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Fakultät Biologie, Molekularbiologie I

Anschrift
Universitätsstr. 2
45141 Essen
Raum
S03 V04 F44

Funktionen

  • Professor/in, Molekularbiologie I

  • Vorsitzender, Prüfungsausschuss für Medizinische Biologie

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Gahlot, Pinki; Kravic, Bojana; Rota, Giulia; van den Boom, Johannes; Levantovsky, Sophie; Schulze, Nina; Maspero, Elena; Polo, Simona; Behrends, Christian; Meyer, Hemmo
    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
    In: Molecular Cell (2024) in press
  • Mirsanaye, Ann Schirin; Hoffmann, Saskia; Weisser, Melanie; Mund, Andreas; Lopez Mendez, Blanca; Typas, Dimitris; van den Boom, Johannes; Benedict, Bente; Hendriks, Ivo A.; Nielsen, Michael Lund; Meyer, Hemmo; Duxin, Julien P.; Montoya, Guillermo; Mailand, Niels
    VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates
    In: Nature Communications Jg. 15 (2024) Nr. 1, 2459
  • van den Boom, Johannes; Marini, Guendalina; Meyer, Hemmo; Saibil, Helen R
    Structural basis of ubiquitin-independent PP1 complex disassembly by p97
    In: The EMBO Journal Jg. 42 (2023) Nr. 14, e113110
  • Meyer, Hemmo; van den Boom, Johannes
    Targeting of client proteins to the VCP/p97/Cdc48 unfolding machine
    In: Frontiers in Molecular Biosciences Jg. 10 (2023) 1142989
  • Blüggel, Mike; Kröning, Alexander; Kracht, Matthias; van den Boom, Johannes; Dabisch, Matthias; Göhring, Anna; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter; Meyer, Hemmo; Beuck, Christine
    The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase
    In: Nature Communications Jg. 14 (2023) Nr. 1, 3258
  • Seaayfan, Elie; Nasrah, Sadiq; Quell, Lea; Kleim, Maja; Weber, Stefanie; Meyer, Hemmo; Laghmani, Kamel; Kömhoff, Martin
    MAGED2 Is Required under Hypoxia for cAMP Signaling by Inhibiting MDM2-Dependent Endocytosis of G-Alpha-S
    In: Cells Jg. 11 (2022) Nr. 16, 2546
  • Kravić, Bojana; Bionda, Tihana; Siebert, Alexander; Gahlot, Pinki; Levantovsky, Sophie; Behrends, Christian; Meyer, Hemmo
    Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1
    In: Molecular Cell Jg. 82 (2022) Nr. 14, S. 2633 - 2649.e7
  • Kröning, Alexander; van den Boom, Johannes; Kracht, Matthias; Kück, Anja; Meyer, Hemmo
    Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN
    In: The Journal of Biological Chemistry (JBC) Jg. 298 (2022) Nr. 6, 101976
  • Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Buitrago-Molina, Laura Elisa; Lu, Mengji; Meyer, Hemmo; Tong, Chun-Kit
    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
    In: Autophagy Jg. 17 (2021) Nr. 1, S. 1 - 382
  • van den Boom, Johannes; Kück, Anja; Kravic, Bojana; Müschenborn, Helen; Giesing, Maike; Pan, Dongqing; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Meyer, Hemmo
    Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly
    In: Nature Structural & Molecular Biology Jg. 28 (2021) Nr. 12, S. 964 - 971
  • Kollenda, Sebastian; Kopp, Mathis; Wens, Jasmin; Koch, Johannes; Schulze, Nina; Papadopoulos, Chrisovalantis; Pöhler, Robert; Meyer, Hemmo; Epple, Matthias
    A pH-sensitive fluorescent protein sensor to follow the pathway of calcium phosphate nanoparticles into cells
    In: Acta Biomaterialia Jg. 111 (2020) S. 406 - 417
  • Kracht, Matthias; van den Boom, Johannes; Seiler, Jonas; Kröning, Alexander; Kaschani, Farnusch; Kaiser, Markus; Meyer, Hemmo
    Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain Adapters
    In: Journal of Molecular Biology (JMB) Jg. 432 (2020) Nr. 23, S. 6061 - 6074
  • Kravic, Bojana; Behrends, Christian; Meyer, Hemmo
    Regulation of lysosome integrity and lysophagy by the ubiquitin-conjugating enzyme UBE2QL1
    In: Autophagy Jg. 16 (2020) Nr. 1, S. 179 - 180
  • Papadopoulos, Chrisovalantis; Kravic, Bojana; Meyer, Hemmo
    Repair or Lysophagy : Dealing with Damaged Lysosomes
    In: Journal of Molecular Biology (JMB) Jg. 432 (2020) Nr. 1, S. 231 - 239
  • Krahn, Daniel; Heilmann, Geronimo; Vogel, Felix C. E.; Papadopoulos, Chrisovalantis; Zweerink, Susanne; Kaschani, Farnusch; Meyer, Hemmo; Rösch, Alexander; Kaiser, Markus
    Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family
    In: Chemistry - A European Journal Jg. 26 (2020) Nr. 39, S. 8524 - 8531
  • Blüggel, Mike; van den Boom, Johannes; Meyer, Hemmo; Bayer, Peter; Beuck, Christine
    Structure of the PUB Domain from Ubiquitin Regulatory X Domain Protein 1 (UBXD1) and Its Interaction with the p97 AAA+ ATPase
    In: Biomolecules Jg. 9 (2019) Nr. 12, 876
  • Körver, Lisa; Papadopoulos, Chrisovalantis; Liu, Bin; Kravic, Bojana; Rota, Giulia; Brecht, Lukas; Veenendaal, Tineke; Polajnar, Mira; Blümke, Anika; Ehrmann, Michael; Klumperman, Judith; Jäättelä, Marja; Behrends, Christian; Meyer, Hemmo
    The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage
    In: EMBO Reports (2019) S. e48014
  • Arhzaouy, Khalid; Papadopoulos, Chrisovalantis; Schulze, Nina; Pittman, Sara K.; Meyer, Hemmo; Weihl, Conrad C.
    VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle
    In: Autophagy Jg. 15 (2019) Nr. 6, S. 1082 - 1099
  • Pöhler, Robert; Krahn, Jan; van den Boom, Johannes; Dobrynin, Grzegorz; Kaschani, Farnusch; Eggenweiler, Hans-Michael; Zenke, Frank T.; Kaiser, Markus; Meyer, Hemmo
    A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases
    In: Angewandte Chemie International Edition Jg. 57 (2018) Nr. 6, S. 1576 - 1580
  • Hülsmann, Julia; Kravic, Bojana; Weith, Matthias; Gstaiger, Matthias; Aebersold, Ruedi; Collins, Ben C.; Meyer, Hemmo
    AP-SWATH reveals direct involvement of VCP/ p97 in integrated stress response signaling through facilitating CReP/PPP1R15B degradation
    In: Molecular and Cellular Proteomics (MCP) Jg. 17 (2018) Nr. 7, S. 1295 - 1307
  • Weith, Matthias; Seiler, Jonas; van den Boom, Johannes; Kracht, Matthias; Hülsmann, Julia; Primorac, Ivana; Del Pino Garcia, Javier; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Bollen, Mathieu; Meyer, Hemmo
    Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation
    In: Molecular Cell Jg. 72 (2018) Nr. 4, S. 766 - 777
  • van den Boom, Johannes; Meyer, Hemmo
    VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling
    In: Molecular Cell Jg. 69 (2018) Nr. 2, S. 182 - 194
  • Kopp, Mathis; Rotan, Olga; Papadopoulos, Chrisovalantis; Schulze, Nina; Meyer, Hemmo; Epple, Matthias
    Delivery of the autofluorescent protein R-phycoerythrin by calcium phosphate nanoparticles into four different eukaryotic cell lines (HeLa, HEK293T, MG-63, MC3T3) : Highly efficient, but leading to endolysosomal proteolysis in HeLa and MC3T3 cells
    In: PLoS ONE Jg. 12 (2017) Nr. 6, S. e0178260
  • Papadopoulos, Chrisovalantis; Meyer, Hemmo
    Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and Lysophagy
