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Experimental Neurology („Motor Control Laboratory“)
Dagmar Timmann-Braun, MD, Associate Professor
Research Interests
The motor control group is interested in the physiology of the human cerebellum.
A major interest is the involvement of the human cerebellum in different forms of motor and cognitive learning. Questions addressed are whether the cerebellum is involved in particular forms of learning, which cerebellar areas are involved and what the mechanisms of cerebellar involvement are. Another interest is its role in motor coordination. Single and multijoint movements are studied in cerebellar patients. A more recent interest is the study of motor and cognitive impairment in children following acute cerebellar lesions.
In general, patients with defined cerebellar pathology are studied as well as regions of cerebellar activation in healthy subjects using PET and fMRI. A major aim is to correlate the localization of focal cerebellar lesions and extent of atrophy in cerebellar degeneration based on 3D-MRI data sets with findings in neurophysiological and neuropsychological experiments..
Members of the Group (Phone, Email)
Group leader: Dagmar Timmann-Braun, MD, Associate Professor, +49 201 723 3816, Dagmar.Timmann@uni-essen.de
Deputy group leader: Dr. med. Marcus Gerwig,
+49 201 723 3815, Markus.Gerwig@uni-duisburg-essen.de
Group members:
Beate Brol, MTA, +49 201 723 2594, Beate.Brol@uni-essen.de
Dipl.Psych. Barbara Brandauer, Doktorandin (DFG), + 49 201 723 3815,
Barbara.Brandauer@campus.lmu.de
Dipl. Ing. Hans-Gerd Elles, +49 201 723 2594, Hans-Gerd.Elles@uni-essen.de
Dr. med. Markus Frings, +49 201 723 3815, Markus.Frings@uni-essen.de
Nicole Fritsche, Krankengymnastin, +49 201 723 2884,
Nicole.Fritsche@medizin,uni-essen.de
Dipl. Päd. Christoph Hein-Kropp, Sprachheilpädagoge, +49 201 723 2712,
Christoph.Hein-Kropp@uni-essen.de
Dr. med. Kasja Rabe, +49 201 723 3815, kasja.rabe@uni-duisburg-essen.de
Dr. med. Christoph Schorn, +49 201 723 3815, schornc@web.de
Dr. med. Michael Küper, +49 201 723 3815, michaelkueper@web.de
Student help:
Anna Katharina Esser, MS, +49 201 723 2594, Anca.Esser@web.de
Bendikt Frank, +49 201 723 2594, Benedikt.Frank@gmx.net
Medical students:
Bakiye Aslan, Nadia Awad, Raoul Boenisch, Julia Bohrenkämper, Paul Buderath, Uta Bultmann, Kathrin Döring, Maren Erichsen, Anna Esser, Kristina Gärtner, Benedikt Frank, Hanjo Groetschel, Hana Guberina, Karim Hajjar, Aidan Hogan, Olaf Kaiser, Katrin Matthies, Tobias Ohde, Daniela Pierscianek, Sonja Sturm, Dominik Zeljko
Former members and students of the group:
Dr. med. Andrea Banaski; Dr. med. Claudia Belting; Stefanie Bruckmann, MRTA;
Dipl. Psych. Katja Bürgerhoff; Dipl. Psych. Sandra Calabrese; Dr. rer. nat. Albena Dimitrova; Dpl. Psych. Johannes Drepper, Dr. med. Barbara Gorissen; Dr. med. Katharina Haerter; Dr. med. Kerstin Kindsvater; Dr. med. Ulrich Krause; Stefan Kruscona, MRTA; Dr. med. Asha Kunnel; Dr. med. Petra Mummel; Dr. med. Alexandra Ozimek; Chris Plummer, MD; Dr. med. Norman Putzki; Dr. rer. nat. Stefanie Richter; Carmen Riedel, MTA; Dr. med. Achim Schwabe; Gisbert Wortmann
Phone numbers
+49 201 723 3815/ 2594 (Motor Control Laboratory)
+49 201 723 2865 (Beate Brol)
+49 201 723 3816 (Dagmar Timmann-Braun)
Funding
The group is funded since 1995 by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG), intramural funding, the German Heredoataxia Society and the Bernd Fink Foundation.
