ZMB Member Hemmo Meyer, Publications

Prof. Dr. Hemmo Meyer


Selected Recent Publications

Weith M, Seiler J, van den Boom J, Kracht M, Hülsmann J, Primorac I, del Pino Garcia J, Kaschani F, Kaiser M, Musacchio A, Bollen M, Meyer H. Ubiquitin-independent disassembly by a p97 AAA-ATPase complex drives PP1 holoenzyme formation. Mol Cell, 2018, doi: 10.1016/j.molcel.2018.09.020.

Papadopoulos C, Meyer H. Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and Lysophagy. Curr Biol. 2017 Dec 18;27(24):R1330-R1341.

van den Boom J, and Meyer H. VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. Mol. Cell, 2017, doi: 10.1016/j.molcel.2017.10.028. Review.

Papadopoulos C, Kirchner P, Bug M, Grum D, Koerver L, Schulze N, Poehler R, Dressler A, Fengler S, Arhzaouy K, Lux V, Ehrmann M, Weihl CC, Meyer H. VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy.  EMBO J 2017 Jan 17;36(2):135-150.

van den Boom J, Wolf M, Weimann L, Schulze N, Li F, Kaschani F, Riemer A, Zierhut C, Kaiser M, Iliakis G, Funabiki H, Meyer H. VCP/p97 extracts sterically trapped Ku70/80 rings from DNA in double strand break repair. Mol. Cell, 2016, 64: 189–198.

Eiteneuer A, Seiler J, Weith M, Beullens M, Lesage B, Krenn V, Musacchio A, Bollen M, Meyer H. Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1. EMBO J. 2014, 33(22):2704-20

Meyer HH, Bug M, Bremer S. Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system. Nat Cell Biol. 2012 Feb 2;14(2):117-23. Review.

Ritz D, Vuk M, Kirchner P, Bug M, Schütz S, Hayer A, Bremer S, Lusk C, Baloh RH, Lee H, Glatter T, Gstaiger M, Aebersold R, Weihl CC, Meyer H. Endolysosomal sorting of ubiquitinated caveolin-1 is regulated by VCP/p97 and UBXD1 and impaired by VCP disease mutations. Nat. Cell Biol. 2011 Aug 7;13(9):1116-23.

Ramadan K, Bruderer R, Spiga F, Popp O, Baur T, Gotta M, and Meyer HH. Cdc48/p97 promotes reformation of the nucleus by extracting Aurora B kinase from chromatin. Nature 2007, 450: 1258-62.

All Publications

Original research papers

Arhzaouy K, Papadopoulos C, Schulze N, Pittman SK, Meyer H, Weihl CC. VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle. Autophagy, 2019, doi.org/10.1080/15548627.2019.1569933.

Weith M, Seiler J, van den Boom J, Kracht M, Hülsmann J, Primorac I, del Pino Garcia J, Kaschani F, Kaiser M, Musacchio A, Bollen M, Meyer H. Ubiquitin-independent disassembly by a p97 AAA-ATPase complex drives PP1 holoenzyme formation. Mol Cell, 2018, doi: 10.1016/j.molcel.2018.09.020.

Hülsmann J, Kravic B, Weith M, Gstaiger M, Aebersold R, Collins BC, Meyer H. AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation. Mol Cell Proteomics. 2018 Jul;17(7):1295-1307. doi: 10.1074/mcp.RA117.000471. Epub 2018 Mar 29.

Pöhler R, Krahn JH, van den Boom J, Dobrynin G, Kaschani F, Eggenweiler HM, Zenke FT, Kaiser M, Meyer H. A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases. Angew Chem Int Ed Engl. 2017 Dec 22. doi: 10.1002/anie.201711429.

Papadopoulos C, Kirchner P, Bug M, Grum D, Koerver L, Schulze N, Poehler R, Dressler A, Fengler S, Arhzaouy K, Lux V, Ehrmann M, Weihl CC, Meyer H. VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. EMBO J., 2017 Jan 17;36(2):135-150.

van den Boom J, Wolf M, Weimann L, Schulze N, Li F, Kaschani F, Riemer A, Zierhut C, Kaiser M, Iliakis G, Funabiki H, Meyer H. VCP/p97 extracts sterically trapped Ku70/80 rings from DNA in double strand break repair. Mol. Cell, 2016, 64: 189–198.

Trusch F, Matena A, Vuk M, Koerver L, Knævelsrud H, Freemont PS, Meyer H, Bayer P. (2015) The N-terminal Region of the UBX Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97. J Biol Chem. 2015, 290, 29414–29427.

Eiteneuer A, Seiler J, Weith M, Beullens M, Lesage B, Krenn V, Musacchio A, Bollen M, Meyer H. Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1. EMBO J. 2014 Oct 8., advanced online publication DOI 10.15252/embj.201489054

Riemer A, Dobrynin G, Dressler A, Bremer S, Soni A, Iliakis G, Meyer H. The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation. Cell Cycle. 2014 Jan 15;13(6).

Kress E, Schwager F, Holtackers R, Seiler J, Prodon F, Zanin E, Eiteneuer A, Toya M, Sugimoto A, Meyer H, Meraldi P, Gotta M. The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A. J Cell Biol. 2013 May 13; 201 (4).

Kirchner P, Bug M, Meyer HH. Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by VCP/p97. J Biol Chem. 2013 Mar 8;288(10):7363-72.

Bebeacua C, Förster A, McKeown C, Meyer HH, Zhang X, Freemont PS. Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy. Proc Natl Acad Sci U S A. 2012, 109: 1098-1103.

