CRC 1430-News https://www.uni-due.de/crc1430/ Wed, 12 Nov 2025 10:05:42 +0100 UDE-Logo https://www.uni-due.de/ https://www.uni-due.de/imperia/md/images/portal/2011/wolken/udelogo_rss.png Female Scientists Get-Together https://www.uni-due.de/crc1430/events.php?date=2025-10-09&viewMode=month&id=25674#event-25674 81 Wed, 01 Oct 2025 13:35:08 +0200 ]]> PhD thesis defense https://www.uni-due.de/crc1430/project-a03.php 78 Wed, 06 Aug 2025 22:05:24 +0200 ]]> ATXN3 Identified as Key Regulator of Lysosome Regeneration https://www.embopress.org/doi/full/10.1038/s44318-025-00517-x 77 Tue, 29 Jul 2025 21:56:01 +0200 ]]> New Insights into Protein Folding Inside Cells https://www.uni-due.de/2025-07-21-proteinfaltung-im-zellinneren-neu-verstanden 74 Mon, 21 Jul 2025 13:21:04 +0200
Using single-particle electron microscopy and biochemical analyses, the team visualized the transient interaction between BiP and GRP94, homologs of Hsp70 and Hsp90, capturing the dynamic structural states that enable substrate handover. These findings provide important insights into proteostasis in the secretory pathway and will serve as a basis for future research.
https://www.nature.com/articles/s41594-025-01619-0.
]]> Female Scientists Get-Together https://www.uni-due.de/crc1430/events.php 73 Wed, 09 Jul 2025 17:47:37 +0200 ]]> Female Scientists Get-Together https://www.uni-due.de/crc1430/events.php?date=2025-05-09&viewMode=month&id=25088#event-25088 71 Wed, 28 May 2025 19:41:12 +0200 ]]> Career Day 2025 https://www.uni-due.de/crc1430/career_day_2025.php 72 Fri, 16 May 2025 21:54:33 +0200
The event wrapped up with a group dinner at Brauhaus Dampfe, offering a relaxed setting for networking. It provided valuable guidance for PhD students planning their next career steps.
]]> Humbolt-Professorship 2025 for Dr. Dana Branzei https://www.humboldt-foundation.de/entdecken/newsroom/pressemitteilungen/verleihung-der-humboldt-professuren-2025 69 Mon, 05 May 2025 20:15:52 +0200 ]]> The Spc105/Kre28 complex promotes mitotic error correction by outer kinetochore recruitment of Ipl1/Sli15 https://www.embopress.org/doi/full/10.1038/s44318-025-00437-w 66 Fri, 25 Apr 2025 10:15:10 +0200 ]]> Animal Welfare Award https://www.uni-due.de/zentrales-tierlabor/preis2024.php 64 Sun, 13 Apr 2025 17:01:38 +0200 Her innovative work on melanoma patient-derived organoids helps reduce the need for mouse models in the development of metastasis-specific cancer therapies.

]]> New Paper on Selective DPP8/9 Inhibitors Published in Nature Communications https://www.uni-due.de/2025-04-15-ude-researchers-develop-novel-class-of-active-ingedrients 63 Thu, 03 Apr 2025 16:11:07 +0200
Despite major advances in chemoproteomic profiling, developing selective covalent probes for DPP8/9 remains challenging. This study shows that Sulphostin-inspired N-phosphonopiperidones achieve improved DPP8/9 inhibition, enhanced proteome-wide selectivity, and confirmed cellular engagement—offering a promising strategy for selective targeting of exoproteases like DPPs.
]]> New DNA Repair Expert at the University Alliance Ruhr https://www.uni-due.de/2025-04-16-humboldt-professorin-dana-branzei 65 Tue, 01 Apr 2025 18:44:37 +0200 Her research focuses on how DNA repair mechanisms and chromosome structure interact during the duplication of genetic material.
In recognition of her outstanding scientific achievements, she has been awarded the 2025 Humboldt Professorship by the Alexander von Humboldt Foundation!