Recent Publications
Frank B, Schoch B, Hein-Kropp C, Dimitrova A, Hövel M, Ziegler W, Gizewski ER, Richter S, Timmann D. (2007) Verb generation in children and adolescents with acute cerebellar lesions. Neuropsychologia 45: 977-988
Nowak DA, Timmann D, Hermsdörfer J. (2007) Dexterity in cerebellar agenesis. Neuropsychologia 45: 696-703
Dimitrova A, De Greiff A, Schoch B, Gerwig M, Frings M, Gizewski ER, Timmann D. (2006) Activation of cerebellar nuclei comparing finger, foot and tongue movements as revealed by fMRI. Brain Res. Bull. 71: 233-241
Frings M, Dimitrova A, Schorn CF, Elles H-G, Hein-Kropp C, Gizewski ER, Diener HC, Timmann D. (2006) Cerebellar involvement in verb generation: an fMRI study. Neurosci. Lett. 409: 19-23
Gerwig M, Hajjar K, Frings M, Dimitrova A, Thilmann AF, Kolb FP, Forsting M, Timmann D. (2006) Extinction of conditioned eyeblink responses in patients with cerebellar disorders. Neurosci. Lett. 406: 87-91
Frings M, Awad N, Jentzen W, Dimitrova A, Kolb FP, Diener HC, Timmann D, Maschke M. (2006) Involvement of the human cerebellum and brain stem in short-term and long-term habituation of the acoustic startle response: A serial PET study. Clin. Neurophysiol. 117: 1290-1300
Frings M, Maschke M, Gerwig M, Diener HC, Timmann D. (2006) Learning of simple auditory and visual sequences in cerebellar patients. Cerebellum 5: 206-211
Schoch B, Dimitrova A, Gizewski ER, Timmann D. (2006) Functional localization in the human cerebellum based on voxelwise statistical analysis: a study of 90 patients. NeuroImage 30: 36-51
Dimitrova A, Zeljko D, Schwarze F, Redies C, Maschke M, Gerwig M, Frings M, Beck A, Aurich V, Forsting M, Timmann D. (2006) Probabilistic 3D MRI atlas of the human cerebellar nuclei. NeuroImage 30: 12-25
Gerwig M, Haerter K, Hajjar K, Dimitrova A, Maschke M, Kolb FP, Thilmann AF, Gizewski E, Timmann D. (2006) Trace eyeblink conditioning in human subjects with cerebellar lesions. Exp. Brain Res. 170: 7-21
Gizewski ER, Lambertz N, Timmann D, Forsting M. (2005) Differential cerebellar activation patterns in deaf subjects for perception of sign language and written text: correlation with cortical activations. Neuroreport 16: 1913-1917
Richter S, Schoch B, Kaiser O, Groetschel H, Hein-Kropp C, Maschke M, Dimitrova A, Gizewski E, Ziegler W, Karnath HO, Timmann D. (2005) Children and adolescents with chronic cerebellar lesions show no clinically relevant signs of aphasia or neglect. J. Neurophysiol. 94: 4108-4120
Gerwig M, Dimitrova A, Maschke M, Kolb FP, Frings M, Thilmann AF, Forsting M, Diener HC, Timmann D. (2005) Timing of conditioned eyeblink responses is impaired in cerebellar patients. J. Neurosci. 25: 3919-3931
Richter S, Schoch B, Kaiser O, Groetschel H, Dimitrova A, Hein-Kropp C, Maschke M, Gizewski E, Timmann D. (2005) Behavioral and affective changes in children and adolescents with chronic cerebellar lesions. Neurosci. Lett. 381: 102-107
Richter S, Dimitrova A, Maschke M, Gizewski E, Beck A, Aurich V, Timmann D. (2005) Degree of cerebellar ataxia correlates with 3D-MRI based cerebellar volume in pure cerebellar degeneration. Eur. Neurol. 54: 23-27
Konczak J, Schoch B, Dimitrova A, Gizewski E, Timmann D. (2005) Functional recovery of children and adolescents after cerebellar tumour resection.. Brain 128: 1428-1441
Richter S, Dimitrova A, Hein-Kropp C, Wilhelm H, Gizewski E, Timmann D. (2005) Cerebellar agenesis II: Motor and language functions. Neurocase 11: 103-113
Rost K, Nowak DA, Timmann D, Hermsdörfer J. (2005) Preserved and impaired aspects of predictive grip force control in cerebellar patients. Clin. Neurophysiol. 116: 1405-1414
