ZMB Member Robert Huber

Robert Huber

Prof. Dr. h.c. mult. Robert Huber FRS

+49 201 183 4141

Zentrum für Medizinische Biotechnologie (ZMB)
Room S03 S02 A45
Universität Duisburg-Essen
45117 Essen


Structure Research

Max Planck Institut für Biochemie, Martinsried

Research Overview

Professional interests

Structure and function of biological macromolecules, in particular those of large complex aggregates.

Systems studied

  • Proteases and their natural and synthetic inhibitors.
  • Metalloenzymes (iron, nickel, molybdenum, copper).
  • Proteins of the immune system (antibodies and antibody receptors).
  • Protein hormones and their receptors.
  • Protein kinases.
  • Proteins of amino acid biosynthesis (PLP containing enzymes).
  • Proteins of cofactor and vitamin biosynthesis.
  • Proteins of energy and electron transport.

Methods development

  • Patterson methods in crystallography.
  • Methods of structure determination of proteins and protein ligand complexes by NMR.
  • Synthesis and use of electron rich metal clusters.
  • Crystal annealing and improvement, methods and instruments.
  • Analysis and evaluation of targets for research and application in pharmacology and crop science.