Research Overview
 

Professional interests

Structure and function of biological macromolecules, in particular those of large complex aggregates.

Systems studied

• Proteases and their natural and synthetic inhibitors.
• Metalloenzymes (iron, nickel, molybdenum, copper).
• Proteins of the immune system (antibodies and antibody receptors).
• Protein hormones and their receptors.
• Protein kinases.
• Proteins of amino acid biosynthesis (PLP containing enzymes).
• Proteins of cofactor and vitamin biosynthesis.
• Proteins of energy and electron transport.

Methods development

• Patterson methods in crystallography.
• Methods of structure determination of proteins and protein ligand complexes by NMR.
• Synthesis and use of electron rich metal clusters.
• Crystal annealing and improvement, methods and instruments.
• Analysis and evaluation of targets for research and application in pharmacology and crop science.