ZMB Member Michael Ehrmann, Publications

Prof. Dr. Michael Ehrmann

Selected Publications

Köcher S, Rey J, Bongard J, Tiaden AN, Meltzer M, Richards PJ, Ehrmann M, Kaiser M. Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease Inhibitors. 2017. Angew Chem Int Ed Engl 56:8555-8558.

Poepsel S, Sprengel A, Sacca B, Kaschani F, Kaiser M, Gatsogiannis C, Raunser S, Clausen T, Ehrmann M. Determinants of amyloid fibril degradation by the PDZ protease HTRA1. Nat Chem Biol. 2015 Nov;11(11):862-9.

Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodriguez CDA, Rudner DZ, Clausen T. 2013. CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis. Cell. 155:647–658.

Malet M, Canellas F, Sawa J, Yan J, Thalassinos K, Ehrmann M, Clausen T, and H. Saibil. 2012. Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ. Nat Struct Mol Biol. 19(2):152-7.

Merdanovic M, Clausen T, Kaiser M, Huber R and M. Ehrmann. 2011. Protein quality control in the bacterial periplasm. Annu. Rev. Microbiol. 65:149-168.

Kley J, Schmidt B, Boyanov B, Stolt-Bergner PC, Kirk R, Ehrmann M, Knopf RR, Naveh L, Adam Z, Clausen T. Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure. 2011 Nat. Struct. Mol. Biol. 18:728-731.

Clausen T, Kaiser M, Huber R and M. Ehrmann. 2011. HtrA proteases: Regulated proteolysis in protein quality control. Nat. Rev. Mol. Cell Biol. 12:152-62.

Trübestein L, Tennstaedt A, Mönig T, Krojer T, Canellas F, Kaiser M, Clausen T, and M. Ehrmann. 2011. Substrate induced remodeling of the active site regulates human HtrA1 activity. Nat. Struct. Mol. Biol. 18:386-388.

Merdanovic M, Mamant N, Meltzer M, Poepsel S, Auckenthaler A, Melgaard R, Hauske P, Nagel-Steger L, Clarke AR, Kaiser M, Huber R, and M. Ehrmann. 2010. Determinants of structural and functional plasticity of a widely conserved protease chaperone complex. Nat. Struct. Mol. Biol. 17:837-43.

Krojer T, Sawa J, Schäfer E, Saibil HR, Ehrmann M and T. Clausen (2008). Structural basis for the regulated protease and chaperone function of DegP. Nature 453, 885-890.

Meltzer M, Hasenbein S, Hauske P, Kucz N, Merdanovic M, Grau S, Beil A, Jones D, Krojer T, Clausen T, Ehrmann M,* and M. Kaiser* (2008). Allosteric activation of HtrA protease DegP by stress signals in bacterial protein quality control. Angew Chem. Int. Ed. Engl. 47:1332-1334 *corresponding authors.

Hasselblatt H, Kurzbauer R, Wilken C, Krojer T, Sawa J, Kurt J, Kirk R, Hasenbein S, Ehrmann M, and T. Clausen (2007). Regulation of the sE stress response by DegS: How the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress. Genes Dev. 21: 2659-2670.

Hasenbein S, Merdanovic M, and M. Ehrmann (2007). Determinants of regulated proteolysis in signal transduction. Genes Dev. 21: 6-10.

Ehrmann, M. and T. Clausen (2004). Proteolysis as a regulatory mechanism. Annu. Rev. Genet. 38: 709-724.

Wilken C, Kitzing K, Kurzbauer R, Ehrmann M, and T. Clausen (2004). Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease domain. Cell 117:483-494, (Highlighted in 2004 Cell 117:417-419).

Clausen T, Southan C, and Ehrmann, M. (2002). The HtrA family of proteases, implications for protein composition and cell fate. Mol. Cell 10:443-455.

Krojer T, Garrido-Franco M, Huber R, Ehrmann M, and T. Clausen. (2002). Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine. Nature 416: 455-459, (Highlighted in 2002 Nature Rev. Mol. Cell Biol. 3:310).

Spiess C, Beil A, and M. Ehrmann (1999). A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein. Cell 97: 339-347.

