ZMB Research Programme I

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ZMB Research Programme I Oncology

The concept of this research programme is to understand fundamental processes in tumour biology in order to develop novel molecularly defined and rationally applied cancer treatments. Participating researchers from biology, experimental and clinical medicine study tumours as "biological systems" and so called "neo-organs". A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumour development, growth, progression and tumour cell migration.

A first focus lies on the investigation of the behaviour of malignant cells, their signalling interactions, cell death (apoptosis) and proliferation rates, as well as changes in their differentiation programme. Moreover, as most drug targets are proteins, researchers in this programme focus on the molecular analysis of cancer-relevant proteins. Protein function is linked to expression levels, specific subcellular localization, interaction with other proteins and post-translational modifications. These events contribute to the various functional properties that are important for the malignant transformation of cells.

A second focus lies on the investigation of the molecular details of migration and metastasis of tumour cells, as well as cellular responses to cell damage. In addition, in cooperation with researchers from the Programme on Immunology and Infectious Diseases, the interactions between the immune system and tumours are of particular interest.

Participating ZMB members:

MEMBER DEPARTMENT
Prof. Dr. Dr. Jürgen C. Becker Translational Skin Cancer Research (TSCR)
Prof. Dr. Sven Brandau Department of Otorhinolaryngology
Prof. Dr. Ulrich Dührsen Klinik für Hämatologie
Prof. Dr. Dr. Dagmar Führer-Sakel Forschungslabor Endokrinologie
Dr. Barbara Grüner Innere Klinik (Tumorforschung)
Prof. Dr. Erich Gulbins Institut für Molekularbiologie (Tumorforschung)
PD Dr. Iris Helfrich Vascular Oncology & Metastasis
Klinik für Dermatologie
Prof. Dr. George Iliakis Institut für Medizinische Strahlenbiologie
Prof. Dr. Verena Jendrossek Institut für Zellbiologie (Tumorforschung)
PD Dr. Ludger Klein-Hitpass Institut für Zellbiologie (Tumorforschung)
Prof. Dr. Shirley Knauer Molecular Biology II
Prof. Dr. Ralf Küppers Institut für Zellbiologie (Tumorforschung)
Prof. Dr. Annette Paschen Molecular Tumor Immunology
Klinik für Dermatologie
Prof. Dr. Tienush Rassaf Klinik für Kardiologie und Angiologie
Westdeutsches Herz- und Gefäßzentrum
PD Dr. Henning Reis Institut für Pathologie
Prof. Dr. Alexander Roesch Tumor Heterogeneity & Plasticity
Klinik für Dermatologie
Prof. Dr. Dirk Schadendorf Klinik für Dermatologie
Prof. Dr. Kurt W. Schmid Institut für Pathologie und Neuropathologie
Prof. Dr. Alexander Schramm Molekulare Onkologie,
Innere Klinik (Tumorforschung)
Prof. Dr. Martin Schuler Innere Klinik (Tumorforschung)
Westdeutsches Tumorzentrum (WTZ)
Prof. Dr. Jens Siveke Innere Klinik (Tumorforschung)
PD Dr. Jürgen Thomale Institut für Zellbiologie (Tumorforschung)
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