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Struktur des IFZ Forschung im IFZ Mitarbeiter Leistungen aus dem IFZ Seminare Stellenangebote Links IFZ-Fördervereinigung Informationen: Ph. D. Thesis (Dr. rer. nat.) |
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KONTAKT IMPRESSUM |
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Publikationen (2000 - 2008) |
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Vlad A, Röhrs S, Klein-Hitpass L, Müller O. (2008) The first five years of the Wnt targetome. Cell Signal. 2008 May;20(5):795-802. Epub 2007 Nov 17. PMID: 18160255 Schilling T, Küffner R, Klein-Hitpass L, Zimmer R, Jakob F, Schütze N. (2008) Microarray analyses of transdifferentiated mesenchymal stem cells. J Cell Biochem. 2008 Feb 1;103(2):413-33. PMID: 17610236 Schulte JH, Horn S, Otto T, Samans B, Heukamp LC, Eilers UC, Krause M, Astrahantseff K, Klein-Hitpass L, Buettner R, Schramm A, Christiansen H, Eilers M, Eggert A, Berwanger B. (2008) MYCN regulates oncogenic MicroRNAs in neuroblastoma. Int J Cancer. 2008 Feb 1;122(3):699-704. PMID: 17943719 Grigo K, Wirsing A, Lucas B, Klein-Hitpass L, Ryffel GU. (2008) HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells. Biol Chem. 2008 Feb;389(2):179-87. PMID: 18163890 Schubert SW, Lamoureux N, Kilian K, Klein-Hitpass L, Hashemolhosseini S. (2008) Identification of Integrin-{alpha}4, Rb1, and Syncytin A as Murine Placental Target Genes of the Transcription Factor GCMa/Gcm1. J Biol Chem. 2008 Feb 29;283(9):5460-5. Epub 2007 Dec 31. PMID: 18167345 Koldehoff M, Zakrzewski JL, Klein-Hitpass L, Beelen DW, Elmaagacli AH. (2008) Gene profiling of growth factor independence 1B gene (Gfi-1B) in leukemic cells. Int J Hematol. 2008 Jan;87(1):39-47. Epub 2007 Dec 6. PMID: 18224412 Schilling T, Nöth U, Klein-Hitpass L, Jakob F, Schütze N. (2007) Plasticity in adipogenesis and osteogenesis of human mesenchymal stem cells. Mol Cell Endocrinol. 2007 Jun 15;271(1-2):1-17 PMID: 17475397 Knauer SK, Bier C, Schlag P, Fritzmann J, Dietmaier W, Rodel F, Klein-Hitpass L, Kovacs AF, Doring C, Hansmann ML, Hofmann WK, Kunkel M, Brochhausen C, Engels K, Lippert BM, Mann W, Stauber RH (2007) The Survivin Isoform Survivin-3B is Cytoprotective and can Function as a Chromosomal Passenger Complex Protein Cell Cycle. 2007 Apr 15;6(12) [Epub ahead of print] PMID: 17582222 Lu H, Chen J, Planko L, Zigrino P, Klein-Hitpass L, Magin TM. (2007) Induction of Inflammatory Cytokines by a Keratin Mutation and their Repression by a Small Molecule in a Mouse Model for EBS. J Invest Dermatol. 2007 Jun 21; [Epub ahead of print] Related Articles, LinkOut PMID: 17581617 Schilling T, Kuffner R, Klein-Hitpass L, Zimmer R, Jakob F, Schütze N. (2007) Microarray analyses of transdifferentiated mesenchymal stem cells. J Cell Biochem. 2007 Jul 3; [Epub ahead of print] PMID: 17610236 Dürig J, Bug S, Klein-Hitpass L, Boes T, Jons T, Martin-Subero JI, Harder L, Baudis M, Dührsen U, Siebert R. (2007) Combined single nucleotide polymorphism-based genomic mapping and global gene expression profiling identifies novel chromosomal imbalances, mechanisms and candidate genes important in the pathogenesis of T-cell prolymphocytic leukemia with inv(14)(q11q32). Leukemia. 2007 Aug 16; [Epub ahead of print] PMID: 17713554 Hoppeler-Lebel A, Celati C, Bellett G, Mogensen MM, Klein-Hitpass L, Bornens M, Tassin A-M (2007) Centrosomal CAP350 protein stabilizes microtubles associated with the Golgi complex. J Cell Science 120 (18), 3299-3308 PMID: 17878239 Schulte JH, Horn S, Otto T, Samans B, Heukamp LC, Eilers UC, Krause M, Astrahantseff K, Klein-Hitpass L, Buettner R, Schramm A, Christiansen H, Eilers M, Eggert A, Berwanger B. MYCN regulates oncogenic MicroRNAs in neuroblastoma. Int J Cancer. 