Uni DuE
Fakultät für Chemie
Intro_CR


The research group of Dr. Christoph Rehbock focuses on the utilization of laser-fabricated metal and alloy nanoparticles in different fields of biomedicine. These nanoparticles are particularly useful in biomedical science as they can be obtained at high purity and are initially ligand free. This allows their efficient functionalization with specific biomolecules, their integration into matrices and their deposition on surfaces with high efficiency, while on the other hand potentially toxic side effects, originating e.g. from artificial ligands during chemical synthesis can be avoided. Furthermore, the laser-based production process offers an outstanding material variety, which allows the facile fabrication of alloy nanoparticles with well controlable composition.The primary research topics in the Nano-Bio group are:

1) Size and composition controlled nanomaterials for Bioimaging, Diagnostics and Biosafety

The Rehbock group develops metal and espacially alloy nanoparticles (e.g. FeAu, AgAu, PtAu) tuned for specific optical features (surface plasmon resonance) as well as magnetic properties. This entails a controlled variation of the particle composition by choice of the target and the solvent in correlation with efficient size control strategies. Another research area involves the synthesis of non plasmonic metal nanoclusters. In contrast to nanoparticles these nanoclusters only consist of a few metal atoms and are designed and studied for their characteristic photoluminescence properties. Furthermore, the group has generated a variety of metal and alloy nanoparticles as reference materials for biosafety evaluations.

2) Nanobioconjugates for drug delivery and therapy

The group uses metal and alloy nanoparticles as a platform for a variety of biomolecules and drugs, which are directly coupled to the metal surfasce, predominatly via thiol chemistry. This includes the coupling of nucleotides, peptides, proteins as well as small functional molecules to the particle´s surface, while the parallel arrangement of multiple different ligands on one particle as well as a precise control of surface coverage are vital. These nanobioconjugates can be used as functional components in bioassays and as platforms for photo-induced drug delivery. Furthermore, they may serve as potential nanodrugs counteracting protein misfolding in neurodegenerative diseases like Alzheimer´s disease.

3) Nanoparticle imobilization- nanocomposites and coatings

Another focus of the Nano-Bio team is the immobilization of ligand-free nanoparticles in a polymer matrix forming nanocomposite materials. Here the nanoparticles are embedded into the polymer via a specialized in situ embedding procedure (= laser synthesis of particles directly in the monomer or polymer solution). In this context, the embedded nanoparticles can alter the surface charge of the polymer and serve as a source for the release of biofunctional metal ions. These novel biomaterials were demonstrated to improve cellular growth and proliferation and can be utilized in tissue engineering and implant design. In another approach we examine the immobilization of metal nanoparticles on the surface of neural electrodes, utilizing the electrophoretic deposition (EPD) technique. These electrodes are routinely applied during the treatment of neurological movement disorders like Parkinson´s disease. Central aim in this context is to examine how nanoscopic coatings stabilize and potentially decrease the electrode´s impedance in order to improve the stimulation efficiency of the electrode and prolong battery lifetime in long term stimulation application in vivo.


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Letzte Änderung: 22. Mai 2018 - © Technische Chemie I - Kontakt: Webmaster TC

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