All Publications
 

Köcher S, Rey J, Bongard J, Tiaden AN, Meltzer M, Richards PJ, Ehrmann M, Kaiser M. Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease Inhibitors. Angew Chem Int Ed Engl. 2017 May 17, [Epub ahead of print].

Sprengel A, Lill P, Stegemann P, Rodriguez KB, Merdanovic M, Schöneweiß, EC, Gudnason DA, Aznauryan M, Gamrad L, Barcikowski S, Sáncez-García E, Birkedal V, Gatsogiannis C, Ehrmann, M. and B. Saccà. 2017. Encapsulation of a single protein guest into a DNA origami host using geometrically constrained supramolecular interactions. Nat. Comm. 2017 Feb 16;8:14472.

Papadopoulos C, Kirchner P, Bug M, Grum D, Koerver L, Schulze N, Poehler R, Dressler A, Fengler S, Arhzaouy K, Lux V, Ehrmann M, Weihl CC, Meyer H. VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. EMBO J. 2017 Jan 17;36(2):135-150.

Ehrmann, M and M. Kaiser. 2017. Small molecules deep from the gut. ChemBiochem 18:967-968.

Rotan, O, Severin, KN, Pöpsel, S, Peetsch, A, Merdanovic, M, Ehrmann, M & M Epple. 2017. Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles. Beilstein J. Nanotechnol., 8:381-393

Kaiser, M., Huber, R. and M. Ehrmann. 2016. Proteases. Reference Module in Life Sciences. Elsevier http://dx.doi.org/10.1016/B978-0-12-809633-8.06970-3.

Schmidt N, Irle I, Ripkens K, Lux V, Nelles J, Johannes C, Parry L, Greenow K, Amir S, Campioni M, Baldi A, Oka C, Kawaichi M, Clarke AR, Ehrmann M. Epigenetic silencing of serine protease HTRA1 drives polyploidy. BMC Cancer. 2016 Jul 7;16:399.

Poepsel S, Sprengel A, Sacca B, Kaschani F, Kaiser M, Gatsogiannis C, Raunser S, Clausen T, Ehrmann M. Determinants of amyloid fibril degradation by the PDZ protease HTRA1. Nat Chem Biol. 2015 Nov;11(11):862-9.Comment http://www.alzforum.org/news/research-news/two-one-single-protein-untangles-and-chops-tau-fibrils.

Ehrmann M, Kaschani F, Kaiser M. 2015. Chemical proteomics versus leishmaniasis. Chem Biol. Mar 19;22(3):309-10.

Beaufort N, Scharrer E, Kremmer E, Lux V, Ehrmann M,Huber R, Houlden H, Werring D, Haffner C, Dichgans M. Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16496-501.

Thompson NJ, Merdanovic M, Ehrmann M, van Duijn E, Heck AJ. Substrate occupancy at the onset of oligomeric transitions of DegP. Structure. 2014 Feb 4;22(2):281-90.

Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodriguez CDA, Rudner DZ, Clausen T. 2013. CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis. Cell. 155:647–658.

Gloeckl S, Ong VA, Patel P, Tyndall JD, Timms P, Beagley KW, Allan JA, Armitage CW, Turnbull L, Whitchurch CB, Merdanovic M, Ehrmann M, Powers JC, Oleksyszyn J, Verdoes M, Bogyo M, Huston WM. 2013. Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis.Mol Microbiol. Aug;89(4):676-89.

Stolze SC, Meltzer M, Ehrmann M, Kaiser M. 2013. Ahp cyclodepsipeptides: the impact of the ahp residue on the "canonical inhibition" of s1 serine proteases.Chembiochem 14(11):1301-8.

Merdanovic M, Mönig T, Ehrmann M, Kaiser M. 2013. The diversity of allosteric regulation in proteases. ACS Chem Biol 8:19-26.

Tiaden AN, Breiden M, Mirsaidi A, Weber FA, Bahrenberg G, Glanz S, Cinelli P, Ehrmann M, Richards PJ. 2012. Human Serine Protease HTRA1 Positively Regulates Osteogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells and Mineralization of Differentiating Bone-Forming Cells through the Modulation of Extracellular Matrix Proteins. Stem Cells. 30:2271-2282.

