigen-related cell adhesion molecule 1 on murine dendritic cells is a potent regulator of T cell stimulation.
J Immunol. 2001 Jun 1;166(11):6537-44.

Hübinger G, Müller E, Scheffrahn I, Schneider C, Hildt E, Singer BB, Sigg I, Graf J, Bergmann L.:
CD30-mediated cell cycle arrest associated with induced expression of p21(CIP1/WAF1) in the anaplastic large cell lymphoma cell line Karpas 299.
Oncogene. 2001 Feb 1;20(5):590-8.

Singer BB, Scheffrahn I, Obrink B.:
The tumor growth-inhibiting cell adhesion molecule CEACAM1 (C-CAM) is differently expressed in proliferating and quiescent epithelial cells and regulates cell proliferation.
Cancer Res. 2000 Mar 1;60(5):1236-44.

Kammerer R, Hahn S, Singer BB, Luo JS, von Kleist S.:
Biliary glycoprotein (CD66a), a cell adhesion molecule of the immunoglobulin superfamily, on human lymphocytes: structure, expression and involvement in T cell activation.
Eur J Immunol. 1998 Nov;28(11):3664-74.

 

Patentanmeldungen:

Gediminas Greicius and Bernhard B. Singer:
A novel method for the generation of monoclonal antibodies using the costimulatory effect of CEACAM1 in B lymphocytes.
Swedish and US patent application, PCT/SE01/01714

Bernhard B. Singer:
Use of CEACAM8-specific substances for treating autoimmune diseases and a method for screening substances which induce apoptosis.
European Patent Application No. 05090302.0 (01.11.2005)

Bernhard B. Singer:
Use of soluble CEACAM8 for diagnosing, treating or monitoring diseases , and a method for screening compounds that prevent apoptosis.
European Patent Application No. 07117396.7-2123 (27.09.2007)

 

Online-Review:

B.B. Singer, Lucka, L.
CEACAM1. AfCS Nature Molecule Pages (2005)
doi: 10.1038/mp.a003597.01

B.B. Singer and Lucka, L. (2003) Molecule pages A003597 (ceacam1), A003599 (ceacam3), A003602 (ceacam6), A003604 (ceacam8). Alliance for cell signaling (AfCS),
Nature publishing group
http://www.signaling-gateway.org

 

Buchbeiträge:

R. Kammerer, J.S. Luo, B.B. Singer and S. von Kleist:
Reactivity of the CD66 panel and myeloid blind panel mAbs with T cells: modulation of antigen expression of T cells by activation with IL-2. Leucocyte typing VI,
ed. T. Kishimoto et al., Garland Publishing, Inc., New York (1997)

L. Lucka, M.M. Müller, M. Budt, E. Ragge and B.B. Singer:
Multifunctional carcinoembryonic antigen cell adhesion molecule.
1. Falk Workshop Cell Adhesion Molecules in Health and Disease
,
ed. Reutter, Schuppan, Tauber and Zeitz.
Kluwer Academic Publishers, Dordrecht/Boston/London; (2003)

 

 

 

 

   
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