CRC 1093 - Principal Investigator Herbert de Groot
Area B: Biological Targets B3: Supramolecular specific inhibitors of intestinal proteases against ischemia/reperfusion in-jury
Project B3 investigates the significance of specific digestive proteases and common hydrolases in ischemia/reperfusion injury of the small intestines. To this end, selective inhibitors for single digestive hydrolases will be developed by the chemists and probed within the pathogenetic network of the disease. The most specific and effective inhibitors will then be administered intraluminally in the rat small intestine. Biocompatibility, toxicity and effects on tissue regeneration of the inhibitors will be assessed.
Read moreCurriculum Vitae
Professional career
| 1992-today | Full Professor (C4) and Chairman, Institut für Physiologische Chemie, Universitätsklinikum Essen |
| 1988-1992 | Head of the Clinical Research Group Liver Injury, Universität Düsseldorf |
| 1988 | Habilitation in Physiologische Chemie, Universität Düsseldorf |
| 1982-1988 | Research Associate, Institut für Physiologische Chemie I, Universität Düsseldorf (Prof. Dr. H. Sies) |
Scientific education and degrees
| 1987 | Dr. Med., Universität Düsseldorf |
| 1982 | Staatsexamen (Approbation) Medizin |
| 1982 | Dr. rer. nat., Universität Düsseldorf |
| 1979 | Diplom-Biologe |
| 1974-1982 | Study of Biology (Dipl.) and Medicine at the Universities of Aachen and Düsseldorf |
Selected Publications
Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischemia-reperfusion injury: current knowledge. F. Petrat, K. Böngler, R. Schulz, H. de Groot, Br. J. Pharmacol. 2012, 165, 2059-2072.
The necessity for the coating of perfluorodecalin-filled poly(lactide-co-glycolide) microcapsules in the presence of physiological cholate concentrations: Tetronic-908 as an exemplary polymeric surfactant. M. Kirsch, T. Bramey, I.N. Waack, F. Petrat, C. Mayer, H. de Groot, J. Microencapsul. 2012, 29, 30-38.
Protection by pyruvate infusion in a rat model of severe intestinal ischemia-reperfusion injury. F. Petrat, T. Rönn, H. de Groot, J. Surg. Res. 2011, 167, e93-e101.
Effect of molecular clips and tweezers on enzymatic reactions by binding coenzymes and basic amino acids. F.-G. Klärner, T. Schrader, J. Polkowska, F. Bastkowski, P. Talbiersky, M. Campana Kuchenbrandt, T. Schaller, H. de Groot, M. Kirsch, Pure Appl. Chem. 2010, 82, 991-999.
A mechanism of efficient G6PD inhibition by a molecular clip. P. Talbiersky, J. Polkowska, F. Bastkowski, M. Kirsch, H. de Groot, F. Klärner, T. Schrader, Angew. Chem. Int. Ed 2009, 48, 2886-2890.
