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Struktur des IFZ Forschung im IFZ Mitarbeiter Leistungen aus dem IFZ Seminare Stellenangebote Links IFZ-Fördervereinigung Informationen: Ph. D. Thesis (Dr. rer. nat.) |
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Publikationen der Arbeitsgruppe Molekulare Genetik (1994 -2011) |
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Sellmann L, de Beer D, Bartels M, Opalka B, Nückel H, Dührsen U, Dürig J, Seifert M, Siemer D, Küppers R, Baerlocher GM, Röth A. (2011) Telomeres and prognosis in patients with chronic lymphocytic leukaemia. Int. J. Hematol. 93, 74-82 Rosenwald A, Küppers R. (2011) Pathology and molecular pathology of Hodgkin lymphoma. in Hodgkin lymphoma. Chapter 3, p. 33-48. Edited by A. Engert and S.J. Horning. Springer Verlag, Berlin Heidelberg Philipp C, Edelmann J, Bühler A, Winkler D, Stilgenbauer S, Küppers R. (2011) Mutation analysis of the TNFAIP3 (A20) tumor suppressor gene in CLL. Int. J. Cancer, 128, 1747-1750 Sellmann L, Scholtysik R, Kreuz M, Cyrull S, Tiacci E, Stanelle J, Carpinteiro A, Nückel H, Boes T, Gesk S, Siebert R, Klein-Hitpass L, Dührsen U, Dürig J, Küppers R. (2010) Gene dosage effects in chronic lymphocytic leukemia. Cancer Genetics Cytogenetics, 203, 149-160 Scholtysik R, Kreuz M, Klapper W, Burkhardt B, Feller AC, Hummel M, Loeffler M, Rosolowski M, Schwaenen C, Spang R, Stein H, Thorns C, Trümper L, Vater I, Wessendorf S, Zenz T, Siebert R, Küppers R, for the "Molecular Mechanisms in Malignant Lymphomas" Network Project of the Deutsche Krebshilfe. (2010) Detection of genomic aberrations in molecularly defined Burkitt lymphoma by array-based high resolution single nucleotide polymorphism analysis. Haematologica, 95, 2047-2055 Hansmann M-L, Hartmann S, Küppers R. (2010) Hodgkin lymphoma. Chapter 34. p 143-155; in The Lymphoid Neoplasms, 3rd Edition Edited by I. Magrath, K. Bathia, P. Boffetta, C. Deardon, V. Diehl, R. Gascoyne, H.K. Müller-Hermelink, M. Potter, A.Z. Rohatiner. Hodder Education, London, UK Küppers R. (2010) Overview of the immune system. Chapter 9. p. 587-607; in The Lymphoid Neoplasms, 3rd Edition; Edited by I. Magrath, K. Bathia, P. Boffetta, C. Deardon, V. Diehl, R. Gascoyne, H.K. Müller-Hermelink, M. Potter, A.Z. Rohatiner. Hodder Education, London, UK Stanelle J, Döring C, Hansmann M-L, Küppers R. (2010) Mechanisms of aberrant GATA-3 expression in classical Hodgkin lymphoma and its consequences for the cytokine profile of Hodgkin and Reed/Sternberg cells. Blood, 116, 4202-4211 Montesinos-Rongen M, Schmitz R, Brunn A, Gesk S, Richter J, Hong K, Wiestler OD, Siebert R, Küppers R, Deckert M. (2010) Mutations of CARD11 but not TNFAIP3 may activate the NF-kappaB pathway in primary CNS lymphoma. Acta Neuropathol., 120, 529-535 Schmidt A, Schmitz R, Giefing M, Martin-Subero JI, Gesk S, Vater I, Massow A, Maggio E, Schneider M, Hansmann M-L, Siebert R, Küppers R. (2010) Rare occurrence of biallelic CYLD gene mutations in classical Hodgkin lymphoma, Genes Chrom. Cancer, 48, 803-809 Küppers R. (2010) Genomic imbalances in Hodgkin lymphoma. Blood, 116, 309-311 (Commentary) Nückel H, Switala M, Sellmann L, Horn PA, Dürig J, Dührsen U, Küppers R, Grosse-Wilde H, Rebmann V. (2010) The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia. Leukemia, 24, 1152-1159 Küppers R. (2010) Side population cells in Hodgkin lymphoma. Leukemia Lymphoma, 51,741-742 (Commentary) Müller C, Siemer D, Lehnerdt G, Lang S, Küppers R. (2010) Molecular analysis of IgD-positive human germinal centres. Int. Immunol., 22, 289-298 Rosenwald A, Küppers R. (2010) Pathologie und molekulare Pathologie des Hodgkin-Lymphoms. Der Onkologe, 16, 9-17 Hartmann S, Gesk S, Scholtysik R, Kreuz M, Bug S, Vater I, Döring C, Cogliatti S, Parrens M, Merlio J-P, Kwiecinska A, Porwit A, Piccaluga PP, Pileri P, Hoefler G, Küppers R, Siebert R, Hansmann M-L. (2010) High resolution SNP array genomic profiling of peripheral T cell lymphomas, not otherwise specified, identifies a subgroup with chromosomal aberrations affecting the REL locus. Br. J. Haematol., 148, 402-412 Schumacher MA, Schmitz