Laboratory for Toxicological In-vitro-Analyses
|
Here you will find informations about the wide range of services offered by the Laboratory for Toxicological In-vitro-Analyses
Contact
|
 |
|
Investigations of the Toxicity of Substances and Compounds
The implementation of REACH requires a large-scale study of chemicals especially with respect to their cell-damaging, mutagenic and estrogenic properties. In order to meet these requirements, our laboratory offers a variety of toxicological tests on the cell culture level. In-vitro cultivation of mammalian cells provides a suitable testing system for the analyses on the toxicity of substances and compounds, since it is relatively low in effort, time and cost. As a testing system it is to be placed between complex, yet time-intensive, costly and controversial animal experiments and strongly simplifying systems that merely work with components of biological systems such as enzyme extracts.
In order to include a maximum of parameters, we offer various test systems. The analysis begins with the determination of general toxicity. This offers a general toxic profile. The next step is the determination of genetic toxicity, which indicates if the respective substance can cause damage to the DNA. If that is the case, the mutagenicity of the substance is analysed. As a further parameter, the production of cytokines offers insights into a possible immunotoxic potential of the compound. Finally, the estrogenic activity of the compounds in question can also be determined.
The selection of suitable tests can be adapted individually.
|
|