Maschke M, Maschke M, Weber J, Dimitrova A, Bonnet U, Bohrenkaemper J, Sturm S, Kindsvater K, Mueller BW, Gastpar M, Diener HC, Forsting M, Timmann D. (2005) Vermal atrophy of alcoholics correlate with thiamine deficiency but not with dentate iron concentration as estimated by MRI. J. Neurol. 252: 704-711
Timmann D, Gerwig M, Maschke M, Kolb FP. (2005) Eyeblink conditioning in patients with hereditary ataxia: a one year follow-up study. Exp. Brain Res. 162: 332-345
Hermsdörfer J, Nowak DA, Lee A, Rost K, Timmann D, Boecker H. (2005) The representation of predictive force control and internal forward models: evidence from lesion studies and brain imaging. Cogn. Process. 6: 48-58
Richter S, Schoch B, Ozimek A, Schnepf B, Hein-Kropp C, Kaiser O, Hövel M, Wieland R, Gizewski E, Ziegler W, Timmann D. (2005) Incidence of dysarthria in children with cerebellar tumors: a prospective study. Brain and Language 92: 153-167
Frings M, Antoch G, Knorrn P, Freudenberg L, Timmann D, Maschke M. (2005) Strategies in detection of the primary tumor in anti-Yo associated paraneoplastic cerebellar degeneration. J. Neurol. 252: 197-201
Nowak DA, Hermsdörfer J, Timmann D, Rost K, Topka H. (2005) Impaired generalization of weight-related information during grasping in cerebellar degeneration. Neuropsychologia 43: 20-27
Scientific Collaborations
Within the University Medical School of Essen:
Michael Forsting, MD, Head; Elke Gizewski, MD, Mark Ladd, PhD, Department of Diagnostic and Interventional Radiaology
Hanna Christiansen, MS, Johannes Hebebrand, MD, Head of the Children’s Department of Psychiatry, Rheinische Kliniken
Matthias Hövel, MD, Department of Orthopedic Surgery (Head: Professor F. Löer);
Walter Jentzen, PhD, Stefan Müller, MD, Department of Nuclear Medicine
(Head: Professor A. Bockisch);
Beate Schoch, MD, Department of Neurosurgery (Head: Professor D. Stolke);
Alfred F. Thilmann, MD, M. Kolen, MD, Department of Neurology, Fachklinik Rhein-Ruhr, Essen;
Regina Wieland, MD, Department of Pediatric Oncology and Hematology (Head: Professor W. Havers)
Outside the University Medical School of Essen:
Volker Aurich, PhD, Department of Informatics, University of Düsseldorf;
Otmar Bock, MD, Department of Anatomy and Physiology, Sports College Cologne;
Mitchell Glickstein, PhD, University College London, London, GB;
Joachim Hermsdörfer, PhD, Dennis Nowak, MD, Entwicklungsgruppe Klin. Neuropsychologie, Munich-Bogenhausen
Jonathan Hore, PhD, Department of Physiology, University of Western Ontario, London, Ontario, Canada;
Winfried Ilg, PhD, Hertie-Institute for Clinical Brain Research, Tübingen
Hans-Otto Karnath, MD, PhD, Stefanie Richter, PhD, Hertie-Institute for Clinical Brain Research, Tübingen
Florian P. Kolb, PhD, Department of Physiology, University of Munich;
Jürgen Konczak, PhD, Human Sensorimotor Control Laboratory, University of Minnesota, USA;
Martin Kronenbürger, MD, Department of Neurology, RWTH Aachen;
Matthias Maschke, MD, Trier;
Wolfram Ziegler, PhD, Entwicklungsgruppe Klin. Neuropsychologie, Munich-Bogenhausen
Meetings:
„Journal-Club“: The members of the group meet to present and discuss recent scientifc publications and current projects. Meetings take place on Tuesdays, 6 pm– 7 pm every other week in the Motor Control Laboratory.
„Neurophysiologal Seminar“: Invited speakers present their scientifc work. Speakers frequently work on the physiology of the cerebellum. Meetings take place on Thursdays, 5.15 pm to 6.15 pm in the lecture theatre of the Herzzentrum in der groundfloor.
Office hours for students:
Fridays, 1 pm-2 pm, in Dagmar Timmann-Braun’s office in the basement of the Department of Neurology.
Links:
Homepage: www.uni-essen.de/˜tnk0b0/
Weblog: www.dagmar-timmann.de
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Motor control