ZMB Member Matthias Gunzer

Prof. Dr. Matthias Gunzer

Prof. Dr. Matthias Gunzer

Phone
+49 201 183 6640
Email

Medical Faculty (Campus Essen)
Room S05 V01 E29
University of Duisburg-Essen
45141 Essen

Research Overview
 

The research interest of my group is to characterize the dynamics of immune cell behaviour, their motility and migratory pattern as well as formation of cell-cell interaction within the course of the immune response in vivo. My lab employs a wide range of specialized imaging technologies by which we investigate a number of projects how immune cells function in vivo in important organs such as the lymph node, the bone marrow, the brain and the lung.

    Journal articles

  • Dalal, Prarthana J.; Sullivan, David P.; Weber, Evan W.; Sacks, David B.; Gunzer, Matthias; Grumbach, Isabella M.; Heller Brown, Joan; Muller, William A.
    Spatiotemporal restriction of endothelial cell calcium signaling is required during leukocyte transmigration
    In: Journal of Experimental Medicine (JEM) Vol. 218 (2021) Nr. 1, pp. e20192378
    ISSN: 1540-9538; 0022-1007
  • Gunzer, Matthias; Thornton, Christopher R.; Beziere, Nicolas
    Advances in the in vivo molecular imaging of invasive aspergillosis
    In: Journal of Fungi Vol. 6 (2020) Nr. 4, pp. 338
    ISSN: 2309-608X
  • Ballesteros, Iván; Rubio-Ponce, Andrea; Genua, Marco; Lusito, Eleonora; Kwok, Immanuel; Fernández-Calvo, Gabriel; Khoyratty, Tariq E.; van Grinsven, Erinke; González-Hernández, Sara; Nicolás-Ávila, José Ángel; Vicanolo, Tommaso; Maccataio, Antonio; Benguría, Alberto; Li, Jackson LiangYao; Adrover, José M.; Aroca-Crevillen, Alejandra; Quintana, Juan A.; Martín-Salamanca, Sandra; Mayo, Francisco; Ascher, Stefanie; Barbiera, Giulia; Soehnlein, Oliver; Gunzer, Matthias; Ginhoux, Florent; Sánchez-Cabo, Fátima; Nistal-Villán, Estanislao; Schulz, Christian; Dopazo, Ana; Reinhardt, Christoph; Udalova, Irina A.; Ng, Lai Guan; Ostuni, Renato; Hidalgo, Andrés
    Co-option of Neutrophil Fates by Tissue Environments
    In: Cell Vol. 183 (2020) Nr. 5, pp. 1282 - 1297.e18
    ISSN: 1097-4172; 0092-8674
  • Gonzalez-Beltran, Alejandra N.; Masuzzo, Paola; Ampe, Christophe; Bakker, Gert-Jan; Besson, Sébastien; Eibl, Robert H.; Friedl, Peter; Gunzer, Matthias; Kittisopikul, Mark; Dévédec, Sylvia E Le; Leo, Simone; Moore, Josh; Paran, Yael; Prilusky, Jaime; Rocca-Serra, Philippe; Roudot, Philippe; Schuster, Marc; Sergeant, Gwendolien; Strömblad, Staffan; Swedlow, Jason R.; van Erp, Merijn; Van Troys, Marleen; Zaritsky, Assaf; Sansone, Susanna-Assunta; Martens, Lennart
    Community standards for open cell migration data
    In: GigaScience Vol. 9 (2020) Nr. 5, pp. giaa041
    ISSN: 2047-217X
  • Bornemann, Lea; Schuster, Marc; Schmitz, Saskia; Sobczak, Charlyn; Bessen, Clara; Merz, Simon F.; Jöckel, Karl-Heinz; Haverkamp, Thomas; Gunzer, Matthias; Göthert, Joachim Rudolf
    Defective migration and dysmorphology of neutrophil granulocytes in atypical chronic myeloid leukemia treated with ruxolitinib
    In: BMC Cancer Vol. 20 (2020) Nr. 1, pp. 650
    ISSN: 1471-2407
  • Boivin, Gael; Faget, Julien; Ancey, Pierre-Benoit; Gkasti, Aspasia; Mussard, Julie; Engblom, Camilla; Pfirschke, Christina; Contat, Caroline; Pascual, Justine; Vazquez, Jessica; Bendriss-Vermare, Nathalie; Caux, Christophe; Vozenin, Marie-Catherine; Pittet, Mikael J.; Gunzer, Matthias; Meylan, Etienne
    Durable and controlled depletion of neutrophils in mice
    In: Nature Communications Vol. 11 (2020) pp. 2762
    ISSN: 2041-1723
  • Hagemann, Nina; Mohamud Yusuf, Ayan; Martiny, Carlotta; Zhang, Xiaoni; Kleinschnitz, Christoph; Gunzer, Matthias; Kolesnick, Richard; Gulbins, Erich; Hermann, Dirk M.
    Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia
    In: Basic Research in Cardiology Vol. 115 (2020) Nr. 6, pp. 64
    ISSN: 1435-1803; 0300-8428
  • Khatib-Massalha, Eman; Bhattacharya, Suditi; Massalha, Hassan; Biram, Adi; Golan, Karin; Kollet, Orit; Kumari, Anju; Avemaria, Francesca; Petrovich-Kopitman, Ekaterina; Gur-Cohen, Shiri; Itkin, Tomer; Brandenburger, Isabell; Spiegel, Asaf; Shulman, Ziv; Gerhart-Hines, Zachary; Itzkovitz, Shalev; Gunzer, Matthias; Offermanns, Stefan; Alon, Ronen; Ariel, Amiram; Lapidot, Tsvee
    Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 3547
    ISSN: 2041-1723
  • Wang, Chen; Börger, Verena; Sardari, Maryam; Murke, Florian; Skuljec, Jelena; Pul, Refik; Hagemann, Nina; Dzyubenko, Egor; Dittrich, Robin; Gregorius, Jonas; Hasenberg, Mike; Kleinschnitz, Christoph; Popa-Wagner, Aurel; Döppner, Thorsten R.; Gunzer, Matthias; Giebel, Bernd; Hermann, Dirk M.
    Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils
    In: Stroke Vol. 9 (2020) Nr. 10, pp. 1825 - 1834
    ISSN: 1524-4628; 0039-2499
  • Ueki, Hiroshi; Wang, I-Hsuan; Zhao, Dongming; Gunzer, Matthias; Kawaoka, Yoshihiro
    Multicolor two-photon imaging of in vivo cellular pathophysiology upon influenza virus infection using the two-photon IMPRESS
    In: Nature Protocols Vol. 15 (2020) pp. 1041 - 1065
    ISSN: 1750-2799; 1754-2189
  • Mülling, Kerstin; Fischer, Alexa Josephine; Siakaeva, Elena; Richter, Mathis; Bordbari, Sharareh; Spyra, Ilona; Köster, Christian; Hermann, Dirk M.; Gunzer, Matthias; Felderhoff-Müser, Ursula; Bendix, Ivo; Jablonska, Jadwiga; Herz, Josephine
    Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia–ischemia
    In: Brain, Behavior, and Immunity (2020)
    ISSN: 1090-2139; 0889-1591
  • Schleier, Lena; Wiendl, Maximilian; Heidbreder, Karin; Binder, Marie-Theres; Atreya, Raja; Rath, Timo; Becker, Emily; Schulz-Kuhnt, Anja; Stahl, Annette; Schulze, Lisa Lou; Ullrich, Karen; Merz, Simon F.; Bornemann, Lea; Gunzer, Matthias; Watson, Alastair J.M.; Neufert, Clemens; Atreya, Imke; Neurath, Markus F.; Zundler, Sebastian
    Non-classical monocyte homing to the gut via α4β7 integrin mediates macrophage-dependent intestinal wound healing
    In: Gut Vol. 69 (2020) pp. 252 - 263
    ISSN: 1468-3288; 0017-5749
  • Heichler, Christina; Scheibe, Kristina; Schmied, Anabel; Geppert, Carol I; Schmid, Benjamin; Wirtz, Stefan; Thoma, Oana-Maria; Kramer, Viktoria; Waldner, Maximilian J; Büttner, Christian; Farin, Henner; Pešić, Marina; Knieling, Ferdinand; Merkel, Susanne; Grüneboom, Anika; Gunzer, Matthias; Grützmann, Robert; Rose-John, Stefan; Koralov, Sergei; Kollias, George; Vieth, Michael; Hartmann, Arndt; Greten, Florian; Neurath, Markus F; Neufert, Clemens
    STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis
