Universität Duisburg-Essen
 Kopfgrafik Rad Biology


George Iliakis

George Iliakis Contact

Prof. Dr. George Iliakis
Address: Institut für medizinische Strahlenbiologie
Universitätsklinikum Essen
Hufelandstr.55
45122 Essen
Location: Institutsgruppe 1, Bauteil A, 4.OG, R38
Phone: +49 (0)201 723 4152
Email: Georg.Iliakis@UK-Essen.de

Education

Physics, M.Sc.
University of Athens, Greece

Biophysics, Ph.D.
University of Frankfurt/Main, Germany


Positions Held

1978-1982 Research Associate, Gesellschaft für Strahlen und Umweltforschung, Frankfurt/Main, W. Germany.
1982-1983 Research Associate, University of Frankfurt/Main, W. Germany.
1983-1985 Project Scientist, Cleveland Clinic Foundation, Research Division, Cleveland, OH.
1985-1989 Associate Professor, Thomas Jefferson University, Department of Radiation Therapy and Nuclear Medicine, Philadelphia, PA.
1985-1989 Assistant Professor, University of Crete/Greece, Faculty of Medicine, Department of Radiology.
1989-2001 Professor (tenured), Department of Radiation Oncology, Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA.
1991-1998 Associate Division Director, Division of Radiation Biology, Department of Radiation Oncology, Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA.
1998-2001 Director, Division of Experimental Radiation Oncology, Department of Radiation Oncology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107.
2001-present Adjunct Professor, Department of Radiation Oncology, Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA.
2001-present Director and Professor, Institute of Medical Radiation Biology, University of Duisburg-Essen, Medical School



Bibliography

1. Iliakis G, Pohlit W.
Quantitative aspects of repair of potentially lethal damage in mammalian cells.
Int J Radiat Biol Relat Stud Phys Chem Med. 1979 Dec;36(6):649-58.

2. Iliakis G.
Repair of potentially lethal damage in unfed plateau phase cultures of Ehrlich ascites tumour cells. I. Suspension cultures.
Int J Radiat Biol Relat Stud Phys Chem Med. 1980 Apr;37(4):365-72.

3. Iliakis G.
Repair of potentially lethal damage in unfed plateau phase cultures of Ehrlich ascites tumour cells. II. Monolayer cultures.
Int J Radiat Biol Relat Stud Phys Chem Med. 1980 Jun;37(6):591-600.

4. Iliakis G.
Effects of beta-arabinofuranosyladenine on the growth and repair of potentially lethal damage in Ehrilch ascites tumor cells.
Radiat Res. 1980 Sep;83(3):537-52.

5. Iliakis G.
Characterization and properties of repair of potentially lethal damage as measured with the help of beta-arabinofuranosyladenine in plateau-phase EAT cells.
Radiat Res. 1981 Apr;86(1):77-90.

6. Iliakis G, Nüsse M.
Aphidicolin promotes repair of potentially lethal damage in irradiated mammalian cells synchronized in S-phase.
Biochem Biophys Res Commun. 1982 Feb 26;104(4):1209-14.

7. Iliakis G, Nüsse M.
Evidence that progression of cells into S-phase is not a prerequisite for recovery between split doses of U.V.-light in synchronized and plateau phase cultures of Ehrlich ascites tumour cells.
Int J Radiat Biol Relat Stud Phys Chem Med. 1982 May;41(5):503-15.

8. Iliakis G, Nüsse M.
Conditions supporting repair of potentially lethal damage cause a significant reduction of ultraviolet light-induced division delay in synchronized and plateau-phase Ehrlich ascites tumor cells.
Radiat Res. 1982 Sep;91(3):483-506.

9. Iliakis G, Nüsse M, Bryant P.
Effects of aphidicolin on cell proliferation, repair of potentially lethal damage and repair of DNA strand breaks in Ehrlich ascites tumour cells exposed to X-rays.
Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Oct;42(4):417-34.

10. Iliakis G, Nüsse M.
The importance of G1/S-border and mitosis in the fixation of potentially lethal damage.
Radiat Environ Biophys. 1983;22(3):201-7.

11. Iliakis G, Bryant PE.
Effects of the nucleoside analogues alpha-ara A, beta-ara A and beta-ara C on cell growth and repair of both potentially lethal damage and DNA double strand breaks in mammalian cells in culture.
Anticancer Res. 1983 Mar-Apr;3(2):143-9.

12. Iliakis G.
Effects of beta-arabinofuranosyladenine on potentially lethal damage induced in plateau phase mammalian cells exposed to U.V.-light.
Int J Radiat Biol Relat Stud Phys Chem Med. 1983 May;43(5):529-40.

13. Iliakis G, Nüse M.
Effects of caffeine on X-irradiated synchronous, asynchronous and plateau phase mouse ascites cells: the importance of progression through the cell cycle for caffeine enhancement of killing.
Int J Radiat Biol Relat Stud Phys Chem Med. 1983 Jun;43(6):649-63.

14. Bertsche U, Iliakis G, Kraft G.
Inactivation of Ehrlich ascites tumor cells by heavy ions.
Radiat Res. 1983 Jul;95(1):57-67.

15. Iliakis G, Nüsse M.
Evidence that repair and expression of potentially lethal damage cause the variations in cell survival after X irradiation observed through the cell cycle in Ehrlich ascites tumor cells.
Radiat Res. 1983 Jul;95(1):87-107.

