ZMB Member Erich Gulbins

Prof. Dr. Erich Gulbins

Prof. Dr. Erich Gulbins

Phone
+49 201 723 3118
Email

Medizinische Fakultät
Universitätsklinikum Essen
Hufelandstr. 55
45122 Essen

Research Overview
 

Tumor-Host interactions

  • Role of sphingolipids for hematogenous and lymphatic tumor metastasis
  • Regulation of tumor cell migration by host ceramide and sphingomyelinases
  • Targeted induction of tumor cell death by manipulation of the sphingolipid metabolism
  • Regulation of tumor stem cells by ceramide and the acid sphingomyelinase
  • Role of mitochondrial ceramide for tumor cell death
  • Function of ceramide for radiation- and chemotherapy-induced cell death

Host-pathogen interactions

  • Role of sphingolipids, in particular ceramide, and sphingomyelinases for infection of mammalian cells with Pseudomonas aeruginosa, Staphylococcus aureus and Mycobacteria
  • Role of CFTR for infections with P. aeruginosa
  • Regulation of lysosomal maturation by sphingolipids during bacterial infections
  • Function of mitochondrial ceramide for infection with P. aeruginosa

Regulation of cystic fibrosis and autoimmune disorders by ceramide and the acid sphingomyelinase

  • Cystic fibrosis: Role of ceramide and the acid sphingomyelinase
  • Treatment of cystic fibrosis with stem cell therapy
  • Sphingolipids in Multiple Sclerosis and Autoimmune Arthritis

Regulation and function of mitochondrial Kv1.3 channels

Role of sphingolipids in major depression