    In: Gut Vol. 69 (2020) Nr. 7, pp. 1269 - 1282
    ISSN: 0017-5749
  • Metzger, Philipp; Kirchleitner, Sabrina V.; Boehmer, Daniel F. R.; Hörth, Christine; Eisele, Angelika; Ormanns, Steffen; Gunzer, Matthias; Lech, Maciej; Lauber, Kirsten; Endres, Stefan; Duewell, Peter; Schnurr, Max; König, Lars M.
    Systemic but not MDSC-specific IRF4 deficiency promotes an immunosuppressed tumor microenvironment in a murine pancreatic cancer model
    In: Cancer Immunology, Immunotherapy Vol. 69 (2020) Nr. 10, pp. 2101 - 2112
    ISSN: 1432-0851; 0340-7004
  • Dümig, Michaela; Binder, Jasmin; Gaculenko, Anastasia; Daul, Franziska; Winandy, Lex; Hasenberg, Mike; Gunzer, Matthias; Fischer, Reinhard; Künzler, Markus; Krappmann, Sven
    The infectious propagules of Aspergillus fumigatus are coated with antimicrobial peptides
    In: Cellular Microbiology (2020) pp. e13301
    ISSN: 1462-5822; 1462-5814
  • Amich, Jorge; Mokhtari, Zeinab; Strobel, Marlene; Vialetto, Elena; Sheta, Dalia; Yu, Yidong; Hartweg, Julia; Kalleda, Natarajaswamy; Jarick, Katja J.; Brede, Christian; Jordán-Garrote, Ana-Laura; Thusek, Sina; Schmiedgen, Katharina; Arslan, Berkan; Pinnecker, Jürgen; Thornton, Christopher R.; Gunzer, Matthias; Krappmann, Sven; Einsele, Hermann; Heinze, Katrin G.; Beilhack, Andreas
    Three-Dimensional Light Sheet Fluorescence Microscopy of Lungs To Dissect Local Host Immune-Aspergillus fumigatus Interactions
    In: mBio Vol. 11 (2020) Nr. 1, pp. e02752 - 19
    ISSN: 2150-7511; 2161-2129
  • Rassaf, Tienush; Totzeck, Matthias; Mahabadi, Amir Abbas; Hendgen-Cotta, Ulrike B.; Korste, Sebastian; Settelmeier, Stephan; Lüdike, Peter; Dittmer, Ulf; Herbstreit, Frank; Brenner, Thorsten; Klingel, Karin; Hasenberg, Mike; Walkenfort, Bernd; Gunzer, Matthias; Schlosser, Thomas Wilfried; Weymann, Alexander; Kamler, Markus; Schmack, Bastian; Ruhparwar, Arjang
    Ventricular assist device for a coronavirus disease 2019-affected heart
    In: ESC Heart Failure (2020) in press
    ISSN: 2055-5822
  • Grüneboom, Anika; Hawwari, Ibrahim; Weidner, Daniela; Culemann, Stephan; Müller, Sylvia; Henneberg, Sophie; Brenzel, Alexandra; Merz, Simon; Bornemann, Lea; Zec, Kristina; Wülling, Manuela; Kling, Lasse; Hasenberg, Mike; Voortmann, Sylvia; Lang, Stefanie; Baum, Wolfgang; Ohs, Alexandra; Kraff, Oliver; Quick, Harald H.; Jäger, Marcus; Landgraeber, Stefan; Dudda, Marcel; Danuser, Renzo; Stein, Jens V.; Rohde, Manfred; Gelse, Kolja; Garbe, Annette I.; Adamczyk, Alexandra; Westendorf, Astrid; Hoffmann, Daniel; Christiansen, Silke; Engel, Daniel Robert; Vortkamp, Andrea; Krönke, Gerhard; Herrmann, Martin; Kamradt, Thomas; Schett, Georg; Hasenberg, Anja; Gunzer, Matthias
    A network of trans-cortical capillaries as mainstay for blood circulation in long bones
    In: Nature Metabolism Vol. 1 (2019) Nr. 2, pp. 236 - 250
    ISSN: 2522-5812
  • Dmitrieva-Posocco, Oxana; Dzutsev, Amiran; Posocco, David F.; Hou, Vivianty; Yuan, Wuxing; Thovarai, Vishal; Mufazalov, Ilgiz A.; Gunzer, Matthias; Shilovskiy, Igor P.; Khaitov, Musa R.; Trinchieri, Giorgio; Waisman, Ari; Grivennikov, Sergei I.
    Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer
    In: Immunity Vol. 50 (2019) Nr. 1, pp. 166 - 180.e7
    ISSN: 1097-4180; 1074-7613
  • Merz, Simon F.; Korste, Sebastian; Bornemann, Lea; Michel, Lars; Stock, Pia; Squire, Anthony; Soun, Camille; Engel, Daniel Robert; Detzer, Julia; Lörchner, Holger; Hermann, Dirk M.; Kamler, Markus; Klode, Joachim; Hendgen-Cotta, Ulrike B.; Rassaf, Tienush; Gunzer, Matthias; Totzeck, Matthias
    Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2312
    ISSN: 2041-1723
  • Cunin, Pierre; Lee, Pui Y.; Kim, Edy; Schmider, Angela B.; Cloutier, Nathalie; Pare, Alexandre; Gunzer, Matthias; Soberman, Roy J.; Lacroix, Steve; Boilard, Eric; Lefort, Craig T.; Nigrovic, Peter A.
    Differential attenuation of β2 integrin-dependent and -independent neutrophil migration by Ly6G ligation
    In: Blood Advances Vol. 3 (2019) Nr. 3, pp. 256 - 267
    ISSN: 2473-9537; 2473-9529
  • Sody, Simon; Uddin, Mohib; Grüneboom, Anika; Görgens, André; Giebel, Bernd; Gunzer, Matthias; Brandau, Sven
    Distinct spatio-temporal dynamics of tumor-associated neutrophils in small tumor lesions
    In: Frontiers in Immunology Vol. 10 (2019) pp. 1419
    ISSN: 1664-3224
  • Jackstadt, Rene; van Hooff, Sander R.; Leach, Joshua D.; Cortes-Lavaud, Xabier; Lohuis, Jeroen O.; Ridgway, Rachel A.; Wouters, Valérie M.; Roper, Jatin; Kendall, Timothy J.; Roxburgh, Campbell S.; Horgan, Paul G.; Nixon, Colin; Nourse, Craig; Gunzer, Matthias; Clark, William; Hedley, Ann; Yilmaz, Omer H.; Rashid, Mamunur; Bailey, Peter; Biankin, Andrew V.; Campbell, Andrew D.; Adams, David J.; Barry, Simon T.; Steele, Colin W.; Medema, Jan Paul; Sansom, Owen J.
    Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis
    In: Cancer Cell Vol. 36 (2019) Nr. 3, pp. 319 - 336.e7
    ISSN: 1535-6108
  • Silvestre-Roig, Carlos; Braster, Quinte; Wichapong, Kanin; Lee, Ernest Y.; Teulon, Jean Marie; Berrebeh, Nihel; Winter, Janine; Adrover, José M.; Santos, Giancarlo Santiago; Froese, Alexander; Lemnitzer, Patricia; Ortega-Gómez, Almudena; Chevre, Raphael; Marschner, Julian; Schumski, Ariane; Winter, Carla; Perez-Olivares, Laura; Pan, Chang; Paulin, Nicole; Schoufour, Tom; Hartwig, Helene; González-Ramos, Silvia; Kamp, Frits; Megens, Remco T. A.; Mowen, Kerri A.; Gunzer, Matthias; Maegdefessel, Lars; Hackeng, Tilman; Lutgens, Esther; Daemen, Mat; von Blume, Julia; Anders, Hans-Joachim; Nikolaev, Viacheslav O.; Pellequer, Jean-Luc; Weber, Christian; Hidalgo, Andrés; Nicolaes, Gerry A. F.; Wong, Gerard C. L.; Soehnlein, Oliver
    Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death
    In: Nature Vol. 569 (2019) Nr. 7755, pp. 236 - 240
    ISSN: 0028-0836; 1476-4687
  • Lin, Yong; Wu, Chunchen; Wang, Xueyu; Kemper, Thekla; Squire, Anthony; Gunzer, Matthias; Zhang, Jiming; Chen, Xinwen; Lu, Mengji
    Hepatitis B virus is degraded by autophagosome-lysosome fusion mediated by Rab7 and related components
    In: Protein & Cell Vol. 10 (2019) Nr. 1, pp. 60 - 66
    ISSN: 1674-8018; 1674-800X
  • Windmann, Sonja; Otto, Lucas; Hrycak, Camilla Patrizia; Malyshkina, Anna; Bongard, Nadine; David, Paul; Gunzer, Matthias; Dittmer, Ulf; Bayer, Wibke
    Infection of B Cell Follicle-Resident Cells by Friend Retrovirus Occurs during Acute Infection and Is Maintained during Viral Persistence
