Dr. Farnusch Kaschani

Peer-reviewed papers

Poepsel S, Sprengel A, Sacca B, Kaschani F, Kaiser M, Gatsogiannis C, Raunser S, Clausen T, Ehrmann M. Determinants of amyloid fibril degradation by the PDZ protease HTRA1. Nat Chem Biol. 2015 Oct 5. [Epub ahead of print]

Ehrmann M, Kaschani F, Kaiser M. Chemical proteomics versus leishmaniasis. Chem Biol. 2015 Mar 19;22(3):309-10.

Villamor JG, Kaschani F, Colby T, Oeljeklaus J, Zhao D, Kaiser M, Patricelli MP, van der Hoorn RA. Profiling protein kinases and other ATP binding proteins in Arabidopsis using Acyl-ATP probes. Mol Cell Proteomics. 2013 Sep;12(9):2481-96.

van den Boom J, Mamić M, Baccelliere D, Zweerink S, Kaschani F, Knauer S, Bayer P, Kaiser M. Peptidyl Succinimidyl Peptides as Taspase 1 Inhibitors. Chembiochem. 2014 Aug 21.

Misas-Villamil JC, Kolodziejek I, Crabill E, Kaschani F, Niessen S, Shindo T, Kaiser M, Alfano JR, van der Hoorn RA. Pseudomonas syringae pv. syringae uses proteasome inhibitor syringolin A to colonize from wound infection sites. PLoS Pathog. 2013 Mar;9(3):e1003281.

Lu H, Wang Z, Shabab M, Oeljeklaus J, Verhelst SH, Kaschani F, Kaiser M, Bogyo M, van der Hoorn RA (2013) A Substrate-Inspired Probe Monitors Translocation, Activation, and Subcellular Targeting of Bacterial Type III Effector Protease AvrPphB. Chem Biol 20: 168-176.

Misas-Villamil JC, Kolodziejek I, Crabill E, Kaschani F, Niessen S, Shindo T, Kaiser M, Alfano JR, van der Hoorn RA (2013) Pseudomonas syringae pv. syringae Uses Proteasome Inhibitor Syringolin A to Colonize from Wound Infection Sites. PLoS Pathog 9: e1003281.

Misas-Villamil JC, Toenges G, Kolodziejek I, Sadaghiani AM, Kaschani F, Colby T, Bogyo M, van der Hoorn RA (2013) Activity profiling of vacuolar processing enzymes reveals a role for VPE during oomycete infection. Plant J 73: 689-700.

Oeljeklaus J, Kaschani F, Kaiser M (2013) Streamlining chemical probe discovery: libraries of "fully functionalized" small molecules for phenotypic screening. Angew Chem Int Ed 52: 1368-1370.

Villamor JG, Kaschani F, Colby T, Oeljeklaus J, Zhao D, Kaiser M, Patricelli MP, van der Hoorn RA (2013) Profiling protein kinases and other ATP bindingproteins in Arabidopsis using acyl-ATP probes. Mol Cell Proteomics 2013 May 29. [Epub ahead of print].

Gu C, Shabab M, Strasser R, Wolters PJ, Shindo T, Niemer M, Kaschani F, Mach L, van der Hoorn RAL (2012) Post-Translational Regulation and Trafficking of the Granulin-Containing Protease RD21 of Arabidopsis thaliana. PLos One 7: e32422.

Kaschani F, Clerc J, Krahn D, Bier D, Hong TN, Ottmann C, Niessen S, Colby T, van der Hoorn RA, Kaiser M (2012) Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenases. Angew Chem Int Ed 51: 5230-5233.

Kaschani F, Gu C, van der Hoorn RAL (2012) Activity-based protein profiling of infected plants. Methods Mol Biol 835: 47-59.

Kaschani F, Nickel S, Pandey B, Cravatt BF, Kaiser M, van der Hoorn RAL (2012) Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP. Bioorg Med Chem 20: 597-600.