R, Brune V, Tiacci E, Döring C, Hansmann M-L, Siebert R, Küppers R. (2010) Mutations in the genes coding for the NF-κB regulating factors IκBα and A20 are uncommon in nodular lymphocyte-predominant Hodgkin lymphoma. Haematologica, 95, 153-157 Küppers R. (2010) Developmental and functional biology of B lymphocytes. In: Non-Hodgkin lymphomas; 2nd ed. (Eds: J.O. Armitage, P.M. Mauch, N.L. Harris, B. Coffier, R. Dalla-Favera) Lippincott Williams & Wilkins, Philadelphia Zenz T, Mertens D, Küppers R, Döhner H, Stilgenbauer S. (2010) From pathogenesis to treatment of chronic lymphocytic leukaemia. Nature Rev. Cancer, 10, 37-50 Schmitz R, Hansmann M-L, Bohle V, Martin-Subero JI, Hartmann S, Mechtersheimer G, Klapper W, Vater I, Giefing M, Gesk S, Stanelle J, Siebert R, Küppers R (2009) TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. J. Exp. Med., 206, 981-989 Martín-Subero JI, Kreuz M, Bibikova M, Bentink S, Ammerpohl O, Wickham-Garcia E, Rosolowski M, Richter J, Lopez-Serra L, Ballestar E, Berger H, Agirre X, Bernd H-W, Calvanese V, Cogliatti SB, Drexler HG, Fan J-B, Fraga M-F, Hansmann M-L, Hummel M, Klapper W, Korn B, Küppers R, MacLeod RA, Möller P, Ott G, Pott C, Prosper F, Rosenwald A, Schwaenen C, Schübeler D, Seifert M, Stürzenhofecker B, Weber M, Wessendorf S, Loeffler M, Trümper L, Stein H, Spang R, Esteller M, Barker D, Hasenclever D, Siebert R. (2009) New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic and transcriptional profiling. Blood, 113, 2488-2497 Küppers R (2009) Biology of Hodgkin lymphoma. Nature Rev. Cancer, 9, 15-27 Schmitz R, Stanelle J, Hansmann M-L, Küppers R. (2009) Pathogenesis of classical and lymphocyte predominant Hodgkin lymphoma. Annu. Rev. Pathol., 4, 151-174 Seifert M, Steimle-Grauer SA, Goossens T, Hansmann M-L, Bräuninger A, Küppers R. (2009) A model for the development of human IgD-only B cells: genotypic analyses suggest their generation in superantigen driven immune responses. Mol. Immunol., 46, 630-639 Brune V, Tiacci E, Pfeil I, Döring C, Eckerle S, van Noesel CJM, Klapper W, Falini B, von Heydebreck A, Metzler D, Bräuninger A, Hansmann M-L, Küppers R. (2008) Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis. J. Exp. Med., 205, 2251-2268 Küppers R. (2008) Memory B cells of a special kind. Immunol. Cell Biol., 86, 635-636 (News and Commentary Szymanowska N, Klapper W, Gesk S, Küppers R, Martín-Subero JI, Siebert R. (2008) BCL2 and BCL3 are recurrent translocation partners of the IGH locus in classical Hodgkin lymphoma. Cancer Genetics Cytogenetics, 186, 110-114 Tiacci E, Brune V, Küppers R. (2008) Aspects of gene expression in B cell lymphomas. In: Microarrays in inflammation (Series: Progress in Inflammation Research) Editors: Bosio, A, Gerstmayer, B. Birkhäuser-Verlag, Basel, Switzerland Hartmann S, Martin-Subero JI, Gesk S, Hüsken J, Giefing M, Nagel I, Riemke J, Chott A, Klapper W, Parrens M, Küppers R, Bräuninger A, Siebert R, Hansmann ML. (2008) Detection of genomic imbalances in microdissected Hodgkin- and Reed-Sternberg cells of classical Hodgkin lymphoma by array based comparative genomic hybridization. Haematologica, 93, 1318-1326 Giefing M, Arnemann J, Martin-Subero JI, Nieländer I, Bug S, Hartmann S, Arnold N, Tiacci E, Frank M, Hansmann ML, Küppers R, Siebert R. (2008) Identification of candidate tumor suppressor gene loci for Hodgkin and Reed-Sternberg cells by characterization of homozygous deletions in classical Hodgkin lymphoma cell lines. Br. J. Haematol., 142, 916-924 Courts C, Montesinos-Rongen M, Brunn A, Bug S, Siemer D, Hans V, Blümcke I, Klapper W, Schaller C, Wiestler OD, Küppers R, Siebert R, Deckert M. (2008) Recurrent inactivation of the PRDM1 gene in primary central nervous system lymphoma. J. Neuropathol. Exp. Neurol., 67, 720-727 Gleissner B, Küppers R, Siebert R, Glass B, Trümper L, Hiddemann W, Dreyling M. (2008) Report of a workshop on malignant lymphoma: a review of molecular and clinical risk profiling. Br. J. Haematol., 142, 176-178 Siemer D, Kurth J, Lang S, Lehnerdt G, Stanelle J, Küppers R. (2008) EBV transformation overrides gene expression patterns of B