    In: mBio Vol. 10 (2019) Nr. 1,
    ISSN: 2150-7511; 2161-2129
  • Otxoa-de-Amezaga, Amaia; Gallizioli, Mattia; Pedragosa, Jordi; Justicia, Carles; Miró-Mur, Francesc; Salas-Perdomo, Angelica; Díaz-Marugan, Laura; Gunzer, Matthias; Planas, Anna M.
    Location of Neutrophils in Different Compartments of the Damaged Mouse Brain After Severe Ischemia/Reperfusion
    In: Stroke: journal of the American Heart Association Vol. 50 (2019) Nr. 6, pp. 1548 - 1557
    ISSN: 1524-4628; 0039-2499; 0749-7954
  • Otxoa-de-Amezaga, Amaia; Miró-Mur, Francesc; Pedragosa, Jordi; Gallizioli, Mattia; Justicia, Carles; Gaja-Capdevila, Núria; Ruíz-Jaen, Francisca; Salas-Perdomo, Angélica; Bosch, Anna; Calvo, Maria; Márquez-Kisinousky, Leonardo; Denes, Adam; Gunzer, Matthias; Planas, Anna M.
    Microglial cell loss after ischemic stroke favors brain neutrophil accumulation
    In: Acta Neuropathologica Vol. 137 (2019) Nr. 2, pp. 321 - 341
    ISSN: 1432-0533; 0001-6322
  • Si, Yu; Merz, Simon F.; Jansen, Philipp; Wang, Baoxiao; Bruderek, Kirsten; Altenhoff, Petra; Mattheis, Stefan; Lang, Stephan; Gunzer, Matthias; Klode, Joachim; Squire, Anthony; Brandau, Sven
    Multidimensional imaging provides evidence for down-regulation of T cell effector function by MDSC in human cancer tissue
    In: Science Immunology Vol. 4 (2019) Nr. 40,
    ISSN: 2470-9468
  • Grüneboom, Anika; Kling, Lasse; Christiansen, Silke; Mill, Leonid; Maier, Andreas; Engelke, Klaus; Quick, Harald H.; Schett, Georg; Gunzer, Matthias
    Next-generation imaging of the skeletal system and its blood supply
    In: Nature Reviews Rheumatology Vol. 15 (2019) Nr. 9, pp. 533 - 549
    ISSN: 1759-4804; 1759-4790
  • Hermann, Dirk M.; Gunzer, Matthias
    Polymorphonuclear Neutrophils Play a Decisive Role for Brain Injury and Neurological Recovery Poststroke
    In: Stroke Vol. 50 (2019) Nr. 3, pp. e40 - e41
    ISSN: 1524-4628; 0039-2499
  • Merz, Simon F.; Korste, Sebastian; Bornemann, Lea; Michel, Lars; Stock, Pia; Squire, Anthony; Soun, Camille; Engel, Daniel Robert; Detzer, Julia; Lörchner, Holger; Hermann, Dirk M.; Kamler, Markus; Klode, Joachim; Hendgen-Cotta, Ulrike B.; Rassaf, Tienush; Gunzer, Matthias; Totzeck, Matthias
    Publisher Correction: Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2768
    ISSN: 2041-1723
  • Sokolova, Viktoriya; Loza, Kateryna; Knuschke, Torben; Heinen-Weiler, J.; Jastrow, Holger; Hasenberg, Mike; Buer, Jan; Westendorf, Astrid; Gunzer, Matthias; Epple, Matthias
    A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cells
    In: Acta Biomaterialia Vol. 80 (2018) pp. 352 - 363
    ISSN: 1878-7568; 1742-7061
  • Neumann, Jens; Henneberg, Sophie; Kenne, Susanne von; Nolte, Niklas; Müller, Andreas J.; Schraven, Burkhart; Görtler, Michael W.; Reymann, Klaus G.; Gunzer, Matthias; Riek-Burchardt, Monika
    Beware the intruder : Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo
    In: PLoS ONE Vol. 13 (2018) Nr. 3, pp. e0193970
    ISSN: 1932-6203
  • Gunzer, Matthias
    Fine structure analysis to detect bone pores
    In: Annals of the Rheumatic Diseases Vol. 77 (2018) Nr. Suppl. 2,
    ISSN: 1468-2060; 0003-4967
  • Kamradt, Thomas; Amling, Michael; Dankbar, Berno; Dudeck, Anne; Gunzer, Matthias; Ignatius, Anita; Krönke, Gerhard; Kubatzky, Katharina F.; Pap, Thomas; Prinz, Immo; Schett, Georg Andreas; Schinke, Thorsten; Tuckermann, Jan Peter; Waisman, Ari
    Gegenseitige Beeinflussung von Immunsystem und Knochen
    In: Zeitschrift für Rheumatologie Vol. 77 (2018) Nr. Suppl. 1, pp. 8 - 11
    ISSN: 0340-1855; 1435-1250
  • Geissler, Klaus; Gunzer, Matthias; Ostermann, Helmut
    How Safe Is the Administration of Long-Acting Granulocyte Colony-Stimulating Factor in Cancer Patients?
    In: Oncology Research and Treatment Vol. 41 (2018) Nr. 5, pp. 316 - 326
    ISSN: 2296-5262; 2296-5270
  • Otto, Lucas; Zelinskyy, Gennadiy; Schuster, Marc; Dittmer, Ulf; Gunzer, Matthias
    Imaging of cytotoxic antiviral immunity while considering the 3R principle of animal research
    In: Journal of Molecular Medicine Vol. 96 (2018) Nr. 3-4, pp. 349 - 360
    ISSN: 0946-2716; 0946-2716
  • Hermann, Dirk M.; Kleinschnitz, Christoph; Gunzer, Matthias
    Implications of polymorphonuclear neutrophils for ischemic stroke and intracerebral hemorrhage : Predictive value, pathophysiological consequences and utility as therapeutic target
    In: Journal of Neuroimmunology Vol. 321 (2018) pp. 138 - 143
    ISSN: 1872-8421; 0165-5728
  • Dennhardt, Sophie; Pirschel, Wiebke; Wissuwa, Bianka; Daniel, Christoph; Gunzer, Florian; Lindig, Sandro; Medyukhina, Anna; Kiehntopf, Michael; Rudolph, Wolfram W.; Zipfel, Peter F.; Gunzer, Matthias; Figge, Marc Thilo; Amann, Kerstin; Coldewey, Sina M.
    Modeling hemolytic-uremic syndrome : In-depth characterization of distinct murine models reflecting different features of human disease
    In: Frontiers in Immunology Vol. 9 (2018) pp. 1459
    ISSN: 1664-3224
  • Knier, Benjamin; Hiltensperger, Michael; Sie, Christopher; Aly, Lilian; Lepennetier, Gildas; Engleitner, Thomas; Garg, Garima; Muschaweckh, Andreas; Mitsdörffer, Meike; Koedel, Uwe; Höchst, Bastian; Knolle, Percy; Gunzer, Matthias; Hemmer, Bernhard; Rad, Roland; Merkler, Doron; Korn, Thomas
    Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity
    In: Nature Immunology Vol. 19 (2018) Nr. 12, pp. 1341 - 1351
    ISSN: 1529-2916; 1529-2908
  • Westmeier, Dana; Solouk-Saran, Djamschid; Vallet, Cecilia; Siemer, Svenja; Docter, Dominic; Götz, Hermann; Männ, Linda; Hasenberg, Anja; Hahlbrock, Angelina; Erler, Kathrin; Reinhardt, Christoph; Schilling, Oliver; Becker, Sven; Gunzer, Matthias; Hasenberg, Mike; Knauer, Shirley; Stauber, Roland H.
    Nanoparticle decoration impacts airborne fungal pathobiology
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 115 (2018) Nr. 27, pp. 7087 - 7092
    ISSN: 1091-6490; 0027-8424
  • Schett, Georg Andreas; Bozec, Aline; Bekeredjian-Ding, Isabelle Béatrice; Chang, Hyundong; David, Jean Pierre; Dörner, Thomas; Grässel, Susanne; Gunzer, Matthias; Manz, Rudolf Armin; Mei, Henrik E.; Mielenz, Dirk; Müller-Ladner, Ulf; Neumann, Elena; Radbruch, Andreas H.; Richter, Wiltrud; Straub, Rainer H.
    Neue Einblicke in die Funktion des Knochenmarks
    In: Zeitschrift für Rheumatologie Vol. 77 (2018) Nr. Supplement 1, pp. 4 - 7
    ISSN: 1435-1250; 0340-1855
