NeuroScienceLab Essen
Ulf Brockmeier, Dr.

Post-doctoral scientist
Office: MFZ, 2nd floor, room 2.016
Phone: +49 201 723 1661
Fax: +49 201 723 6903

Ulf Brockmeier received his diploma in biology in 2002 at University of Bochum. In 2006, he earned his Ph.D. in the field of biotechnology at Research Centre Jülich in the Institute for Molecular Enzyme Technology (IMET). From 2006-2008 he was a postdoctoral fellow at University of Toronto (UofT) in the Department of Biochemistry. After his return to Germany, he worked for the Institute of Physiology at University Hospital Essen focusing on hypoxia and ER stress in cancer cells. In October 2019 he joined the research group "Vascular Neurology, Dementia and Ageing Research" of Prof. Dirk M. Hermann.
Research interests

Ulf Brockmeier investigates hypoxia-induced stress signaling in neurovascular cells.
Key publications

Kranz P, Neumann F, Wolf A, Classen F, Pompsch M, Ocklenburg T, Baumann J, Janke K, Baumann M, Goepelt K, Riffkin H, Metzen E, Brockmeier U. PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR). Cell Death Dis. 2017 Aug 10;8(8)

Hussmann M, Janke K, Kranz P, Neumann F, Mersch E, Baumann M, Goepelt K, Brockmeier U, Metzen E. Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics. Oncotarget. 2015 Nov 17;6(36):39247-61.

Jin F, Brockmeier U, Otterbach F, Metzen E. New insight into the SDF-1/CXCR4 axis in a breast carcinoma model: hypoxia-induced endothelial SDF-1 and tumor cell CXCR4 are required for tumor cell intravasation. Mol Cancer Res. 2012 Aug;10(8):1021-31.

Panaretakis T, Kepp O, Brockmeier U, Tesniere A, Bjorklund AC, Chapman DC, Durchschlag M, Joza N, Pierron G, van Endert P, Yuan J, Zitvogel L, Madeo F, Williams DB, Kroemer G. Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J. 2009 Mar 4;28(5):578-90

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