TH receptor α1 at the crossroad of autonomic and cardiac functions in mice

Prof. Dr. Jens Mittag

TH is of great importance for cardiac rhythmicity, as tachycardia is often observed in hyperthyroidism, while bradycardia is a leading symptom in hypothyroid patients. It is commonly assumed that the regulation of heart rate by TH is predominantly an effect of TH within the heart; however, recent studies showed that also central TH actions contribute to this phenotype. In the proposed project we now aim to dissect the local from the central actions of TH in the control of heart rate with a focus on the predominant receptor in heart and brain, TRα1.

Project Team Members

Name Position Phone Email
Dr. rer. nat. Riccardo Dore Postdoc +49 451 3101 7821 Mail
Julia Maier PhD candidate  +49 451 3101 7822 Mail

 

Further Information

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Selected Publications

Maternal thyroid hormone programs cardiovascular functions in the offspring.
Pedaran M, Oelkrug R, Sun Q, Resch J, Schomburg L, Mittag J.
2021. Thyroid. doi: 10.1089/thy.2021.0275

Maternal Thyroid Hormone is Required for Parvalbumin Neuron Development in the Anterior Hypothalamic Area.
Harder L, Dudazy-Gralla S, Müller-Fielitz H, Hjerling Leffler J, Vennström B, Heuer H, Mittag J.
2018. J Neuroendocrinol 30(3):e12573. doi: 10.1111/jne.12573

Thermoregulatory and Cardiovascular Consequences of a Transient Thyrotoxicosis and Recovery in Male Mice.
Hoefig CS, Harder L, Oelkrug R, Meusel M, Vennström B, Brabant G, Mittag J.
2016. Endocrinology 157(7):2957-67. doi: 10.1210/en.2016-1095

Inappropriate heat dissipation ignites brown fat thermogenesis in mice with a mutant thyroid hormone receptor α1.
Warner A, Rahman A, Solsjö P, Gottschling K, Davis B, Vennström B, Arner A, Mittag J.
2013. Proc Natl Acad Sci U S A 110(40):16241-16246. doi: 10.1073/pnas.1310300110

Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions.
Mittag J, Lyons DJ, Sällström J, Vujovic M, Dudazy-Gralla S, Warner A, Wallis K, Alkemade A, Nordström K, Monyer H, Broberger C, Arner A, Vennström B.
2013. J Clin Invest 2;123(1):509-516. doi: 10.1172/JCI65252

Thyroid Hormone Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption.
Johann K, Cremer AL, Fischer AW, Heine M, Pensado ER, Resch J, Nock S, Virtue S, Harder L, Oelkrug R, Astiz M, Brabant G, Warner A, Vidal-Puig A, Oster H, Boelen A, Lopez M, Heeren J, Dalley JW, Backes H, Mittag J.
2019. Cell Rep 27(11):3385-3400. doi: 10.1016/j.celrep.2019.05.054