  • Casanova-Acebes, Maria; Nicolás-Ávila, José A.; Li, Jackson LiangYao; García-Silva, Susana; Balachander, Akhila; Rubio-Ponce, Andrea; Weiss, Linnea A.; Adrover, José M.; Burrows, Kyle; A-González, Noelia; Ballesteros, Ivan; Devi, Sapna; Quintana, Juan A.; Crainiciuc, Georgiana; Leiva, Magdalena; Gunzer, Matthias; Weber, Christian; Nagasawa, Takashi; Soehnlein, Oliver; Merad, Miriam; Mortha, Arthur; Ng, Lai Guan; Peinado, Hector; Hidalgo, Andrés
    Neutrophils instruct homeostatic and pathological states in naive tissues
    In: Journal of Experimental Medicine Vol. 215 (2018) Nr. 11, pp. 2778 - 2795
    ISSN: 0022-1007; 1540-9538
  • Holland, Tristan; Wohlleber, Dirk; Marx, Samira; Kreutzberg, Thomas; Vento-Asturias, Salvador; Schmitt-Mbamunyo, Christine; Welz, Meike; Janas, Marianne; Komander, Karl; Eickhoff, Sarah; Brewitz, Anna; Hasenberg, Mike; Männ, Linda; Gunzer, Matthias; Wilhelm, Christoph; Kastenmüller, Wolfgang; Knolle, Percy; Abdullah, Zeinab; Kurts, Christian; Garbi, Natalio
    Rescue of T-cell function during persistent pulmonary adenoviral infection by Toll-like receptor 9 activation
    In: The Journal of Allergy and Clinical Immunology Vol. 141 (2018) Nr. 1, pp. 416 - 419.e10
    ISSN: 1097-6825; 0091-6749
  • Stegemann-Koniszewski, Sabine; Behrens, Sarah; Boehme, Julia D.; Bruder, Dunja; Schreiber, Jens; Guzmán, Carlos A.; Kröger, Andrea; Riese, Peggy; Gunzer, Matthias; Hochnadel, Inga
    Respiratory Influenza A Virus Infection Triggers Local and Systemic Natural Killer Cell Activation via Toll-Like Receptor 7
    In: Frontiers in Immunology Vol. 9 (2018) pp. 245
    ISSN: 1664-3224
  • Hermann, Dirk M.; Kleinschnitz, Christoph; Gunzer, Matthias
    Role of polymorphonuclear neutrophils in the reperfused ischemic brain : insights from cell-type-specific immunodepletion and fluorescence microscopy studies
    In: Therapeutic Advances in Neurological Disorders Vol. 11 (2018) pp. 1756286418798607
    ISSN: 1756-2856; 1756-2864
  • Schuster, Marc; Moeller, Mischa; Bornemann, Lea; Bessen, Clara; Sobczak, Charlyn; Schmitz, Saskia; Witjes, Laura; Kruithoff, Katja; Kohn, Christina; Just, Olga; Kundgen, Andrea; Pundt, Noreen; Pelzer, Benedikt; Ampe, Christophe; Troys, Marleen van; Nusch, Arnd; Haas, Rainer; Germing, Ulrich; Martens, Lennart; Jöckel, Karl-Heinz; Gunzer, Matthias
    Surveillance of myelodysplastic syndrome via migration analyses of blood neutrophils : A potential prognostic tool
    In: The Journal of Immunology Vol. 201 (2018) Nr. 12, pp. 3546 - 3557
    ISSN: 0022-1767; 1550-6606
  • Lugo-Hernandez, Erlen; Squire, Anthony; Hagemann, Nina; Brenzel, Alexandra; Sardari, Maryam; Schlechter, Jana; Sanchez-Mendoza, Eduardo H; Gunzer, Matthias; Faissner, Andreas; Hermann, Dirk M.
    3D visualization and quantification of microvessels in the whole ischemic mouse brain using solvent-based clearing and light sheet microscopy
    In: Journal of Cerebral Blood Flow and Metabolism Vol. 37 (2017) Nr. 10, pp. 3355 - 3367
    ISSN: 1559-7016; 0271-678X
  • Gunzer, Matthias
    Escaping the traps of your own hunters
    In: Science Vol. 358 (2017) Nr. 6367, pp. 1126 - 1127
    ISSN: 0036-8075; 1095-9203
  • Klingberg, Anika; Hasenberg, Anja; Ludwig-Portugall, Isis; Medyukhina, Anna; Männ, Linda; Brenzel, Alexandra; Engel, Daniel Robert; Figge, Marc Thilo; Kurts, Christian; Gunzer, Matthias
    Fully automated evaluation of total glomerular number and capillary tuft size in nephritic kidneys using lightsheet microscopy
    In: Journal of the American Society of Nephrology Vol. 28 (2017) Nr. 2, pp. 452 - 459
    ISSN: 1533-3450; 1046-6673
  • Lu, M.; Gunzer, Matthias; Lin, Y.; Wang, X.; Squire, Anthony; Kemper, T.
    Hepatitis B virus production is enhanced through early autophagic flux but degraded through autophagosome-lysosome fusion
    In: Journal of Hepatology Vol. 66 (2017) Nr. 1, pp. S701
    ISSN: 0168-8278; 1600-0641
  • Hawkins, Ryder F Whittaker; Patenaude, Alexandre; Dumas, Aline; Jain, Rajiv; Tesfagiorgis, Yodit; Kerfoot, Steven; Matsui, Takeshi; Gunzer, Matthias; Poubelle, Patrice E; Larochelle, Catherine; Pelletier, Martin; Vallières, Luc
    ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B cell-dependent autoimmune encephalomyelitis.
    In: JCI Insight Vol. 2 (2017) Nr. 23,
    ISSN: 2379-3708
  • Henneberg, S.; Thornton, C.; Wiehr, S.; Rolle, A. M.; Pichler, B.; Hasenberg, Mike; Weski, Juliane; Hasenberg, Anja; Gunzer, Matthias
    Intravital lung imaging to study the interactions between immune cells and Aspergillus fumigatus
    In: European Journal of Immunology Vol. 47 (2017) Nr. Suppl. 2, pp. 40 - 40
    ISSN: 0014-2980
  • Bornemann, L.; Sobczak, C.; Jöckel, Karl-Heinz; Göthert, Joachim Rudolf; Schuster, Marc; Gunzer, Matthias
    Introduction of 2D human leucocyte migration assays suited for the application in the clinical setup
    In: European Journal of Immunology Vol. 47 (2017) Nr. Suppl. 2, pp. 232
    ISSN: 0014-2980; 1521-4141
  • Pohl, Judith-Mira; Gutweiler, Sebastian; Thiebes, Stephanie; Volke, Julia K.; Klein-Hitpaß, Ludger; Zwanziger, Denise; Gunzer, Matthias; Jung, Steffen; Agace, William W.; Kurts, Christian; Engel, Daniel Robert
    Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus
    In: Gut Vol. 66 (2017) Nr. 12, pp. 2110 - 2120
    ISSN: 1468-3288; 0017-5749
  • Männ, Linda; Klingberg, Anika; Gunzer, Matthias; Hasenberg, Mike
    Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy
    In: Journal of Visualized Experiments (2017) Nr. 123, pp. e55450
    ISSN: 1940-087X
  • Seddigh, Pegah; Bracht, Thilo; Molinier-Frenkel, Valerie; Castellano, Flavia; Kniemeyer, Olaf; Schuster, Marc; Weski, Juliane; Hasenberg, Anja; Kraus, Andreas; Poschet, Gernot; Hager, Thomas; Theegarten, Dirk; Opitz, Christiane A.; Brakhage, Axel A.; Sitek, Barbara; Hasenberg, Mike; Gunzer, Matthias
    Quantitative analysis of proteome modulations in alveolar epithelial type II cells in response to pulmonary aspergillus fumigatus infection
    In: Molecular and Cellular Proteomics Vol. 16 (2017) Nr. 12, pp. 2184 - 2198
    ISSN: 1535-9476; 1535-9484
  • Zundler, Sebastian; Klingberg, Anika; Schillinger, Daniela; Fischer, Sarah; Neufert, Clemens; Atreya, Imke; Gunzer, Matthias; Neurath, Markus F.
    Three-Dimensional Cross-Sectional Light-Sheet Microscopy Imaging of the Inflamed Mouse Gut
    In: Gastroenterology Vol. 153 (2017) Nr. 4, pp. 898 - 900
    ISSN: 1528-0012; 0016-5085