16. Bryant PE, Iliakis G.
Possible correlations between cell killing, chromosome damage and DNA repair after X-irradiation.
Nucleic Acids Symp Ser. 1984;(13):291-308.

17. Iliakis G.
The influence of PLD repair on the induction frequency of 6-thioguanine resistant mutants in Ehrlich ascites tumour cells after exposure to X-rays and ultraviolet light.
Br J Cancer Suppl. 1984;6:113-7.

18. Iliakis G.
The influence of conditions affecting repair and fixation of potentially lethal damage on the induction of 6-thioguanine resistance after exposure of mammalian cells to X-rays.
Mutat Res. 1984 Apr;126(2):215-25.

19. Iliakis G.
The mutagenicity of alpha particles in Ehrlich ascites tumor cells.
Radiat Res. 1984 Jul;99(1):52-8.

20. Iliakis G, Nüsse M.
Arrest of irradiated G1, S, or G2 cells at mitosis using nocodazole promotes repair of potentially lethal damage.
Radiat Res. 1984 Aug;99(2):346-51.

21. Iliakis G, Ngo FQ.
Effects of adenosine deaminase inhibitor 2'-deoxycoformycin on the repair and expression of potentially lethal damage sensitive to beta-araA.
Radiat Environ Biophys. 1985;24(2):81-8.

22. Iliakis G.
Evidence for the induction of two types of potentially lethal damage after exposure of plateau phase Chinese hamster V79 cells to gamma-rays.
Radiat Environ Biophys. 1985;24(3):185-202.

23. Iliakis G, Ngo FQ.
Effects of aphidicolin on the repair and fixation of potentially lethal damage sensitive to beta-araA.
Int J Radiat Oncol Biol Phys. 1985 Jun;11(6):1149-55.

24. Iliakis G, Ngo FQ, Roberts WK, Youngman K.
Evidence for similarities between radiation damage expressed by beta-araA and damage involved in the interaction effect observed after exposure of V79 cells to mixed neutrons and gamma radiation.
Radiat Res. 1985 Dec;104(3):303-16.

25. Iliakis G, Bryant PE, Ngo FQ.
Independent forms of potentially lethal damage fixed in plateau-phase Chinese hamster cells by postirradiation treatment in hypertonic salt solution or araA.
Radiat Res. 1985 Dec;104(3):329-45.

26. Ngo FQ, Youngman K, Suzuki S, Koumoundouros I, Iliakis G.
Evidence for reduced capacity for damage accumulation and repair in plateau-phase C3H 10T1/2 cells following multiple-dose irradiation with gamma rays.
Radiat Res. 1986 Jun;106(3):380-95.

27. Iliakis G, Nüsse M, Egner J.
Enhancement of adriamycin-induced killing after delayed plating of plateau-phase V79-cells.
Br J Cancer. 1986 Aug;54(2):245-9.

28. Iliakis G, Wright E, Roberts WK, Ngo FQ.
Evidence for differences among the sectors of potentially lethal damage expressed by hypertonic treatment in plateau-phase V79 cells after exposure to neutrons or gamma rays: the importance of distinction between alpha and beta-PLD forms.
Radiat Res. 1986 Oct;108(1):23-33.

29. Ganapathi R, Grabowski D, Schmidt H, Yen A, Iliakis G.
Modulation of adriamycin and N-trifluoroacetyladriamycin-14-valerate induced effects on cell cycle traverse and cytotoxicity in P388 mouse leukemia cells by caffeine and the calmodulin inhibitor trifluoperazine.
Cancer Res. 1986 Nov;46(11):5553-7.

30. Iliakis G, Nüsse M, Ganapathi R, Egner J, Yen A.
Differential reduction by caffeine of adriamycin induced cell killing and cell cycle delays in Chinese hamster V79 cells.
Int J Radiat Oncol Biol Phys. 1986 Nov;12(11):1987-95.

31. Iliakis G, Wright E, Ngo FQ.
Repair and fixation of potentially lethal damage (PLD) as demonstrated by delayed plating or incubation with araA in contact inhibited refed plateau-phase C3H mouse embryo 10 T1/2 cells grown in the presence of BrdUrd.
Radiat Environ Biophys. 1987;26(1):47-62.

32. Iliakis G, Wright E, Ngo FQ.
Possible importance of PLD repair in the modulation of BrdUrd and IdUrd-mediated radiosensitization in plateau-phase C3H10T1/2 mouse embryo cells.
Int J Radiat Biol Relat Stud Phys Chem Med. 1987 Mar;51(3):541-8.

33. Iliakis G.
Evidence for induction and repair of potentially lethal damage in plateau-phase V79 cells after exposure to adriamycin. The importance of removal of adriamycin released from the cells during the post-treatment incubation period.
Br J Cancer. 1987 Apr;55(4):381-4.

34. Iliakis G, Lazar W.
Effect of sodium chloride concentration on adriamycin and N-trifluoroacetyladriamycin-14-valerate (AD32)-induced cell killing and DNA damage in Chinese hamster V79 cells.
Cancer Res. 1987 Apr 1;47(7):1853-8.

35. Iliakis G, Lazar W.
Reduction by caffeine of adriamycin-induced cell killing and DNA damage in Chinese hamster cells: correlation with modulation in intracellular adriamycin content.
Cancer Res. 1987 May 1;47(9):2224-9.

36. Bertsche U, Iliakis G.
Modifications in repair and expression of potentially lethal damage (alpha-PLD) as measured by delayed plating or treatment with beta-araA in plateau-phase Ehrlich ascites tumor cells after exposure to charged particles of various specific energies.
Radiat Res. 1987 Jul;111(1):26-46.