Lenger J, Kaschani F, Lenz T, Dalhoff C, Villamor JG, Koster H, Sewald N, van der Hoorn RAL (2012) Labeling and enrichment of Arabidopsis thaliana matrix metalloproteases using an active-site directed, marimastat-based photoreactive probe. Bioorg Med Chem 20: 592-596.

Nickel S, Kaschani F, Colby T, van der Hoorn RA, Kaiser M (2012) A para-nitrophenol phosphonate probe labels distinct serine hydrolases of Arabidopsis. Bioorg Med Chem 20: 601-606.

Richau KH, Kaschani F, Verdoes M, Pansuriya TC, Niessen S, Stuber K, Colby T, Overkleeft HS, Bogyo M, Van der Hoorn RAL (2012) Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics. Plant Physiol 158: 1583-1599.

Stolze SC, Deu E, Kaschani F, Li N, Florea BI, Richau KH, Colby T, van der Hoorn RA, Overkleeft HS, Bogyo M, Kaiser M (2012) The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains. Chem Biol 19: 1546-1555.

van der Linde K, Hemetsberger C, Kastner C, Kaschani F, van der Hoorn RAL, Kumlehn J, Doehlemann G (2012) A maize cystatin suppresses host immunity by inhibiting apoplastic cysteine proteases. Plant Cell 24: 1285-1300.

van der Linde K, Mueller AN, Hemetsberger C, Kaschani F, Van der Hoorn RAL, Doehlemann G (2012) The maize cystatin CC9 interacts with apoplastic cysteine proteases. Plant Signal Behav 7: 1397-1401.

Kaschani F, Van der Hoorn RAL (2011) A model of the C14-EPIC complex indicates hotspots for a protease-inhibitor arms race in the oomycete-potato interaction. Plant Signal Behav 6: 109-112.

Kolodziejek I, Misas-Villamil JC, Kaschani F, Clerc J, Gu C, Krahn D, Niessen S, Verdoes M, Willems LI, Overkleeft HS, Kaiser M, van der Hoorn RAL (2011) Proteasome activity imaging and profiling characterizes bacterial effector syringolin A. Plant Physiol 155: 477-489.

Kaschani F, Shabab M, Bozkurt T, Shindo T, Schornack S, Gu C, Ilyas M, Win J, Kamoun S, van der Hoorn RAL (2010) An effector-targeted protease contributes to defense against Phytophthora infestans and is under diversifying selection in natural hosts. Plant Physiol 154: 1794-1804.

Kaschani F, Gu C, Niessen S, Hoover H, Cravatt BF, van der Hoorn RAL (2009) Diversity of serine hydrolase activities of unchallenged and botrytis-infected Arabidopsis thaliana. Mol Cell Proteomics 8: 1082-1093.

Kaschani F, Verhelst SH, van Swieten PF, Verdoes M, Wong CS, Wang Z, Kaiser M, Overkleeft HS, Bogyo M, van der Hoorn RAL (2009) Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click chemistry'. Plant J 57: 373-385.

Song J, Win J, Tian M, Schornack S, Kaschani F, Ilyas M, van der Hoorn RAL, Kamoun S (2009) Apoplastic effectors secreted by two unrelated eukaryotic plant pathogens target the tomato defense protease Rcr3. Proc Natl Acad Sci USA 106: 1654-1659.

Kaschani F, van der Hoorn RAL (2007) Small molecule approaches in plants. Curr Opin Chem Biol 11: 88-98.

Shabab M, Shindo T, Gu C, Kaschani F, Pansuriya T, Chintha R, Harzen A, Colby T, Kamoun S, van der Hoorn RAL (2008) Fungal effector protein AVR2 targets diversifying defense-related cys proteases of tomato. Plant Cell 20: 1169-1183.

Kaschani F, van der Hoorn RAL (2007) Small molecule approaches in plants. Curr Opin Chem Biol 11: 88-98.

Patents

Van der Hoorn, R. A. L., Gu, C., Kaschani, F., Misas, J., Richau, K., Kolodziejek, I. Moquet, F., Malliart, C., Berthet, X. (2011) Seed trait prediction by activity-based protein profiling, Application No: 11152509.3