Subproject A4
| Curriculum vitae | |
| PhD. Hong-Bing Shu | |
| Date of birth: | |
| Place of birth: | |
| Work address: | College of Life Sciences, Wuhan University |
Professor and Dean |
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TelFax: 86-27-6875-3780 |
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Email: shuh@whu.edu.cn |
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| Academic education and qualifications: | |
| 1983-1987 | B.S., Department of Biology, Lanzhou University, Lanzhou, China |
| 1987-1990 | M.S., Advisors: Professors Jingbo Zhang and Shepu Xue |
| 1992-1995 | Ph.D., Advisor: Dr. Harish C. Joshi, Department of Cell Biology |
| 1995-1997 | Post-doctoral Fellow, Mentor: Dr. David V. Goeddel, Tularik, Inc. |
| Professional appointments: | |
| 1990-1992 | Research Associate, Drs. Gary Nabel and Elizabeth Nabel’s Laboratories |
| 1997-1998 | Senior Scientist, Magainin Pharmaceuticals Inc., Plymouth Meeting, Pennsylvania, USA |
| 1998-2003 | Assistant Professor, Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado, USA |
| 2003-2005 | Associate Professor, Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado, USA |
| 2000-2005 | Member, University of Colorado Cancer Center, Denver, Colorado, USA |
| 1999-2005 | Graduate Faculty Member |
| 2000-2004 | Changjiang Professor, College of Life Sciences, Peking University, Beijing, China |
| 2005 | Professor and Dean, College of Life Sciences, Wuhan University, Wuhan, China |
III. HONORS AND AWARDS:
2006 Chief Scientist, “Basic Research of Infection and Immunity”
2005 Natural Sciences Research Award
2004 Dolph Adams Award
2001 Harmon Foundation Award for Arthritis Research
2001 Outstanding Junior Faculty Award
2000 New Scholar Award
1999 National Outstanding Young Scientist Award
Publications (10 most important publications of the last 5 years):
1. Bin L, Xu L, Shu HB* TIRP: a novel TIR domain-containing adapter protein involved in
toll/interleukin-1 receptor signaling. J Biol Chem 2003;27:24526-24532.
2. Han KJ, Su X, Xu LG, Bin LH, Zhang J, Shu HB* Mechanisms of TRIF-induced ISRE
and NF-kappa B activation and apoptosis pathways. J Biol Chem 2004;279:15652-15661.
3. Huang J, Teng L, Li L, Liu T, Li L, Chen D, Xu LG, Zhai Z, Shu HB* ZNF216 is an
A20-like and IKKgamma -interacting inhibitor of NF-kappa B activation. J Biol Chem
2004;279:16847-16853.
4. Li L, Bin LH, Li F, Liu Y, Chen D, Zhai Z, Shu HB*TRIP6 is a RIP2-associated common
signaling component of multiple NF-_B activation pathways. Journal of Cell Science
2005;118:555-563.
5. Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB* VISA is an adapter protein required
for virus-triggered signaling. Molecular Cell 2005;19:727-740.
6. Huang J, Liu T, Chen D, Zhai Z, Shu HB* SIKE is an IKK-relative kinases-associated
suppressor of TLR3- and virus-triggered IRF-3 activation pathways. EMBO Journal
2005;24:4018-4028.
7. Zha J, Han K, Xu LG, Zhou Q, Chen D, Zhai Z, Shu HB*. The Ret finger protein inhibits
signaling mediated by the noncanonical and canonical IKK family members. Journal of
Immunology 2006;176:1072-1080.
8. Tian Y, Zhang Y, Zhong B, Wang YY, Diao FC, Wang RP, Zhang M, Chen DY, Zhai
ZH, Shu HB*. RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-
triggered NF-kappaB activation by targeting TAB2/3 for degradation. J Biol Chem
2007;282:16776-16782.
9. Diao F, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Chen D, Zhai Z, Zhong B,
Tien P, Shu HB*. Negative regulation of MDA5- but not RIG-I-mediated innate antiviral
signaling by the dihydroxyacetone kinase. Proc Natl Acad Sci USA 2007; 104:11706-11711.
10. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P, Shu HB.
The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor
Activation. Immunity 2008;29:538-550.