Widespread Dependence of Backup NHEJ on Growth State: Ramifications for the Use of DNA-PK Inhibitors.
Int J Radiat Oncol Biol Phys. 2011 Feb 1;79(2):540-8.
Evidence of an adaptive response targeting DNA nonhomologous end joining and its transmission to bystander cells.
Cancer Res. 2010 Nov 1;70(21):8498-506. Epub 2010 Sep 22.
Investigation of bystander effects in hybrid cells by means of cell fusion and premature chromosome condensation induction.
Radiat Res. 2010 Jun;173(6):789-801.
Extensive repair of DNA double-strand breaks in cells deficient in the DNA-PK-dependent pathway of NHEJ after exclusion of heat-labile sites.
Radiat Res. 2009 Aug;172(2):152-64.
Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin.
Nucleic Acids Res. 2008 Oct;36(17):5678-94. Epub 2008 Sep 4.
Enhanced use of backup pathways of NHEJ in G2 in Chinese hamster mutant cells with defects in the classical pathway of NHEJ.
Radiat Res. 2008 Oct;170(4):512-20.
DNA double strand break repair inhibition as a cause of heat radiosensitization: re-evaluation considering backup pathways of NHEJ.
Int J Hyperthermia. 2008 Feb;24(1):17-29.
Analysis of inhibition of DNA replication in irradiated cells using the SV40-based in vitro assay of DNA replication.
Methods Mol Biol. 2006;314:61-71.
Homology-directed repair is required for the development of radioresistance during S phase: interplay between double-strand break repair and checkpoint response. (PubMed)
Radiat Res. 2007 Jan;167(1):1-11
Postreplicative Joining of DNA Double-Strand Breaks Causes
Genomic Instability in DNA-PKcs–Deficient Mouse
Embryonic Fibroblasts
Cancer Res 2005; 65: (22). November 15, 2005
Complex H2AX Phosphorylation Patterns by
Multiple Kinases Including ATM and DNA-PK in Human
Cells Exposed to Ionizing Radiation and Treated
With Kinase Inhibitors
JOURNAL OF CELLULAR PHYSIOLOGY 202:492–502 (2005)
ATR Affecting Cell Radiosensitivity Is Dependent on Homologous Recombination
Repair but Independent of Nonhomologous End Joining
CANCER RESEARCH 64, 7139–7143, October 1, 2004
Involvement of Hus1 in the chain elongation step of
DNA replication after exposure to camptothecin or
ionizing radiation
Nucleic Acids Research, 2004, Vol. 32, No. 2 767 - 775
Caffeine Could Not Efficiently Sensitize Homologous Recombination
Repair-Deficient Cells to Ionizing Radiation-Induced Killing
RADIATION RESEARCH 159, 420–425 (2003)
An Overactivated ATR/CHK1 Pathway Is Responsible for the
Prolonged G2 Accumulation in Irradiated AT Cells
THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 278, No. 33, Issue of August 15, pp. 30869–30874, 2003
Ku Affects the Ataxia and Rad 3-related/CHK1-dependent S Phase Checkpoint
Response after Camptothecin Treatment
CANCER RESEARCH 62, 2483–2487, May 1, 2002
Results of a Pilot Study Involving the Use of an Antisense
Oligodeoxynucleotide Directed Against the Insulin-Like
Growth Factor Type I Receptor in Malignant Astrocytomas
Journal of Clinical Oncology, Vol 19, No 8 (April 15), 2001: pp 2189-2200
The Radioresistance to Killing of A1–5 Cells Derives from Activation
of the Chk1 Pathway
THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 276, No. 21, Issue of May 25, pp. 17693–17698, 2001
RPA facilitates rejoining of DNA double-strand breaks in an
in vitro assay utilizing genomic DNA as substrate
int. j. radiat. biol 2001, vol. 77, no. 5, 593± 607
Nonhomologous End-Joining of Ionizing Radiation-induced DNA Double-Stranded
Breaks in Human Tumor Cells Deficient in BRCA1 or BRCA2
CANCER RESEARCH 61, 270–277, January 1, 2001
Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells
Nucleic Acids Research, 2001, Vol. 29, No. 8 1653-1660
Regulation of DNA Replication after Heat Shock by Replication
Protein A-Nucleolin Interactions THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 276, No. 23, Issue of June 8, pp. 20579–20588, 2001
Effcient rejoining of radiation-induced DNA double-strand breaks in
vertebrate cells deficient in genes of the RAD52 epistasis group
Oncogene (2001) 20, 2212 - 2224
Replication Protein A2 Phosphorylation after DNA Damage by the Coordinated
Action of Ataxia Telangiectasia-Mutated and DNA-dependent Protein Kinase CANCER RESEARCH 61, 8554–8563, December 1, 2001
Deficiency of human BRCA2 leads to impaired
homologous recombination but maintains
normal nonhomologous end joining
8644–8649 | PNAS | July 17, 2001 | vol. 98 | no. 15
Homologous recombination as a potential target for caffeine
radiosensitization in mammalian cells: reduced caffeine radiosensitization in
XRCC2 and XRCC3 mutants Oncogene (2000) 19, 5788 - 5800
The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replication
Nucleic Acids Research, 2000, Vol. 28, No. 5 1183-1192