  • Davies, Genna; Rolle, Anna-Maria; Maurer, Andreas; Spycher, Philipp R.; Schillinger, Claudia; Solouk-Saran, Djamschid; Hasenberg, Mike; Weski, Juliane; Fonslet, Jesper; Dubois, Adrien; Boschetti, Frederic; Denat, Franck; Gunzer, Matthias; Eichner, Martin; Ryder, Lauren S; Jensen, Mikael; Schibli, Roger; Pichler, Bernd J.; Wiehr, Stefan; Thornton, Christopher R.
    Towards translational ImmunoPET/MR imaging of invasive pulmonary aspergillosis : The humanised monoclonal antibody JF5 detects aspergillus lung infections in vivo
    In: Theranostics Vol. 7 (2017) Nr. 14, pp. 3398 - 3414
    ISSN: 1838-7640
  • Knier, B.; Hiltensperger, M.; Sie, C.; Aly, L.; Garg, G.; Koedel, U.; Gunzer, Matthias; Hemmer, B.; Korn, T.
    Unexpected role of neutrophil granulocytes during both murine and human central nervous system autoimmunity
    In: Multiple Sclerosis Journal Vol. 23 (2017) Nr. Suppl. 3, pp. 42
    ISSN: 1352-4585
  • Wang, Jing; Hossain, Mokarram; Thanabalasuriar, Ajitha; Gunzer, Matthias; Meininger, Cynthia; Kubes, Paul
    Visualizing the function and fate of neutrophils in sterile injury and repair
    In: Science Vol. 358 (2017) Nr. 6359, pp. 111 - 116
    ISSN: 1095-9203; 0036-8075
  • Stegemann-Koniszewski, S; Jeron, Andreas; Gereke, Marcus; Geffers, Robert; Kröger, Andrea; Gunzer, Matthias; Bruder, Dunja
    Alveolar Type II Epithelial Cells Contribute to the Anti-Influenza A Virus Response in the Lung by Integrating Pathogen- and Microenvironment-Derived Signals
    In: mBio Vol. 7 (2016) Nr. 3,
    ISSN: 2150-7511
  • Männ, Linda; Kochupurakkal, Nora; Martin, Christian; Verjans, Eva; Klingberg, Anika; Sody, Simon; Kraus, Andreas; Dalimot, Jill; Bergmüller, Eileen; Jung, Steffen; Voortman, Sylvia; Winterhager, Elke; Brandau, Sven; Garbi, Natalio; Kurrer, Michael; Eriksson, Urs; Gunzer, Matthias; Hasenberg, Mike
    CD11c.DTR mice develop a fatal fulminant myocarditis after local or systemic treatment with diphtheria toxin
    In: European Journal of Immunology Vol. 46 (2016) Nr. 8, pp. 2028 - 2042
    ISSN: 0014-2980
  • Rolle, Anna-Maria; Wiehr, Stefan; Gunzer, Matthias; Pichler, Bernd J.; Davies, Genna; Krappmann, Sven; Autenrieth, Stella E.; Severin, Gregory W.; Bruder, Dunja; Stegemann-Koniszewskif, Sabine; Boschetti, Frederic; Schibli, Roger; Spycher, Philipp R.; Fischer, Eliane; Maurer, Andreas; Weski, Juliane; Männ, Linda; Solouk-Saran, Djamschid; Thornton, Christopher R.; Hasenberg, Mike
    ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 113 (2016) Nr. 8, pp. E1026 - E1033
    ISSN: 1091-6490; 0027-8424
  • Zec, Kristina; Volke, Julia; Vijitha, Nirojah; Thiebes, Stephanie; Gunzer, Matthias; Kurts, Christian; Engel, Daniel Robert
    Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages
    In: Pathogens Vol. 5 (2016) Nr. 1,
    ISSN: 2076-0817
  • Moses, Katrin; Klein, Johanna C; Männ, Linda; Klingberg, Anika; Gunzer, Matthias; Brandau, Sven
    Survival of residual neutrophils and accelerated myelopoiesis limit the efficacy of antibody-mediated depletion of Ly-6G+ cells in tumor-bearing mice
    In: Journal of Leukocyte Biology Vol. 99 (2016) Nr. 6, pp. 811 - 823
    ISSN: 0741-5400
  • Hasenberg, Anja; Hasenberg, Mike; Männ, Linda; Neumann, Franziska; Borkenstein, Lars; Stecher, Manuel; Kraus, Andreas; Engel, Daniel Robert; Klingberg, Anika; Seddigh, Pegah; Abdullah, Zeinab; Klebow, Sabrina; Engelmann, Swen; Reinhold, Annegret; Brandau, Sven; Seeling, Michaela; Waisman, Ari; Schraven, Burkhart; Göthert, Joachim Rudolf; Nimmerjahn, Falk; Gunzer, Matthias
    Catchup : a mouse model for imaging-based tracking and modulation of neutrophil granulocytes
    In: Nature Methods Vol. 12 (2015) Nr. 5, pp. 445 - 452
    ISSN: 1548-7091; 1548-7105
  • Stoffels, Ingo; Morscher, S.; Helfrich, Iris; Hillen, Uwe; Lehy, J.; Burton, N.; Pöppel, Thorsten; Gunzer, Matthias; Schadendorf, Dirk; Klode, Joachim
    Clinical application of noninvasive and nonradioactive determination of microscopic lymph node tumor status by multispectral optoacoustic imaging
    In: Journal of Nuclear Medicine Vol. 56 (2015) Nr. Suppl. 3, pp. 40
    ISSN: 0161-5505
  • Stoffels, Ingo; Morscher, S.; Helfrich, Iris; Hillen, Uwe; Lehy, J.; Burton, N. C.; Poppel, T.; Rösch, Alexander; Griewank, Klaus; Schadendorf, Dirk; Gunzer, Matthias; Klode, Joachim
    Die multispektraloptoakustische Tomographie (MSOT) zur nichtinvasiven Diagnostik des Schildwächterlymphknotens bei Patienten mit malignem Melanom
    In: Journal der Deutschen Dermatologischen Gesellschaft Vol. 13 (2015) Nr. 12, pp. 1323
    ISSN: 1610-0379; 1610-0387
  • Stoffels, Ingo; Morscher, Stefan; Helfrich, Iris; Hillen, Uwe; Leyh, Julia; Burton, Neal C.; Sardella, Thomas C.P.; Claussen, Jing; Pöppel, Thorsten; Bachmann, Hagen Sjard; Rösch, Alexander; Griewank, Klaus; Schadendorf, Dirk; Gunzer, Matthias; Klode, Joachim
    Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging
    In: Immunotherapy Vol. 7 (2015) Nr. 317, pp. 317ra199
    ISSN: 1750-7448; 1750-743X
  • Herz, Josephine; Sabellek, Pascal; Lane, Thomas E; Gunzer, Matthias; Hermann, Dirk M.; Döppner, Thorsten R.
    Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice
    In: Stroke Vol. 46 (2015) Nr. 10, pp. 2916 - 2925
    ISSN: 0039-2499; 1524-4628
  • Gunzer, Matthias
    Tracking phagocyte function in vivo
    In: The Journal of Clinical Investigation Vol. 45 (2015) Nr. Suppl. 2, Special Issue: Abstracts of the 49th Annual Scientific Meeting of the European Society for Clinical Investigation Cluj‐Napoca, Romania 27 – 30 May 2015, pp. 48
    ISSN: 0014-2972; 1365-2362
  • Neumann, Jens; Riek-Burchardt, Monika; Herz, Josephine; Döppner, Thorsten R.; König, Rebecca; Hütten, Heiko; Etemire, Eloho; Männ, Linda; Klingberg, Anika; Fischer, Thomas; Görtler, Michael W; Heinze, Hans-Jochen; Reichardt, Peter; Schraven, Burkhart; Hermann, Dirk M.; Reymann, Klaus G; Gunzer, Matthias
    Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke
    In: Acta Neuropathologica Vol. 129 (2015) Nr. 2, pp. 259 - 277
    ISSN: 0001-6322; 1432-0533
  • Mokhtari, Z.; Mech, F.; Zitzmann, C.; Hasenberg, Mike; Gunzer, Matthias
    Correction: Automated Characterization and Parameter-Free Classification of Cell Tracks Based on Local Migration Behavior
    In: PLoS ONE Vol. 9 (2014) Nr. 12, pp. e115158
    ISSN: 1932-6203
  • Stoffels, Ingo; Gunzer, Matthias; Leyh, J.; Hillen, Uwe; Helfrich, Iris; Schadendorf, Dirk; Klode, Joachim
    Die Photooptoakustische Tomographie zur nicht invasiven und nicht radioaktiven Bestimmung des Schildw € achterlymphknotenstatus bei Melanompatienten