Meerang M, Ritz D, Paliwal S, Garajova Z, Bosshard M, Mailand N, Janscak P, Hübscher U, Meyer H and Ramadan K. The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nat. Cell Biol. 2011 Oct 23;13(11):1376-82.

Ritz D, Vuk M, Kirchner P, Bug M, Schütz S, Hayer A, Bremer S, Lusk C, Baloh RH, Lee H, Glatter T, Gstaiger M, Aebersold R, Weihl CC, Meyer H. Endolysosomal sorting of ubiquitinated caveolin-1 is regulated by VCP/p97 and UBXD1 and impaired by VCP disease mutations. Nat. Cell Biol. 2011 Aug 7;13(9):1116-23.

Dobrynin G, Popp O, Romer T, Bremer S, Schmitz MHA, Gerlich DW and Meyer H. Cdc48/p97(Ufd1-Npl4) antagonizes Aurora B during chromosome segregation in HeLa cells. J Cell Sci, 124:1571-80.

Hayer A, Stoeber M, Ritz D, Engel S, Meyer HH, Helenius A. Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation. J Cell Biol. 2010, 191:615-29.

Ramadan K, Bruderer R, Spiga F, Popp O, Baur T, Gotta M, and Meyer HH. Cdc48/p97 promotes reformation of the nucleus by extracting Aurora B kinase from chromatin. Nature 2007, 450: 1258-62.

Baur T, Ramadan K, Schlundt A, Kartenbeck J, and Meyer HH. NSF- and SNARE-mediated membrane fusion is required for nuclear envelope formation and completion of nuclear pore complex assembly in Xenopus laevis egg extracts. J Cell Sci, 2007, 120: 2895-903.

Isaacson RL, Pye VE, Simpson P, Meyer HH, Zhang X, Freemont PS, Matthews S. Detailed structural Insight into the p97-Npl4-Ufd1 interface. J Biol Chem., 2007, 282:21361-9

Pye VE, Beuron F, Keetch C, McKeown C, Robinson CV, Meyer HH, Zhang X, and PS Freemont. The p97-Ufd1-Npl4 Complex: First Structural Insights. PNAS, 2007, 104:467-72.

Bruderer RM, Brasseur C, and Meyer HH. The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism. J Biol Chem., 2004, 279:49609-16.

Wang Y, Satoh A, Warren G, and Meyer HH. VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments. J Cell Biol., 2004, 164: 973-978.

Cao K, Nakajima R, Meyer HH, and Zheng Y. The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis. Cell, 2003, 115: 355-367.

Ye Y, Meyer HH, Rapoport TA. Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J Cell Biol., 2003, 162: 71-84.

Wang B, Alam SL, Meyer HH, Payne M, Stemmler TL, Davis DR, Sundquist WI. Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4. J Biol Chem., 2003, 278: 20225-34.

Meyer HH, Wang Y, and Warren G. Direct binding of ubiquitin-conjugates by the mammalian p97 adapter complexes, p47 and Ufd1-Npl4. EMBO J, 2002, 21: 5645-5652.

Ye, Y, Meyer HH, and TA Rapoport. The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature 2001, 414: 652-656.

Hetzer M*, Meyer HH*, Walther TC, Bilbao-Cortes D, Warren G & I W Mattaj. Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Nature Cell Biol. 2001, 3: 1086 - 1091.

Meyer HH, Shorter JG, Seemann J, Pappin D, Warren G. A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. EMBO J. 2000, 19:2181-92.

Zhang X, Shaw A, Bates PA, Newman RH, Gowen B, Orlova E, Gorman MA, Kondo H, Dokurno P, Lally J, Leonard G, Meyer HH, van Heel M, Freemont PS. Structure of the AAA ATPase p97. Mol Cell., 2000, 6:1473-84.

Muller JM, Meyer HH, Ruhrberg C, Stamp GW, Warren G, Shima DT. The mouse p97 (CDC48) gene. Genomic structure, definition of transcriptional regulatory sequences, gene expression, and characterization of a pseudogene. J Biol Chem., 1999, 274:10154-62.

Meyer HH, Kondo H, Warren G. The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97. FEBS Lett., 1998, 437:255-7.

Reviews

Papadopoulos C, Meyer H. Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and Lysophagy. Curr Biol. 2017 Dec 18;27(24):R1330-R1341.

van den Boom J, and Meyer H. VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. Mol. Cell, 2017, doi: 10.1016/j.molcel.2017.10.028. Review.

Meyer H, and Weihl CC. The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis. J. Cell Sci., 2014, 127:3877-83

Meyer HH. p97 complexes as signal integration hubs. BMC Biol. 2012 Jun 13;10:48.

Meyer HH, Bug M, Bremer S. Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system. Nat Cell Biol. 2012 Feb 2;14(2):117-23. doi: 10.1038/ncb2407. Review.

Bug M, Meyer H. Expanding into new markets - VCP/p97 in endocytosis and autophagy J. Struct. Biol. 2012, doi: 10.1016/j.jsb.2012.03.003.

Meyer H, Drozdowska A, and Dobrynin G. A role for Cdc48/p97 and Aurora B in controlling chromatin condensation during exit from mitosis. Biochem Cell Biol 2010 Feb; 88(1):23-8.

Meyer HH and Popp O. Role(s) of Cdc48/p97 in mitosis. Biochem Soc Trans 2008; 36, 126-30.

Meyer HH. Golgi reassembly after mitosis: the AAA family meets the ubiquitin family. Biochim Biophys Acta, 2005, 1744:481-92.

Department

Molekularbiologie I

ZMB/Faculty of Biology
University of Duisburg-Essen
45117 Essen

Room S05 V04 F44