Too much too soon – Tissue-specific inactivation of deiodinase type 3 prematurely exposes brown fat to thyroid hormone.
Rebecca Oelkrug, Jens Mittag.
2022. Endocrinology bqac032. doi: org/10.1210/endocr/bqac032

The interplay of thyroid hormones and the immune system – where we stand and why we need to know about it.
Wenzek C, Boelen A, Westendorf AM, Engel DR, Möller LC, Führer D.
2022. Eur J Endocrinol EJE-21-1171. doi: 10.1530/EJE-21-1171

Distinct actions of the thyroid hormone transporters Mct8 and Oatp1c1 in murine mouse adult hippocampal neurogenesis.
Mayerl S, Alcaide Martin A, Bauer R, Schwaninger M, Heuer H*, ffrench-Constant C*. *equal contribution
2022. Cells 11(3):524. doi: 10.3390/cells11030524

Canonical thyroid hormone receptor β action stimulates hepatocyte proliferation in male mice.
Hönes GS, Kerp H, Hoppe C, Kowalczyk M, Zwanziger D, Baba HA, Führer D, Moeller LC.
2022. Endocrinology bqac003. doi: org/10.1210/endocr/bqac003

Thyroid hormone transporter deficiency in mice impacts multiple stages of GABAergic interneuron development.
Mayerl S, Chen J, Salveridou E, Boelen A, Darras VM, Heuer H.  
2022. Cerebral Cortex. 32(2):329-341. doi: 10.1093/cercor/bhab211

Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring.
Ramhøj L, Svingen T, Frädrich C, Rijntjes E, Wirth EK, Pedersen K, Köhrle J, Axelstad M. 
2022. Toxicol Lett 354:44-55. doi: 10.1016/j.toxlet.2021.10.010. 

Natural Autoimmunity to Selenoprotein P Impairs Selenium Transport in Hashimoto's Thyroiditis.
Sun Q, Mehl S, Renko K, Seemann P, Görlich CL, Hackler J, Minich WB, Kahaly GJ, Schomburg L.
2021. Int J Mol Sci 22(23):13088. doi: 10.3390/ijms222313088

The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice.
Lossow K, Renko K, Schwarz M, Schomburg L, Schwerdtle T, Kipp AP.
2021. Nutrients 13(11):3773. doi: 10.3390/nu13113773

Copper Isotopes and Copper to Zinc Ratio as Possible Biomarkers for Thyroid Cancer.
Kazi Tani LS, Gourlan AT, Dennouni-Medjati N, Telouk P, Dali-Sahi M, Harek Y, Sun Q, Hackler J, Belhadj M, Schomburg L, Charlet L.
2021. Front Med (Lausanne) 8:698167. doi: 10.3389/fmed.2021.698167

Selenium Deficiency Due to Diet, Pregnancy, Severe Illness, or COVID-19-A Preventable Trigger for Autoimmune Disease.
Schomburg L.
2021. Int J Mol Sci 22(16):8532. doi: 10.3390/ijms22168532

Age-dependent response to T4 overtreatment and recovery on systemic and organ level.
Kerp H, Renko K, Hönes GS, Brix K, Köhrle J, Moeller LC, Führer D. 
2021. J Mol Endocrinol 67(4):161-172. doi: 10.1530/JME-21-0109

Thyroid hormone system disrupting chemicals.
Köhrle J, Frädrich C. 
2021. Best Pract Res Clin Endocrinol Metab 35(5):101562. doi: 10.1016/j.beem.2021.101562

Testing for heterotopia formation in rats after developmental exposure to selected in vitro inhibitors of thyroperoxidase.
Ramhøj L, Frädrich C, Svingen T, Scholze M, Wirth EK, Rijntjes E, Köhrle J, Kortenkamp A, Axelstad M. 
2021. Environ Pollut 283:117135. doi: 10.1016/j.envpol.2021.117135

Design and Characterization of a Fluorescent Reporter Enabling Live-cell Monitoring of MCT8 Expression.
Graffunder AS, Paisdzior S, Opitz R, Renko K, Kühnen P, Biebermann H.
2021. Exp Clin Endocrinol Diabetes. doi: 10.1055/a-1522-8535

Caloric restriction disrupts the microbiota and colonization resistance.
Jumpertz von Schwartzenberg R, Bisanz E, Lyalina S, Spanogiannopoulos P, Ang Q, Cai J, Dickmann S, Friedrich M, Liu  S, Collins S, Ingebrigsten D, Miller S, Turnbaugh J, Patterson A, Pollard K, Mai K, Spranger J, Turnbaugh P.
2021. Nature. doi: 10.1038/s41586-021-03663-4

Protective effects of thyroid hormone deprivation on progression of maladaptive cardiac hypertrophy and heart failure.
Kerp H, Hönes GS, Tostik E, Hönes-Wendland J, Gassen J, Moeller LC, Lorenz K, Führer D. 
2021. Frontiers in Cardiovascular Medicine. 8:683522 doi: 10.10.3389/fcvm2021.683522