]]> PhD thesis defense https://www.uni-due.de/crc1430/project-a02.php 62 Tue, 01 Apr 2025 18:00:35 +0200 ]]> Female Scientists Get-Together https://www.uni-due.de/gcplus/de/team.php 61 Wed, 26 Mar 2025 16:11:07 +0100 Together with Viktoria, our female scientists discussed how to shape future Get-Togethers to make them as impactful as possible. The goal is to create a supportive space that actively contributes to the career development of young female scientists—through focused topics, tailored workshops, and inspiring guest speakers.
]]> Dataverse Upload Event https://www.uni-due.de/crc1430/project-inf.php 60 Tue, 18 Mar 2025 21:18:34 +0100 ]]> PhD thesis defense https://www.uni-due.de/crc1430/project-a12.php 68 Fri, 14 Mar 2025 21:38:03 +0100 ]]> Interview with CRC 1430 Data Champion Gina Simon https://www.uni-due.de/rds/en/datachampion_gsimon.php 56 Tue, 04 Mar 2025 13:07:19 +0100 ]]> CRC1430 PI Retreat https://www.uni-due.de/crc1430/pi_retreat.php 55 Mon, 24 Feb 2025 12:48:17 +0100 ]]> Dana Branzei joins the CRC1430 https://www.uni-due.de/crc1430/associates_dana_branzei.php 59 Fri, 14 Feb 2025 09:18:39 +0100 ]]> PhD thesis defense https://www.uni-due.de/crc1430/project-a14.php 54 Thu, 06 Feb 2025 14:15:50 +0100 ]]> Female Scientists Get-Together https://www.uni-due.de/crc1430/events.php?date=2025-01-15&viewMode=day&id=24446#event-24446 53 Wed, 15 Jan 2025 15:11:15 +0100 ]]> Women in Science Networking Event /crc1430/events.php?date=2024-12-06&viewMode=month&id=24310#event-24310 46 Wed, 04 Dec 2024 14:45:42 +0100 This gathering offered an excellent opportunity for the talented women of CRC 1430 to share their experiences in research, discuss strategies for advancing their careers, and build a supportive network. These dynamic sessions alternate every six weeks between the UKE "Casino" and the Essen campus "Brücke," offering a welcoming space to connect, exchange ideas, and empower each other in the scientific community.


]]> How HTRA1 Degrades Folded Proteins – A Collaborative Discovery https://www.sciencedirect.com/science/article/pii/S0021925824023135?ref=cra_js_challenge&fr=RR-1 67 Sat, 30 Nov 2024 10:42:32 +0100 Using mass spectrometry, CD spectroscopy, and bioinformatics, the team identified 178 cleavage sites in ANXA1, uncovering how HTRA1 recognizes specific sequences and unfolds its substrates during degradation. The approach also offers a blueprint for studying post-translational modifications in complex protein systems
]]> PhD thesis defense /crc1430/project-b03.php 45 Mon, 28 Oct 2024 09:44:53 +0100
]]> Preis der Klüh Stiftung an Kathrin Thedieck https://www.duesseldorf.de/aktuelles/news/detailansicht/newsdetail/preisverleihung-der-klueh-stiftung-im-rathaus-4 44 Fri, 25 Oct 2024 12:44:07 +0200 ]]> Female Scientists Get-Together https://www.uni-due.de/crc1430/events.php?date=2024-10-23&viewMode=day&id=24143#event-24143 52 Wed, 23 Oct 2024 14:30:00 +0200 ]]> Female Scientists Get-Together https://www.uni-due.de/crc1430/events.php?date=2024-09-13&viewMode=month&id=24023#event-24023 51 Wed, 18 Sep 2024 13:30:00 +0200 ]]> Malte Gersch Receives ORCHEM Prize 2024 https://www.mpi-dortmund.mpg.de/news/orchem-prize-malte-gersch 79 Fri, 13 Sep 2024 22:36:53 +0200 ]]> Role of protein kinase PLK1 in the epigenetic maintenance