    In: Journal der Deutschen Dermatologischen Gesellschaft Vol. 12 (2014) Nr. Suppl. 3, pp. 5 - 6
    ISSN: 1610-0379; 1610-0387
  • Lother, Jasmin; Breitschopf, Tanja; Krappmann, Sven; Morton, Charles O.; Bouzani, Maria; Kurzai, Oliver; Gunzer, Matthias; Hasenberg, Mike; Einsele, Hermann; Löffler, Jürgen
    Human dendritic cell subsets display distinct interactions with the pathogenic mould Aspergillus fumigatus
    In: International Journal of Medical Microbiology Vol. 304 (2014) Nr. 8, pp. 1160 - 1168
    ISSN: 1438-4221; 1618-0607
  • Gunzer, Matthias
    Traps and hyper inflammation - new ways that neutrophils promote or hinder survival
    In: British Journal of Haematology Vol. 164 (2014) Nr. 2, pp. 189 - 199
    ISSN: 0007-1048; 1365-2141
  • Reichardt, Peter; Patzak, Irene; Jones, Kristian; Etemire, Eloho; Gunzer, Matthias; Hogg, Nancy
    A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes
    In: The EMBO Journal Vol. 32 (2013) Nr. 6, pp. 829 - 843
    ISSN: 1460-2075; 0261-4189
  • Mokhtari, Zeinab; Mech, Franziska; Zitzmann, Carolin; Hasenberg, Mike; Gunzer, Matthias; Figge, Marc Thilo
    Automated characterization and parameter-free classification of Cell tracks based on local migration behavior
    In: PLoS ONE Vol. 8 (2013) Nr. 12,
    ISSN: 1932-6203
  • Hasenberg, Mike; Stegemann-Koniszewski, Sabine; Gunzer, Matthias
    Cellular immune reactions in the lung
    In: Immunological Reviews Vol. 251 (2013) Nr. 1, pp. 189 - 214
    ISSN: 0105-2896; 1600-065X
  • Neumann, J.; Riek-Burchardt, M.; Konig, R.; Gortler, M. W.; Heinze, H. J.; Reymann, K. G.; Gunzer, Matthias
    Dynamic crosstalk of neutrophil granulocytes and microglia at the ischemic blood-brain interface - role of very late antigen-4
    In: Cerebrovascular Diseases Vol. 35 (2013) Nr. Suppl. 3, pp. 27
    ISSN: 1015-9770; 1421-9786
  • Gunzer, Matthias
    Imaging Immunity
    In: Vox Sanguinis Vol. 105 (2013) Nr. Suppl. 1, pp. 45
    ISSN: 0042-9007; 1423-0410
  • De Filippo, Katia; Dudeck, Anne; Hasenberg, Mike; Nye, Emma; Van Rooijen, Nico; Hartmann, Karin; Gunzer, Matthias; Roers, Axel; Hogg, Nancy
    Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation
    In: Blood Vol. 121 (2013) Nr. 24, pp. 4930 - 4937
    ISSN: 1528-0020; 0006-4971
  • Philipsen, Lars; Engels, Thomas; Schilling, Kerstin; Gurbiel, Slavyana; Fischer, Klaus-Dieter; Tedford, Kerry; Schraven, Burkhart; Gunzer, Matthias; Reichardt, Peter
    Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clusters
    In: Molecular and Cellular Proteomics Vol. 12 (2013) Nr. 9, pp. 2551 - 2567
    ISSN: 1535-9476; 1535-9484
  • Orrskog, S.; Rounioja, S.; Spadafina, T.; Gallotta, M.; Norman, M.; Hentrich, K.; Fälker, S.; Ygberg-Eriksson, S.; Hasenberg, Mike; Johansson, B.; Uotila, L. M.; Gahmberg, C. G.; Barocchi, M.; Gunzer, Matthias; Normark, S.; Henriques-Normark, B.
    Pilus adhesin RrgA interacts with complement receptor 3, thereby affecting macrophage function and systemic pneumococcal disease
    In: mBio Vol. 4 (2013) Nr. 1, pp. e00535 - 12
    ISSN: 2150-7511
  • Stirnweiss, Anja; Hartig, Roland; Gieseler, Steffi; Lindquist, Jonathan A.; Reichardt, Peter; Philipsen, Lars; Simeoni, Luca; Poltorak, Mateusz; Merten, Camilla; Zuschratter, Werner; Prokazov, Yury; Paster, Wolfgang; Stockinger, Hannes; Harder, Thomas; Gunzer, Matthias; Schraven, Burkhart
    T cell activation results in conformational changes in the Src family kinase Lck to induce its activation
    In: Science Signaling Vol. 6 (2013) Nr. 263,
    ISSN: 1945-0877; 1937-9145
  • Stegemann-Koniszewski, Sabine; Gereke, Marcus; Orrskog, Sofia; Lienenklaus, Stefan; Pasche, Bastian; Bader, Sophie R.; Gruber, Achim D.; Akira, Shizuo; Weiss, Siegfried; Henriques-Normark, Birgitta; Bruder, Dunja; Gunzer, Matthias
    TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza a virus infection
    In: Journal of Innate Immunity Vol. 5 (2013) Nr. 1, pp. 84 - 96
    ISSN: 1662-8128; 1662-811X
  • Etemire, Eloho; Krull, Marco; Hasenberg, Mike; Reichardt, Peter; Gunzer, Matthias
    Transiently Reduced PI3K/Akt Activity Drives the Development of Regulatory Function in Antigen-Stimulated Naïve T-Cells
    In: PLoS ONE Vol. 8 (2013) Nr. 7, pp. e68378
    ISSN: 1932-6203
  • Sasse, Christoph; Hasenberg, Mike; Weyler, Michael; Gunzer, Matthias; Morschhäuser, Joachim
    White-opaque switching of Candida albicans allows immune evasion in an environment-dependent fashion
    In: Eukaryotic Cell Vol. 12 (2013) Nr. 1, pp. 50 - 58
    ISSN: 1535-9778; 1535-9786
  • Florian, Maria Carolina; Dörr, Karin; Niebel, Anja; Daria, Deidre; Schrezenmeier, Hubert; Rojewski, Markus; Filippi, Marie-Dominique; Hasenberg, Anja; Gunzer, Matthias; Scharffetter-Kochanek, Karin; Zheng, Yi; Geiger, Hartmut; Florian, Maria Carolina
    Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation
    In: Cell Stem Cell Vol. 10 (2012) Nr. 5, pp. 520 - 530
    ISSN: 1875-9777; 1934-5909
  • Gonzalez-Nieto, D.; Li, L.; Kohler, A.; Ghiaur, G.; Ishikawa, E.; Sengupta, A.; Madhu, M.; Arnett, J. L.; Santho, R. A.; Dunn, S. K.; Fishman, G. I.; Gutstein, D. E.; Civitelli, R.; Barrio, L. C.; Gunzer, Matthias; Cancelas, J. A.
    Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors
    In: Blood Vol. 119 (2012) Nr. 22, pp. 5144 - 5154
    ISSN: 0006-4971; 1528-0020
  • Etemire, E.; Krull, M.; Reichardt, P.; Gunzer, Matthias
    Functional roles for defective PI3K signaling and differing costimulatory activity of APCs in T-Cell plasticity
    In: Immunology Vol. 137 (2012) Nr. Suppl. 1, pp. 408 - 409
    ISSN: 0019-2805; 1365-2567
  • Dudeck, A.; Dudeck, J.; Scholten, J.; Petzold, A.; Surianarayanan, S.; Kohler, A.; Peschke, K.; Voehringer, D.; Waskow, C.; Krieg, T.; Muller, W.; Waisman, A.; Hartmann, K.; Gunzer, Matthias; Roers, A.
    Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens
    In: Experimental Dermatology Vol. 21 (2012) Nr. 3, pp. e34 - e34
    ISSN: 0906-6705; 1600-0625
  • Konig, R.; Riek-Burchardt, M.; Holze, S.; Neumann, J.; Gunzer, Matthias; Reymann, K.
    Microglia-neutrophil interactions : A new field of application for the phagocytosis Marker pHrodo
    In: Journal of Neuroimmunology Vol. 253 (2012) Nr. 1-2, pp. 100 - 101
    ISSN: 0165-5728
  • Philipsen, L.; Engels, T.; Schilling, K.; Fischer, K.; Tedford, K.; Schraven, B.; Gunzer, Matthias; Reichardt, P.
    Multi-molecular three-dimensional analysis of the stable immunological synapse reveals sustained recruitment and sequential assembly of signaling clusters
