ZMB Member Robert Huber

Robert Huber

Prof. Dr. h.c. mult. Robert Huber FRS

Phone
+49 201 183 4141
Email

Zentrum für Medizinische Biotechnologie (ZMB)
Room S03 S02 A45
Universität Duisburg-Essen
45117 Essen

Department

Structure Research

Max Planck Institut für Biochemie, Martinsried

Research Overview
 

Professional interests

Structure and function of biological macromolecules, in particular those of large complex aggregates.

Systems studied

  • Proteases and their natural and synthetic inhibitors.
  • Metalloenzymes (iron, nickel, molybdenum, copper).
  • Proteins of the immune system (antibodies and antibody receptors).
  • Protein hormones and their receptors.
  • Protein kinases.
  • Proteins of amino acid biosynthesis (PLP containing enzymes).
  • Proteins of cofactor and vitamin biosynthesis.
  • Proteins of energy and electron transport.

Methods development

  • Patterson methods in crystallography.
  • Methods of structure determination of proteins and protein ligand complexes by NMR.
  • Synthesis and use of electron rich metal clusters.
  • Crystal annealing and improvement, methods and instruments.
  • Analysis and evaluation of targets for research and application in pharmacology and crop science.