of centromes https://www.science.org/doi/full/10.1126/science.ado5178 42 Thu, 05 Sep 2024 11:42:26 +0200 ]]> Alternating binding and p97-mediated dissociation of SDS22 and I3 recycles active PP1 between holophosphatases https://www.pnas.org/doi/10.1073/pnas.2408787121 43 Thu, 29 Aug 2024 08:43:16 +0200 ]]> Sex and Gender in the Life Sciences /ekfg/sex-and-gender-in-the-life-sciences_2024.php 41 Tue, 20 Aug 2024 14:41:38 +0200 ]]> Female Scientists Get-Together /crc1430/events.php?date=2024-06-06&viewMode=year&id=23495#event-23495 37 Wed, 31 Jul 2024 13:52:11 +0200 ]]> tracerDB: a crowdsourced fluorescent tracer database for target engagement analysis https://www.nature.com/articles/s41467-024-49896-5 40 Fri, 05 Jul 2024 08:55:06 +0200 ]]> Barbara Gruenwald joins the CRC1430 https://www.uni-due.de/crc1430/associates_barbara_gruenwald.php 58 Sun, 09 Jun 2024 11:01:45 +0200 ]]> Kathrin Thedieck joins the CRC1430 https://www.uni-due.de/crc1430/kathrin_thedieck 57 Wed, 05 Jun 2024 10:44:39 +0200 ]]> Max Planck scientists honoured with Biomedicine Award https://www.mpi-dortmund.mpg.de/4487122/24-05-29 80 Fri, 24 May 2024 22:43:31 +0200 ]]> Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor https://www.cell.com/current-biology/fulltext/S0960-9822(24)00402-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982224004020%3Fshowall%3Dtrue 39 Tue, 21 May 2024 10:54:08 +0200 ]]> Sex and Gender in the Life Sciences /ekfg/sex-and-gender-in-the-life-sciences_2024.php 38 Sun, 12 May 2024 13:53:22 +0200 ]]> Female Scientists Get-Together /crc1430/events.php?date=2024-04-24&viewMode=day&id=23340#event-23340 50 Wed, 24 Apr 2024 13:30:00 +0200 ]]> Female Scientists Get-Together /crc1430/events.php?date=2024-03-20&viewMode=day&id=23199#event-23199 49 Wed, 20 Mar 2024 13:00:00 +0100 ]]> Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH https://www.sciencedirect.com/science/article/pii/S1097276524001722?via%3Dihub#abs0020 36 Mon, 18 Mar 2024 15:51:06 +0100 ]]> PhD thesis defense /crc1430/project-a08.php 35 Thu, 14 Mar 2024 09:50:16 +0100 ]]> PhD thesis defense /crc1430/project-a03.php 34 Mon, 04 Mar 2024 16:49:26 +0100 ]]> Female Scientists Get-Together /crc1430/events.php?date=2024-02-13&viewMode=month&id=23424#event-23424 48 Wed, 07 Feb 2024 13:30:00 +0100 ]]> How Cells migrate /2024-02-01-neue-erkenntnisse-zu-signalproteinen 33 Thu, 01 Feb 2024 17:47:33 +0100 ]]> PhD thesis defense /crc1430/project-b02.php 32 Thu, 30 Nov 2023 11:21:40 +0100 ]]> PhD thesis defense https://duepublico2.uni-due.de/receive/duepublico_mods_00081325 31 Tue, 21 Nov 2023 13:45:51 +0100 ]]> PhD thesis defense https://duepublico2.uni-due.de/receive/duepublico_mods_00081308 30 Fri, 27 Oct 2023 15:45:00 +0200 ]]> 1st International Symposium of CRC 1430: „Triggers of cell state transitions“ /crc1430/international-symposium-2023.php 29 Tue, 10 Oct 2023 12:17:06 +0200 ]]> Katarzyna Kliza joins the CRC1430 /crc1430/associates_katarzyna_kliza.php 28 Sun, 24 Sep 2023 13:43:11 +0200 ]]> PhD Fellowship for Eda Samiloglu Tengirsek /crc1430/project-a04.php 27 Fri, 22 Sep 2023 11:42:16 +0200 ]]> A new super resolution microscope is available at the ICCE! /2023-09-18-neues-superresolution-mikroskop 25 Mon, 18 Sep 2023 17:38:10 +0200 ]]> A Link Between Melanoma Resistance and