2007 Oct 17; [Epub ahead of print] Pargmann D, Yücel R, Kosan C, Saba I, Klein-Hitpass L, Schimmer S, Heyd F, Dittmer U, Möröy T. (2007) Differential impact of the transcriptional repressor Gfi1 on mature CD4(+) and CD8(+) T lymphocyte function. Eur J Immunol. 2007 Nov 22 PMID: 18034420 Van Langendonckt A, Punyadeera C, Kamps R, Dunselman G, Klein-Hitpass L, Schurgers LJ, Squifflet J, Donnez J, Groothuis P. (2007) Identification of novel antigens in blood vessels in rectovaginal endometriosis. Mol Hum Reprod. 2007 Dec;13(12):875-86. Epub 2007 Nov 6. PMID: 17989082 Erdmann S, Senkel S, Arndt T, Lucas B, Lausen J , Klein-Hitpass L, Ryffel GU, Thomas H (2007) Tissue-specific transcription factor HNF4alpha inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 beta-cell line. Biol Chem. 2007 Jan;388(1):91-106 Gratias S, Rieder H, Ullmann R, Klein-Hitpass L, Schneider S, Boloni R, Kappler M, Lohmann DR (2007) Allelic loss in a minimal region on chromosome 16q24 is associated with vitreous seeding of retinoblastoma. Cancer Res. 2007 Jan 1;67(1):408-16 Eisele L, Klein-Hitpass L, Chatzimanolis N, Opalka B, Boes T, Seeber S, Moritz T, Flasshove M (2006) Differential Expression of Drug Resistance-Related Genes between Sensitive and Resistant Blasts in Acute Myeloid Leukemia. Acta Haematol. 2006 Nov 8;117(1):8-15 [Epub ahead of print] PMID: 17095854 Knauer SK, Kramer OH, Knosel T, Engels K, Rodel F, Kovacs AF, Dietmaier W, Klein-Hitpass L, Habtemichael N, Schweitzer A, Brieger J, Rodel C, Mann W, Petersen I, Heinzel T, Stauber RH (2006) Nuclear export is essential for the tumor-promoting activity of survivin. FASEB J. 2006 Nov 10; [Epub ahead of print] Hüttmann A, Klein-Hitpass L, Thomale J, Deenen R, Carpinteiro A, Nuckel H, Ebeling P, Fuhrer A, Edelmann J, Sellmann L, Dührsen U, Dürig J (2006) Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status. Leukemia. 2006 Oct;20(10):1774-82. Epub 2006 Aug 17. PMID: 16932341 Woenckhaus M, Klein-Hitpass L, Grepmeier U, Merk J, Pfeifer M, Wild P, Bettstetter M, Wuensch P, Blaszyk H, Hartmann A, Hofstaedter F, Dietmaier W (2006) Smoking and cancer-related gene expression in bronchial epithelium and non-small-cell lung cancers. J Pathol. 2006 Oct;210(2):192-204. PMID: 16915569 Welters H J, Senkel S, Klein-Hitpass L, Erdmann S, Thomas H, Harries LW, Pearson ER, Bingham C, Hattersley AT, Ryffel GU, Morgan NG (2006) Conditional expression of hepatocyte nuclear factor-1{beta}, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic {beta}-cells J Endocrinol , 190, 171-181 Hüttmann A, Dührsen U, Heydarian K, Klein-Hitpass L, Boes T, Boyd AW, Li CL (2006). Gene expression profiles in murine hematopoietic stem cells revisited: analysis of cDNA libraries reveals high levels of translational and metabolic activities. Stem Cells, 24, 1719-1727 Nückel H, Hüttmann A, Klein-Hitpass L, Schroers R, Fuhrer A, Sellmann L, Dührsen U, Dürig J (2006) Lipoprotein lipase expression is a novel prognostic factor in B-cell chronic lymphocytic leukemia. Leuk Lymphoma, 47(6), 1053-61. Schulte JH, Schramm A, Klein-Hitpass L, Klenk M, Wessels H, Hauffa BP, Eils J, Eils R, Brodeur GM, Schweigerer L, Havers W, Eggert A. (2005) Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas. Oncogene, 24(1), 165-77. Gruemmer R, Klein-Hitpaß L, Neulen J (2005) Regulation of gene expression in endothelial cells: the role of human follicular fluid. J. Mol. Endocrinology 