Supramolecular chemistry, bioorganic chemistry, medicinal chemistry, self-assembling nanomaterials
- Design and synthesis of host-guest systems for applications in aqueous solvents: e.g. peptide recognition, receptors for carbohydrates, anion sensing (organic synthesis, combinatorial chemistry, solid phase peptide synthesis).
- Quantitative thermodynamic studies of indiviual interactions within supramolecular host-guest systems using "knock-out" analogues (isothermal microcalorimetry, nmr, UV/Vis and fluorescence spectroscopy).
- Peptides and proteins with non-natural amino acids - downsizing enzymes.
- Combinatorial development of peptide based organocatalysts (kinetic studies).
- Development of enzyme inhibitors as new potential drug candidates agains infectious diseases (enzyme assays, kinetic studies, synthesis of labelled inhibitors, microbiological testing).
- Supramolecular polymers (atomic force microscopy, transmission electron microscopy, light scattering, small angle neutron scattering).
- Self-assembling zwitterions as a new class of vesicle formers.