NeuroScienceLab Essen
Prof. Christoph Kleinschnitz

Chair of the Department of Neurology
Office: MZ, 1st floor, room 1.219
Phone: +49 201 723 2461
Fax: +49 201 723 5901

Christoph Kleinschnitz studied medicine at the Würzburg University from 1994 to 2000. Following his doctorate in 2001, he performed his residency at the Department of Neurology of the University Hospital Wurzburg and qualified as a neurologist in 2007. In 2009, he became head of the stroke unit and out-patient clinic, in which cerebrovascular disorders are treated. From 2010, he also led the Clinical Research Group for multiple sclerosis and neuroimmunology and soon later, he became executive consultant of the Department of Neurology and professor at the University Hospital Würzburg. He has received several prizes for his pioneering works.
Research interests

His research focuses on thrombo-inflammatory disease mechanisms in stroke and multiple sclerosis, with strong translational focus. Together with his team, Prof. Kleinschnitz is aiming to identify new biomarkers and therapeutic targets that allow improving stroke treatment without the risk of adverse events.
Key publications

Göbel K, …, Kleinschnitz C, Meuth SG. Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. Nature Commun. 2016; 7:11626.

Hopp S, …, Kleinschnitz C. Targeting coagulation factor XII as a novel therapeutic option in brain trauma. Ann Neurol. 2016; 79:970-82.

Kraft P, …, Kleinschnitz C. Efficacy and safety of platelet glycoprotein receptor blockade in aged and comorbid mice with acute experimental stroke. Stroke. 2015; 46:3502-6.

Schleicher RI, …, Kleinschnitz C, …, Langer HF. Platelets induce apoptosis via membrane-bound FasL. Blood. 2015; 126:1483-93.

Verhenne S, …, Kleinschnitz C, …, De Meyer SF. Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice. Blood. 2015; 126:1715-22.

Mezger M, …, Kleinschnitz C, Langer HF. Platelets and vascular inflammation of the brain. Hamostaseologie. 2015; 35:244-51.

Göb E, …, Kleinschnitz C. Blocking of plasma kallikrein ameliorates stroke by reducing thromboinflammation. Ann Neurol. 2015; 77:784-803.

Schuhmann MK, …, Kleinschnitz C. CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke. J Cereb Blood Flow Metab. 2015; 35:6-10.

Kleinschnitz C, …, Wiendl H. Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 2013; 121:679-91.

Langhauser F, …, Kleinschnitz C. Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation. Blood. 2012; 120:4082-92.
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