NeuroScienceLab Essen
Dr. rer. nat. Anne K. Mausberg

Post-doctoral scientist
Office: IG1, 9th floor, BIC, Room 9.002
Phone: +49 201 723 82225
Fax: +49 201 723 4736

Anne K. Mausberg studied biology at the Heinrich Heine University in Düsseldorf. Her diploma thesis focused on the T cell response after Toxoplasma gondii infection and the characterization of the protective T cell receptor repertoire. She sticked to the field of immunology and performed her PhD thesis at the Institute for Microbiology and Virology under the supervision of PD Dr. G. Reichmann and Prof. Dr. K. Pfeffer. Here she analyzed the effect of the cytokine GM-CSF on dendritic cells of the central nervous system and set the basis for her special interest in neuroimmunology. To further pursue this topic after the PhD she joined the research group of Prof. Dr. B. C. Kieseier at the Department of Neurology. Since 2016 she is a member of the research group "Clinical and experimental neuroimmunology" within the NeuroScienceLab.
Research interests

Autoimmune diseases of the peripheral and central nervous system are not sufficiently treatable. Different immune cell subpopulations like T cells and NK cells as well as macrophages influence the course of diseases and determine disease outcome. To better understand their pathogenesis, the group is interested in mechanisms underlying autoimmune attacks that subsequently result in nervous system dysfunction and damage. Additionally the work group also characterizes treatment responses to drugs in order to improve currently available treatment options for autoimmune diseases.
Key publications

Szepanowski F, Donaldson DM, Hartung HP, Mausberg AK, Kleinschnitz C, Kieseier BC, Stettner M. Dimethyl fumarate accelerates peripheral nerve regeneration via activation of the anti-inflammatory and cytoprotective Nrf2/HO-1 signaling pathway. Acta Neuropathol. 2017; 133:489–491.

Buerth C*, Mausberg AK*, Heininger MK, Hartung HP, Kieseier BC, Ernst JF. Oral tolerance induction in experimental autoimmune encephalomyelitis with Candida utilis expressing the immunogenic MOG35-55 peptide. PLoS ONE. 2016; 11:e0155082.

Warnke C*, Mausberg AK*, Stettner M, Dehmel T, Nekrich L, Meyer Zu Hörste G, Hartung HP, Fogdell-Hahn A, Adams O, Kieseier BC. Natalizumab affects the T-cell receptor repertoire in patients with multiple sclerosis. Neurology. 2013; 81:1400–1408.

Mausberg AK, Dorok M, Stettner M, Müller M, Hartung HP, Dehmel T, Warnke C, Meyer Zu Hörste G, Kieseier BC. Recovery of the T-cell repertoire in CIDP by IV immunoglobulins. Neurology. 2013; 80:296–303.

Stettner M, Wolffram K, Mausberg AK, Wolf C, Heikaus S, Derksen A, Dehmel T, Kieseier BC. A reliable in vitro model for studying peripheral nerve myelination in mouse. J Neurosci Methods. 2013; 214:69–79.

Mausberg AK, Meyer Zu Hörste G, Dehmel T, Stettner M, Lehmann HC, Sheikh KA, Kieseier BC. Erythropoietin ameliorates rat experimental autoimmune neuritis by inducing transforming growth factor-β in macrophages. PLoS ONE. 2011; 6:e26280.

Mausberg AK, Jander S, Reichmann G. Intracerebral granulocyte-macrophage colony-stimulating factor induces functionally competent dendritic cells in the mouse brain. Glia. 2009; 57:1341–1350.
NeuroScienceLab Sekretariat