Nigro A, Menon R, Bergamaschi A, Clovis Y, Baldi A, Ehrmann M, Comi G, De Pietri Tonelli D, Farina C, Martino G, and Muzio L. 2012. MiR-30e and miR-181d control Radial Glial cell proliferation via HtrA1 modulation. Cell Death Dis. 3:e360.

Tiaden AN, Klawitter M, Lux V, Mirsaidi A, Bahrenberg G, Glanz S, Quero L, Liebscher T, Wuertz K, Ehrmann M, Richards PJ. 2012. A detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration. J Biol Chem. 287:21335-21345.

Tennstaedt A, Poepsel S, Truebestein L, Hauske P, Brockmann A, Schmidt N, Irle I, Sacca B, Niemeyer CM, Brandt R, Ksiezak-Reding H, Tirniceriu AL, Egensperger R, Baldi A, Dehmelt L, Kaiser M, Huber R, Clausen T, Ehrmann M. 2012. Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates. J Biol Chem. 287(25):20931-41.

Weski J, Ehrmann M. 2012. Genetic analysis of 15 protein folding factors and proteases of the E. coli cell envelope. J Bacteriol. 194(12):3225-33.

Lütticke C, Hauske P, Lewandrowski U, Sickmann A, Kaiser M, and M. Ehrmann. 2012. E. coli LoiP (YggG), a metalloprotease hydrolyzing Phe-Phe bonds. Mol. Biosys. 8(6):1775-82.

Weski J, Meltzer M, Spaan L, Mönig T, Oeljeklaus J, Hauske P, Vouilleme L, Volkmer R, Boisguerin P, Boyd D, Huber R, Kaiser M, Ehrmann M. 2012. Chemical biology approaches reveal conserved features of a C-terminal processing PDZ protease. Chembiochem. 13(3):402-8.

Stolze SC, Meltzer M, Ehrmann M, Kaiser M. 2012. Development of a solid-phase approach to the natural product class of Ahp containing cyclodepsipeptides. Eur. J. Org. Chem. 1616-1625.

Malet M, Canellas F, Sawa J, Yan J, Thalassinos K, Ehrmann M, Clausen T, and H. Saibil. 2012. Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ. Nat Struct Mol Biol. 19(2):152-7.

Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, Schrader T, Wang C, Bitan G. 2011. Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. JACS. 133(42):16958-69.

Sawa J, Malet H, Krojer T, Canellas F, Ehrmann M, and T. Clausen 2011. Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope. J. Biol. Chem. 286:30680-30690.

Kaiser M, Huber R, and M. Ehrmann. 2011. Proteases. Encyclopedia of Genetics. S. Maloy and K. Hughes (eds.), Academic Press: 978-0123749840.

Wu J, Zawistowski A, Ehrmann M, and C. Schmuck. 2011. Peptide functionalized Polydiacetylene Liposomes act as a Fluorescent Turn-On Sensor for Bacterial Lipopolysaccharide. JACS. 133(25):9720-3.

Merdanovic M, Clausen T, Kaiser M, Huber R, and M. Ehrmann. 2011. Protein quality control in the bacterial periplasm. Annu. Rev. Microbiol. 65:149-168.

Kley J, Schmidt B, Boyanov B, Stolt-Bergner PC, Kirk R, Ehrmann M, Knopf RR, Naveh L, Adam Z, Clausen T. Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure. 2011 Nat. Struct. Mol. Biol. 18:728-731.

Clausen T, Kaiser M, Huber R and M. Ehrmann. 2011. HtrA proteases: Regulated proteolysis in protein quality control. Nat. Rev. Mol. Cell Biol. 12:152-62.

Trübestein L, Tennstaedt A, Mönig T, Krojer T, Canellas F, Kaiser M, Clausen T, and M. Ehrmann. 2011. Substrate induced remodeling of the active site regulates human HtrA1 activity. Nat. Struct. Mol. Biol. 18:386-368.

Stolze SC, Meltzer M, Ehrmann M, and M. Kaiser. 2010. Solid Phase Total Synthesis of the 3-Amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide Symplocamide A. RSC Chem. Commun. 46:8857-8859.

