ZMB Member Joachim Fandrey

Prof. Dr. Joachim Fandrey

Prof. Dr. Joachim Fandrey

Phone: +49 201 723 4600
Email

 
Medizinische Fakultät
Universitätsklinikum Essen
Hufelandstr. 55
45122 Essen

Research Overview

Oxygen-dependent Gene Expression – Structure and Function of the Cellular Oxygen Sensor

  • Activation of the transcription factor complex hypoxia-inducible factor-1 (HIF-1) – molecular imaging of HIF-1 assembly
  • In vivo 2-photon microscopy and three-dimensional localization of intracellular proteins
  • Regulation of the oxygen-dependent expression of the erythropoietin gene
  • The role of oxygen-dependent expression of the angiogenic protein VEGF for tumor vascularisation

Mechanisms of inflammatory Reactions Role of HIF-1 Complexes in Muscle Trauma

  • Non-hypoxic activation of hypoxia-inducible factor-1 by inflammatory cytokines and signalling molecules
  • Role of reactive oxygen and nitrogen species for the function of cellular oxygen sensors
  • Cross-talk of hypoxic and proinflammatory cytokine-mediated activation of genes important for angiogenesis and vascular permeability
  • Pathophysiology of erythropoietin production in chronic inflammatory and malignant diseases

Role of HIF-1 Complexes in Muscle Trauma

  • Activation of HIF-1 in traumatised tissue
  • Role of HIF-1 activation for the severity of tissue trauma
  • Influence of reactive oxygen and nitrogen species for regeneration processes in skeletal muscle