cell differentiation stages. Mol. Immunol., 45, 3133-3141 Röck J, Schneider E, Grün JR, Grützkau A, Küppers R, Schmitz J, Winkels G. (2007) CD303 (BDCA-2) signals in plasmacytoid dendritic cells by a BCR-like signalosome involving Syk, Slp65 and PLC2. Eur. J. Immunol., 37, 3564-3575 Sellmann L, Gesk S, Walter C, Ritgen M, Harder L, Martín-Subero JI, Schroers R, Siemer D, Nückel H, Dyer MJS, Dührsen U, Siebert R, Dürig J, Küppers R. (2007) Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B-chronic lymphocytic leukemia. Br. J. Haematol., 138, 217-220 Renné C, Minner S, Küppers R, Hansmann M-L, Bräuninger A. (2008) Autocrine NGF/TRKA signalling is an important survival factor for Hodgkin lymphoma derived cell lines. Leuk. Res., 32, 163-167 Maggio E, Benharroch D, Gopas J, Dittmer U, Hansmann M-L, Küppers R (2007) Absence of measles virus genome and transcripts in Hodgkin-Reed/Sternberg cells of a cohort of Hodgkin lymphoma patients. Int. J. Cancer, 121, 448-453 Küppers R, Re D (2007) Nature of Reed-Sternberg and L&H cells, and their molecular biology in Hodgkin lymphoma. In: Hoppe RT, Armitage JO, Diehl V, Mauch PM, Weiss LM (eds) Hodgkin lymphoma. Lippincott Williams & Wilkins, Philadelphia, 2nd ed., p.73-86 Renné C, Willenbrock K, Martin-Subero JI, Hinsch N, Döring C, Tiacci E, Klapper W, Möller P, Küppers R, Hansmann M-L, Siebert R, Bräuninger A (2007) High expression of several tyrosine kinases and activiation of P13K/AKT pathway in mediastinal large B cell lymphoma reveals further similarities to Hodgkin lymphoma. Leukemia, 21, 780-787 Courts C, Montesinos-Rongen M, Martin-Subero JI, Brunn A, Siemer D, Zühlke-Jenisch R, Pels H, Jürgens A, Schlegel U, Schmidt-Wolf IGH, Schaller C, Reifenberger G, Sabel M, Warnecke-Eberz U, Wiestler OD, Küppers R, Siebert R, Deckert M (2007) Transcriptional profiling of the NF-KB pathway identifies a subgroup of primary lymphoma of the central nervous system with low BCL10 expression. J. Neuropathol. Exp. Neurol., 66, 230-237 Renné C, Hinsch N, Willenbrock K, Fuchs M, Klapper W, Engert A, Küppers R, Hansmann M-L, Bräuninger A (2007) The aberrant expression of several receptor tyrosine kinase is largely restricted to EBV-negative cases of classical Hodgkin lymphoma. Int. J. Cancer, 120, 2504-2509 Kluiver J, Kok K, Pfeil I, de Jong D, Blokzijl T, Harms G, van der Vlies P, Diepstra A, Atayar C, Poppema S, Küppers R, van den Berg A (2007) Global correlation of genome and transcriptome changes in classical Hodgkin lymphoma. Hematol. Oncol., 25, 21-29 Martin-Subero JI, Klapper W, Sotnikova A, Callet-Bauchu E, Harder L, Bastard C, Distler V, Schmitz R, Grohmann S, Höppner J, Riemke J, Barth TFE, Berger F, Bernd H-W, Claviez A, Gesk S, Frank GA, Kaplanskaya IB, Möller P, Parwaresch RM, Rüdiger T, Stein H, Küppers R, Hansmann M-L, Siebert R (2006) Chromosomal breakpoints affecting immunoglobulin loci are recurrent in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma. Cancer Res., 66, 10332-10338 Frey UH, Nückel H, Sellmann L, Bechtel D, Küppers R, Dürig J, Dührsen U, Siffert W (2006) The GNAS1 T393C polymorphism is assiociated with disease progression and survival in chronic lymphocytic leukemia. Clin. Cancer Res., 12, 5686-5692 Renné C, Martin-Subero JI, Eickernjäger M, Hansmann M-L, Küppers R, Siebert R, Bräuninger A (2006) Aberrant expression of ID2, a suppressor of B-cell-specific gene expression, in Hodgkin's lymphoma. Am. J. Pathol., 169, 655-664 Küppers R, Tiacci E (2006) Lymphoma. In: Encyclopedia of Respiratory Medicine. Vol 4, Editors: Geoffrey J. Laurent and Steven D. Shapiro. Academic Press, London, UK, 344-349 Schmitz R, Thomas RK, Harttrampf AC, Wickenhauser C, Schultze JL, Hansmann M-L, Wolf J, Küppers R (2006) The major subtypes of human B cell lymphomas lack mutations in BCL-2 family member BAD. Int. J. Cancer, 119, 1738-1740 Küppers R, Bräuninger A (2006) Reprogramming of tumour B cell phenotypes in Hodgkin lymphoma. Trends Immunol., 27, 203-205 Willenbrock K, Küppers R, Renné C, Brune V, Eckerle S, Weidmann E, Bräuninger A, Hansmann M-L (2006) Common features and differences in the transcriptome of