ZMB Member Andrea Vortkamp, Publications

Prof. Dr. Andrea Vortkamp

Selected Publications

Piombo V, Jochmann K, Hoffmann D, Wuelling M, Vortkamp A. 2018. Signaling systems affecting the severity of multiple osteochondromas. Bone. 111:71-81.

Veistinen LK, Mustonen T, Hasan MR, Takatalo M, Kobayashi Y, Kesper DA, Vortkamp A, Rice DP. 2017. Regulation of calvarial osteogenesis by concomitant de-repression of GLI3 and activation of IHH targets. Frontiers in Physiology. 8(DEC).

Willie BM, Pap T, Perka C, Schmidt CO, Eckstein F, Arampatzis A, Hege HC, Madry H, Vortkamp A, Duda GN. 2017. OVERLOAD of joints and its role in osteoarthritis: Towards understanding and preventing progression of primary osteoarthritis. English version. Zeitschrift fur Rheumatologie. 7

Bandari S, Exner S, Ortmann C, Bachvarova V, Vortkamp A, Grobe K. 2015. Sweet on hedgehogs: Regulatory roles of heparan sulfate proteoglycans in hedgehog-dependent cell proliferation and differentiation. Current Protein and Peptide Science. 16(1):66-76.

Dierker T, Bachvarova V, Krause Y, Li JP, Kjellén L, Seidler DG, Vortkamp A. 2016. Altered heparan sulfate structure in Glce-/-mice leads to increased Hedgehog signaling in endochondral bones. Matrix Biology. 49:82-92.

Hu Y, Kim JH, He K, Wan Q, Kim J, Flach M, Kirchhausen T, Vortkamp A, Winau F. 2016. Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion. Journal of Experimental Medicine. 213(12):2759-2772.

Mattheij NJ, Braun A, Van Kruchten R, Castoldi E, Pircher J, Baaten CC, Wulling M, Kuijpers MJ, Kohler R, Poole AW, Schreiber R, Vortkamp A, Collins PW, Nieswandt B, Kunzelmann K, Cosemans JM, Heemskerk JW. 2016. Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling and swelling. Nederlands Tijdschrift voor Klinische Chemie en Laboratoriumgeneeskunde. 41(3):207-208.

Mattheij NJA, Braun A, Van Kruchten R, Castoldi E, Pircher J, Baaten CCFMJ, Wülling M, Kuijpers MJE, Köhler R, Poole AW, Schreiber R, Vortkamp A, Collins PW, Nieswandt B, Kunzelmann K, Cosemans JMEM, Heemskerk JWM. 2016. Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage. FASEB Journal. 30(2):727-7

Wuelling M, Vortkamp A. Molecular control of cartilage differentiation.  Cartilage: Volume 1: Physiology and Development. 2016. p. 191-213.

Liu G, Liu G, Chen H, Borst O, Gawaz M, Vortkamp A, Schreiber R, Kunzelmann K, Lang F. 2015. Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and Apoptosis. Cellular Physiology and Biochemistry. 37(5):1934-1944.

Severmann AC, Vortkamp A. 2015. Hypertrophic chondrocytes: Programmed cell death or stem cell reservoir? Zeitschrift fur Rheumatologie. 74(10):898-901.

Willie BM, Pap T, Perka C, Schmidt CO, Eckstein F, Arampatzis A, Hege HC, Madry H, Vortkamp A, Duda GN. 2015. OVERLOAD of joints and its role in osteoarthritis: Towards understanding and preventing progression of primary osteoarthritis. Zeitschrift fur Rheumatologie. 74(7):618-621.

Ousingsawat J, Wanitchakool P, Schreiber R, Wuelling M, Vortkamp A, Kunzelmann K. Anoctamin 6 controls bone mineralization by activating the calcium transporter NCX1. J Biol Chem. 2015 Jan 14.

Chau M, Lui JC, Landman EB, Späth SS, Vortkamp A, Baron J, Nilsson O. Gene expression profiling reveals similarities between the spatial architectures of postnatal articular and growth plate cartilage. PLoS One. 2014 Jul 28;9(7):e103061.

Rebollido-Rios R, Bandari S, Wilms C, Jakuschev S, Vortkamp A, Grobe K, Hoffmann D. Signaling domain of Sonic Hedgehog as cannibalistic calcium-regulated zinc-peptidase. PLoS Comput Biol. 2014 Jul 17;10(7):e1003707.

Dittmann K, Wuelling M, Uhmann A, Dullin C, Hahn H, Schweyer S, Vortkamp A, Wienands J. Inactivation of patched1 in murine chondrocytes causes spinal fusion without inflammation. Arthritis Rheumatol. 2014 Apr;66(4):831-40.

Jochmann K, Bachvarova V, Vortkamp A. Reprint of: Heparan sulfate as a regulator of endochondral ossification and osteochondroma development. Matrix Biol. 2014 Apr;35:239-47.

Wuelling M, Vortkamp A. Cartilage explant cultures. Methods Mol Biol. 2014;1130:89-97

Jochmann K, Bachvarova V, Vortkamp A. Reprint of: Heparan sulfate as a regulator of endochondral ossification and osteochondroma development. Matrix Biol. 2014 Apr 8. pii: S0945-053X(14)00060-2. Review.

Dittmann K, Wuelling M, Uhmann A, Dullin C, Hahn H, Schweyer S, Vortkamp A, Wienands J. Inactivation of Patched 1 in chondrocytes causes spinal fusion without inflammation. Arthritis Rheum. 2013 Dec 24.

