ZMB Member Erich Gulbins

Prof. Dr. Erich Gulbins

Prof. Dr. Erich Gulbins

Phone
+49 201 723 3118
Email

Medizinische Fakultät
Universitätsklinikum Essen
Hufelandstr. 55
45122 Essen

Research Overview
 

Tumor-Host interactions

  • Role of sphingolipids for hematogenous and lymphatic tumor metastasis
  • Regulation of tumor cell migration by host ceramide and sphingomyelinases
  • Targeted induction of tumor cell death by manipulation of the sphingolipid metabolism
  • Regulation of tumor stem cells by ceramide and the acid sphingomyelinase
  • Role of mitochondrial ceramide for tumor cell death
  • Function of ceramide for radiation- and chemotherapy-induced cell death

Host-pathogen interactions

  • Role of sphingolipids, in particular ceramide, and sphingomyelinases for infection of mammalian cells with Pseudomonas aeruginosa, Staphylococcus aureus and Mycobacteria
  • Role of CFTR for infections with P. aeruginosa
  • Regulation of lysosomal maturation by sphingolipids during bacterial infections
  • Function of mitochondrial ceramide for infection with P. aeruginosa

Regulation of cystic fibrosis and autoimmune disorders by ceramide and the acid sphingomyelinase

  • Cystic fibrosis: Role of ceramide and the acid sphingomyelinase
  • Treatment of cystic fibrosis with stem cell therapy
  • Sphingolipids in Multiple Sclerosis and Autoimmune Arthritis

Regulation and function of mitochondrial Kv1.3 channels

Role of sphingolipids in major depression

ZMB Research Programme

Prof. Erich Gulbins participates in the ZMB research programme I, Oncology.

DFG Research Unit 2123

Sphingolipid dynamics in infection control (FOR 2123)