large cell anaplastic lymphoma and classical Hodgkin lymphoma. Haematologica/The Hematology Journal, 91, 596-604 Bräuninger A, Schmitz R, Bechtel D, Renné C, Hansmann M-L, Küppers R (2006) Molecular biology of Hodgkin's and Reed/Sternberg cells in Hodgkin's lymphoma. Int. J. Cancer, 118, 1853-1861 Küppers R, Yahalom J, Josting A (2006) Advances in biology, diagnostics and treatment of Hodgkin's disease. Biol. Blood Marrow Transpl., 12 (Suppl., 1), 66-76 Bechtel D, Kurth J, Unkel C, Küppers R (2005) Transformation of BCR-deficient germinal center B Cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and post transplant lymphoma. Blood, 106, 4345-4350 Willenbrock K, Jungnickel B, Hansmann M-L, Küpper R (2005) Human splenic marginal zone B cells lack expression of activation-induced cytidine deaminase (AID). Eur. J. Immunol., 35, 3002-3007 Re D, Küppers R, Diehl V (2005) Molecular pathogenesis of Hodgkin's lymphoma. J. Clin. Oncol., 23, 6379-6386 Küppers R (2005) Biology of Hodgkin's lymphoma. Haematology (Eur. Hematol. Assos. Edu. Programme), 1, 167-171 Schmitz R, Renné C, Rosenquist R, Tinguely M, Distler V, Menestrina F, Lestani M, Stankovic T, Austen B, Bräuninger A, Hansmann M-L, Küppers R (2005) Insight into the multistep transformation process of lymphomas: IgH-associated translocations and tumor suppressor gene mutations in clonally related composite Hodgkin and non-Hodgkin lymphomas. Leukemia, 19, 1452-1458 Thomas RK, Schmitz R, Harttrampf AC, Hadi AA, Winckenhauser C, Distler V, Hansmann M-L, Schultze JL, Küppers R, Wolf J (2005) Apoptosis-resistant phenotype of classical Hodgkin's lymphoma is not mediated by somatic mutations within the genes encoding for members of the death-inducing signaling complex (DISC). Leukemia, 19, 1079-1082 Küppers R, Schmitz R, Distler V, Renné C, Bräuninger A, Hansmann M-L (2005) Pathogenesis of Hodgkin's lymphoma. Eur. J. Haematol., 75 (Suppl. 66), 26-33 Montesinos-Rongen M, Schmitz R, Stenzel W, Courts C, Bechtel D, Niedobitek G, Blümcke I, Reifenberger G, von Deimling A, Jungnickel B, Wiestler OD, Küppers R, Deckert M (2005) Absence of immunoglobulin class switch in primary lymphomas of the central nervous system. Am. J. Pathol., 166, 1773-1779 Renné C, Willenbrock K, Küppers R, Hansmann M-L, Bräuninger A (2005) Autocrine- and paracrine-activated receptor tyrosine kinases in classic Hodgkin lymphoma. Blood, 105, 4051-4059 Küppers R (2005) Mechanisms of B cell lymphoma pathogenesis. Nature Rev. Cancer, 5, 251-262 Küppers R, Hansmann M-L (2005) The Hodgkin and Reed-Sternberg cell. Int. J. Biochem. Cell Biol., 37, 511-517 Küppers R (2004) Prognosis in follicular lymphoma - it's in the microenvironment (Perspective). N. Engl. Med., 351, 2152-2153 Rosenquist R, Roos G, Erlanson M, Küppers R, Bräuninger A, Hansmann ML (2004) Clonally related splenic marginal zone lymphoma and Hodgkin lymphoma with unmutated V gene rearrangements and a 15-yr time gap between diagnosis. Eur. J. Haematol., 73, 210-214 Thomas RK, Wickenhauser C, Tawadros S, Diehl V, Küppers R, Jürgen Wolf J, Schmitz R (2004) Mutational analysis of the IkBa gene in activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL). Br. J. Haematol., 126, 50-54 Küppers R (2004) Molecular single cell PCR analysis of rearranged immunoglobulin genes as a tool to determine the clonal composition of normal and malignant human B cells. Meth. Mol. Biol. , 271, 225-238 Rosenquist R, Menestrina F,Lestani M, Küppers R, Hansmann M-L, Bräuninger A (2004) Indications for peripheral light-chain revision and somatic hypermutation without a functional B-cell receptor in precursors of a composite diffuse large B-cell and Hodgkin lymphoma. Lab. Invest., 84, 253-262 Küppers R, Rajewsky K (2003) Developmental and functional biology of B lymphocytes. In: Non-Hodgkin's lymphomas (Eds: P.M. Mauch, J.O. Armitage, N.L. Harris, B. Coffier, R. Dalla-Favera) Lippincott Williams & Wilkins, Baltimore Falini B, Tiacci E, Pucciarini A, Bigerna B, Kurth J, Hatzivassiliou G, Droetto S, Galletti BV, Gambacorta M, Orazi A, Pasqualucci L, Miller I, Küppers R, Dalla-Favera R, Cattoretti G (2003) Expression of the IRTA1 receptor identifies intra-epithelial and sub-epithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT). Blood, 102, 3684-369 Tinguely M, Rosenquist R, Sundström C, Amini R-M, Küppers R, Hansmann M-L, Bräuninger A (2003) Analysis of a clonally related mantle cell and Hodgkin lymphoma indicates Epstein-Barr virus infection of a Hodgkin/Reed-Sternberg cell precursor in a germinal center. Am. J. Surg. Pathol., 27, 1483-1488 Küppers R (2003) B cells under influence: transformation of B cells by Epstein-Barr virus. Nature Rev. Immunol. 