ZMB Selected publications

Selected publications 2009

Podolsky DK, Gerken G, Eyking A, Cario E . Colitis-associated variant of TLR2 causes impaired mucosal repair due to TFF3 deficiency. Gastroenterology. 2009, 137:209-220.

Zelinskyy G, Dietze KK, Sparwasser T , Dittmer U . Regulatory T cell suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus. PLoS Pathogens. 2009, 5:e1000406.

Zelinskyy G, Dietze KK, Hüsecken, YP, Schimmer S, Nair S, Werner T, Gibbert K, Kershaw O, Gruber AD, Sparwasser T, Dittmer U. (2009) The regulatory T cell response during actue retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T cell response.Blood. 2009, 114:3199-3207.

Röth A, Hüttmann A, Rother A, Dührsen U , Philipp T. Long-term efficacy of the complement inhibitor eculizumab in cold agglutinin disease. Blood. 113:3885-3886.

Otto T, Horn S, Brockmann M, Eilers U, Schüttrumpf L, Popov N, Kenney AM, Schulte JH, Beijersbergen R, Christiansen H, Berwanger B, Eilers M. Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell. 2009, 15:67-78.

Gassert E, Avota E, Harms H, Krohne G, Gulbins E, Schneider-Schaulies S. Induction of membrane ceramides: a novel strategy to interfere with T lymphocyte cytoskeletal reorganisation in viral immunosuppression. PLoS Pathog. 2009, 5:e1000623.

Koehler A, Schmithorst V, Filippi MD, Ryan M, Daria D, Gunzer M *, and Geiger H*. Altered endosteal location and cellular dynamics of aged hematopoietic stem cells in the marrow of long bones in vivo. Blood. 2009, 114(2):290-298.

Herroeder S, Reichardt P, Sassmann A, Zimmermann B, Hogg N, Hollmann MW, Fischer KD, Vogt S, Grosse R, Gunzer M , et al. G-proteins of the G12/G13 family shape immune functions by controlling CD4+ T-cell adhesiveness. Immunity. 2009, 30(5):708-720.

Hosseini BH, Louban I, Djandji D, Wabnitz GH, Deeg J, Bulbuc N, Samstag Y, Gunzer M , Spatz JP, Hämmerling G. Immune synapse formation determines interaction forces between T cells and antigen-presenting cell measured by atomic force microscopy. Proc Natl Acad Sci U S A. 2009, 106 (42): 17852-17857

Heid IM, et al. Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design? PLoS Genet. 2009, 5:e1000694.

Birnbaum S, et al. Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24. Nat Genet. 2009, 41(4):473-7.

Kanber D, Berulava T, Ammerpohl O, Mitter D, Richter J, Siebert R, Horsthemke B, Lohmann D, Buiting K. The Human Retinoblastoma Gene Is Imprinted. Plos Genetics. 2009, 5:12.

Wolschner C, Giese A, Kretzschmar HA, Huber R , Moroder L. Budisa N. Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein. Proc. Natl. Acad. Sci. USA. 2009, 106:7756-7761.

Clerc J, Groll M, Illich DJ, Bachmann AS, Huber R, Schellenberg B, Dudler R, Kaiser M. Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition. Proc. Natl. Acad. Sci. USA. 2009, 106:6507-6512.

Sanglas L, Aviles FX, Huber R , Gomis-Rüth FX, Arolas JL. Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite. Proc. Natl. Acad. Sci. USA. 2009, 106:1743-1747.

Knoth T, Warburg K, Katzka C, Rai A, Wolf A, Brockmeyer A, Janning P, Reubold TF, Eschenburg S, Manstein DJ, Hübel K, Kaiser M, Waldmann H. The Ras pathway modulator Melophlin A targets dynamins. Angew. Chem. Int. Ed. 2009, 48:7240-7245.