37. Iliakis G, Pantelias GE, Okayasu R, Seaner R.
125IdUrd-induced chromosome fragments, assayed by premature chromosome condensation, and DNA double-strand breaks have similar repair kinetics in G1-phase CHO-cells.
Int J Radiat Biol Relat Stud Phys Chem Med. 1987 Nov;52(5):705-22.

38. Iliakis G, Seaner R.
Differences in inhibition by beta-arabinofuranosyladenine (araA) of radiation induced DNA damage repair in exponentially growing and plateau-phase CHO-cells.
Radiat Environ Biophys. 1988;27(4):295-305.

39. Iliakis G, Okayasu R.
The level of induced DNA double-strand breaks does not correlate with cell killing in X-irradiated mitotic and G1-phase CHO cells.
Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Mar;53(3):395-404.

40. Iliakis G.
Radiation-induced potentially lethal damage: DNA lesions susceptible to fixation.
Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Apr;53(4):541-84. Review.

41. Okayasu R, Bloecher D, Iliakis G.
Variation through the cell cycle in the dose-response of DNA neutral filter elution in X-irradiated synchronous CHO-cells.
Int J Radiat Biol Relat Stud Phys Chem Med. 1988 May;53(5):729-47.

42. Iliakis G, Pantelias GE, Seaner R.
Effect of arabinofuranosyladenine on radiation-induced chromosome damage in plateau-phase CHO cells measured by premature chromosome condensation: implications for repair and fixation of alpha-PLD.
Radiat Res. 1988 May;114(2):361-78.

43. Iliakis G, Okayasu R, Seaner R.
Radiosensitive xrs-5 and parental CHO cells show identical DNA neutral filter elution dose-response: implications for a relationship between cell radiosensitivity and induction of DNA double-strand breaks.
Int J Radiat Biol. 1988 Jul;54(1):55-62.

44. Iliakis GE, Pantelias GE.
Effects of hyperthermia on chromatin condensation and nucleoli disintegration as visualized by induction of premature chromosome condensation in interphase mammalian cells.
Cancer Res. 1989 Mar 1;49(5):1254-60.

45. Okayasu R, Iliakis G.
Linear DNA elution dose response curves obtained in CHO cells with non-unwinding filter elution after appropriate selection of the lysis conditions.
Int J Radiat Biol. 1989 Apr;55(4):569-81.

46. Iliakis G, Pantelias G, Okayasu R, Seaner R.
Comparative studies on repair inhibition by araA, araC and aphidicolin of radiation induced DNA and chromosome damage in rodent cells: comparison with fixation of PLD.
Int J Radiat Oncol Biol Phys. 1989 May;16(5):1261-5.

47. Iliakis G, Kurtzman S.
Application of non-hypoxic cell sensitizers in radiobiology and radiotherapy: rationale and future prospects.
Int J Radiat Oncol Biol Phys. 1989 May;16(5):1235-41. Review.

48. Iliakis G, Kurtzman S, Pantelias G, Okayasu R.
Mechanism of radiosensitization by halogenated pyrimidines: effect of BrdU on radiation induction of DNA and chromosome damage and its correlation with cell killing.
Radiat Res. 1989 Aug;119(2):286-304.

49. Iliakis GE, Okayasu R.
Radiosensitivity throughout the cell cycle and repair of potentially lethal damage and DNA double-strand breaks in an X-ray-sensitive CHO mutant.
Int J Radiat Biol. 1990 Jun;57(6):1195-211.

50. Iliakis GE, Pantelias GE.
Production and repair of chromosome damage in an X-ray sensitive CHO mutant visualized and analysed in interphase using the technique of premature chromosome condensation.
Int J Radiat Biol. 1990 Jun;57(6):1213-23.

51. Iliakis G, Seaner R.
A DNA double-strand break repair-deficient mutant of CHO cells shows reduced radiosensitization after exposure to hyperthermic temperatures in the plateau phase of growth.
Int J Hyperthermia. 1990 Jul-Aug;6(4):801-12.

52. Iliakis G, Seaner R, Okayasu R.
Effects of hyperthermia on the repair of radiation-induced DNA single- and double-strand breaks in DNA double-strand break repair-deficient and repair-proficient cell lines.
Int J Hyperthermia. 1990 Jul-Aug;6(4):813-33.

53. Iliakis G, Metzger L, Muschel RJ, McKenna WG.
Induction and repair of DNA double strand breaks in radiation-resistant cells obtained by transformation of primary rat embryo cells with the oncogenes H-ras and v-myc.
Cancer Res. 1990 Oct 15;50(20):6575-9.

54. Iliakis G, Pantelias G, Kurtzman S.
Mechanism of radiosensitization by halogenated pyrimidines: effect of BrdU on cell killing and interphase chromosome breakage in radiation-sensitive cells.
Radiat Res. 1991 Jan;125(1):56-64.

55. Iliakis GE, Metzger L, Denko N, Stamato TD.
Detection of DNA double-strand breaks in synchronous cultures of CHO cells by means of asymmetric field inversion gel electrophoresis.
Int J Radiat Biol. 1991 Feb;59(2):321-41.

56. Iliakis GE, Cicilioni O, Metzger L.
Measurement of DNA double-strand breaks in CHO cells at various stages of the cell cycle using pulsed field gel electrophoresis: calibration by means of 125I decay.
Int J Radiat Biol. 1991 Feb;59(2):343-57.

