The Centre for Medical Biotechnology (ZMB) is an interdisciplinary scientific centre of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.
Recent Publications
Meyer H, Bug M, Bremer S. Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system. Nat. Cell Biol. 2012 Feb 2;14:117-23. Review.
Wawra S, Bain J, Durward E, de Bruijn I, Minor KL, Matena A, Löbach L, Whisson SC, Bayer P, Porter AJ, Paul R. J. Birch PR, Secombes C, van West P (2012) SpHtp1 from the oomycete Saprolegnia parasitica translocates specifically into fish cells in a tyrosine-O-sulphate–dependent manner. Proc Natl Acad Sci U S A, Epub ahead of print, January 20, 2012.
Bebeacua C, Förster A, McKeown C, Meyer HH, Zhang X, Freemont PS. Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy. Proc Natl Acad Sci U S A. 2012, 109: 1098-1103.
Malet M, Canellas F, Sawa J, Yan J, Thalassinos K, Ehrmann M, Clausen T, and H. Saibil. 2011. Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ. Nat. Struct. Mol. Biol., 2012 Jan 15; doi: 10.1038/nsmb.2210.
Mueller JW, Link NM, Matena A, Hoppstock L, Rüppel A, Bayer P, Blankenfeldt W. Crystallographic proof for an extended hydrogen-bonding network in small prolyl isomerases. JACS 2011 Dec 21;133(50):20096-9.
Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, Schrader T, Wang C, Bitan G. Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. JACS 2011 Oct 26;133(42):16958-69.
Meerang M, Ritz D, Paliwal S, Garajova Z, Bosshard M, Mailand N, Janscak P, Hübscher U, Meyer H and Ramadan K. The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nat. Cell Biol. 2011 23 Oct 2011. [Epub ahead of print], doi:10.1038/ncb2367.
Eyking A, Ey B, Rünzi M, Roig AI, Reis H, Schmid KW, Gerken G, Podolsky DK, and Cario E. Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer. Gastroenterology. 2011 Sep 12. [Epub ahead of print]
Ehrentraut S, Hassler M, Oppikofer M, Kueng S, Weber JM, Mueller JW, Gasser SM, Ladurner AG, Ehrenhofer-Murray AE. Structural basis for the role of the Sir3 AAA+ domain in silencing: Interaction with Sir4 and unmethylated histone H3K79. Genes Dev Sep 1, 2011; 25 (17).
Lättig-Tünnemann G, Prinz M, Hoffmann D, Behlke J, Palm-Apergi C, Morano I, Herce HD, Cardoso MC. Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides. Nat. Commun. 2011 Aug 30;2:453. doi:10.1038/ncomms1459.
Ritz D, Vuk M, Kirchner P, Bug M, Schütz S, Hayer A, Bremer S, Lusk C, Baloh RH, Lee H, Glatter T, Gstaiger M, Aebersold R, Weihl CC, Meyer H. Endolysosomal sorting of ubiquitinated caveolin-1 is regulated by VCP/p97 and UBXD1 and impaired by VCP disease mutations. Nat. Cell Biol., DOI: 10.1038/ncb2301, Epub 7. August 2011
Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, Dummer R, Garbe C, Testori A, Maio M, Hogg D, Lorigan P, Lebbe C, Jouary T, Schadendorf D, Ribas A, O'Day SJ, Sosman JA, Kirkwood JM, Eggermont AM, Dreno B, Nolop K, Li J, Nelson B, Hou J, Lee RJ, Flaherty KT, McArthur AG; BRIM-3 Study Group.
Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011 Jun 30;364(26):2507-16.
Epub 2011 Jun 5.
Merdanovic M, Clausen T, Kaiser M, Huber R, and M. Ehrmann. 2011. Protein quality control in the bacterial periplasm. Annu. Rev. Microbiol. 65:149-168.
Kley J, Schmidt B, Boyanov B, Stolt-Bergner PC, Kirk R, Ehrmann M, Knopf RR, Naveh L, Adam Z, Clausen T. Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure. 2011 Nat. Struct. Mol. Biol. 18:728-731.
Dietze KK, Zelinskyy G, Gibbert K, Schimmer S, Francois S, Myers L, Sparwasser T, Hasenkrug KJ, Dittmer U. Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2420-5. Epub 2011 Jan 24.
Clausen T, Kaiser M, Huber R, and M. Ehrmann. 2011. HtrA proteases: Regulated proteolysis in protein quality control. Nat. Rev. Mol. Cell Biol., 12:152-62.
Zhang Y, Li X, Carpinteiro A, Goettel JA, Soddemann M, Gulbins E. 2011. Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections. Nat. Med. 17(3):341-6. Epub 2011 Feb 6.
Trübestein L, Tennstaedt A, Mönig T, Krojer T, Canellas F, Kaiser M, Clausen T, and M. Ehrmann. 2011. Substrate induced remodeling of the active site regulates human HtrA1 activity. Nat. Struct. Mol. Biol., 18:386-388.
Mestdagh P, Bostro AK, Impens F, Fredlund E, Van Peer G, De Antonellis P, von Stedingk K, Ghesquie B, Schulte S, Dews M, Thomas-Tikhonenko A, Schulte JH, Zollo M, Schramm A, Gevaert K, Axelson H, Speleman F, and Vandesompele J. (2010) The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in Neuroblastoma. Molecular Cell 40, 762–773, December 10.
Merdanovic M, Mamant N, Meltzer M, Poepsel S, Auckenthaler A, Melgaard R, Hauske P, Nagel-Steger L, Clarke AR, Kaiser M, Huber R, Ehrmann M. 2010. Determinants of structural and functional plasticity of a widely conserved protease chaperone complex. Nat. Struct. Mol. Biol., 17:837-43.
Dybowski JN, Heider D, Hoffmann D. Prediction of Co-Receptor Usage of HIV-1 from Genotype. PLoS Comput Biol. Apr. 2010 6(4): e1000743.
Ehrentraut S, Weber JM, Dybowski JN, Hoffmann D, Ehrenhofer-Murray AE. Rpd3-dependent boundary formation at telomeres by removal of Sir2 substrate. PNAS Jan 2010.
Jones KB, Piombo V, Searby C, Kurriger G, Yang B, Grabellus F, Roughley PJ, Morcuende JA, Buckwalter JA, Capecchi MR, Vortkamp A, Sheffield VC. A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2054-9. Epub 2009 Dec 22.