Campioni M, Severino A, Manente L, Tuduce, IL, Toldo S, Caraglia M, Crispi S, Ehrmann M, He X, Maguire J, De Falco M, De Luca A, Shridhar V, and A. Baldi 2010. The serine protease HtrA1 specifically intercats and degrades the Tuberous Sclerosis Complex 2 protein. Mol Cancer Res. 8:1248-1260.

Merdanovic M, Mamant N, Meltzer M, Poepsel S, Auckenthaler A, Melgaard R, Hauske P, Nagel-Steger L, Clarke AR, Kaiser M, Huber R, and M. Ehrmann. 2010. Determinants of structural and functional plasticity of a widely conserved protease chaperone complex. Nat. Struct. Mol. Biol. 17:837-43.

Hasenbein S, Meltzer M, Hauske P, Kaiser M, Huber R, Clausen T and M. Ehrmann. 2010. Conversion of a regulatory into a degradative protease. J. Mol. Biol. 397:957-966.

Sawa J, Alexander Heuck P, Ehrmann M, and T. Clausen. 2010. Molecular transformers in the cell: Lessons learned from the DegP protease-chaperone. Curr. Opin. Struct. Biol. 20:253-258.

Meltzer M, Hasenbein S, Mamant N, Merdanovic M, Poepsel S, Hauske P, Kaiser M, Huber R, Krojer T, Clausen T, and M. Ehrmann. 2009. Structure, function and regulation of the conserved serine proteases DegP and DegS of E. coli. Res. Microbiol. 160:660-666.

Hauske P, Mamant N, Hasenbein S, Nickel S, Ottmann C, Clausen T, Ehrmann M, and M. Kaiser 2009 Peptidic small molecule activators of the stress sensor DegS. Mol. BioSyst. 5:980-985.

Hauske P, Meltzer M, Ottmann C, Krojer T, Clausen T, Ehrmann M*, and M. Kaiser*. 2009 Selectivity profiling of DegP substrates and inhibitors. Bioorg. Med. Chem. 17:2920-2924, Cover article, *corresponding authors.

Hauske P, Ottmann C, Meltzer M, Ehrmann M, and M. Kaiser. 2008 Allosteric regulation of proteases. Chem. Biochem. 9:2920-2928.

Krojer T, Sawa J, Schäfer E, Saibil HR, Ehrmann M, and T. Clausen. 2008 Structural basis for the regulated protease and chaperone function of DegP. Nature 453:885-890.
   Highlighted in 2008 Structure 16:989-990.

Krojer T, Pangerl K, Kurt J, Sawa J, Stingl C, Mechtler K, Huber R, Ehrmann M, and T. Clausen 2008 The interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins. Proc. Natl. Acad. Sci. USA 105:7702-7707.

Launay S, Maubert E, Lebeurrier N, Tennstaedt A, Campioni M, Docagne F, Gabriel C, Ehrmann M., Baldi, A., and D. Vivien 2008 HtrA1-dependent proteolysis of TGF- controls both neuronal maturation and developmental survival. Cell Death Diff. 15:1408-1416.

Meltzer M, Hasenbein S, Hauske P, Kucz N, Merdanovic M, Grau S, Beil A, Jones D, Krojer T, Clausen T, Ehrmann M*, and M. Kaiser* 2008 Allosteric activation of HtrA protease DegP by stress signals in bacterial protein quality control. Angew Chem. Int. Ed. Engl., 47:1332-1334; Angew. Chem. 120:1352-1355 *corresponding authors.

Baldi A, Mottolese M, Vincenzi B, Campioni M, Mellone P, Di Marino M, di Crescenzo VG, Visca P, Menegozzo S, Spugnini EP, Citro G, Ceribelli A, Mirri A, Chien J, Shridhar V, Ehrmann M, Santini M, Facciolo F. 2008 The serine protease HtrA1 is a novel prognostic factor for human mesothelioma. Pharmacogenomics 9:1069-1077.

Hasselblatt H, Kurzbauer R, Wilken C, Krojer T, Sawa J, Kurt J, Kirk R, Hasenbein S, Ehrmann M, and T. Clausen 2007 Regulation of the E stress response by DegS: How the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress. Genes Dev. 21: 2659-2670.