57. Borrelli MJ, Rausch CM, Seaner R, Iliakis G.
Sensitization to hyperthermia by 3,3'-dipentyloxacarbocyanine iodide: a positive correlation with DNA damage and negative correlations with altered cell morphology, oxygen consumption inhibition, and reduced ATP levels.
Int J Hyperthermia. 1991 Mar-Apr;7(2):243-61.

58. McKenna WG, Iliakis G, Weiss MC, Bernhard EJ, Muschel RJ.
Increased G2 delay in radiation-resistant cells obtained by transformation of primary rat embryo cells with the oncogenes H-ras and v-myc.
Radiat Res. 1991 Mar;125(3):283-7.

59. Blocher D, Iliakis G.
Size distribution of DNA molecules recovered from non-denaturing filter elution.
Int J Radiat Biol. 1991 Apr;59(4):919-26.

60. Iliakis G, Blocher D, Metzger L, Pantelias G.
Comparison of DNA double-strand break rejoining as measured by pulsed field gel electrophoresis, neutral sucrose gradient centrifugation and non-unwinding filter elution in irradiated plateau-phase CHO cells.
Int J Radiat Biol. 1991 Apr;59(4):927-39.

61. Metzger L, Iliakis G.
Kinetics of DNA double-strand break repair throughout the cell cycle as assayed by pulsed field gel electrophoresis in CHO cells.
Int J Radiat Biol. 1991 Jun;59(6):1325-39.

62. Iliakis G, Kurtzman S.
Mechanism of radiosensitization by halogenated pyrimidines: bromodeoxyuridine and beta-arabinofuranosyladenine affect similar subsets of radiation-induced potentially lethal lesions in plateau-phase Chinese hamster ovary cells.
Radiat Res. 1991 Jul;127(1):45-51.

63. Muschel RJ, Zhang HB, Iliakis G, McKenna WG.
Cyclin B expression in HeLa cells during the G2 block induced by ionising radiation.
Cancer Res. 1991 Oct 1;51(19):5113-7.

64. Iliakis G.
The role of DNA double strand breaks in ionizing radiation-induced killing of eukaryotic cells.
Bioessays. 1991 Dec;13(12):641-8. Review.

65. Wang Y, Iliakis G.
Effects of 5'-iododeoxyuridine on the repair of radiation induced potentially lethal damage interphase chromatin breaks and DNA double strand breaks in Chinese hamster ovary cells.
Int J Radiat Oncol Biol Phys. 1992;23(2):353-60.

66. Wang Y, Iliakis G.
Prolonged inhibition by X-rays of DNA synthesis in cells obtained by transformation of primary rat embryo fibroblasts with oncogenes H-ras and v-myc.
Cancer Res. 1992 Feb 1;52(3):508-14.

67. Iliakis G, Wang Y, Pantelias GE, Metzger L.
Mechanism of radiosensitization by halogenated pyrimidines: effect of BrdU on repair of DNA breaks, interphase chromatin breaks, and potentially lethal damage in plateau-phase CHO cells.
Radiat Res. 1992 Feb;129(2):202-11.

68. Iliakis G, Mehta R, Jackson M.
Level of DNA double-strand break rejoining in Chinese hamster xrs-5 cells is dose-dependent: implications for the mechanism of radiosensitivity.
Int J Radiat Biol. 1992 Mar;61(3):315-21.

69. Okayasu R, Iliakis G.
The shape of DNA elution dose-response curves under non-denaturing conditions: the contribution of the degree of chromatin condensation.
Int J Radiat Biol. 1992 Apr;61(4):455-63.

70. Cheong N, Wang Y, Jackson M, Iliakis G.
Radiation-sensitive irs mutants rejoin DNA double-strand breaks with efficiency similar to that of parental V79 cells but show altered response to radiation-induced G2 delay.
Mutat Res. 1992 Aug;274(2):111-22.

71. Iliakis GE, Pantelias GE, Okayasu R, Blakely WF.
Induction by H2O2 of DNA and interphase chromosome damage in plateau-phase Chinese hamster ovary cells.
Radiat Res. 1992 Aug;131(2):192-203.

72. Muschel RJ, Zhang HB, Iliakis G, McKenna WG.
Effects of ionizing radiation on cyclin expression in HeLa cells.
Radiat Res. 1992 Nov;132(2):153-7. Review.

73. Pantelias GE, Iliakis GE, Sambani CD, Politis G.
Biological dosimetry of absorbed radiation by C-banding of interphase chromosomes in peripheral blood lymphocytes.
Int J Radiat Biol. 1993 Mar;63(3):349-54.

74. Wang Y, Cheong N, Iliakis G.
Persistent inhibition of DNA synthesis in irradiated rat embryo fibroblasts expressing the oncogenes H-ras plus v-myc derives from inhibition of replicon initiation and is mitigated by staurosporine.
Cancer Res. 1993 Mar 15;53(6):1213-7.

75. Cheong N, Wang Y, Iliakis G.
Radioresistance induced in rat embryo cells by transfection with the oncogenes H-ras plus v-myc is cell cycle dependent and maximal during S and G2.
Int J Radiat Biol. 1993 May;63(5):623-9.

76. Wang X, Iliakis G.
Persistent inhibition of DNA synthesis after radiation exposure in four clones obtained from rat embryo fibroblasts by transfection with the oncogenes H-ras plus v-myc.
Int J Radiat Biol. 1993 Aug;64(2):165-8.