Thyroid wars: the rise of central actions.
Capelli V, Diéguez C, Mittag J, López M.
2021. Trends Endocrinol Metab 32(9):659-671 doi: 10.1016/2021.05.006

Maternal thyroid hormone programs cardiovascular functions in the offspring.
Pedaran M, Oelkrug R, Sun Q, Resch J, Schomburg L, Mittag J.
2021. Thyroid. doi: 10.1089/thy.2021.0275

A New Mechanism in THRA Resistance: The First Disease-Associated Variant Leading to an Increased Inhibitory Function of THRA2.
Paisdzior S, Knierim E, Kleinau G, Biebermann H, Krude H, Straussberg R, Schuelke M.
2021. Int J Mol Sci 22(10):5338. doi: 10.3390/ijms22105338

Thyroid Hormone Deficiency Modifies Hepatic Lipid Droplet Morphology and Molecular Properties in Lithogenic-Diet Supplemented Mice.
Kube I, Jastrow H, Führer D, Zwanziger D
2021. Exp Clin Endocrinol Diabetes, 129(12):926-930. doi: 10.1055/a-1404-7939

Relation of Serum Copper Status to Survival in COVID-19.
Hackler J, Heller RA, Sun Q, Schwarzer M, Diegmann J, Bachmann M, Moghaddam A, Schomburg L.
2021. Nutrients, doi: 10.3390/nu13061898

Predicting neurological recovery after traumatic spinal cord injury by time-resolved analysis of monocyte subsets.
Heller RA, Seelig J, Crowell HL, Pilz M, Haubruck P, Sun Q, Schomburg L, Daniel V, Moghaddam A, Biglari B.
2021. Brain, 144(10):3159-3174 doi: 10.1093/brain/awab203

Natural Autoimmunity to the Thyroid Hormone Monocarboxylate Transporters MCT8 and MCT10.
Porst T, Johannes J, Gluschke H, Köhler R, Mehl S, Kühnen P, Renko K, Minich WB, Wiegand S, Schomburg L.
2021. Biomedicines, 9(5):496, doi: 10.3390/biomedicines9050496

Serum Selenium Status as a Diagnostic Marker for the Prognosis of Liver Transplantation.
Gül-Klein S, Haxhiraj D, Seelig J, Kästner A, Hackler J, Sun Q, Heller RA, Lachmann N, Pratschke J, Schmelzle M, Schomburg L.
2021. Nutrients, doi: 10.3390/nu13020619

Noncanonical Thyroid Hormone Receptor α Action Mediates Arterial Vasodilation.
Geist D, Hönes GS, Gassen J, Kerp H, Kleinbongard P, Heusch G, Führer D, Moeller LC.
2021. Endocrinology, 162(7):bqab099 doi: org/10.1210/endocr/bqab099

Oligodendrocyte progenitor cell maturation is dependent on dual function of MCT8 in the transport of thyroid hormone across brain barriers and the plasma membrane.
Vatine GD, Shelest O, Barriga BK, Ofan R, Rabinski T, Mattis VB, Heuer H, Svendsen CN.
2021. Glia, 69(9):2146-2159 doi: org/10.1002/glia.24014

Comparative analysis of the effects of long-term 3,5-T2 treatment on the murine hepatic proteome and transcriptome under conditions of normal diet and high-fat diet.
Lietzow J, Golchert J, Pietzner M, Völker U, Poutanen M, Ohlsson C, Homuth G, Köhrle J.
2021. Thyroid, 31(7):11135-1146 doi: 10.1089/thy.2020.0160

Hypothyroidism increases cholesterol gallstone prevalence in mice by elevated hydrophobicity of primary bile acids.
Kube I, Tardio LB, Hofmann U, Ghallab A, Hengstler JG, Führer D, Zwanziger D.
2021. Thyroid, 31(6):973-984 doi: 10.1089/thy.2020.0636

Brain gene expression in systemic hypothyroidism and mouse models of MCT8 deficiency: the Mct8-Oatp1c1-Dio2 triad. 
Morte B, Gil-Ibanez P, Heuer H, Bernal J.
2021. Thyroid, 31(6):337-353, doi: 10.1089/thy.2020.0649

Evidence Based Use of LT4/LT3 Combinations in Treating Hypothyroidism: A Consensus Document.
Jonklaas J, Bianco AC, Cappola AR, Celi F, Fliers E, Heuer H, McAninch EA, Moeller LC, Nygaard B, Sawka AM, Watt T, Dayan CM.
2021. Thyroid, 31(2):156-182, doi: 10.1089/thy.2020.0720

Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.
Luongo C, Butruille L, Sebillot A, Le Blay K, Schwaninger M, Heuer H, Demeneix BA, Remaud S.
2021. Stem Cell Reports, 16(2): 337-353, doi: 10.1016/j.stemcr.2020.12.009

Thyroid hormones in the regulation of brown adipose tissue thermogenesis.
Sentis SC, Oelkrug R, Mittag J.
2021. Endocr Connect, 20(2):R106-R115, doi: org/10.1530/EC-20-0562