Wuelling M, Pasdziernik M, Moll CN, Thiesen AM, Schneider S, Johannes C, Vortkamp A. The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosis. Cell Cycle 2013 Jun 20;12(14).

Ehlen HW, Chinenkova M, Moser M, Munter HM, Krause Y, Gross S, Brachvogel B, Wuelling M, Kornak U, Vortkamp A. Inactivation of Anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues. J Bone Miner Res. 2012 Aug 30. [Epub ahead of print]

Gross S, Krause Y, Wuelling M, Vortkamp A. Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice. PLoS One. 2012;7(8):e43553. Epub 2012 Aug 20.

Galli GG, Honnens de Lichtenberg K, Carrara M, Hans W, Wuelling M, Mentz B, Multhaupt HA, Fog CK, Jensen KT, Rappsilber J, Vortkamp A, Coulton L, Fuchs H, Gailus-Durner V, Hrabû de Angelis M, Calogero RA, Couchman JR, Lund AH. Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing Bone. PLoS Genet. 2012 May;8(5):e1002711. Epub 2012 May 10.

Veistinen L, Takatalo M, Tanimoto Y, Kesper DA, Vortkamp A, Rice DP. Loss-of-Function of Gli3 in Mice Causes Abnormal Frontal Bone Morphology and Premature Synostosis of the Interfrontal Suture. Front Physiol. 2012;3:121.

Laufer E, Kesper D, Vortkamp A, King P. Sonic hedgehog signaling during adrenal development.Mol Cell Endocrinol. 2012 Mar 31;351(1):19-27.

Wuelling M, Vortkamp A. Chondrocyte proliferation and differentiation. Endocr Dev. 2011;21:1-11. Epub 2011 Aug 22.

Friedrichs M, Wirsdorfer F, Flohe SB, Schneider S, Wuelling M, Vortkamp A. Bmp-signaling balances proliferation and differentiation of muscle satellite cell descendants. BMC Cell Biol. 2011 Jun 6;12(1):26. [Epub ahead of print]

Kesper DA, Didt-Koziel L, Vortkamp A. Gli2 activator function in preosteoblasts is sufficient to mediate Ihh-dependent osteoblast differentiation, whereas the repressor function of Gli2 is dispensable for endochondral ossification. Dev Dyn. 2010 Jun;239(6):1818-26.

Ratzka A, Mundlos S, Vortkamp A. Expression patterns of sulfatase genes in the developing mouse embryo. Dev Dyn. 2010 Jun;239(6):1779-88.

Jones KB, Piombo V, Searby C, Kurriger G, Yang B, Grabellus F, Roughley PJ, Morcuende JA, Buckwalter JA, Capecchi MR, Vortkamp A, Sheffield VC. A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2054-9. Epub 2009 Dec 22.

Wuelling M, Kaiser FJ, Buelens LA, Braunholz D, Shivdasani RA, Depping R, Vortkamp A (2009). Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3. Dev Biol. 328(1):40-53.

Ratzka A, Kalus I, Moser M, Dierks T, Mundlos S, Vortkamp A (2008). Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development. Dev Dyn. 237(2):339-53.

Nogai H, Rosowski M, Grün J, Rietz A, Debus N, Schmidt G, Lauster C, Janitz M, Vortkamp A, Lauster R (2008). Follistatin antagonizes transforming growth factor-beta3-induced epithelial-mesenchymal transition in vitro: implications for murine palatal development supported by microarray analysis. Differentiation 76(4):404-16.

Tagariello A, Luther J, Streiter M, Didt-Koziel L, Wuelling M, Surmann-Schmitt C, Stock M, Adam N, Vortkamp A, Winterpacht A (2008). Ucma--A novel secreted factor represents a highly specific marker for distal chondrocytes. Matrix Biol. 27(1):3-11.

Probst B, Rock R, Gessler M, Vortkamp A, Püschel AW (2007). The rodent Four-jointed ortholog Fjx1 regulates dendrite extension. Dev Biol. 312(1):461-70.

Ehlen HW, Buelens LA, Vortkamp A (2006). Hedgehog signaling in skeletal development. Birth Defects Res C Embryo 78(3):267-79. Review.

Koziel L, Wuelling M, Schneider S, Vortkamp A (2005). Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation. Development 132(23):5249-60.

Koziel L, Kunath M, Kelly OG, Vortkamp A (2004). Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification. Dev Cell. 6(6):801-13.

Zhou HM, Weskamp G, Chesneau V, Sahin U, Vortkamp A, Horiuchi K, Chiusaroli R, Hahn R, Wilkes D, Fisher P, Baron R, Manova K, Basson CT, Hempstead B, Blobel CP (2004). Essential role for ADAM19 in cardiovascular morphogenesis. Mol Cell Biol. 24(1):96-104.

Minina E, Kreschel C, Naski MC, Ornitz DM, Vortkamp A (2002). Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation. Dev Cell. 3(3):439-49.

Minina E, Wenzel HM, Kreschel C, Karp S, Gaffield W, McMahon AP, Vortkamp A (2001). BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development 128(22):4523-34.

Lanske B, Karaplis AC, Lee K, Luz A, Vortkamp A, Pirro A, Karperien M, Defize LH, Ho C, Mulligan RC, Abou-Samra AB, Juppner H, Segre GV, Kronenberg HM (1996). PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 273(5275):663-6.

Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ (1996). Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273(5275):613-22.

Vortkamp A, Gessler M, Grzeschik KH (1991). GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families. Nature 352(6335):539-40.

Department

Entwicklungsbiologie

ZMB/Faculty of Biology
University of Duisburg-Essen
45117 Essen

Room S03 S01 A51