Subproject A2
Curriculum vitae |
|
|
Prof. Dr. rer. nat. Ralf Küppers |
Date of birth: |
25.09.1962 |
Place of birth: |
Grefrath (Niederrhein), Germany |
Work address: |
Institute for Cell Biology (Tumor Research) |
|
University of Duisburg-Essen, Medical School |
|
Virchowstr. 173 |
|
45122 Essen, Germany |
|
Tel.: +49 (0) 201 723-3384, |
|
e-mail: ralf.kueppers@uk-essen.de |
|
|
Academic education and qualifications: |
|
1983-1989 |
Study of Biology at the University of Cologne, Cologne, Germany |
1989 |
Diploma in biology, University of Cologne |
1989- 1995 |
PhD study at the University of Cologne, Institute for Genetics, Department of Prof. K. Rajewsky |
1995 |
Dr. rer. nat. (PhD) |
1999 |
Habilitation |
|
|
Professional appointments: |
|
1996-2002: |
Postdoctoral fellow and group leader in a special research program (Sonderforschungsbereich) on Hodgkin's lymphoma, University of Cologne |
1999-2003: |
Heisenberg-Stipend of the German Research Council (Deutsche Forschungsgemeinschaft) |
1999-2003: |
Lecturer (Privatdozent) at the Institute for Genetics, University of Cologne |
2000-2001: |
Sabbatical (6 months) at the Institute for Cancer Genetics, Columbia University, New York, USA, Dept. of Prof. R. Dalla-Favera |
since 2004: |
Professor (C4) for Molecular Genetics, Institute for Cell Biology (Tumor Research), Medical Faculty, University of Duisburg-Essen, Essen |
Awards and honours:
PCR Award for young scientists (Boehringer Mannheim, 1996), 1. Prize
Georges-Köhler-Prize of the German Society for Immunology, 1998
Heisenberg-Stipend of the German Research Council (Deutsche Forschungsgemeinschaft), 1999
German Cancer Aid Prize (Deutscher Krebshilfepreis) 2001
(together with K. Rajewsky and M.-L. Hansmann)
Wilhelm-Warner-Prize for Cancer Research, 2004
Selected publications Ralf Küppers
1. Küppers R. Mechanisms of B cell lymphoma pathogenesis. Nat Rev Cancer 2005;5:251-62.
2. Schmitz R, Renné C, Rosenquist R, Tinguely M, Distler V, Menestrina F, Lestani M, Stankovic T, Austen B, Bräuninger A, Hansmann ML, Küppers R. Insights into the multistep transformation process of lymphomas: IgH-associated translocations and tumor suppressor gene mutations in clonally related composite Hodgkin’s and non-Hodgkin’s lymphomas. Leukemia 2005;19:1452-8.
3. Bechtel D, Kurth J, Unkel C, Küppers R. Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphoma. Blood 2005;106:4345-50.
4. Schmitz R, Thomas RK, Harttrampf AC, Wickenhauser C, Schultze JL, Hansmann ML, Wolf J, Küppers R. The major subtypes of human B-cell lymphomas lack mutations in BCL-2 family member BAD. Int J Cancer 2006;119:1738-40.
5. Maggio E, Benharroch D, Gopas J, Dittmer U, Hansmann ML, Küppers R. Absence of measles virus genome and transcripts in Hodgkin-Reed/Sternberg cells of a cohort of Hodgkin lymphoma patients. Int J Cancer 2007;121:448-53.
6. Brune V, Tiacci E, Pfeil I, Döring C, Eckerle S, van Noesel CJ, Klapper W, Falini B, von Heydebreck A, Metzler D, Bräuninger A, Hansmann ML, Küppers R. Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis. J Exp Med 2008;205:2251-68. (MLH and RK share last authorship).
7. Küppers R. Biology of Hodgkin lymphoma. Nat Rev Cancer 2009;9:15-27.
8. Schmitz R, Hansmann M-L, Bohle V, Martin-Subero JI, Hartmann S, Mechtersheimer G, Klapper W, Vater I, Giefing M, Gesk S, Stanelle J, Siebert R, Küppers R. TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. J Exp Med, 2009;206:981-989
9. Schumacher MA, Schmitz R, Brune V, Tiacci E, Döring C, Hansmann M-L, Siebert R, Küppers R. Mutations in the genes coding for the NF-κB regulating factors IκBα and A20 are uncommon in nodular lymphocyte-predominant Hodgkin lymphoma. Haematologica, in press
10. Eckerle S, Brune V, Döring C, Tiacci E, Bohle V, Sundström C, KodetR, Paulli M, Falini B, Klapper W, Baur Chaubert A, Willenbrock K, Metzler D, Bräuninger A, Küppers R, Hansmann M-L. Gene expression profiling of isolated tumour cells from anaplastic large cell lymphomas: insights into its cellular origin, pathogenesis and relation to Hodgkin lymphoma. Leukemia, in press (RK and M-LH share last authorship)