HLA-II Antigen Presentation https://aacrjournals.org/clincancerres/article-abstract/29/15/2894/727968/HLA-Class-II-Loss-and-JAK1-2-Deficiency-Coevolve?redirectedFrom=fulltext 24 Tue, 01 Aug 2023 10:37:15 +0200 ]]> Cell-Based Assays for PROTAC https://www.sciencedirect.com/science/article/abs/pii/S2451945623001575 23 Thu, 20 Jul 2023 12:36:24 +0200 ]]> New Study Reveals Potential Biomarker for Melanoma Treatment Response https://www.nature.com/articles/s43018-023-00610-2 22 Sat, 01 Jul 2023 00:00:00 +0200 ]]> Innovative Catalyst-Free Method for Oxazolidinone Synthesis https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.202300135 21 Sat, 17 Jun 2023 13:34:04 +0200 ]]> CRC 1430 Retreat 2023 /crc1430/retreat-2023-report.php 20 Mon, 05 Jun 2023 08:18:35 +0200 ]]> Verena Cmentowski wins poster prize /crc1430/project-a02.php 19 Wed, 17 May 2023 11:17:46 +0200 ]]> CRC 1430 Guest Lectures /crc1430/past_speaker.php 18 Thu, 11 May 2023 13:13:03 +0200
11.07.2023: Renata Basto (Institute Curie Paris);

05.12.2023: Patrizia Agostinis (VIB-Center for Cancer Biology Leuven)
]]> Christian Reinhardt ausgezeichnet /2023-03-31-christian-reinhardt-erhaelt-deutschen-krebspreis 17 Fri, 31 Mar 2023 15:23:14 +0200 ]]> Exzellente Forschung? - Mit gerechten Chancen! https://www.exzellenz-entdecken.de/ 16 Wed, 23 Nov 2022 11:11:14 +0100 ]]> Barbara Grüner Appointed Professor /2022-10-26-tumore-barbara-gruener 15 Wed, 26 Oct 2022 11:18:37 +0200 ]]> PhD thesis defense https://duepublico2.uni-due.de/receive/duepublico_mods_00077123 14 Mon, 24 Oct 2022 16:07:42 +0200 ]]> Novel Web Tool PPI-Affinity https://pubs.acs.org/doi/10.1021/acs.jproteome.2c00020 13 Sun, 21 Aug 2022 11:05:48 +0200 ]]> Andrea Musacchio honored by Vallee Foundation https://www.mpi-dortmund.mpg.de/news/musacchio-valle-visiting-professor 12 Fri, 29 Jul 2022 15:05:03 +0200 ]]> Congratulations! /crc1430/melanoma-cell-state-transition-upon-immune-modulatory-drug-treatment.php 11 Mon, 18 Jul 2022 09:04:03 +0200 ]]> Controlling the Danger Within /2022-07-06-how-cells-control-lysosomes 10 Wed, 06 Jul 2022 10:01:59 +0200 ]]> A new strategy to treat persisting cancer cells in melanoma /crc1430/news-publication-roesch-a11 9 Sun, 12 Jun 2022 13:00:57 +0200 ]]> A boost for cutting-edge research https://www.uni-muenster.de/news/view.php?cmdid=12622 8 Fri, 03 Jun 2022 11:58:38 +0200 ]]> Peter und Traudl Engelhorn Stiftung Research Prize awarded to Prof. Dr. Doris Hellerschmied https://www.engelhorn-stiftung.de/forschungspreis 7 Tue, 31 May 2022 12:57:34 +0200 ]]> ETOS trophy 2022 awarded to Dr. Batool Shannan /med/meldung.php?id=1313 6 Thu, 17 Feb 2022 12:55:06 +0100 ]]> PhD thesis defense /crc1430/project-a03.php 5 Wed, 26 Jan 2022 12:52:25 +0100 ]]> PhD thesis defense /crc1430/project-a01.php 4 Fri, 17 Dec 2021 12:50:41 +0100 ]]> Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore /crc1430/news-first-publication-westermann-a1.php 3 Mon, 02 Aug 2021 12:49:35 +0200 ]]> Molekulare Mechanismen der Zellvermehrung entschlüsseln /2021-05-21-neuer-sfb-mechanismen-der-zellvermehrung-entschluesseln 2 Tue, 25 May 2021 12:43:01 +0200 ]]> DFG fördert elf neue Sonderforschungsbereiche https://www.dfg.de/de/service/presse/pressemitteilungen/2021/pressemitteilung-nr-16 1 Tue, 25 May 2021 12:23:59 +0200 ]]>