77. Iliakis G, Okayasu R, Varlotto J, Shernoff C, Wang Y.
Hypertonic treatment during premature chromosome condensation allows visualization of interphase chromosome breaks repaired with fast kinetics in irradiated CHO cells.
Radiat Res. 1993 Aug;135(2):160-70.

78. Okayasu R, Varlotto J, Iliakis G.
Hypertonic treatment does not affect the radiation yield of interphase chromosome breaks in DNA double-strand break repair-deficient xrs-5 cells.
Radiat Res. 1993 Aug;135(2):171-7.

79. Okayasu R, Pantelias GE, Iliakis G.
Increased frequency of formation of interphase ring-chromosomes in radiosensitive irs-1 cells exposed to X-rays.
Mutat Res. 1993 Oct;294(3):199-206.

80. Okayasu R, Iliakis G.
Ionizing radiation induces two forms of interphase chromosome breaks in Chinese hamster ovary cells that rejoin with different kinetics and show different sensitivity to treatment in hypertonic medium or beta-araA.
Radiat Res. 1993 Nov;136(2):262-70.

81. Okayasu R, Cheong N, Iliakis G.
Technical note: comparison of yields and repair kinetics of interphase chromosome breaks visualized by Sendai-virus or PEG-mediated cell fusion in irradiated CHO cells.
Int J Radiat Biol. 1993 Dec;64(6):689-94.

82. Cheng X, Pantelias GE, Okayasu R, Cheong N, Iliakis G.
Mitosis-promoting factor activity of inducer mitotic cells may affect radiation yield of interphase chromosome breaks in the premature chromosome condensation assay.
Cancer Res. 1993 Dec 1;53(23):5592-6.

83. Cheong N, Wang X, Wang Y, Iliakis G.
Loss of S-phase-dependent radioresistance in irs-1 cells exposed to X-rays.
Mutat Res. 1994 Jan;314(1):77-85.

84. Okayasu R, Iliakis G.
Evidence that the product of the xrs gene is predominantly involved in the repair of a subset of radiation-induced interphase chromosome breaks rejoining with fast kinetics.
Radiat Res. 1994 Apr;138(1):34-43.

85. Wang Y, Pantelias GE, Iliakis G.
Mechanism of radiosensitization by halogenated pyrimidines: the contribution of excess DNA and chromosome damage in BrdU radiosensitization may be minimal in plateau-phase cells.
Int J Radiat Biol. 1994 Aug;66(2):133-42.

86. Okayasu R, Iliakis G.
Mitotic metaphase cells from different cell lines cause different levels of expression of the alpha-form of interphase chromosome breaks in irradiated CHO cells.
Mutat Res. 1994 Oct 1;310(1):65-71.

87. Kinashi Y, Okayasu R, Iliakis GE, Nagasawa H, Little JB.
Induction of DNA double-strand breaks by restriction enzymes in X-ray-sensitive mutant Chinese hamster ovary cells measured by pulsed-field gel electrophoresis.
Radiat Res. 1995 Feb;141(2):153-9.

88. Cheng X, Iliakis G.
Effect of ionizing radiation on the expression of chloramphenicol acetyltransferase gene under the control of commonly used constitutive or inducible promoters.
Int J Radiat Biol. 1995 Mar;67(3):261-7.

89. Badie C, Iliakis G, Foray N, Alsbeih G, Pantellias GE, Okayasu R, Cheong N, Russell NS,
Begg AC, Arlett CF, et al.
Defective repair of DNA double-strand breaks and chromosome damage in fibroblasts from a radiosensitive leukemia patient.
Cancer Res. 1995 Mar 15;55(6):1232-4.

90. Wang Y, Huq MS, Cheng X, Iliakis G.
Regulation of DNA replication in irradiated cells by trans-acting factors.
Radiat Res. 1995 May;142(2):169-75.

91. Badie C, Iliakis G, Foray N, Alsbeih G, Cedervall B, Chavaudra N, Pantelias G, Arlett C, Malaise EP.
Induction and rejoining of DNA double-strand breaks and interphase chromosome breaks after exposure to X rays in one normal and two hypersensitive human fibroblast cell lines.
Radiat Res. 1995 Oct;144(1):26-35.

92. Ganguly T, Iliakis G.
A cell-free assay using cytoplasmic cell extracts to study rejoining of radiation-induced DNA double-strand breaks in human cell nuclei.
Int J Radiat Biol. 1995 Oct;68(4):447-57.

93. Foray N, Fertil B, Alsbeih MG, Badie C, Chavaudra N, Iliakis G, Malaise EP.
Dose-rate effect on radiation-induced DNA double-strand breaks in the human fibroblast HF19 cell line.
Int J Radiat Biol. 1996 Feb;69(2):241-9.

94. Wang Y, Huq MS, Iliakis G.
Evidence for activities inhibiting in trans initiation of DNA replication in extract prepared from irradiated cells.
Radiat Res. 1996 Apr;145(4):408-18.

95. Cheng X, Cheong N, Wang Y, Iliakis G.
Ionizing radiation-induced phosphorylation of RPA p34 is deficient in ataxia telangiectasia and reduced in aged normal fibroblasts.
Radiother Oncol. 1996 Apr;39(1):43-52.

96. Cheong N, Okayasu R, Shah S, Ganguly T, Mammen P, Iliakis G.
In vitro rejoining of double-strand breaks in cellular DNA by factors present in extracts of HeLa cells.
Int J Radiat Biol. 1996 Jun;69(6):665-77.