3, 801-812 Bräuninger A, Spieker T, Mottok A, Baur AS, Küppers R, Hansmann M-L (2003) Epstein-Barr virus (EBV)-positive lymphoproliferations in post-transplant patients show immunoglobulin V gene mutation patterns suggesting interference of EBV with normal B cell differentiation processes. Eur. J. Immunol., 33, 1593-1602 Küppers R, Rajewsky K, Staratschek-Jox A, Wolf J, Diehl V (2003) Morbus Hodgkin. In: Molekularmedizinische Grundlagen von hämatologischen Neoplasien (Eds: Ganten, Ruckpaul) Springer Verlag, Berlin, Heidelberg, 479-494 Schwering I, Bräuninger A, Distler V, Jesdinsky J, Diehl V, Hansmann M-L, Rajewsky K, Küppers R (2003) Gene expression profiling of the Hodgkin's lymphoma cell line L1236 and germinal center B cells for the identification of Hodgkin's lymphoma-specific genes. Mol. Med., 9, 85-95 Küppers R (2003) Somatic hypermutation and B cell receptor selection in normal and transformed human B cells. In: Immune mechanisms and disease, (Eds: N. Chiorazzi et al.) Ann. N. Y. Acad. Sci., 987, 173-179 Kurth J, Hansmann M-L, Rajewsky K, Küppers R (2003) Epstein-Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction. Proc. Natl. Acad. Sci. USA, 100, 4730-4735 (RK and KR share last authorship) Bräuninger A, Wacker H-H, Rajewsky K, Küppers R, Hansmann M-L (2003) Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin´s lymphoma in relation to tumor cells of classical and lymphocyte-predominance Hodgkin´s lymphoma. Cancer Res., 63, 1644-1651 Küppers R, Klein U, Schwering I, Distler V, Bräuninger A, Cattoretti G, Tu Y, Stolovitzky GA, Califano A, Hansmann M-L, Dalla-Favera R (2003) Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling. J. Clin. Invest., 111, 529-537 (RK, UK and IS share first authorship) Schwering I, Bräuninger A, Klein U, Jungnickel B, Tinguely M, Diehl V, Hansmann M-L, Dalla-Favera R, Rajewsky K, Küppers R (2003) Loss of the B lineage-specific gene expression program in Hodgkin and Reed/Sternberg cells of Hodgkins lymphoma. Blood, 101, 1505-1512 Kurth J, Perniok A, Schmitz R, Iking-Konert C, Chiorazzi N, Thompson KM, Winkler T, Rajewsky K, Küppers R (2002) Lack of deleterious somatic mutations in the CD95 gene of plasmablasts from systemic lupus erythematosus patients and autoantibody-producing cell lines. Eur.J.Immunol., 32, 2785-2792 Küppers R, Schwering I, Bräuninger A, Rajewsky K, Hansmann M-L (2002) Biology of Hodgkin's lymphoma. Ann. Oncol., 13, suppl. 1, 11-18 Küppers R, Sonoki T, Satterwhite E, Gesk S, Harder L, Oscier DG, Tucker PW, Dyer MJS, Siebert R (2002) Lack of somatic hypermutation of IG VH genes in lymphoid malignancies with t(2;14)(p13;q32) translocation involving the BCL11A gene. Leukemia, 16, 937-939 Oeschger S, Bräuninger A, Küppers R, Hansmann M-L (2002) Tumor cell dissemination in follicular lymphoma. Blood, 99, 2192-2198 Müschen M, Rajewsky K, Krönke M, Küppers R (2002) The origin of CD95-gene mutations in B-cell lymphoma. Trends Immunol., 23, 75-80 Küppers R (2002) Molecular biology of Hodgkin's lymphoma. Adv. Cancer Res., 84, 277-312 Goossens T, Bräuninger A, Klein U, Küppers R. Rajewsky K (2001) Receptor revision plays no major role in shaping the receptor repertoire of human memory B cells after the onset of somatic hypermutation. Eur.J. Immunol., 31, 3638-3648 Bräuninger A, Goossens T, Rajewsky K, Küppers R (2001) Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the human. Eur.J. Immunol., 31, 3631-3637 Küppers R, Dalla-Favera R (2001) Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene, 20, 5580-5594 Bräuninger A, Spieker T, Willenbrock