Clerc J, Groll M, Illich DJ, Bachmann AS, Huber R, Schellenberg B, Dudler R, Kaiser M. Synthetic and structural studies on Syringolin A and B reveal critical determinants for selectivity and potency of proteasome inhibition. Proc. Natl. Acad. Sci. USA. 2009, 106:6507-6512.

Ottmann C, Rose R, Huttenlocher F, Cedzich A, Hauske P, Kaiser M, Huber R, Schaller A. Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3. Proc. Natl. Acad. Sci. USA. 2009, 106:17223-17228.

Werninghaus K, Babiak A, Gross O, Hölscher C, Dietrich H, Agger EM, Mages J, Mocsai A, Schoenen H, Finger K, Nimmerjahn F, Brown GD, Kirschning C, Heit A, Andersen P, Wagner H, Ruland J, Lang R. Adjuvanticity of a synthetic cord factor analog for subunit M. tuberculosis vaccination requires Fcrgamma-Syk-Card9-dependent innate immune activation. J Exp Med.2009, 206(1):89-97.

Conrad ML, Ferstl R, Teich R, Brand S, Blümer N, Yildirim AO, Patrascan CC, Hanuszkiewicz A, Akira S, Wagner H, Holst O, von Mutius E, Pfefferle PI, Kirschning CJ, Garn H, Renz H. Maternal TLR signaling is required for prenatal asthma protection by the non-pathogenic microbe Acinetobacter lwoffii F78. J Exp Med. 2009, 206(13):2869-77.

Krämer OH, Knauer SK, Greiner G, Jandt E, Reichardt S, Gührs KH, Stauber RH, Böhmer FD, Heinzel T. A phosphorylation-acetylation switch regulates STAT1 signaling. Gene Dev. 2009, 23:223-235.

Küppers R. Biology of Hodgkin lymphoma. Nature Rev. Cancer. 2009, 9:15-27.

Martín-Subero JI, et al. New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic and transcriptional profiling. Blood. 2009, 113:2488-2497.

Schmitz R, Hansmann M-L, Bohle V, Martin-Subero JI, Hartmann S, Mechtersheimer G, Klapper W, Vater I, Giefing M, Gesk S, Stanelle J, Siebert R, Küppers R. TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. J. Exp. Med. 2009, 206:981-989.

Mottok A, Renné C, Seifert M, Oppermann E, Bechstein W, Hansmann M-L, Küppers R, Bräuninger A. (2009) Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B cell lymphoma entities. Blood. 2009, 114:4503-4506.

Seifert M, Küppers R. Molecular footprints of a germinal center derivation of human IgM+(IgD+)CD27+ B cells and the dynamics of memory B cell generation. J. Exp. Med. 2009, 206:2659-2669.

Machacek M, Hodgson L, Welch C, Elliott H, Pertz O, Nalbant P , Abell A, Johnson GL, Hahn KM, Danuser G. Coordination of Rho GTPase activities during cell protrusion. Nature. 2009, 461(7260):99-103.

Kribben A, Witzke O, Hillen U, Barkhausen J, Daul AE, Erbel R. Nephrogenic systemic fibrosis: pathogenesis, diagnosis, and therapy. J Am Coll Cardiol. 2009, 53(18):1621-8.

Lakshmikanth T, Burke S, Ali TH, Kimpfler S, Ursini F, Ruggeri L, Capanni M, Umansky V, Paschen A, Sucker A, Pende D, Groh V, Biassoni R, Höglund P, Kato M, Shibuya K, Schadendorf D, Anichini A, Ferrone S, Velardi A, Kärre K, Shibuya A, Carbone E, Colucci F NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo. J Clin Invest. 2009, 119(5):1251-63.

Bottomley A, Coens C, Suciu S, Santinami M, Kruit W, Testori A, Marsden J, Punt C, Salès F, Gore M, Mackie R, Kusic Z, Dummer R, Patel P, Schadendorf D, Spatz A, Keilholz U, Eggermont A Adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma: a phase III randomized controlled trial of health-related quality of life and symptoms by the European Organisation for Research and Treatment of Cancer J Clin Oncol. 2009, 27(18):2916-23.