    In: Immunology Vol. 137 (2012) Nr. Suppl. 1, pp. 12 - 12
    ISSN: 0019-2805; 1365-2567
  • Donat, Stefanie; Hasenberg, Mike; Schäfer, Tina; Ohlsen, Knut; Gunzer, Matthias; Einsele, Hermann; Löffler, Jürgen; Beilhack, Andreas; Krappmann, Sven
    Surface display of Gaussia princeps luciferase allows sensitive fungal pathogen detection during cutaneous aspergillosis
    In: Virulence Vol. 3 (2012) Nr. 1, pp. 50 - 61
    ISSN: 2150-5608; 2150-5594
  • Riek-Burchardt, M.; Neumann, J.; Konig, R.; Reymann, K. G.; Gunzer, Matthias
    Taking neutrophils out of play in developing secondary neuronal damage after stroke by anti-VLA-4 treatment
    In: Journal of Neuroimmunology Vol. 253 (2012) Nr. 1-2, pp. 112 - 112
    ISSN: 0165-5728
  • Gunzer, Matthias
    Vaccine adjuvants : Tailor-made mast-cell granules
    In: Nature Materials Vol. 11 (2012) Nr. 3, pp. 181 - 182
    ISSN: 1476-4660; 1476-1122
  • Ambach, A.; Bonnekoh, B.; Gunzer, Matthias; Gollnick, H.; Reichardt, P.
    CD8(+) T Cells regulate by means of their Perforin-Granula Systems of IgE Production in vitro by directly Killing the B Cells
    In: Journal der Deutschen Dermatologischen Gesellschaft Vol. 9 (2011) Nr. Suppl. 1, pp. 130 - 131
    ISSN: 1610-0379; 1610-0387
  • Ambach, A.; Bonnekoh, B.; Gunzer, Matthias; Gollnick, H.; Reichardt, P.
    CD8(+) T cells regulate IgE-production in vitro via direct killing of B cells using their perforin-granule system
    In: Experimental Dermatology Vol. 20 (2011) Nr. 2, pp. 164
    ISSN: 0906-6705; 1600-0625
  • Hasenberg, Mike; Köhler, A.; Bonifatius, S.; Jeron, A.; Gunzer, Matthias
    Direct observation of phagocytosis and NET-formation by neutrophils in infected lungs using 2-photon microscopy
    In: Journal of Visualized Experiments (2011) Nr. 52,
    ISSN: 1940-087X
  • Köhler, A.; De Filippo, K.; Hasenberg, Mike; van den Brandt, C.; Nye, E.; Hosking, M. P.; Lane, T. E.; Männ, Linda; Ransohoff, R. M.; Hauser, A. E.; Winter, O.; Schraven, B.; Geiger, H.; Hogg, N.; Gunzer, Matthias
    G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands
    In: Blood Vol. 117 (2011) Nr. 16, pp. 4349 - 4357
    ISSN: 0006-4971; 1528-0020
  • Schmidt, Angelika; Oberle, Nina; Weiss, Eva-Maria; Vobis, Diane; Frischbutter, Stefan; Baumgrass, Ria; Falk, Christine S.; Haag, Mathias; Brugger, Britta; Lin, Hongying; Mayr, Georg W.; Reichardt, Peter; Gunzer, Matthias; Suri-Payer, Elisabeth; Krammer, Peter H.
    Human Regulatory T Cells Rapidly Suppress T Cell Receptor-Induced Ca(2+), NF-kappa B, and NFAT Signaling in Conventional T Cells
    In: Science Signaling Vol. 4 (2011) Nr. 204, pp. ra90
    ISSN: 1937-9145
  • Köhler, Annette G.; Geiger, H.; Gunzer, Matthias
    Imaging hematopoietic stem cells in the marrow of long bones in vivo
    In: Methods in Molecular Biology Vol. 750 (2011) pp. 215 - 224
    ISSN: 1064-3745
  • Dudeck, A.; Dudeck, J.; Scholten, J.; Petzold, A.; Surianarayanan, S.; Köhler, A.; Peschke, K.; Vöhringer, D.; Waskow, C.; Krieg, T.; Müller, W.; Waisman, A.; Hartmann, K.; Gunzer, Matthias; Roers, A.
    Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens
    In: Immunity Vol. 34 (2011) Nr. 6, pp. 973 - 984
    ISSN: 1074-7613
  • Albrecht, D.; Kniemeyer, O.; Mech, F.; Gunzer, Matthias; Brakhage, A.; Guthke, R.
    On the way toward systems biology of Aspergillus fumigatus infection
    In: International Journal of Medical Microbiology Vol. 301 (2011) Nr. 5, pp. 453 - 459
    ISSN: 1438-4221; 1618-0607
  • Hasenberg, Mike; Behnsen, J.; Krappmann, S.; Brakhage, A.; Gunzer, Matthias
    Phagocyte responses towards Aspergillus fumigatus
    In: International Journal of Medical Microbiology Vol. 301 (2011) Nr. 5, pp. 436 - 444
    ISSN: 1438-4221; 1618-0607
  • Hasenberg, Mike; Köhler, A.; Bonifatius, S.; Borucki, K.; Riek-Burchardt, M.; Achilles, J.; Männ, Linda; Baumgart, K.; Schraven, B.; Gunzer, Matthias
    Rapid Immunomagnetic Negative Enrichment of Neutrophil Granulocytes from Murine Bone Marrow for Functional Studies In Vitro and In Vivo
    In: PLoS ONE Vol. 6 (2011) Nr. 2, pp. e17314
    ISSN: 1932-6203
  • Hartmann, T.; Sasse, C.; Schedler, A.; Hasenberg, Mike; Gunzer, Matthias; Krappmann, S.
    Shaping the fungal adaptome--stress responses of Aspergillus fumigatus
    In: International Journal of Medical Microbiology Vol. 301 (2011) Nr. 5, pp. 408 - 416
    ISSN: 1438-4221; 1618-0607
  • Ocaña-Morgner, C.; Reichardt, P.; Chopin, M.; Braungart, S.; Wahren, C.; Gunzer, Matthias; Jessberger, R.
    Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA
    In: The Journal of Immunology Vol. 186 (2011) Nr. 9, pp. 5345 - 5355
    ISSN: 0022-1767
  • Reichardt, Peter; Dornbach, Bastian; Gunzer, Matthias
    APC, T cells, and the immune synapse
    In: Current Topics in Microbiology and Immunology Vol. 340 (2010) pp. 229 - 249
    ISSN: 0070-217X
  • Hosseini, Babak H.; Louban, Ilia; Djandji, Dominik; Wabnitz, Guido H.; Deeg, Janosch; Bulbuc, Nadja; Samstag, Yvonne; Gunzer, Matthias; Spatz, Joachim P.; Hummerling, Guenter J.
    Immune synapse formation determines interaction forces between T cells and antigen-presenting cells measured by atomic force microscopy (vol 106, pg 17852, 2009)
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 107 (2010) Nr. 5, pp. 2373
    ISSN: 0027-8424; 1091-6490
  • Ryan, Marnie A; Nattamai, Kalpana J; Xing, Ellen; Schleimer, David; Daria, Deidre; Sengupta, Amitava; Köhler, Anja; Liu, Wei; Gunzer, Matthias; Jansen, Michael; Ratner, Nancy; Le Cras, Timothy D; Waterstrat, Amanda; Van Zant, Gary; Cancelas, Jose A; Zheng, Yi; Geiger, Hartmut
    Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization
    In: Nature Medicine Vol. 16 (2010) Nr. 10, pp. 1141 - 1146
    ISSN: 1078-8956; 1546-170X
  • Bruns, Sandra; Kniemeyer, Olaf; Hasenberg, Mike; Aimanianda, Vishukumar; Nietzsche, Sandor; Thywissen, Andreas; Jeron, Andreas; Latgé, Jean-Paul; Brakhage, Axel A; Gunzer, Matthias
    Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA
    In: PLoS Pathogens Vol. 6 (2010) Nr. 4, pp. e1000873
    ISSN: 1553-7366; 1553-7374
  • Garin, Alexandre; Meyer-Hermann, Michael; Contie, Mathias; Figge, Marc Thilo; Buatois, Vanessa; Gunzer, Matthias; Toellner, Kai-Michael; Elson, Greg; Kosco-Vilbois, Marie H
    Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation
    In: Immunity Vol. 33 (2010) Nr. 1, pp. 84 - 95
    ISSN: 1074-7613; 1097-4180
  • Articles

