Local TH action in acute and chronic ischaemic heart disease

Prof. Dr. Dagmar FührerProf. Dr.  Lars C. Möller  &  Prof. Dr. Kristina Lorenz

This project pursues the hypothesis that targeted TH action can be applied to reduce injury in acute myocardial infarction (MI) and to ameliorate post-MI remodelling. Using cell-specific mouse models, we will comprehensively characterise local control of TH action in acute and chronic ischaemic heart disease (IHD) and in these conditions will dissect the role of TR isoform, and the mode of TR action in endothelial cells and cardiomyocytes. Furthermore, we will define the optimal timing for TH intervention and will explore selective targeting. Our long-term goal is to exploit local TH action for the benefit of patients with IHD.

Project Team Member

Name Position Phone Email
M.Sc. Gassen, Janina Team Führer, Möller +49 201 723 83081

Mail

Göbel, Julius VMTA (Team Möller) +49 201 723 6057

Mail

Rehn, Stefanie MTA (Team Führer) +49 201 723 6057

Mail

Schättel, Konstanze  Tierpflegemeisterin (Team Lorenz) +49 201 723 82527

Mail

Hoffmann-Posorske, Edeltraut  PTA (Team Lorenz) +49 231 1392 243

Mail

Further Information

Homepage Team Führer

Homepage Team Möller

Selected Publications

Hönes GS, Geist D, Moeller LC. Noncanonical Action of Thyroid Hormone Receptors α and β. Exp Clin Endocrinol Diabetes. 2020 Jun;128(6-07):383-387.

Kohler H, Latteyer S, Hönes GS, ...,Schmid KW, Führer D, Moeller LC. Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice.  Thyroid. 2019 Oct;29(10):1438-1446.

Latteyer S, Christoph S, Theurer S, Hönes GS, Schmid KW, Führer D, Moeller LC. Thyroxine promotes lung cancer growth in an orthotopic mouse model. Endocr Relat Cancer. 2019 Jun;26(6):565-574.

Hönes GS, Rakov H, Logan J, Liao XH, ..., Führer D, Moeller LC  Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo. . Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11323-E11332.

Latteyer S, Klein-Hitpass L,.., Schmid KW, Führer D, Moeller LC. A 6-Base Pair in Frame Germline Deletion in Exon 7 Of RET Leads to Increased RET Phosphorylation, ERK Activation, and MEN2A.  J Clin Endocrinol Metab. 2016 Mar;101(3):1016-22.

Lorenz K, Schmitt JP, Schmitteckert EM, Lohse MJ. 2009 A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. Nat Med 15(1):75-83

Tomasovic T, Brand T, Schanbacher C, ....Cuello F, Zernecke A, Lorenz K. Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects. Nat Commun 2020 doi:10.1038/s41467-020-15505-4

Vettel C, Lindner M, Dewenter M, Lorenz K, …, Leroy J, Vandecasteele G, Wagner M, Fischmeister R, El-Armouche A. Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction. Circ Res. 2017; 120(1):120-132

Ruppert C, Deiss K, Herrmann S, Vidal M, Oezkur M, Gorski A, Weidemann F, Lohse MJ, Lorenz K. Interference with ERKThr188-phosphorylation impairs pathological but not physiological cardiac hypertrophy. Proc Natl Acad Sci U S A. 2013; 110:7440-7445.

Schmid E, Neef S, Berlin C,… Lohse MJ, Lorenz K. Cardiac RKIP causes a beneficial beta-adrenoceptor-dependent positive inotropy. Nat Med. 2015; 21:1298-1306.