Findeisen P, Zapatka M, Peccerella T, Matzk H, Neumaier M, Schadendorf D , Ugurel S Serum amyloid A as a prognostic marker in melanoma identified by proteomic profiling. J Clin Oncol. 2009, 27(13):2199-208.

Hauschild A, Weichenthal M, Rass K, Linse R, Ulrich J, Stadler R, Volkenandt M, Grabbe S, Proske U, Schadendorf D, Brockmeyer N, Vogt T, Rompel R, Kaufmann R, Kaatz M, Näher H, Mohr P, Eigentler T, Livingstone E, Garbe C Prospective randomized multicenter adjuvant dermatologic cooperative oncology group trial of low-dose interferon alfa-2b with or without a modified high-dose interferon alfa-2b induction phase in patients with lymph node-negative melanoma. J Clin Oncol. 2009, 27(21):3496-502.

Hauschild A, Agarwala SS, Trefzer U, Hogg D, Robert C, Hersey P, Eggermont A, Grabbe S, Gonzalez R, Gille J, Peschel C, Schadendorf D, Garbe C, O'Day S, Daud A, White JM, Xia C, Patel K, Kirkwood JM, Keilholz U. Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. J Clin Oncol. 2009, 27(17):2823-30.

Haldar D, Schmuck C. Metal free double helices from abiotic backbones. Chem. Soc. Rev. 2009, 38:363-371.

Küstner B, Gellner M, Schütz M, Schöppler F, Marx A, Ströbel P, Adam P, Schmuck C, Schlücker S. SERS labels for red laser excitation: silica-encapsulated SAM on tunable gold/silver nanoshells. Angew. Chem. 2009, 121:1984-1987; Angew. Chem. Int. Ed. 2009, 48:1950-1953.

Lindgren NJ, Geiger L, Razkin J, Schmuck C, Baltzer L. Downsizing Enzymatic Function by Chemical Methods – Arginine Mimics with Low pKa Values Increase Rates of Hydrolysis of RNA Model Compounds. Angew. Chem. 2009, 121:6850-6853;Angew. Chem. Int. Ed. 2009, 48:6722-6725.

Breitenbuecher F, Markova B, Kasper S, Carius B, Stauder T, Böhmer FD, Masson K, Rönnstrand L, Huber C, Kindler T, Fischer T. A novel molecular mechanism of primary resistance to FLT3-kinase inhibitors in AML. Blood. 2009, 113:4063-73.

Breitenbuecher F, Schnittger S, Grundler R, Markova B, Carius B, Brecht A, Duyster J, Haferlach T, Huber C, Fischer T. Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor. Blood. 2009, 113:4074-t.

Kayser S, Schlenk RF, Londono MC, Breitenbuecher F, Wittke K, Du J, Groner S, Späth D, Krauter J, Ganser A, Döhner H, Fischer T, Döhner K; German-Austrian AML Study Group (AMLSG). Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome. Blood. 2009, 114:2386-92.

Dazert E, Neumann-Haefelin C, Bressanelli S, Fitzmaurice K, Kort J, Timm J , McKiernan S, Kelleher D, Gruener N, Tavis JE, Rosen HR, Shaw J, Bowness P, Blum HE, Klenerman P, Bartenschlager R, Thimme R. Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest. 2009, 119:376-86.

Barth S, Edlich F, Berchner-Pfannschmidt U, Gneuss S, Jahreis G, Hasgall PA, Fandrey J, Wenger RH, Camenisch G. Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38. J Biol Chem. 2009 Aug 21;284(34):23046-58. Epub 2009 Jun 22.

Selected publications 2008

Haile LA, von Wasielewski R, Gamrekelashvili J, Krüger C, Bachmann O, Westendorf AM, Buer J, Liblau R, Manns MP, Korangy F, Greten TF. Myeloid-derived suppressor cells in inflammatory bowel disease: a new immunoregulatory pathway. Gastroenterology. 2008, 135:871-81.