K, Gaulard P, Wacker HH, Rajewsky K, Hansmann M-L, Küppers R (2001) Survival and clonal expansion of mutating forbidden (immunoglobulin receptor-deficient) Epstein-Barr virus-infected B cells in angioimmunoblastic T cell lymphoma. J. Exp. Med., 194, 927-940 Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti RSK, Küppers R, Dalla-Favera R (2001) Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphoma. Nature, 412, 341-346 Küppers R, Sousa AB, Baur AS, Strickler JG, Rajewsky K, Hansmann M-L (2001) Common germinal-center B-cell origin of the malignant cells in two composite lymphomas, involving classical Hodgkins disease and either follicular lymphoma or B-CLL. Mol. Med., 7, 285-292 (RK und ABS share first authorships) Willenbrock K, Roers A, Seidl C,Wacker HH, Küppers R, Hansmann M-L (2001) Analysis of T-cell subpopulations in T-cell non-Hodgkin's lymphoma of angioimmunoblastic lymphadenopathy with dysproteinemia type by single target gene amplification of T-cell receptor beta gene rearrangements. Am.J.Pathol., 158, 1851-1857 Müschen M, Küppers R, Spieker T, Bräuninger A, Rajewsky K, Hansmann M-L (2001) Molecular single-cell analysis of Hodgkin- and Reed-Sternberg cells harboring unmutated immunoglobulin variable region genes. Lab.Invest., 81, 289-295 Küppers R, Bräuninger A, Müschen M, Distler V, Hansmann M-L, Rajewsky K (2001) Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions. Blood, 97, 818-821 Bräuninger A, Yang W, Wacker H-H, Rajewsky K, Küppers R, Hansman M-L (2001) B cell development in progressively transformed germinal centers: similarities and differences compared with classical germinal centers and lymphocyte predominant Hodgkin disease. Blood, 97, 714-719 Müschen M, Re D, Jungnickel B, Diehl V, Rajewsky K, Küppers R (2000) Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction. J.Exp. Med., 192, 1833-1839 Müschen M, Re D, Bräuninger A, Wolf J, Hansmann M-L, Diehl V, Küppers R, Rajewsky K (2000) Somatic mutations of the CD95 gene in Hodgkin- and Reed-Sternberg cells. Cancer Res., 60, 5640-5643 Spieker T, Kurth J, Küppers R, Rajewsky K, Bräuninger A, Hansmann M-L (2000) Molecular single-cell analysis of the clonal relationship of small Epstein-Barr virus-infected cells and Epstein-Barr virus-harboring Hodgkin and Reed/Sternberg cells in Hodgkin disease. Blood 96, 3133-3138 Kurth J, Spieker T, Wustrow J, Strickler JG, Hansmann M-L, Rajewsky K, Küppers R (2000) EBV-infected B cells in infectious mononucleosis: Viral strategies for spreading in the B cell compartment and establishing latency. Immunity, 13, 485-495 Geiger KD, Klein U, Bräuninger A, Berger S, Leder K, Rajewsky K, Hansmann M-L, Küppers R (2000) CD5-positive B cells in healthy elderly humans are a polyclonal B cell population. Eur.J.Immunol. 30, 2918-2923 Roers A, Hansmann M-L, Rajewsky K, Küppers R (2000) Single cell PCR analysis of T helper cells in human lymph node germinal centers. Am. J. Pathol. 156, 1067-1071 Kanzler H, Küppers R, Helmes S, Wacker HH, Chott A, Hansmann ML, Rajewsky K (2000) Hodgkin and Reed-Sternberg-like cells in B cell chronic lymphocytic leukemia represent the outgrowth of single germinal-center B cell-derived clones: Potential precursors of Hodgkin and Reed-Sternberg cells in Hodgkins disease? Blood 95, 1023-1031 Jungnickel B, Staratschek-Jox A, Bräuninger A, Spieker T, Wolf J, Diehl V, Hansmann M-L, Rajewsky K, Küppers R (2000) Clonal deleterious mutations in the IB gene in the malignant cells in Hodgkins lymphoma. J.Exp.Med. 191, 395-401 Müschen M, Rajewsky K, Bräuninger A, Baur AS, Oudejans JJ, Roers A, Hansmann ML, Küppers R (2000) Rare occurrence of classical Hodgkins disease as a T cell lymphoma. J.Exp.Med. 191, 387-394 Montesinos-Rongen M, Küppers R, Schlüter D, Spieker T, van Roost D, Schaller C, Reifenberger G, Wiestler OD, Deckert-Schlüter M (1999) Primary central nervous system lymphomas are derived from germinal center B cells and show a preferential usage of the V4-34 gene segment. Am. J. Pathol. 