Comments on Publications
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DENKER, H.-W.:
Wir brauchen eine Neudefinition des Begriffs "Embryo".
Deutsches Ärzteblatt 120 (33-34): A-1383 / B-1191 (21. August 2023).
Deutsches Ärzteblatt
pdf-download (315 KB)
DENKER, H.-W.:
Blastocyst-like cysts sprouting autonomously from stem cell cultures: Self-organization and implantation potential.
(Comment on: KIME, C., KIYONARI, H., OHTSUKA, S., KOHBAYASHI, E., ASAHI, M., YAMANAKA, S., TAKAHASHI, M. & TOMODA, K.: Induced 2C Expression and Implantation-Competent Blastocyst-like Cysts from Primed Pluripotent Stem Cells. Stem Cell Reports 13:485-498, 2019).
Preprint (2020). DOI: 10.13140/RG.2.2.34000.74242
pdf-download (311 KB)
DENKER, H.-W.:
Recent embryo twinning data prompt reconsideration of theories on a crucial role of segregation of oocyte cytoplasmic constituents in mammals.
(Comment on: CASSER, E., WDOWIK, S., ISRAEL, S., WITTEN, A., SCHLATT, S., NORDHOFF, V., BOIANI, M.: Differences in blastomere totipotency in 2-cell mouse embryos are a maternal trait mediated by asymmetric mRNA distribution. Molec. Hum. Reproduct. 25/11, 729-744, 2019. DOI: 10.1093/molehr/gaz051)
Molec. Hum. Reprod. 26: 193-198 (2020). DOI: 10.1093/molehr/gaaa005
PubMed
MHR
PDF-Download AOV (214 KB)
DENKER, H.-W.:
Implantation: Cell biology of embryo penetration route revisited.
(Comment on: UCHIDA, H. et al.: How to create an embryo penetration route. Am. J. Reprod. Immunol. 75(3): 326-332, 2016. DOI: 10.1111/aji.12476)
Am. J. Reprod. Immunol. 76(6): 429-431 (2016). DOI: 10.1111/aji.12591
PubMed
AJRI
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summary (68 KB)
DENKER, H.-W.:
„Totipotency“ of stem cells: Plasticity vs. self-organization capacity
(Comment on: ISHIUCHI, T., ENRIQUEZ-GASCA, R., MIZUTANI, E., BOSKOVIC, A., ZIEGLER-BIRLING, C., RODRIGUEZ-TERRONES, D., WAKAYAMA, T., VAQUERIZAS, J.M., TORRES-PADILLA, M.E.: Early embryonic-like cells are induced by downregulating replication-dependent chromatin assembly. Nature Struct. Mol. Biol. 22: 662-671, 2015).
Preprint (2015). DOI: 10.13140/RG.2.2.15761.25441
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DENKER, H.-W.:
Stem Cell Terminology and 'Synthetic' Embryos: A New Debate on Totipotency, Omnipotency, and Pluripotency and How It Relates to Recent Experimental Data
(Comment on:
- CONDIC, M.I.: Totipotency: what it is and what it is not. Stem Cells Dev 23: 796-812, 2014;
- XU, P.F., HOUSSIN, N., FERRI-LAGNEAU, K.F., THISSE, B., THISSE, C.: Construction of a vertebrate embryo from two opposing morphogen gradients. Science 344: 87-89, 2014;
- WARMFLASH, A., SORRE, B., ETOC, F., SIGGIA, E.D., BRIVANLOU, A.H.: A method to recapitulate early embryonic spatial patterning in human embryonic stem cells. Nature Methods 11: 847-854, 2014)
Cells Tissues Organs 199: 221-227 (2014).
PubMed
CTO Website (free access)
DENKER, H.-W.:
Comment on G. Herranz: The timing of monozygotic twinning: a criticism of the common model. Zygote (2013).
(Comment on: HERRANZ, G.: Zygote 23(1): 27-40, 2015. DOI: 10.1017/S0967199413000257)
Zygote 23(2): 312-314 (2015). DOI: 10.1017/S0967199413000579
PubMed
Zygote
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DENKER, H.-W., HOLM, S.:
Patenting and stem cell pluripotency.
(Comment on: SMITH, A.: 'No' to ban on stem-cell patents. Nature 472, 418, 2011. DOI: 10.1038/472418a)
Nature 472: 418, 2011; Online Comment #22079.
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Nature Website
DENKER, H.-W.:
Ethical concerns over use of new cloning technique in humans.
(Comment on: BOLAND, M.J. et al.: Adult mice generated from induced pluripotent stem cells. Nature 461(7260): 91-94, 2009. DOI: 10.1038/nature08310 and on: ZHAO, X.Y. et al.: iPS cells produce viable mice through tetraploid complementation. Nature 461(7260): 86-90. DOI: 10.1038/nature08267)
Nature 461: 341 (2009). DOI: 10.1038/461341b
PubMed
pdf-download (5.78 KB)
DENKER, H.-W.:
Comment on Draft NIH Guidelines for Human Stem Cell Research (2009) (Public Comment ID 16452).
pdf-download (15.1 KB) NIH Website
Unfortunately, NIH has removed this webpage.
However, you are still welcome to download my comment as a PDF (15.1 KB).
DENKER, H.-W.:
Induzierte pluripotente Stammzellen (iPS) und das Omnipotenz-/Totipotenzproblem.
(Comment on: RICHTER-KUHLMANN, E.: Stammzellenforschung: Reprogrammierungserfolge entzünden erneut Debatte Deutsches Ärzteblatt 104: C 2799 - C 2800, 2007.)
Leserbrief: pdf-download (12.5 KB)
Slightly shortened version published in: Deutsches Ärzteblatt 105 (Heft 11): A 577- A 578 (2008). to the article
DENKER, H.-W.:
Human embryonic stem cell lines generated without embryo destruction: New strategies, new ethical problems
(Comment on: CHUNG, Y.; KLIMANSKAYA, I.; BECKER, S.; LI, T.; MASERATI, M.; LU, S.-J.; ZDRAVKOVIC, T.; ILIC, D.; GENBACEV, O.; FISHER, S.; KRTOLICA, A.; LANZA, R.: Human embryonic stem cell lines generated without embryo destruction. Cell Stem Cell 2: 113-117, 2008.)
Deutsch (12.2 KB) English (11.3 KB)
DENKER, H.-W.:
Heureka!
(Comment on: DEVOLDER, K. and WARD, C. M.: Rescuing human embryonic stem cell research: The possibility of embryo reconstruction after stem cell derivation. Metaphilosophy, Vol. 38, No. 2, 245-263, 2007.)
pdf-download (14.2 KB)
DENKER, H.-W.:
Comment on:
KLIMANSKAYA, I.; CHUNG, Y.; BECKER, S.; LU, S.-J.; LANZA, R.:
Human embryonic stem cell lines derived from single blastomeres.
Nature 444: 481-485 (2006). pdf-download (7.75 KB)