Nickeleit I, Zender S, Sasse F, Geffers R, Brandes G, Sörensen I, Steinmetz H, Kubicka S, Carlomagno T, Menche D, Gütgemann I, Buer J, Gossler A, Manns MP, Kalesse M, Frank R, Malek NP. (2008). Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition. Cancer Cell 2008, 14:23-35.

Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf A, Buer J, Martin B, Wilhelm C, Stockinger B. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat. Immunol. 2008, 9:1341-1346.

Veldhoen M, Hirota K, Westendorf AM, Buer J, Dumoutier L, Renauld JC, Stockinger B. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature. 2008, 453:106-109.

Hoster E, Dreyling M, Klapper W, Gisselbrecht C, van Hoof A, Kluin-Nelemans HC, Pfreundschuh M, Reiser M, Metzner B, Einsele H, Peter N, Jung W, Wörmann B, Ludwig WD, Dührsen U, Eimermacher H, Wandt H, Hasford J, Hiddemann W, Unterhalt M 2008 A new prognostic index (MIPI) for patients with advanced stage mantle cell lymphoma. Blood. 2008, 111:558-565.

Krojer T, Sawa J, Schäfer E, Saibil HR, Ehrmann M, Clausen T. Structural basis for the regulated protease and chaperone function of DegP. Nature. 2008, 453:885-890

Meltzer M, Hasenbein S, Hauske P, Kucz N, Merdanovic M, Grau S, Beil A, Jones D, Krojer T, Clausen T, Ehrmann M, Kaiser M. Allosteric activation of HtrA protease DegP by stress signals in bacterial protein quality control. Angew Chem. Int. Ed. Engl. 2008, 47:1332-1334; Angew. Chem. 2008, 120:1352-1355.

Krojer T, Pangerl K, Kurt J, Sawa J, Stingl C, Mechtler K, Huber R, Ehrmann M, Clausen T. The interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins. Proc. Natl. Acad. Sci. USA. 2008, 105:7702-7707.

Sokolova V, Epple M. Inorganic nanoparticles as carriers of nucleic acids into cells. Angew Chem Int Ed Engl. 2008, 47:1382-1395.

Neues F, Epple M. X-ray micro computer tomography for the study of biomineralized endo- and exoskeletons of animals. Chemical Reviews. 2008, 108:4734-4741.

Sicking W, Korth HG, de Groot H, Sustmann R. On the functional role of a water molecule in clade 3 catalases: a proposal for the mechanism by which NADPH prevents the formation of compound II. J. Am. Chem. Soc. 2008, 130:7345-7356.

Szabo I, Bock J, Grassmé H, Soddemann M, Wilker B, Lang F, Zoratti M, Gulbins E. Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes. Proc Natl Acad Sci U S A. 2008, 105:14861-6.

Teichgräber V, Ulrich M, Endlich N, Riethmüller J, Wilker B, De Oliveira-Munding CC, van Heeckeren AM, Barr ML, von Kürthy G, Schmid KW, Weller M, Tümmler B, Lang F, Grassmé H, Döring G, Gulbins E. Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis. Nat Med. 2008, 14:382-91.

Loos RJ, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet. 2008, 40:768-75.

Najm J, Horn D, Wimplinger I, Golden JA, Chizhikov VV, Sudi J, Christian SL, Ullmann R, Küchler A, Haas CA, Flubacher A, Charnas LR, Uyanik G, Frank U, Klopocki E, Dobyns WB, Kutsche K. Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum. Nat Genet. 2008, 40(9):1065-1067.

