NeuroScienceLab Essen
Dr. rer.nat. Nina Hagemann

Post-doctoral scientist
Office: MFZ, 2nd floor, room 2.016
Phone: +49 201 723 83550
Fax: +49 201 723 6903

Nina Hagemann (born Stenzel) studied biology at the Ruhr University Bochum and received her diploma in 2007. Her diploma thesis focussed on the hitherto unknown FERM and PDZ domain containing protein 2 and its expression in epithelial cells. Nina Hagemann performed her dissertation in the research group "Biochemistry of polarized cells" at the Department of Molecular Neurobiochemistry of the Faculty of Chemistry and Biochemistry at the Ruhr University Bochum under the supervision of PD Dr. Kai S. Erdmann from 2007 until 2011. Her thesis entitled "Functional characterisation of the PDZ domain proteins FRMPD2 and PTP-BL in polarized cells" was awarded with the grade "with distinction". After a subsequent post-doc time she moved to the University Hospital Essen and joined the NeuroScienceLab within the Chair of Vascular Neurology, Dementia and Ageing Research in 2012.
Research interests

Nina Hagemann is interested in the role of transporters, receptors and sphingolipids in the ischemic brain with special emphasis on blood-brain barrier integrity and angiogenesis. Her group utilizes a wide range of in vitro and in vivo methods, evaluating restorative processes also in the context of vascular risk factors and comorbidities.
Key publications

Lugo-Hernandez E, Squire A, Hagemann N, Brenzel A, Sardari M, Schlechter J, et al. 3D visualization and quantification of microvessels in the whole ischemic mouse brain using solvent-based clearing and light sheet microscopy. J Cereb Blood Flow Metab. 2017: 271678X17698970.

Zechariah A, ElAli A, Hagemann N, Jin F, Doeppner TR, Helfrich I, et al. Hyperlipidemia attenuates vascular endothelial growth factor-induced angiogenesis, impairs cerebral blood flow, and disturbs stroke recovery via decreased pericyte coverage of brain endothelial cells. Arterioscler Thromb Vasc Biol. 2013; 33(7):1561-7.

Jin F, Hagemann N, Schafer ST, Brockmeier U, Zechariah A, Hermann DM. SDF-1 restores angiogenesis synergistically with VEGF upon LDL exposure despite CXCR4 internalization and degradation. Cardiovasc Res. 2013; 100(3):481-91.

Jin F, Hagemann N, Brockmeier U, Schafer ST, Zechariah A, Hermann DM. LDL attenuates VEGF-induced angiogenesis via mechanisms involving VEGFR2 internalization and degradation following endosome-trans-Golgi network trafficking. Angiogenesis. 2013; 16(3):625-37.

Hagemann N, Ackermann N, Christmann J, Brier S, Yu F, Erdmann KS. The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis. Oncogene. 2013; 32(39):4602-13.

Lipinski S, Grabe N, Jacobs G, Billmann-Born S, Till A, Hasler R, et al., Hagemann N, et al. RNAi screening identifies mediators of NOD2 signaling: implications for spatial specificity of MDP recognition. Proc Natl Acad Sci U S A. 2012; 109(52):21426-31.

Hagemann N, Hou X, Goody RS, Itzen A, Erdmann KS. Crystal structure of the Rab binding domain of OCRL1 in complex with Rab8 and functional implications of the OCRL1/Rab8 module for Lowe syndrome. Small GTPases. 2012; 3(2):107-10.

Hou X, Hagemann N, Schoebel S, Blankenfeldt W, Goody RS, Erdmann KS, et al. A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. EMBO J. 2011; 30(8):1659-70.

Stenzel N, Fetzer CP, Heumann R, Erdmann KS. PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells. J Cell Sci. 2009; 122(Pt 18):3374-84.
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