    In: Current Biology Jg. 27 (2017) Nr. 24, S. R1330 - R1341
  • Papadopoulos, Chrisovalantis; Kirchner, Philipp; Bug, Monika; Grum, Daniel; Körver, Lisa; Schulze, Nina; Pöhler, Robert; Dressler, Alina; Fengler, Sven; Arhzaouy, Khalid; Lux, Vanda; Ehrmann, Michael; Weihl, Conrad C.; Meyer, Hemmo
    VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy
    In: The EMBO Journal Jg. 36 (2017) Nr. 2, S. 135 - 150
  • Trusch, Franziska; Kowski, Klaus; Bravo-Rodriguez, Kenny; Beuck, Christine; Sowislok, Andrea; Wettig, Burkhard; Matena, Anja; Sánchez-García, Elsa; Meyer, Hemmo; Schrader, Thomas; Bayer, Peter
    Molecular tweezers target a protein-protein interface and thereby modulate complex formation
    In: Chemical Communications: ChemComm Jg. 52 (2016) Nr. 98, S. 14141 - 14144
  • van den Boom, Johannes; Wolf, Markus; Weimann, Lena; Schulze, Nina; Li, Fanghua; Kaschani, Farnusch; Riemer, Anne; Zierhut, Christian; Kaiser, Markus; Iliakis, George; Funabiki, Hironori; Meyer, Hemmo
    VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair
    In: Molecular Cell Jg. 64 (2016) Nr. 1, S. 189 - 198
  • Trusch, Franziska; Matena, Anja; Vuk, Maja; Körver, Lisa; Knævelsrud, Helene; Freemont, Paul S.; Meyer, Hemmo; Bayer, Peter
    The N-terminal region of the ubiquitin regulatory X (UBX) domain-containing protein 1 (UBXD1) modulates interdomain communication within the valosin-containing protein p97
    In: The Journal of Biological Chemistry (JBC) Jg. 290 (2015) Nr. 49, S. 29414 - 29427
  • Eiteneuer, Annika; Seiler, Jonas; Weith, Matthias; Beullens, Monique; Lesage, Bart; Krenn, Veronica; Musacchio, Andrea; Bollen, Mathieu; Meyer, Hemmo
    Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1
    In: The EMBO Journal Jg. 33 (2014) Nr. 22, S. 2704 - 2720
  • Meyer, Hemmo; Weihl, Conrad C.
    The VCP/p97 system at a glance : connecting cellular function to disease pathogenesis
    In: Journal of Cell Science Jg. 127 (2014) Nr. 18, S. 3877 - 3883
  • Dressler, A.; Riemer, Anne; Dobrynin, Grzegorz; Bremer, Sebastian; Soni, A.; Iliakis, George; Meyer, Hemmo
    The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation
    In: The FEBS Journal Jg. 281 (2014) Nr. Suppl. 1, S. 82
  • Riemer, Anne; Dobrynin, Grzegorz; Dressler, Alina; Bremer, Sebastian; Soni, Aashish; Iliakis, George; Meyer, Hemmo
    The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation
    In: Cell Cycle Jg. 13 (2014) Nr. 6, S. 919 - 927
  • Ehrenhofer-Murray, Ann; Meyer, Hemmo; Nellen, Wolfgang
    Coal mining meets chromatin research: Digging for mechanisms in epigenetic control of gene expression : Report from the 43rd Annual Meeting of the German Genetics Society on "Chromatin and Epigenetics" in Essen, Germany
    In: BioEssays Jg. 35 (2013) Nr. 2, S. 141 - 144
  • Kress, Elsa; Schwager, Françoise; Holtackers, René; Seiler, Jonas; Prodon, François; Zanin, Esther; Eiteneues, Annika; Toya, Mika; Sugimoto, Asako; Meyer, Hemmo; Meraladi, Patrick; Gotta, Monica
    The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A
    In: The Journal of Cell Biology (JCB) Jg. 201 (2013) Nr. 4, S. 559 - 575
  • Kirchner, Philipp; Bug, Monika; Meyer, Hemmo
    Ubiquitination of the n-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase
    In: The Journal of Biological Chemistry (JBC) Jg. 288 (2013) Nr. 10, S. 7363 - 7372
  • Bebeacua, Cecilia; Förster, Andreas; McKeown, Ciarán; Meyer, Hemmo; Zhang, Xiaodong; Freemont, Paul S.
    Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 109 (2012) S. 1098 - 1103.
  • Meyer, Hemmo; Bug, Monika; Bremer, Sebastian
    Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system
    In: Nature Cell Biology Jg. 14 (2012) Nr. 2, S. 117 - 123
  • Bug, Monika; Meyer, Hemmo
    Expanding into new markets – VCP/p97 in endocytosis and autophagy
    In: Journal of Structural Biology Jg. 179 (2012) Nr. 2, S. 78 - 82
  • Meyer, Hemmo
    p97 complexes as signal integration hubs
    In: BMC Biology (incorporating Journal of Biology) Jg. 10 (2012) S. 48
  • Dobrynin, Grzegorz; Popp, Oliver; Romer, Tina; Bremer, Sebastian; Schmitz, Michael H. A.; Gerlich, Daniel W.; Meyer, Hemmo
    Cdc48/p97-Ufd1-Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells.
    In: Journal of Cell Science Jg. 124 (2011) Nr. 9, S. 1571 - 1580
  • Ritz, Danilo; Vuk, Maja; Kirchner, Philipp; Bug, Monika; Schütz, Sabina; Hayer, Arnold; Bremer, Sebastian; Lusk, Caleb; Baloh, Robert H.; Lee, Houkeun; Glatter, Timo; Gstaiger, Matthias; Aebersold, Ruedi; Weihl, Conrad C.; Meyer, Hemmo
    Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations
    In: Nature Cell Biology Jg. 13 (2011) Nr. 9, S. 1116 - 1123
  • Meerang, Mayura; Ritz, Danilo; Paliwal, Shreya; Garajova, Zuzana; Bosshard, Matthias; Mailand, Niels; Janscak, Pavel; Hübscher, Ulrich; Meyer, Hemmo; Ramadan, Kristijan
    The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks
    In: Nature Cell Biology Jg. 13 (2011) Nr. 11, S. 1376 - 1382
  • Meyer, Hemmo; Drozdowska, Alicja; Dobrynin, Grzegorz
    A role for Cdc48/p97 and Aurora B in controlling chromatin condensation during exit from mitosis
    In: Biochemistry and Cell Biology Jg. 88 (2010) Nr. 1, S. 23 - 28
  • Hayer, Arnold; Stoeber, Miriam; Ritz, Danilo; Engel, Sabrina; Meyer, Hemmo; Helenius, Ari
    Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation
    In: The Journal of Cell Biology (JCB) Jg. 191 (2010) Nr. 3, S. 615 - 629
  • Meyer, Hemmo; Popp, Oliver
    Role(s) of Cdc48/p97 in mitosis
    In: Biochemical Society Transactions Jg. 36 (2008) Nr. 1, S. 126 - 130
  • Ramadan, Kristijan; Bruderer, Roland; Spiga, Fabio M.; Popp, Oliver; Baur, Tina; Gotta, Monica; Meyer, Hemmo
    Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin
    In: Nature Jg. 450 (2007) Nr. 7173, S. 1258
  • Isaacson, Rivka L.; Pye, Valerie E.; Simpson, Peter; Meyer, Hemmo; Zhang, Xiaodong; Freemont, Paul S.; Matthews, Steve
    Detailed structural insights into the p97-Npl4-Ufd1 interface
    In: The Journal of Biological Chemistry (JBC) Jg. 282 (2007) Nr. 29, S. 21361 - 21369
  • Baur, Tina; Ramadan, Kristijan; Schlundt, Andreas; Kartenbeck, Jürgen; Meyer, Hemmo
    NSF- and SNARE-mediated membrane fusion is required for nuclear envelope formation and completion of nuclear pore complex assembly in Xenopus laevis egg extracts
    In: Journal of Cell Science Jg. 120 (2007) Nr. 16, S. 2895 - 2903
  • Pye, Valerie E.; Beuron, Fabienne; Keetch, Catherine A.; McKeown, Ciaran; Robinson, Carol V.; Meyer, Hemmo; Zhang, Xiaodong; Freemont, Paul S.