97. Cheong N, Iliakis G.
In vitro rejoining of double strand breaks induced in cellular DNA by bleomycin and restriction endonucleases.
Int J Radiat Biol. 1997 Apr;71(4):365-75.

98. Wang Y, Perrault AR, Iliakis G.
Down-regulation of DNA replication in extracts of camptothecin-treated cells: activation of an S-phase checkpoint?
Cancer Res. 1997 May 1;57(9):1654-9.

99. Wang Y, Cheong N, Miura M, Iliakis G.
Overexpression of insulin-like growth factor (IGF)-I receptor enhances inhibition of DNA replication in mouse cells exposed to x-rays.
Radiat Environ Biophys. 1997 Jun;36(2):117-23.

100. Ouyang H, Nussenzweig A, Kurimasa A, Soares VC, Li X, Cordon-Cardo C, Li W, Cheong N, Nussenzweig M, Iliakis G, Chen DJ, Li GC.
Ku70 is required for DNA repair but not for T cell antigen receptor gene
recombination In vivo.
J Exp Med. 1997 Sep 15;186(6):921-9.

101. Iliakis G.
Cell cycle regulation in irradiated and nonirradiated cells.
Semin Oncol. 1997 Dec;24(6):602-15. Review.

102. Wang Y, Perrault AR, Iliakis G.
Replication protein A as a potential regulator of DNA replication in cells exposed to hyperthermia.
Radiat Res. 1998 Mar;149(3):284-93.

103. Cheong N, Perrault AR, Iliakis G.
In vitro rejoining of DNA double strand breaks: a comparison of genomic-DNA with plasmid-DNA-based assays.
Int J Radiat Biol. 1998 May;73(5):481-93.

104. Cheong N, Perrault AR, Wang H, Wachsberger P, Mammen P, Jackson I, Iliakis G.
DNA-PK-independent rejoining of DNA double-strand breaks in human cell extracts in vitro.
Int J Radiat Biol. 1999 Jan;75(1):67-81.

105. Wachsberger PR, Li WH, Guo M, Chen D, Cheong N, Ling CC, Li G, Iliakis G.
Rejoining of DNA double-strand breaks in Ku80-deficient mouse fibroblasts.
Radiat Res. 1999 Apr;151(4):398-407.

106. Wang Y, Zhou XY, Wang H, Huq MS, Iliakis G.
Roles of replication protein A and DNA-dependent protein kinase in the regulation of DNA replication following DNA damage.
J Biol Chem. 1999 Jul 30;274(31):22060-4.

107. Iliakis G, Cheong N.
In vitro rejoining of double-strand breaks in genomic DNA.
Methods Mol Biol. 1999;113:473-85.

108. Iliakis G, Wang Y, Wang HY.
Analysis of inhibition of DNA replication in irradiated cells using the SV40-based in vitro assay of DNA replication.
Methods Mol Biol. 1999;113:543-53.

109. Kurdoglu B, Cheong N, Guan J, Corn BW, Curran WJ Jr, Iliakis G.
Apoptosis as a predictor of paclitaxel-induced radiosensitization in human tumor cell lines.
Clin Cancer Res. 1999 Sep;5(9):2580-7.

110. DiBiase SJ, Guan J, Curran WJ Jr, Iliakis G.
Repair of DNA double-strand breaks and radiosensitivity to killing in an isogenic group of p53 mutant cell lines.
Int J Radiat Oncol Biol Phys. 1999 Oct 1;45(3):743-51.

111. Guan J, DiBiase S, Iliakis G.
The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replication.
Nucleic Acids Res. 2000 Mar 1;28(5):1183-92.

112. DiBiase SJ, Zeng ZC, Chen R, Hyslop T, Curran WJ Jr, Iliakis G.
DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus.
Cancer Res. 2000 Mar 1;60(5):1245-53.

113. Wachsberger PR, Iliakis G.
Hyperthermia does not affect rejoining of DNA double-strand breaks in a cell-free assay.
Int J Radiat Biol. 2000 Mar;76(3):313-26.

114. Asaad NA, Zeng ZC, Guan J, Thacker J, Iliakis G.
Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants.
Oncogene. 2000 Nov 23;19(50):5788-800.

115. Wang H, Zeng ZC, Bui TA, DiBiase SJ, Qin W, Xia F, Powell SN, Iliakis G.
Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.
Cancer Res. 2001 Jan 1;61(1):270-7.

116. Hu B, Zhou XY, Wang X, Zeng ZC, Iliakis G, Wang Y.
The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway.
J Biol Chem. 2001 May 25;276(21):17693-8.

117. Wang H, Zeng ZC, Perrault AR, Cheng X, Qin W, Iliakis G.
Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells.
Nucleic Acids Res. 2001 Apr 15;29(8):1653-60.

118. Andrews DW, Resnicoff M, Flanders AE, Kenyon L, Curtis M, Merli G, Baserga R, Iliakis G, Aiken RD.
Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas.
J Clin Oncol. 2001 Apr 15;19(8):2189-200.

119. Perrault R, Cheong N, Wang H, Wang H, Iliakis G.
RPA facilitates rejoining of DNA double-strand breaks in an in vitro assay utilizing genomic DNA as substrate.
Int J Radiat Biol. 2001 May;77(5):593-607.

120. Wang Y, Guan J, Wang H, Wang Y, Leeper D, Iliakis G.
Regulation of dna replication after heat shock by replication protein a-nucleolin interactions.
J Biol Chem. 2001 Jun 8;276(23):20579-88.

