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Struktur des IFZ Forschung im IFZ Mitarbeiter Leistungen aus dem IFZ Seminare Stellenangebote Links IFZ-Fördervereinigung Informationen: Ph. D. Thesis (Dr. rer. nat.) |
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Publikationen aus dem DNA Reparatur Labor (1994 - 2010) |
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Aleksunes LM, Goedken MJ, Rockwell CE, Thomale J, Manautu, JE, Klaassen CE (2010) Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity J Pharmacol Exp Ther. 2010 Jul 6. [Epub ahead of print] Geis C, Graulich M, Wissmann A, Hagenacker T, Thomale J, Sommer C, Schäfers M. (2010) Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer pain. Neuroscience. 2010 Aug 11;169(1):463-74. Epub 2010 Apr 24. Oliver TG, Mercer KL, Sayles LC, Burke JR, Mendus D, Lovejoy KS, Cheng MH, Subramanian A, Mu D, Powers S, Crowley D, Bronson RT, Whittaker CA, Bhutkar A, Lippard SJ, Golub T, Thomale J, Jacks T, Sweet-Cordero EA. (2010) Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes Dev;24:837-52. Mohamed D, Mowaka S, Thomale J, Linscheid MW. (2009) Chlorambucil-adducts in DNA analyzed at the oligonucleotide level using HPLC-ESI MS. Chem Res Toxicol.; 22:1435-46. Yoon MZ, Katsarava Z, Obermann M, Schäfers M, Liedert B, Dzagnidze A, Kribben A, Egensperger R. Limmroth V, Diener HC, Thomale J (2009) Erythropoietin overrides the triggering effect of DNA platination products in a mouse model of Cisplatin-induced neuropathy BMC Neurosci. 10:77 Eisele L. Prinz R, Klein-Hitpass L, Thomale J, Möller L, Dührsen U, Dürig J (2009) Combined PER2 and CRY1 expression predicts outcome in chronic lymphocytic leukemia Eur J Haematol. 83:3 Dhar S, Liu Z, Thomale J, Dai H, Lippart S (2008) Targeted single-wall carbon nanotube-mediated PtIV) prodrug delivery using folate as a homing device. J. Am. Chem. Soc., 130:11467-11476 Milsom MD, Jerabek-Willemsen M, Harris CD, Schambach A, Broun E, Bailey J, Jansen M, Schleime D, Nattamai K, Wilhelm J, Watson A, Geiger H, Margison JP, Moritz T, Baum C, Thomale J, Williams, D (2008) Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells. Cancer Res., 68:6171-6180 Dzagnidze A, Katsarava Z, Makhalova J, Liedert B, Yoon M-S, Kaude H, Limmroth V, Thomale J (2007) Repair capacity for platinum-DNA adducts determines the severity of cisplatin-induced peripheral neuropathy. J Neurosci, 27:9451-9457 Sorg UR, Kleff V, Fanaei S, Schumann A, Moellmann M, Opalka B, Thomale J, Moritz T (2007) Hematopoietic stem cell gene therapy utilizing O6-methylguanine-DNA-methyltransferase: Studies addressing safety related issues. DNA Repair, 6:1197-1209 Hüttmann A, Klein-Hitpass L, Thomale J, Deenen R, Carpinteiro A, Nückel H, Führer A, Edelmannn J, Sellmann L, Dührsen U , and Dürig J (2006) Gene signatures separate B-cell chronic lymphocytic leukemia prognostic subgroups defined by ZAP-70 and CD38 expression status. Leukemia, 20:1774-1782 Thomas JP, Lautermann J, Liedert B, Seiler F, Thomale J. High accumulation of platinumDNA adducts in strial marginal cells of the cochlea is an early event in cisplatin but not carboplatin ototoxicity. Mol. Pharmacol. 2006, 70:23-29 Liedert B, Pluim D, Schellens J, Thomale J. Adduct-specific monoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei. Nucleic Acids Res., 2006, 34: e47, 1-12 Bracker TU, Giebel B, Spanholtz J, Sorg UR, Klein-Hitpass L, Moritz, Thomale J. Stringent regulation of DNA repair during human hematopoietic differentiation: a gene expression and functional analysis. Stem Cells, 2006, 24:722-730 Materna V, Liedert B, Thomale J, Lage H. Protection of platinum-DNA adduct formation and reversal of cisplatin resistance by anti-MRP2 hammerhead ribozymes in human cancer cells. Int. J Cancer 2005, 115:393-402 Liedert B, Materna V, Schadendorf D, Thomale J, Lage H. Overexpression of cMOAT (MRP2/ABCC2) is associated with decreased formation of platinum-DNA adducts and decreased G2-arrest in melanoma cells resistant to cisplatin. J Invest Dermatol. 2003 Jul;121(1):172-6. Buschfort-Papewalis C, Moritz T, Liedert B, Thomale J. Down-regulation of DNA repair in human CD34(+) progenitor cells corresponds to increased drug sensitivity and apoptotic response. Blood. 2002 Aug 1;100(3):845-53. Engelbergs J, Thomale J, Rajewsky MF. Role of DNA repair in carcinogen-induced ras mutation. Mutat Res. 2000 May 30;450(1-2):139-53. Rajewsky MF, Engelbergs J, Thomale J, Schweer T. Relevance of DNA repair to carcinogenesis and cancer therapy. Recent Results Cancer Res. 1998;154:127-46. Engelbergs J, Thomale J, Galhoff A, Rajewsky MF. Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1635-40. Buschfort C, Muller MR, Seeber S, Rajewsky MF, Thomale J. DNA excision repair profiles of normal and leukemic human lymphocytes: functional analysis at the single-cell level. Cancer Res. 1997 Feb 15;57(4):651-8 Muller MR, Seiler F, Thomale J, Buschfort C, Rajewsky MF, Seeber S. Capacity of individual chronic lymphatic leukemia lymphocytes and leukemic blast cells for repair of O6-ethylguanine in DNA: relation to chemosensitivity in vitro and treatment outcome. Cancer Res. 1994 Aug 15;54(16):4524-31. Thomale J, Seiler F, Muller MR, Seeber S, Rajewsky MF. Repair of O6-alkylguanines in the nuclear DNA of human lymphocytes and leukaemic cells: analysis at the single-cell level. Br J Cancer. 1994 Apr;69(4):698-705. Thomale J, Hochleitner K, Rajewsky MF. Differential formation and repair of the mutagenic DNA alkylation product O6-ethylguanine in transcribed and nontranscribed genes of the rat. J Biol Chem. 1994 Jan 21;269(3):1681-6 |
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