34, 37-46 Ziegler S, Rohrs S, Tickenbrock L, Möröy T, Klein-Hitpass L, Vetter IR, Müller O (2005) Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation. FEBS J., 272(7), 1600-15. Schroers R, Griesinger F, Trumper L, Haase D, Kulle B, Klein-Hitpass L, Sellmann L, Dührsen U, Dürig J (2005) Combined analysis of ZAP-70 and CD38 expression as a predictor of disease progression in B-cell chronic lymphocytic leukemia. Leukemia,19(5), 750-8. Elmaagacli AH, Koldehoff M, Peceny R, Klein-Hitpass L, Ottinger H, Beelen DW, Opalka B (2005) WT1 and BCR-ABL specific small interfering RNA have additive effects in the induction of apoptosis in leukemic cells. Haematologica, 90(3), 326-34. Gratias S, Schuler A, Klein-Hitpass L, Stephan H, Rieder H, Schneider S, Horsthemke B, Lohmann DR (2005) Genomic gains on chromosome 1q in retinoblastoma: Consequences on gene expression and association with clinical manifestation. Int J Cancer., 10, 116(4), 555-63. Grasemann C, Gratias S, Stephan H, Schüler A, Schramm A, Klein-Hitpass L, Rieder H, Schneider S, Kappes F, Eggert A, Lohmann DR (2005) Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma. Oncogene, 24, 6441-6449 Lucas B, Grigo K, Erdmann S, Lausen J, Klein-Hitpass L, Ryffel GU (2005) HNF4α reduces proliferation of kidney cells and affects genes deregulated in renal cell Carcinoma. Oncogene, 24, 6418-6431 Croner RS, Peters A, Brueckl WM, Matzel KE, Klein-Hitpass L, Brabletz T, Papadopoulos T, Hohenberger W, Reingruber B, Lausen B (2005) Microarray versus conventional prediction of lymph node metastasis in colorectal carcinoma. Cancer 104 (2), 395-404 Schramm A, Schulte JH, Klein-Hitpass L, Havers W, Sieverts H, Berwanger B, Christiansen H, Warnat P, Brors B, Eils J, Eils R, Eggert A (2005) Prediction of clinical outcome and biological characterization of neuroblastoma by expression profiling. Oncogene 24, 7902-7912 Raudies O, Kuban RJ, Hamacher F, Klein-Hitpass L, Tchernitsa OI, Sers C, Herzel HP, Schafer R. (2005) Functional analysis and secondary expression profiling of candidate genes deregulated in conjunction with oncogenic Ras signaling. Adv Enzyme Regul. 45, 63-84 Lehnhardt M, Klein-Hitpass L, Kuhnen C, Homann HH, Daigeler A, Steinau HU, Roehrs S, Schnoor L, Steinstraesser L, Mueller O. (2005) Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancerl, 7, 5:74. Gashaw I, Grummer R, Klein-Hitpass L, Dushaj O, Bergmann M, Brehm R, Grobholz R, Kliesch S, Neuvians TP, Schmid KW, Ostau CV, Winterhager E. (2005) Gene signatures of testicular seminoma with emphasis on expression of ets variant gene 4. Cell Mol Life Sci. 62, 2359-2368 Bracker TU, Giebel B, Spanholtz J, Sorg UR, Klein-Hitpass L, Moritz T, Thomale J (2005) Stringent regulation of DNA repair during human hematopoietic differentiation: a gene expression and functional analysis. Stem Cells. 29 [Epub ahead of print] Klein-Hitpass L, Möröy, T (2005) Affymetrix GeneChip Analyses: The Impact Of RNA Quality. In: DNA Microarrays (Edited by U. Nuber). Taylor & Francis, London ISBN 0415358663 Senkel S, Lucas B, Klein-Hitpass L, Ryffel GU (2005) Identification of target genes of the transcription factor HNF1beta and HNF1alpha in a human embryonic kidney cell line. Biochim Biophys Acta. 2005, 1731(3):179-90 Gellhaus A, Dong X, Propson S, Maass K, Klein-Hitpass L, Kibschull M, Traub O, Willecke K, Perbal B, Lye SJ, Winterhager E. (2004) Connexin43 interacts with NOV: A possible mechanism for negative regulation of cell growth in choriocarcinoma cells. J Biol Chem., 279, 36931-36942 Rother K, Johne C, Spiesbach K, Haugwitz U, Tschop K, Wasner