155, 2077-2086 Küppers R, Klein U, Hansmann ML, Rajewsky K (1999) Cellular origin of human B cell lymphomas. New Engl. J. Med. 341, 1520-1529 Montesinos-Rongen M, Roers A, Küppers R, Rajewsky K, Hansmann ML (1999) Mutations of the p53 gene are not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin's disease. Blood 94, 1755-1760 Küppers R (1999) Identifying the presursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease: Role of the germinal center in B cell lymphomagenesis. J. Acq. Immune Def. Syndr. 21, S74-S79 Jox A, Zander T, Küppers R, Irsch J, Kanzler H, Kornacker M, Bohlen H, Diehl V, Wolf J (1999) Somatic mutations within the untranslated regions of rearranged Ig genes in a case of classical Hodgkin's disease as a potential cause for the absence of Ig in the lymphoma cells. Blood 93, 3964-3972 Küppers R, Goossens T, Klein U (1999) The role of somatic hypermutation in the generation of deletions and duplications in human Ig V region genes and chromosomal translocations. Curr. Top. Microbiol. Immunol. 246, 193-198 Klein U, Rajewsky K, Küppers R (1999) Phenotypic and molecular characterization of human peripheral blood B-cell subsets with special reference to N-region addition and J usage in VJ-joints and /-ratios in naive versus memory B-cell subsets to identify traces of receptor editing processes. Curr. Top. Microbiol. Immunol. 246, 141-146 Bräuninger A, Hansmann ML, Strickler JG, Dummer R, Burg G, Rajewsky K, Küppers R (1999) Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and B cell Non Hodgkin's lymphoma. N. Engl. J. Med. 340, 1239-1247 Bräuninger A, Küppers R, Spieker T, Siebert R, Strickler JG, Schlegelberger B, Rajewsky K, Hansmann ML (1999) Molecular analysis of single B cells from T cell-rich B cell lymphoma reveals the derivation of the tumor cells from mutating germinal center B cells and exemplifies means by which immunoglobulin genes are modified in germinal center B cells. Blood 93, 2679-2687 Küppers R, Hansmann ML, Rajewsky K (1998) Clonality and germinal centre B-cell derivation of Hodgkin/Reed-Sternberg cells in Hodgkin's disease. Ann.Oncol. 9, S17-S20 Klein U, Rajewsky K, Küppers R (1998) Human immunoglobulin (Ig) M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated V region genes: CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med. 188, 1679-1689 Vockerodt M, Soares M, Kanzler H, Küppers R, Kube D, Hansmann, ML, Diehl V, Tesch H (1998) Detection of clonal Hodgkin and Reed-Sternberg cells with identical somatically mutated and rearranged VH genes in different biopsies in relapsed Hodgkin's disease. Blood 92, 2899-2907 Pasqualucci L, Migliazza A, Fracchiolla N, William C, Neri A, Baldini L, Chaganti, RSK, Klein U, Küppers R, Rajewsky K, Dalla-Favera R (1998) BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc. Natl. Acad. Sci. USA 95, 11816-11821 Fischer M, Küppers R (1998) Human IgA and IgM secreting intestinal plasma cells carry heavily mutated VH region genes. Eur. J. Immunol. 28, 2971-2977 Irsch J, Nitsch S, Hansmann, ML, Rajewsky K, Tesch H, Diehl V, Jox A, Küppers R, Radbruch A (1998) Isolation of viable Hodgkin and Reed-Sternberg cells from Hodgkin disease tissues. Proc. Natl. Acad. Sci. USA 95, 10117-10122 (RK und AR share last authorships) Roers A, Montesinos-Rongen M, Hansmann ML, Rajewsky K, Küppers R (1998) Amplification of TCR gene rearrangements from micromanipulated single cells: T cells rosetting around Hodgkin and Reed-Sternberg cells in Hodgkin's disease are polyclonal. Eur. J.Immunol. 28, 2424-2431 Klein U, Goossens, T, Fischer M, Kanzler H, Braeuninger A, Rajewsky K, Küppers R (1998) Somatic hypermutation in normal and transformed human B cells. Immunol.Rev. 162, 261-280 Küppers R, Rajewsky K (1998) The origin of Hodgkin and Reed/Sternberg cells in Hodgkin's disease. Annu.Rev.Immunol. 16, 471-493 Jox A, Zander T, Kornacker M, Kanzler H, Küppers R, Diehl V, Wolf J (1998) Detection of identical Hodgkin-Reed Sternberg cell specific immunoglobulin gene rearrangements in a patient with Hodgkin's disease of mixed cellularity subtype at primary diagnosis and in relapse two and and a half years later. Ann.Oncol. 