121. Wang H, Zeng ZC, Bui TA, Sonoda E, Takata M, Takeda S, Iliakis G.
Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group.
Oncogene. 2001 Apr 26;20(18):2212-24.

122. Xia F, Taghian DG, DeFrank JS, Zeng ZC, Willers H, Iliakis G, Powell SN.
Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining.
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8644-9.

123. Peters KB, Wang H, Brown JM, Iliakis G.
Inhibition of DNA replication by tirapazamine.
Cancer Res. 2001 Jul 15;61(14):5425-31.

124. Wang H, Guan J, Wang H, Perrault AR, Wang Y, Iliakis G.
Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase.
Cancer Res. 2001 Dec 1;61(23):8554-63.

125. Cheong N, Zeng ZC, Wang Y, Iliakis G.
Evidence for factors modulating radiation-induced G2-delay: potential application as radioprotectors.
Phys Med. 2001;17 Suppl 1:205-9.

126. Guan J, Stavridi E, Leeper DB, Iliakis G.
Effects of hyperthermia on p53 protein expression and activity.
J Cell Physiol. 2002 Mar;190(3):365-74.

127. Zhou XY, Wang X, Hu B, Guan J, Iliakis G, Wang Y.
An ATM-independent S-phase checkpoint response involves CHK1 pathway.
Cancer Res. 2002 Mar 15;62(6):1598-603.

128. Wang H, Wang X, Zhou XY, Chen DJ, Li GC, Iliakis G, Wang Y.
Ku affects the ataxia and Rad 3-related/CHK1-dependent S phase checkpoint response after camptothecin treatment.
Cancer Res. 2002 May 1;62(9):2483-7.

129. Zhou XY, Wang X, Wang H, Chen DJ, Li GC, Iliakis G, Wang Y.
Ku affects the ATM-dependent S phase checkpoint following ionizing radiation.
Oncogene. 2002 Sep 12;21(41):6377-81.

130. Wang X, Li GC, Iliakis G, Wang Y.
Ku Affects the CHK1-dependent G2 Checkpoint after Ionizing Radiation.
Cancer Res. 2002 November 1; 62: 6031-34.

131. Wang JL, Wang X, Wang H, Iliakis G, Wang Y.
CHK1-regulated S-phase checkpoint response reduces camptothecin cytotoxicity.
Cell Cycle 2002 Jul-Aug; 1 (4): 267-72.

132. Zeng ZC, Jiang GL, Wang GM, Tang ZY, Curran WJ, Iliakis G.
DNA-PKcs subunits in radiosensitization by hyperthermia on hepatocellular carcinoma hepG(2) cell line.
World J Gastroenterol. 2002 Oct; 8 (5): 797-803.

133. Sharma GG, Gupta A, Wang H, Scherthan H, Dhar S, Gandhi V, Iliakis G, Shay JW, Young CSH, Pandita TK.
hTERT associates with human telomeres and enhances genomic stability and DNA repair.
Oncogene 2003 Jan; 22 (1): 131-146.

134. Wang H, Wang X, Iliakis G, Wang Y.
Caffeine could not efficiently sensitize homologous recombination repair deficient cells to ionizing radiation-induced killing.
Radiat Res. 2003 Mar; 159 (3): 426-432.

135. Wang X, Wang H, Iliakis G, Wang Y.
Caffeine-induced radiosensitization is independent of non-homologous end joining of DNA double strand breaks.
Radiat Res. 2003 Mar; 159 (3): 420-425.

136. Wang X, Khadpe J, Hu B, Iliakis G, Wang Y.
An over-activated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells.
J Biol Chem. 2003 Aug 15; 278 (33): 30869-30874.



137. Dicker AP, Williams TL, Iliakis G, Grant DS.
Targeting angiogenic processes by combination low-dose Paclitaxel and radiation therapy.
Am J Clin Oncol. 2003 Jun; 26 (3): E45-E53.

138. Wang H, Perrault AR, Takeda Y, Qin W, Wang H, Iliakis G.
Biochemical evidence for Ku-independent backup pathways of NHEJ.
Nucleic Acids Res. 2003 Sep. 15; 31 (18): 5377-5388.

139. Iliakis G, Wang Y, Guan J, Wang H.
DNA damage checkpoint control in cells exposed to ionizing radiation.
Oncogene 2003 Sep. 1; 22 (37): 5834-5847.

140. Wang H, Boecker W, Wang H, Wang X, Guan J, Thompson LH, Nickoloff JA, Iliakis G.
Caffeine inhibits homology-directed repair of I-SceI-induced DNA double-strand breaks.
Oncogene 2004; 23 (3), 824-834.

141. Wang X, Guan J, Hu B, Weiss RS, Iliakis G, Wang Y.
Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation.
Nucleic Acids Res. 2004, 32 (2): 767-775.

142. Iliakis G, Krieg T, Guan J, Wang Y, Leeper D.
Evidence for an S-Phase checkpoint regulating DNA replication after heat shock: a review.
Int. J. Hyperthermia 2004, 20 (2): 240-249.

143. Iliakis G, Wang H, Perrault AR, Boecker W, Rosidi B, Windhofer F, Wu W, Guan J, Terzoudi G, Pantelias G.
Mechanisms of DNA double strand break repair and chromosome aberration formation.
Cytogenet Genome Res 2004, 104: 14-20.

144. Perrault R, Wang H, Wang M, Rosidi B, Iliakis G.
Backup Pathways of NHEJ Are Suppressed by DNA-PK.
J Cell Biochem. 2004, 92: 781-794.