M, Klein-Hitpass L, Möröy T, Mossner J, Engeland K. (2004) Identification of Tcf-4 as a transcriptional target of p53 signalling. Oncogene,.23(19):3376-84 Müller O, Gourzoulidou E, Carpintero M, Karaguni IM, Langerak A, Herrmann C, Möröy T, Klein-Hitpass L, Waldmann H. (2004) Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening. Angew Chem Int Ed Engl., 16;43(4):450-4. Croner RS, Foertsch T, Brueckl WM, Guenther K, Siebenhaar R, Stremmel C, Matzel KE, Papadopoulos T, Kirchner T, Behrens J, Klein-Hitpass L, Stuerzl M, Hohenberger W, Reingruber B. (2004) Common denominator genes that distinguish colorectal carcinoma from normal mucosa. Int J Colorectal Dis. 2004 Dec 22 Thomas H, Senkel S, Erdmann S, Arndt T, Turan G, Klein-Hitpass L, Ryffel GU. (2004) Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line. Nucleic Acids Res. 2004 Nov 01;32(19):e150. Zeng H, Yücel R, Kosan C, Klein-Hitpass L, Möröy T. (2004) Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J. 2004 Oct 13;23(20):4116-25. Epub 2004 Sep 23. Karaguni IM, Gourzoulidou E, Carpintero M, Langerak A, Klein-Hitpass L, Möröy T, Winde G, Waldmann H, Müller O. (2004) SMAF-1 inhibits the APC/beta-catenin pathway and shows properties similar to those of the tumor suppressor protein APC. Chembiochem. 2004 Sep 6;5(9):1267-70. Chen J, Rocken C, Klein-Hitpass L, Gotze T, Leodolter A, Malfertheiner P, Ebert MP (2004) Microarray analysis of gene expression in metastatic gastric cancer cells after incubation with the methylation inhibitor 5-aza-2'-deoxycytidine. Clin Exp Metastasis. 2004;21(5):389-97. Yücel, R., Karsunky, H., Klein-Hitpass L., Möröy, T (2003) The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus. J. Exp. Med. 197, 1-15 Dürig J, Nückel H, Cremer M, , Führer A, Halfmeyer K, Fandrey J, Möröy T, Klein-Hitpass L, Dührsen U (2003) ZAP-70 expression is a prognostic factor in chronic lymphatic leukemia Leukemia 17, 2426-2434 Horsthemke B, Nazlican H, Hüsing J, Klein-Hitpass L, Claussen U, Michel S, Lich C, Gillessen-Kaesbach G, Buiting K (2003) Somatic mosaicism for maternal uniparental disomy 15 in a girl with Prader-Willi syndrome: confirmation by cell cloning and identification of candidate downstream genes. Hum Mol Genet. Scheinert P, Klein-Hitpass L, Krupp P (2003) Innovation in der RNA-Amplifikation: Eine neue Methode zur ursprungsgetreuen Amplifikation von geringen mRNA-Mengen. Biospektrum Sonderausgabe 2003, 526-527 Schulte JH, Schramm A, Pressel T, Klein-Hitpass L, Kremens B, Eils J, Havers W, Eggert A (2003) Microarray-analysis: a new approach to study the molecular mechanisms of thermo-chemotherapy. Klin. Pädriatr. 2003, 215: 298-302 Duerig J, Nueckel H, Huettmann A, Kruse E, Hoelter T, Halfmeyer K, Fuehrer A, Rudolph R, Kalhori N, Nusch A, Deaglio S, Malavasi F, Moeroey T, Klein-Hitpass L., Duehrsen U (2002) Expression of ribosomal and translation-associated genes is correlated with a favorable clinical course in chronic lymphocytic leukemia. Blood, 101(7), 2748-55 Epub 2002 Nov 27 Klein-Hitpass L, Möröy T (2001) Der Biochip Neue Horizonte in der Prävention, Diagnose und Nachsorge von Tumorerkrankungen. Essener Unikate 15, 12-19 Klein-Hitpass L, Möröy T (2001) DNA-Mikroarrays: eine neue Technologie zuer Erstellung von RNA-Expressionsprofilen auf Genomebene. Biospektrum 2, 150-156 Xu Y, Klein-Hitpass L, Bagchi MK (2000) E1A-mediated repression of progesterone receptor-dependent transactivation involves inhibition of the assembly of a multisubunit coactivation complex. Mol. Cell. Biol. 20, 2138-2146 |
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