9, 283-287 Küppers R, Rajewsky K, Braeuninger A, Hansmann ML (1998) L&H cells in lymphocyte-predominant Hodgkin's disease. (Letter to the Editor). N.Engl.J.Med. 338, 763-764 Goossens T, Klein U, Küppers R (1998) Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease. Proc.Natl.Acad.Sci. USA 95, 2463-2468 Küppers R, Kanzler H, Rajewsky K, Hansmann ML (1997) Molekulare Analyse der Hodgkin- und Reed/Sternberg-Zellen des Morbus Hodgkin mittels Mikromanipulation und Einzelzell-PCR. Maligne Lymphome Hrsg. Höffkes HG, Uppenkamp M, Springer Verlag Fischer M, Klein U, Küppers R (1997) Molecular single cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vgenes lacking somatic mutation. J.Clin.Invest. 100, 1667-1676 Braeuninger A, Küppers R, Strickler JG, Wacker HH, Rajewsky K, Hansmann ML (1997) Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin's disease represent clonal populations of germinal-center derived tumor cells. Proc.Natl.Acad.Sci. USA 94, 9337-9342 (AB und RK share first authorship) Küppers R, Roers A, Kanzler H (1997) Molecular single cell studies of normal and transformed lymphocytes.Cancer Surveys 30, 45-58 Rajewsky K, Kanzler H, Hansmann ML, Küppers R (1997) Normal and malignant B-cell development with special reference to Hodgkin's disease. Ann.Oncol. 8, S79-S81 (Suppl. 2) Küppers R, Rajewsky K, Hansmann ML (1997) Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression. Eur.J.Immunol 27, 1398-1405 Klein U, Küppers R, Rajewsky K (1997) Evidence for a large compartment of IgM-expressing memory B cells. Blood 89, 1288-1298 Küppers R, Hansmann ML, Rajewsky K (1997) Micromanipulation and PCR analysis of single cells from tissue sections. Handbook of Exp. Immunol. 5th ed., Eds. D.M.Weir, C.Blackwell, L.A.Herzenberg, L.A.Herzenberg, Blackwell Scientific. Kanzler H, Küppers R, Hansmann ML, Rajewsky K (1996) Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J.Exp.Med. 184, 1495-1505 (HK und RK share first authorship) Hansmann ML, Küppers R (1996) Pathology and Molecular Histology of Hodgkin's disease and the border to Non-Hodgkin lymphomas. Baillieres Clin.Haematol. 9, 459-477 Küppers R, Hajadi M, Plank L, Rajewsky K, Hansmann ML (1996) Molecular Ig gene analysis reveals that monocytoid B-cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and indicates that rearrangement of the kappa deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human. Eur.J.Immunol. 26, 1794-1800 Küppers R, Kanzler H, Hansmann ML, Rajewsky K (1996) Single cell analysis of Hodgkin/Reed-Sternberg cells. Ann.Oncol. 7, S27-S30 Kanzler H, Hansmann ML, Kapp U, Wolf J, Diehl V, Rajewsky K, Küppers R (1996) Molecular single cell analysis demonstrates the derivation of a peripheral blood-derived cell line (L1236) from the Hodgkin/Reed-Sternberg cells of a Hodgkin's lymphoma patient. Blood 87, 3429-3436 Küppers R, Kanzler H, Hansmann ML, Rajewsky K (1996) Immunoglobulin V genes in Reed-Sternberg cells (Letter to the Editor). N.Engl.J.Med. 334, 404 Küppers R, Willenbrock K, Rajewsky K, Hansmann ML (1995) Detection of clonal lambda light chain gene rearrangements in frozen and paraffin-embedded tissues by polymerase chain reaction. Am.J.Pathol .147, 806-814 Franzen C, Küppers R, Müller A, Salzberger B, Fätkenheuer G, Vetten B, Diehl V, Schrappe M (1995) Genetic evidence for latent Septata intestinalis infection in human immunodeficiency virus-infected patients with intestinal microsporidiosis. J. Infect. Dis. 173, 1038-1040 Klein U, Klein G, Ehlin-Henriksson B, Rajewsky K, Küppers R (1995) Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes. Molec.Med. 1, 495-505 Küppers R, Hansmann ML, Diehl V, Rajewsky K (1995) Molecular single cell analysis of Hodgkin and Reed-Sternberg cells. Molec.Med.Today 1, 26-30. Ehlich A, Küppers R (1995) Analysis of immunoglobulin gene rearrangements from single B cells. Curr.Opin.Immunol. 7, 281-284. Küppers R, Rajewsky K, Zhao M, Simons G, Laumann R, Fischer R, Hansmann ML (1994) Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc.Natl.Acad.Sci. USA 91, 10962-10966. Klein U, Küppers R, Rajewsky K (1994) Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age. J.Exp.Med. 180, 1383-1393. |
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