Severino A, Campioni M, Straino S, Salloum F, Schmidt N, Herbrand U, Frede S, Toietta G, Di Rocco G, Bussani R, Silvestri F, Piro M, Liuzzo G, Biasucci LM, Mellone P, Feroce F, Capogrossi M, Baldi F, Fandrey J, Ehrmann M, Crea F, Abbate A and A. Baldi 2007 Identification of protein disulfide isomerase (PDI) as a myocardiocyte survival factor during the development of ischemic heart disease. J. Am. Coll. Cardiol. 50:1029-1037.

Hasenbein S, Merdanovic M and M. Ehrmann 2007 Determinants of regulated proteolysis in signal transduction. Genes Dev. 21:6-10.

Eser M, Henrichs T, Boyd D, and M. Ehrmann. 2007 Target directed proteolysis in vivo. Methods Enzymol. 421:68-83.

Meltzer M, Kucz N, and M. Ehrmann. 2006 Periplasmic proteases. In “The PeriplasmM. Ehrmann (ed) ASM Press p. 150-170.

The Periplasm 2006 M. Ehrmann (ed). ASM Press ISBN: 1-55581-398-4.

Chien J, Aletti G, Baldi A, Catalano V, Muretto P, Keeney GL, Kalli KR, Staub J, Ehrmann M, Cliby WA, Lee YK, Bible KC, Hartmann LC, Kaufmann SH and V. Shridhar 2006 Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity. J. Clin. Invest. 116: 1994-2004.

Grau S, Richards P, Kerr B, Hughes C, Caterson B, Williams AS, Junker U, Jones SA, Clausen T, and M. Ehrmann. 2006. The role of human HtrA1 in arthritic disease. J. Biol. Chem. 281:6124-6129.

Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, Yamamoto N, Ehrmann M, Rose-John S, Williams AS, Topley N, and S. A. Jones. 2006. Baculovirus expression and functional characterization of a recombinant human soluble gp130 isoform and its role in the regulation of IL-6 trans-signaling. Arthritis and Rheumatism 54:1662-1672.

Grau S, Baldi A, Bussani R, Tian X, Stefanescu R, Przybylski M, Shridhar V, Clausen T, and M. Ehrmann. 2005. Implications of human HtrA1 in amyloid precursor protein processing. Proc. Natl. Acad. Sci. USA 102:6021-6026.

Henrichs T, Mikhaleva N, Conz C, Deuerling E, Boyd D, E, Zelasny A, Bibi E, Ban N, and M. Ehrmann. 2005. Target-directed proteolysis at the ribosome. Proc. Natl. Acad. Sci. USA 102:4246-4251.

Ehrmann, M. 2005. Folding in the Bacterial Periplasm. in the “Handbook of Protein Folding” J.Buchner & T. Kiefhaber (eds) Wiley-VCH, p 938-964.

Tian X, Cecal R, McLaurin J, Manea M, Stefanescu, Grau S, Harnasch M, Amir S, Ehrmann M, St George-Hyslop P, Kohlmann G, and M. Przybylski 2005. Identification and structural characterisation of carboxy-terminal polypeptides and antibody epitopes of Alzheimer's amyloid precursor protein using high-resolution mass spectrometry.Eur.J. Mass Spectrom. 11: 547-56.

Harnasch M, Grau S, Dove SL, Hochschild N, Iskandar MK, Xia W, and M. Ehrmann. 2004. Bacterial expression and two-hybrid systems for human membrane proteins: Characterisation of presenilin/amyloid precursor interaction. Mol. Membrane Biol.21:373-383.

Ehrmann M, and T. Clausen. 2004 Proteolysis as a regulatory mechanism. Annu. Rev. Genet. 38: 709-724.

Wilken C, Kitzing K, Kurzbauer R, Ehrmann M, and T. Clausen 2004. Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease domain. Cell 117:483-494.
  Highlighted in 2004 Cell 117:417-419.

Eser M, and M. Ehrmann. 2003. SecA-dependent quality control of intracellular protein localisation. Proc. Natl. Acad. Sci. USA 100: 13231-13234.
  Highlighted in 2003 J. Cell Biol. 163:691 & in 2003 Science 203:1296.

