NeuroScienceLab Essen
Dr. rer. nat. Fabian Szepanowski

Post-doctoral scientist
Office: IG1, 9th floor, room 9.002
Phone: +49 201 723 82225
Fax: +49 201 723 79030

Fabian Szepanowski studied biology at the Heinrich-Heine-University Düsseldorf from 2009-2014. His Master thesis focused on the impact of sphingosine-1-phosphate receptor modulation on peripheral nerve regeneration. In subsequent years, he developed expertise in the field of neural regeneration under supervision of Prof. Dr. Bernd C. Kieseier at the Department of Neurology in Düsseldorf, culminating in his PhD thesis on "Therapeutic approaches for the improvement of peripheral nerve regeneration". By late 2018, he joined the lab of Prof. Dr. Dr. Mark Stettner within the Department of Neurology at the University Medicine Essen to pursue his interest in neural regeneration and to apply and extend his knowledge to models of inflammatory neuropathies.
Research interests

Despite an emerging understanding of the cellular and molecular processes underlying the pathophysiology of mechanical nerve injuries as well as immune-mediated neuropathies, no therapy to foster nerve recovery has been translated to clinical practice thus far. Interestingly, nerve degeneration as observed after injury and in inflammatory neuropathies shares mechanistic commonalities: Schwann cell dedifferentiation, demyelination, axonal energy depletion and subsequent disintegration are major hallmarks of both pathologies. Therefore, the exploration of therapeutic approaches in models of mechanical injury and both acute and chronic inflammatory neuropathy models may pave the way for novel regenerative strategies in the inflamed PNS.
Key publications

Szepanowski F, Winkelhausen M, Steubing RD, Mausberg AK, Kleinschnitz C, Stettner M. LPA1 signaling drives Schwann cell dedifferentiation in experimental autoimmune neuritis. J Neuroinflammation. 2021 Dec 17;18(1):293.

Szepanowski F, Warnke C, Meyer Zu Hörste G, Mausberg AK, Hartung HP, Kleinschnitz C, Stettner M. Secondary Immunodeficiency and Risk of Infection Following Immune Therapies in Neurology. CNS Drugs. 2021 Nov;35(11):1173-1188.

Heming M, Li X, Räuber S, Mausberg AK, Börsch AL, Hartlehnert M, Singhal A, Lu IN, Fleischer M, Szepanowski F, Witzke O, Brenner T, Dittmer U, Yosef N, Kleinschnitz C, Wiendl H, Stettner M, Meyer Zu Hörste G. Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid. Immunity. 2021 Jan 12;54(1):164-175.e6.

Szepanowski F, Kleinschnitz C, Stettner M. Glyphosate-based herbicide: a risk factor for demyelinating conditions of the peripheral nervous system? Neural Regen Res. 2019 Dec;14(12):2079-2080.

Szepanowski F, Szepanowski LP, Mausberg AK, Albrecht P, Kleinschnitz C, Kieseier BC, Stettner M. Differential impact of pure glyphosate and glyphosate-based herbicide in a model of peripheral nervous system myelination. Acta Neuropathol. 2018 Dec;136(6):979-982.

Szepanowski F, Szepanowski LP, Mausberg AK, Kleinschnitz C, Kieseier BC, Stettner M. Lysophosphatidic acid propagates post-injury Schwann cell dedifferentiation through LPA1 signaling. Neurosci Lett. 2018 Jan 1;662:136-141.

Szepanowski F, Donaldson DM, Hartung HP, Mausberg AK, Kleinschnitz C, Kieseier BC, Stettner M. Dimethyl fumarate accelerates peripheral nerve regeneration via activation of the anti-inflammatory and cytoprotective Nrf2/HO-1 signaling pathway. Acta Neuropathol. 2017 Mar;133(3):489-491.

Szepanowski F, Kieseier BC. Targeting lysophospholipid signaling as a therapeutic approach towards improved peripheral nerve regeneration. Neural Regen Res. 2016 Nov;11(11):1754-1755.

Szepanowski F, Derksen A, Steiner I, Meyer Zu Hörste G, Daldrup T, Hartung HP, Kieseier BC. Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling. J Neuroinflammation. 2016 Jun 10;13(1):143.
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