• Activation of the transcription factor complex hypoxia-inducible factor-1 (HIF-1) – molecular imaging of HIF-1 assembly
• In vivo 2-photon microscopy and three-dimensional localization of intracellular proteins
• Regulation of the oxygen-dependent expression of the erythropoietin gene
• The role of oxygen-dependent expression of the angiogenic protein VEGF for tumor vascularisation

Mechanisms of inflammatory Reactions Role of HIF-1 Complexes in Muscle Trauma

• Non-hypoxic activation of hypoxia-inducible factor-1 by inflammatory cytokines and signalling molecules
• Role of reactive oxygen and nitrogen species for the function of cellular oxygen sensors
• Cross-talk of hypoxic and proinflammatory cytokine-mediated activation of genes important for angiogenesis and vascular permeability
• Pathophysiology of erythropoietin production in chronic inflammatory and malignant diseases

Role of HIF-1 Complexes in Muscle Trauma

• Activation of HIF-1 in traumatised tissue
• Role of HIF-1 activation for the severity of tissue trauma
• Influence of reactive oxygen and nitrogen species for regeneration processes in skeletal muscle