NeuroScienceLab Essen
Univ.-Prof. Dr. med. Dirk M. Hermann

Chair of Vascular Neurology, Dementia and Ageing Research / Director NeuroScienceLab
Office: OZ1, ground floor, room 179
Phone: +49 201 723 2180
Fax: +49 201 723 5534

Dirk Hermann studied medicine at Justus Liebig University Gießen from 1987-1994. Following his MD thesis at the same University in 1995 and a residency (Arzt im Praktikum) at the Max Planck Institute of Psychiatry Munich in 1994-1995, he performed a postdoc at the Max Planck Institute for Neurological Research Cologne in 1995-1998, followed by his residency at the Department of Neurology of Eberhard Karls University Tübingen in 1998-2001. Following his neurological board examination in 2001 and his state doctorate (habilitation) in 2002, Dirk Hermann was associate professor and consultant neurologist at the University Hospital Zurich (Switzerland) in 2002-2008. Since 2008, Dirk Hermann holds the Chair of Vascular Neurology, Dementia and Ageing Research at the University of Duisburg-Essen.
Research interests

Dirk Hermann's research focusses on post-ischemic brain remodeling and plasticity, evaluating pathomechanisms contributing to secondary brain injury and searching strategies that promote neurological recovery in the post-acute stroke phase. Research activities include studies on post-ischemic axonal, dendritic and synaptic plasticity, angiogenesis, extracellular matrix remodeling, immune responses and vascular risk factors. Dirk Hermann’s group has long-lasting experience and skills in the evaluation of post-ischemic blood-brain barrier integrity. The group bridges in vitro and in vivo studies in animals and humans, combining structural and functional readouts with a broad set of research tools.
Key publications

Bacigaluppi M, Pluchino S, Peruzzotti-Jametti L, Kilic E, Kilic U, Salani G, Brambilla E, West MJ, Comi G, Martino G, Hermann DM. Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. Brain. 2009; 132:2239-51.

ElAli A, Hermann DM. Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain. Sci Signal. 2010; 3:ra72.

Hermann DM, Bassetti CL. Implications of ATP-binding cassette transporters for brain pharmacotherapies. Trends Pharmacol Sci. 2007; 28:128-34.

Hermann DM, Chopp M. Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation. Lancet Neurol. 2012; 11:369-80.

Hermann DM, ElAli A. The abluminal endothelial membrane in neurovascular remodeling in health and disease. Sci Signal. 2012; 5:re4.

Kilic E, Spudich A, Kilic U, Rentsch KM, Vig R, Matter CM, Wunderli-Allenspach H, Fritschy JM, Bassetti CL, Hermann DM. ABCC1: a gateway for pharmacological compounds to the ischaemic brain. Brain. 2008; 131:2679-89.

Reitmeir R, Kilic E, Kilic U, Bacigaluppi M, ElAli A, Salani G, Pluchino S, Gassmann M, Hermann DM. Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity. Brain. 2011; 134:84-99.

Reitmeir R, Kilic E, Reinboth BS, Guo Z, ElAli A, Zechariah A, Kilic U, Hermann DM. Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain. Acta Neuropathol. 2012; 123:273-84.

Spudich A, Kilic E, Xing H, Kilic U, Rentsch KM, Wunderli-Allenspach H, Bassetti CL, Hermann DM. Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia. Nat Neurosci. 2006; 9:487-8.
NeuroScienceLab Sekretariat