  • Merz, Simon F.; Gunzer, Matthias; Klode, Joachim
    Data management plan for the project “Status determination of the sentinel lymph node via light sheet fluorescence microscopy”
    Duisburg, Essen (2019)
  • Prefaces/Postfaces

  • Hermann, Dirk M.; Gunzer, Matthias
    Contribution of polymorphonuclear neutrophils in the blood periphery to ischemic brain injury
    In: Neurology: Neuroimmunology & Neuroinflammation Vol. 6 (2019) Nr. 4, pp. e570
    ISSN: 2332-7812
  • Abstracts

  • Si, Yu; Bruderek, Kirsten; Merz, Simon; Jansen, Philipp; Lang, Stephan; Gunzer, Matthias; Klode, Joachim; Squire, Anthony; Brandau, Sven;
    A subset of mature neutrophils contains the strongest PMN-MDSC activity in blood and tissue of patients with head and neck cancer
    SITC 2020 ; November 9-14, 2020, Virtual,
    In: Journal for ImmunoTherapy of Cancer Vol. 8 (2020) Nr. Suppl 3, pp. A320
    ISSN: 2051-1426
  • Brandau, Sven; Si, Yu; Bruderek, Kirsten; Merz, Simon F.; Jansen, Philipp; Lang, Stephan; Gunzer, Matthias; Klode, Joachim; Squire, Anthony;
    A subset of mature neutrophils contains the strongest PMN-MDSC activity in blood and tissue of patients with head and neck cancer
    Immunology 2020 ; Online,
    In: Journal of Immunology Vol. 204 (2020) Nr. 1, Supplement, pp. 72.15
    ISSN: 0022-1767; 1550-6606
  • Cai, Baiyi; Zindl, Carlene L.; Silberger, Daniel J.; Figge, David A.; Singer, Jeffery R.; Merz, Simon F.; Gunzer, Matthias; Weaver, Casey T.;
    Temporal changes in cellular sources of CXC chemokines control neutrophil recruitment during Citrobacter rodentium infection
    Immunology 2020, Online,
    In: Journal of Immunology Vol. 204 (2020) Nr. 1, Supplement, pp. 158.22
    ISSN: 0022-1767; 1550-6606
  • Gunzer, Matthias
    SP0106 Looking through my back bone
    In: Annals of the Rheumatic Diseases Vol. 78 (2019) Nr. Suppl. 2, pp. 30 - 31
    ISSN: 1468-2060; 0003-4967
  • Dümig, M.; Binder, J.; Gaculenko, A.; Daul, F.; Hasenberg, Mike; Gunzer, Matthias; Krappmann, S.;
    The opportunistic pathogen Aspergillus fumigatus coats its infectious propagules with antimicrobial peptides
    52nd Scientific Conference of the German speaking Mycological Society (DMykG) e. V. together with the Austrian Society for Medical Mycology (ÖGMM), 6 September – 8 September 2018, Innsbruck, Austria,
    In: Mycoses Vol. 61 (2018) Nr. Supplement 1, pp. 11
    ISSN: 0933-7407; 1439-0507
  • Gunzer, Matthias
    Multimodal imaging of A. fumigatus lung infection
    In: Mycoses Vol. 58 (2015) Nr. Suppl. 3, pp. 2
    ISSN: 0933-7407; 1439-0507
  • Solouk, D.; Bergmuller, E.; Weski, Juliane; Rolle, A. M.; Wiehr, S.; Thornton, C.; Gunzer, Matthias; Hasenberg, Mike; Solouk, D.
    Towards the establishment of intravital mouse lung imaging via two Photon Microscopy for the design of a novel antibody-based aspergillosis detection system and the observation of pathogen-immune cell interactions
    In: Mycoses Vol. 58 (2015) Nr. Suppl. 3, Special Issue: Abstracts of the 49. Wissenschaftliche Tagung der Deutschsprachigen Mykologischen Gesellschaft e.V., pp. 56
    ISSN: 0933-7407; 1439-0507
  • Bergmuller, E.; Solouk, D.; Weski, Juliane; Thornton, C.; Gunzer, Matthias; Hasenberg, Mike
    Where do spores go? : Characterization of fungal distribution patterns among different murine Aspergillus fumigatus infection models using light sheet microscopy
    In: Mycoses Vol. 58 (2015) Nr. Suppl. 3, pp. 9
    ISSN: 0933-7407; 1439-0507
  • Geiger, H.; Kohler, A.; Florian, C.; Schmithorst, V.; Ryan, M.; Daria, D.; Gunzer, Matthias;
    Time-lapse intravital imaging in long bones reveals altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells : implications for stem cell aging
    37th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF), Luebeck, Germany 18-20,2010,
    In: Experimental Dermatology Vol. 19 (2010) Nr. 2, pp. 215 - 215
    ISSN: 0906-6705; 1600-0625
  • Book articles / Proceedings papers

  • Hasenberg, Anja; Otto, Lucas; Gunzer, Matthias
    Intravital 2-Photon Microscopy of Diverse Cell Types in the Murine Tibia
    In: Myeloid-Derived Suppressor Cells Brandau, Sven; Dorhoi, Anca; (Eds.) 2021, pp. 189 - 201
    ISBN: 978-1-0716-1059-6; 978-1-0716-1060-2
  • Research report

  • Merz, Simon F.; Jansen, Philipp; Ulankiewicz, Ricarda; Bornemann, Lea; Schimming, Tobias; Griewank, Klaus; Cibir, Zülal; Kraus, Andreas; Stoffels, Ingo; Aspelmeier, Timo; Brandau, Sven; Schadendorf, Dirk; Hadaschik, Eva; Ebel, Gernot; Gunzer, Matthias; Klode, Joachim
    High-resolution 3-D imaging for precise staging in malignant melanoma
    New York (2020) 37 Seiten 37 Seiten

ZMB Research Programme

Prof. Matthias Gunzer participates in the ZMB research programme II, Immunology, Infectious Diseases and Transplantation.

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