    Structural insights into the p97-Ufd1-NpI4 complex
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 104 (2007) Nr. 2, S. 467 - 472
  • Meyer, Hemmo
    Golgi reassembly after mitosis : The AAA family meets the ubiquitin family
    In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Jg. 1744 (2005) Nr. 2, S. 108 - 119
  • Bruderer, Roland M.; Brasseur, Catherine; Meyer, Hemmo
    The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism
    In: The Journal of Biological Chemistry (JBC) Jg. 279 (2004) Nr. 48, S. 49609 - 49616
  • Alam, Steven L; Sun, Ji; Payne, Marielle; Welch, Brett D; Blake, B Kelly; Davis, Darrell R; Meyer, Hemmo; Emr, Scott D; Sundquist, Wesley I
    Ubiquitin Interactions of NZF Zinc Fingers
    In: The EMBO Journal Jg. 23 (2004) Nr. 7, S. 1411 - 1421
  • Wang, Yanzhuang; Satoh, Ayano; Warren, Graham; Meyer, Hemmo
    VCIP135 acts as a deubiquitinating enzyme during p97–p47-mediated reassembly of mitotic Golgi fragments
    In: The Journal of Cell Biology (JCB) Jg. 164 (2004) Nr. 7, S. 973 - 978
  • Ye, Yihong; Meyer, Hemmo; Rapoport, Tom A.
    Function of the p97–Ufd1–Npl4 complex in retrotranslocation from the ER to the cytosol : dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains
    In: The Journal of Cell Biology (JCB) Jg. 162 (2003) Nr. 1, S. 71 - 84
  • Wang, Bin; Alam, Steven L.; Meyer, Hemmo; Payne, Marielle; Stemmler, Timothy L.; Davis, Darrell R.; Sundquist, Wesley I.
    Structure and Ubiquitin Interactions of the Conserved Zinc Finger Domain of Npl4
    In: The Journal of Biological Chemistry (JBC) Jg. 278 (2003) S. 20225 - 20234
  • Cao, Kan; Nakajima, Reiko; Meyer, Hemmo; Zheng, Yixian
    The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis
    In: Cell Jg. 115 (2003) Nr. 3, S. 355 - 367
  • Meyer, Hemmo; Wang, Yanzhuang; Warren, Graham
    Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1–Npl4
    In: The EMBO Journal Jg. 21 (2002) Nr. 21, S. 5645 - 5652.
  • Hetzer, Martin; Meyer, Hemmo; Walther, Tobias C.; Bilbao-Cortes, Daniel; Warren, Graham; Mattaj, Iain W.
    Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly
    In: Nature Cell Biology Jg. 3 (2001) Nr. 12, S. 1086 - 1091
  • Ye, Yihong; Meyer, Hemmo; Rapoport, Tom A.
    The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
    In: Nature Jg. 414 (2001) S. 652 - 656
  • Meyer, Hemmo; Shorter, James G.; Seemann, Joachim; Pappin, Darryl; Warren, Graham
    A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways
    In: The EMBO Journal Jg. 19 (2000) Nr. 10, S. 2181 - 2192
  • Zhang, Xiaodong; Shaw, Anthony; Bates, Paul A.; Newman, Richard H.; Gowen, Brent; Orlova, Elena; Gorman, Michael A.; Kondo, Hisao; Dokurno, Pawel; Lally, John; Leonard, Gordon; Meyer, Hemmo; van Heel, Marin; Freemont, Paul S.
    Structure of the AAA ATPase p97
    In: Molecular Cell Jg. 6 (2000) Nr. 6, S. 1473 - 1484
  • Müller, Joyce M.; Meyer, Hemmo; Ruhrberg, Christiana; Stamp, Gordon W.; Warren, Graham; Shima, David T.
    The mouse p97 (CDC48) gene. Genomic structure, definition of transcriptional regulatory sequences, gene expression, and characterization of a pseudogene.
    In: The Journal of Biological Chemistry (JBC) Jg. 274 (1999) Nr. 15, S. 10154 - 10162
  • Meyer, Hemmo; Kondo, Hisao; Warren, Graham
    The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97
    In: FEBS Letters Jg. 437 (1998) Nr. 3, S. 255 - 257