NeuroScienceLab Essen
Dr. rer.nat. Egor Dzyubenko

Post-doctoral scientist
Office: MFZ, 2nd floor, room 2.032
Phone: +49 201 723 6025
Fax: +49 201 723 6903

Egor Dzyubenko studied biology, biophysics and bionanotechnology at Lomonosov’s Moscow State University and received his diploma in 2011. His diploma thesis focussed on the dynamics of mitochondrial membrane potential during hyperglycaemic stress in cultivated neurons. He performed his PhD thesis at the Department of Cell Morphology and Molecular Neurobiology of the Ruhr University Bochum under the supervision of Prof. Dr. Andreas Faissner from 2012 until 2016. His thesis entitled ‘Modifying synaptogenesis and functional state of neural networks in vitro: insights from antipsychotic treatments and extracellular matrix depletion’ was awarded with the grade "with distinction". Subsequently, he moved to the University Hospital Essen and joined the NeuroScienceLab within the Chair of Vascular Neurology, Dementia and Ageing Research in 2017.
Research interests

Human brain is comprised out of around 100 billion of neurons, interconnected by a quadrillion of synapses, and around a trillion of glial cells. The stable functioning of this enormously complex organ relies on multiple regulatory mechanisms, many of which involve extracellular matrix (ECM) and neuron-glia interactions. Hence, his research on the three main questions:
  • What is the role of astrocytes, ECM and peri-neuronal nets for neuronal plasticity and neuronal network function?
  • Can we modify neuronal networks exogenously, and how can patients with neurological diseases benefit from it?
  • Which are the molecular signals that lead to neurological recovery?
To address these challenging tasks, he combines animal models and cell culture techniques, bridging structural histochemical and electrophysiological methods (e.g., Multi Electrode Arrays, MEA). Within his studies, he establishes cutting-edge superresolution imaging tools (STED, SIM, PALM) and evaluates neuronal connectivity by computational approaches.
Key publications

Dzyubenko E, Juckel G and Faissner A. Antipsychotic drugs olanzapine and haloperidol modify network connectivity and spontaneous activity of neural networks in vitro. Sci Rep., under revision

Gottschling C, Dzyubenko E, Geissler M, Faissner A. The indirect neuron-astrocyte coculture assay: An in vitro set-up for the detailed investigation of neuron-glia interactions. J Vis Exp. 2016; 117.

Dzyubenko E, Rozenberg A, Hermann DM, Faissner A. Colocalization of synapse marker proteins evaluated by STED-microscopy reveals patterns of neuronal synapse distribution in vitro. J Neurosci Meth. 2016; 273: 149-159.

Dzyubenko E, Gottschling C, Faissner A. Neuron-Glia Interactions in neural plasticity: Contributions of neural extracellular matrix and perineuronal nets. Neural Plast. 2016; 2016: 5214961.

Efremov Y, Dzyubenko E, Bagrov D, Maksimov G, Shram S, Shaitan K. Atomic force microscopy study of the arrangement and mechanical properties of astrocytic cytoskeleton in growth medium. Acta Naturae. 2011; 3(3):93-9.
NeuroScienceLab Sekretariat