145. Wang H, Wang H, Powell SN, Iliakis G, Wang Y
ATR Affecting Cell Radiosensitivity Is Dependent on Homologous Recombination Repair but Independent of Nonhomologous End Joining.
Cancer Res. 2004, 64: 7139-7143.

146. Wang H, Wang M, Wang H, Böcker W., Iliakis G
Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors.
J Cell Physiol. 2005, 202: 492-502.

147. Wu WZ, Sun HC, Shen YF, Chen J, Wang L, Tang ZY, Iliakis G, Liu KD
Interferon alpha 2a downregulates VEGF expression through PI3 kinase MAP kinase signaling pathways.
J Cancer Res Clin Oncol. 2005, 131: 169-178.

148. Wang H, Rosidi B, Perrault R, Wang M, Zhang L, Windhofer F, Iliakis G
DNA Ligase III as a Candidate Component of Backup Pathways of Nonhomologous End Joining.
Cancer Res. 2005, 65: 4020-4030.

149. Harder D, Iliakis G
In memoriam.
Radiat Res. 2005, 164: 830-832.

150. Iliakis G, Rosidi B, Wang M, Wang H
Plasmid-Based Assays for DNA End-Joining In Vitro.
Methods Mol Biol. 2005, 314: 123-131.

151. Iliakis G, Wang Ya, Wang H
Analysis of Inhibition of DNA Replication in Irradiated Cells Using the SV40-Based In Vitro Assay of DNA Replication.
Methods Mol Biol. 2005, 314: 61-71.

152. Iliakis G, Cheong N
In Vitro Rejoining of Double-Strand Breaks in Genomic DNA.
Methods Mol Biol. 2005, 314: 95-108.

153. Martin M, Genesca A, Latre L, Jaco I, Taccioli GE, Egozcue J, Blasco MA, Iliakis G, Tusell L
Postreplicative joining of DNA double-strand breaks causes genomic instability in DNA-PKcs-deficient mouse embryonic fibroblasts.
Cancer Res. 2005, 65: 10223-10232.

154. Terzoudi, GI, Manola KN, Pantelias GE, Iliakis G
Checkpoint Abrogation in G2 Compromises Repair of Chromosomal Breaks in Ataxia Telangiectasia Cells.
Cancer Res. 2005, 65: 11292-11296.

155. Banaz-Yasar, F, Tischka R, Iliakis G, Winterhager E, Gellhaus A
Cell Line Specific Modulation of Connexin43 Expression after Exposure to Ionizing Radiation.
Cell Communication and Adhesion 2005, 12: 249-259.

156. Böcker W, Iliakis G
Computational Methods for Analysis of Foci: Validation for Radiation-Induced γ-H2AX Foci in Human Cells.
Radiat Res 2006, 165: 113-124.

157. Wang M, Wu W, Wu W, Rosidi R, Zhang L, Wang H, Iliakis G
PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways.
Nucleic Acids Res. 2006, 34: 6170-6182.

158. Iliakis G, Rosidi B, Wang M, Wang H
Plasmid-based assays for DNA end-joining in vitro.
Methods Mol Biol. 2006, 314: 123-131.

159. Iliakis G, Cheong N
In vitro rejoining of double-strand breaks in genomic DNA.
Methods Mol Biol. 2006, 314: 95-108.

160. Iliakis G, Wang Y, Wang HY
Analysis of inhibition of DNA replication in irradiated cells using the SV40-based in vitro assay of DNA replication.
Methods Mol Biol. 2006, 314: 61-71.

161. Tamulevicius P, Wang M, Iliakis G
Homology-Directed Repair is Required for the Development of Radioresistance during S Phase: Interplay between Double-Strand Break Repair and Checkpoint Response.
Radiat Ress 2007, 167: 1-11

162. Windhofer F, Wu W, Wang M, Sing SK, Saha J, Rosidi B, Iliakis G
Marked dependence on growth state of backup pathways of NHEJ
Int J Radiat Oncol Biol Phys, 2007, 68: 1462-1470

163. Windhofer F, Wu W, Iliakis G
Low levels of DNA ligases III and IV sufficient for effective NHEJ
J Cell Physiol 2007, 213: 475-483

164. Wang H, Wang M, Reiss K, Darbinian-Sarkissian N, Johnson EM, Iliakis G, Amini S, Khalili K, Rappaport J.
Evidence for the Involvement of Puralpha in Response to DNA Replication Stress.
Cancer Biol Ther 2007, 6: 596-602

165. Iliakis G, Wu W, Wang M, Terzoudi GI, Pantelias GE
Backup Pathways of Nonhomologous End Joining May Have a Dominant Role in the Formation of Chromosome Aberrations.
In: Chromosomal Alterations, G. Obe, Vijayalaxmi (Eds.), Springer-Verlag Berlin, Heidelberg, New York 2007, 67-85

166. Wu W, Wang M, Wu W, Singh SK, Mußfeldt T, Iliakis G
Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2
DNA Repair 2008, 7: 329-338

167. Rosidi B, Wang M, Wu W, Sharma A, Wang H, Iliakis G
Histone H1 functions as a stimulatory factor in backup pathways of NHEJ
Nucleic Acids Res 2008, 36: 1610-1623

168. Iliakis G, Wu W, Wang M
DNA double strand break repair inhibition as a cause of heat radiosensitization: Re-evaluation considering backup pathways of NHEJ
Int J Hyperthermia 2008, 24: 17-29
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