Ehrle R, Mikhaleva N, Boyd D, Davidson AL and M. Ehrmann. 2003 Context-dependent effects of charged residues in transmembrane segments of MalF-PhoA fusions. Res. Microbiol. 154:654-657.

Clausen T, Southan C, and M. Ehrmann. 2002. The HtrA family of proteases, implications for protein composition and cell fate. Mol. Cell 10:443-455.

Krojer T, Garrido-Franco M, Huber R, Ehrmann M, and T. Clausen. 2002. Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine. Nature 416: 455-459
   Highlighted in 2002 Nature Struct Biol 9:410-412.

Herskovits AA, Seluanov A, Rajsbaum R, ten Hagen-Jongman CM, Henrichs T, Bochkareva ES, Phillips GJ, Probst FJ, Nakae T, Ehrmann M, Luirink J, and E.Bibi. 2001. Evidence for coupling of membrane-targeting and function of the signal recognition particle-receptor FtsY. EMBO Reports 2: 1040-1046.

Faber KN, Kram AM, Ehrmann M, and M. Veenhuis. 2001. The use of the Tobacco Etch Virus (TEV-) protease as a tool to determine the topology of peroxisomal membrane proteins in vivo. J. Biol. Chem. 276: 36501-36507.

Steinke A, Grau S, Davidson A, Hofmann E, and M. Ehrmann 2001. Characterization of transmembrane domains 3, 4, and 5 of MalF by mutational analysis. J. Bacteriol. 183:375-381.

Uhland K, Mondigler M, Spiess C, Prinz W, and M. Ehrmann 2000. The determinants of translocation and folding of TreF, a trehalase of E. coli. J. Biol. Chem. 275: 23439-23445.

Al-Masoudi NA, Al-Soud YA, Ehrmann M, and E. de Clerq 2000. Synthesis of acyclic 6,7-dihaloquinolone nucleoside analogues as potential antibacterial and antiviral agents. Bioorganic & Medical Chemistry 8: 1407-1413.

Spiess C, Beil A, and M. Ehrmann 1999. A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein. Cell 97: 339-347.
  Highlighted in Nature Science Update

Guan L, Ehrmann M, Yoneyama H, and T. Nakae 1999. Membrane Topology of the Xenobiotic-Exporting Subunits, MexB, of the MexA,B-OprM Extrusion Pump in Pseudomonas aeruginosa. J. Biol. Chem. 274: 10517-10522.

Melchers K, Buhmann A, Schuhmacher A, Weizenegger K, Belin D, Grau S, and M. Ehrmann 1999. Membrane topology of the CadA-homologous P type ATPase of Helicobacter pylori by expression of phoA fusions in Escherichia coli and the positive inside rule. Res. Microbiol. 150: 507-520.

Prinz WA, Boyd DH, Ehrmann M, and J. Beckwith 1998. The protein translocation apparatus contributes to determining the topology of an integral membrane protein in E. coli. J. Biol. Chem. 273: 8419-8424.

Akiyama Y, Ehrmann M, Kihara A, and K. Ito 1998. Polypeptide binding of E. coli FtsH. Mol. Microbiol. 28: 803-812.

Ehrmann M, Ehrle R, Hofmann E, Boos W, and A. Schlösser. 1998. The ABC maltose transporter. Mol. Microbiol. 29:685-694 Cover article.

Al-Masoudi NA, Al-Soud YA, Ehrmann M, and E. de Clerq 1998. Quinolone nucleosides: 6,7-dihalo-N-ß- and a-glycosyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acids and derivatives synthesis, antimicrobial and antiviral activity. Nucleosides & Nucleotides USA 17: 2255-2266.

M. Ehrmann 1998. Eine hochspezifische Protease zur Struktur-und Funktionsanalyse von Proteinen in vivo und in vitro. Biospektrum 2/1998: 53-56.

Ehrmann M, Bolek P, Mondigler M, Boyd D, and R. Lange 1997. TnTIN and TnTAP: mini-transposons for site specific proteolysis in vivo. Proc. Natl. Acad. Sci. USA 94: 13111-13115.

