Subproject A6
Curriculum vitae |
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Univ.-Prof.Dr.rer.nat.Dipl.-Phys. Daniel Hoffmann |
Date of birth: |
30.05.1965 |
Place of birth: |
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Work address: |
Bioinformatics, Centre for Medical Biotechnology |
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University of Duisburg-Essen |
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Universitätsstr. 2-5 |
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45117 Essen, Germany |
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Tel.: +49 (0) 201 183 4391, |
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Academic education and qualifications: |
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1984–1990 |
Study of Physics, Ruprecht-Karls-Universität, Heidelberg |
1988–1990 |
Diploma thesis, Max-Planck-Institut für Medizinische Forschung, Heidelberg, research group “Molecular Crystals” (Prof. U. Haeberlen) |
1990 |
Diploma in Physics, minor in Astronomy |
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Professional appointments: |
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1991–1996 |
Research assistant, Freie Universität Berlin, Institute for Crystallography, research group “Macromolecular Modelling” (Prof. E.-W. Knapp) |
1996 |
Dr. rer. nat. (Ph.D.), Department of Chemistry, Freie Universität Berlin |
| 1996–1999 | Postdoc, GMD-Forschungszentrum Informationstechnik GmbH, Sankt Augustin, research group “Bioinformatics” (Prof. T. Lengauer) |
| 2000–2004 | Group leader, center of advanced european studies and research (caesar), Bonn, simultaneously Guest Researcher at the Max-Planck-Institut for Informatics, Saarbrücken, Department “Computational Biology” (Prof. T. Lengauer) |
| 2004-2006 | Professor (W2) for Bioinformatics, Bingen University of Applied Sciences, simultaneously Research Fellow, caesar, Bonn |
| Since 2006 | Full Professor (W3) for Bioinformatics, Centre for Medical Biotechnology, University of Duisburg-Essen, Essen |
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Selected publications
1. Gronwald, W., Hohm, T. & Hoffmann, D. (2008). Evolutionary Pareto-optimization of stably folding peptides. BMC Bioinformatics, 9, 109.
2. Albert, T., Egler, C., Jakuschev, S., Schuldenzucker, U., Schmitt, A., Brokemper, O., Zabe-Kühn, M., Hoffmann, D., Oldenburg, J. & Schwaab, R. (2008). The B-cell epitope of the monoclonal anti-factor VIII antibody ESH8 characterized by peptide array analysis. Thromb. Haemost., 99, 634-637.
3. Hohm, T., Limbourg, P. & Hoffmann, D. (2006). A multiobjective evolutionary method for the design of peptidic mimotopes. J. Comput. Biol., 13, 113-125.
4. Verheyen, J., Litau, E., Sing, T., Däumer, M., Balduin, M., Oette, M., Fätkenheuer, G., Rockstroh, J.K., Schuldenzucker, U., Hoffmann, D., Pfister, H. & Kaiser, R. (2006). Compensatory mutations at the HIV cleavage sites p7/p1 and p1/p6-gag in therapy-naive and therapy-experienced patients. Antivir. Ther. (Lond.), 11, 879-887.
5. Wefing, S., Schnaible, V. & Hoffmann, D. (2006). SearchXLinks. A program for the identification of disulfide bonds in proteins from mass spectra. Anal. Chem., 78, 1235-1241.
6. Wendeler, M., Werth, N., Maier, T., Schwarzmann, G., Kolter, T., Schoeniger, M., Hoffmann, D., Lemm, T., Saenger, W. & Sandhoff, K. (2006). The enzyme-binding region of human GM2-activator protein. FEBS J., 273, 982-991.
7. Beerenwinkel, N., Däumer, M., Sing, T., Rahnenführer, J., Lengauer, T., Selbig, J., Hoffmann, D. & Kaiser, R. (2005). Estimating HIV evolutionary pathways and the genetic barrier to drug resistance. J. Infect. Dis., 191, 1953-1960.
8. Hohm, T. & Hoffmann, D. (2005). A multi-objective evolutionary approach to peptide structure redesign and stabilization. In H.-G. Beyer (ed.), GECCO'05, , Vol. , p. 423-429.
9. Albrecht, M., Hoffmann, D., Evert, B.O., Schmitt, I., Wüllner, U. & Lengauer, T. (2003). Structural modeling of ataxin-3 reveals distant homology to adaptins. Proteins, 50, 355-370.
10. Beerenwinkel, N., Lengauer, T., Däumer, M., Kaiser, R., Walter, H., Korn, K., Hoffmann, D. & Selbig, J. (2003). Methods for optimizing antiviral combination therapies. Bioinformatics, 19 Suppl 1, i16-25.