Spiess C, Happersberger P, Glocker M, Spiess E, Rippe K, and M. Ehrmann 1997. Biochemical characterization and mass spectrometric disulfide bond mapping of periplasmic α-amylase MalS of Escherichia coli. J. Biol. Chem. 272: 22125-22133.

M. Ehrmann 1997. Biogenese, Struktur und Funktion integraler Membranproteine: die Membrankomponenten des ABC-Maltosetransporters von Escherichia coli. Biospektrum 3/1997: 46-47.

Prinz W, Spiess C, Ehrmann M, Schirle C, and J. Beckwith. 1996. Targeting of signal sequenceless proteins for export in E. coli with altered protein translocase. EMBO J. 15: 5209-5217.

Ehrle R, Pick C, Ulrich R, Hofmann E, and M. Ehrmann. 1996. Characterization of transmembrane domains 6, 7 and 8 of MalF by mutational analysis. J. Bacteriol. 178: 2255-2262.

Mondigler M, and M. Ehrmann. 1996. Site specific proteolysis of the E. coli SecA Protein in vivo. J. Bacteriol. 178: 2986-2988.

Horlacher R, Uhland K, Klein W, Ehrmann M, and W. Boos 1996. Characterization of a cytoplasmic trehalase of E. coli. J. Bacteriol. 178: 6250-6257.

Uhland K, Zander T, and M. Ehrmann 1995. Synthetic competition between cytoplasmic folding and translocation of a soluble membrane protein domain. Res. Microbiol. 146: 121-128.

Whitley P, Zander T, Ehrmann M, Haardt M, Bremer E, and G. von Heijne 1994. Sec-independent translocation of a 100-residue periplasmic N-terminal tail in the E. coli inner membrane protein ProW. EMBO J. 13: 4653-4661.

Hoffmann R, Jung S, Ehrmann M, and H. W. Hofer. 1994. The Yeast Gene PPH3 Encodes A Protein Phosphatase With Properties Different From PPX, PP1 And PP2A. Yeast 10: 567-578.

Uhland K, Ehrle R, Zander T, and M. Ehrmann. 1994. Requirements for translocation of periplasmic domains in polytopic membrane proteins. J. Bacteriol. 176: 4565-4571.

McGovern K, Ehrmann M, and J. Beckwith. 1991. Decoding Signals for Membrane Protein Assembly Using Alkaline Phosphatase Fusions. EMBO J. 10: 2773-2782.

Ehrmann M, and J. Beckwith. 1991. Proper Insertion of Complex Membrane Protein in the Absence of its Amino-terminal Export Signal. J. Biol. Chem. 266: 16530-16533.

Ehrmann M, Boyd D, and J. Beckwith. 1990. Genetic Analysis of Membrane Protein Topology Using a Novel Gene Fusion Approach. Proc. Natl. Acad. Sci. USA 87: 7574-7578.

Reidl A, Römisch K, Ehrmann M, and W. Boos. 1989. MalI, a Novel Protein Involved in Regulation of the Maltose System of E. coli, Is Highly Homologous to the Repressor Proteins GalR, CytR, and LacI. J. Bacteriol. 171: 4888-4899.

Gött P, Ehrmann M, and W. Boos. 1988. Convenient Transfer of lacZ-Gene Fusions to Phage M13 by in vivo Recombination and their Use for Nucleotide Sequencing. Gene 71: 187-191.

Ehrmann M. and W. Boos. 1987. Identification of Endogenous Inducers of the mal Regulon in E. coli. J. Bacteriol. 169:3539-3545.

Ehrmann M, Boos W, Ormseth E, Schweizer H, and T.J. Larson. 1987. Divergent Transcription of the sn-Glycerol-3-Phosphate Active Transport (glpT) and Anaerobic sn-Glycerol-3-Phosphate Dehydrogenase (glpA glpC glpB) Genes of E. coli K12. J. Bacteriol. 169: 526-532.

Bukau B, Ehrmann M, and W. Boos. 1986. Osmoregulation of the Maltose Regulon in E. coli. J. Bacteriol. 166: 884-891.

Larson TJ, Ehrmann M, and W. Boos. 1983. Periplasmic Glycerophospho-diester Phosphodiesterase of E. coli, a new enzyme of the glp regulon. J. Biol. Chem. 258: 5428-5432.