Unger S, Böhm D, Böhm J, Barrionuevo F, Kaiser F, Kaulfuß S, Borozdin W, Buiting K, Burfeind P, Borowski K, Keppler-Noreuil K, Schmitt-Mechelke T, Steiner B, Mortier G, Sandford R, Zabel B, Superti-Furga A, Kohlhase J. Mutations in the Cyclin family member FAM58A cause a novel X-linked dominant disorder characterized by syndactyly, telecanthus, anogenital and renal malformations (STAR syndrome). Nature Genet. 2008, 40:287-9.

Speckmann C, Pannicke U, Wiech E, Schwarz K, Fisch P, Friedrich W, Niehues T, Gilmour K, Buiting K, Schlesier M, Hermann Eibel, Rohr J, Superti-Furga A, Gross-Wieltsch U, Ehl S. Clinical and immunological consequences of a somatic reversion in a patient with X-linked severe combined immunodeficiency. Blood. 2008, 112(10):4090-97.

Groll M, Schellenberg B, Bachmann AS, Archer CR, Huber R, Powell TK, Lindow S, Kaiser M, Dudler R. A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism. Nature. 2008, 452:755-758.

Wang Z, Gu C, Colby T, Shindo T, Balamurugan R, Waldmann H, Kaiser M, van der Hoorn RA. Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana. Nat. Chem. Biol. 2008, 4:557-563.

Nören-Müller A, Wilk W, Saxena K, Schwalbe H, Kaiser M, Waldmann H. Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis (BIOS). Angew.Chem. Int. Ed. 2008, 47:5973-5977.

Hapfelmeier S, Müller AJ, Stecher B, Kaiser P, Barthel M, Endt K, Eberhard M, Robbiani R, Jacobi CA, Heikenwalder M, Kirschning C, Jung S, Stallmach T, Kremer M, Hardt WD. Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis. J Exp Med. 2008, 205(2):437-50.

Spiller S, Elson G, Ferstl R, Dreher S, Mueller T, Freudenberg M, Daubeuf B, Wagner H, Kirschning CJ. TLR4-induced IFNgamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice.

J Exp Med.2008, 205(8):1747-54.

Urbonaviciute V, Fürnrohr BG, Meister S, Munoz L, Heyder P, De Marchis F, Bianchi ME, Kirschning C, Wagner H, Manfredi AA, Kalden JR, Schett G, Rovere-Querini P, Herrmann M, Voll RE. Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. J Exp Med. 2008, 205(13):3007-18.

Brune V, Tiacci E, Pfeil I, Döring C, Eckerle S, van Noesel CJM, Klapper W, Falini B, von Heydebreck A, Metzler D, Bräuninger A, Hansmann M-L, Küppers R. Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis. J. Exp. Med. 2008. 205:2251-2268.

Westermann D, Mersmann J, Melchior A, Freudenberger T, Petrik C, Schaefer L, Lüllmann-Rauch R, Lettau O, Jacoby C, Schrader J, Brand-Herrman SM, Young MF, Schultheiss HP, Levkau B, Baba HA, Unger T, Zacharowski K, Tschöpe C, Fischer JW. Biglycan Is Required for Adaptive Remodeling After Myocardial Infarction. Circulation. 2008, 117:1269-76.

Levkau B, et al. Survivin determines cardiac function by controlling total cardiomyocyte number. Circulation. 2008, 117:1583-93.

Teichgräber V, Ulrich M, Endlich N, Riethmüller J, Wilker B, De Oliveira-Munding CC, van Heeckeren AM, Barr ML, von Kürthy G, Schmid KW, Weller M, Tümmler B, Lang F, Grassme H, Döring G, Gulbins E. Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis. Nat Med. 2008, 14(4):382-91.

Talbiersky P, Bastkowski F, Klärner FG, Schrader T. Molecular Clip and Tweezer introduce new Mechanisms of Enzyme Inhibition. J. Am Chem. Soc. 2008, 130:9824-9828.

Fricke H, Funk A, Schrader T, Gerhards M. Investigation of secondary structure elements by IR/UV double resonance spectroscopy: Analysis of an isolated β-sheet model system. J. Am Chem. Soc. 2008, 130:4692-4698.

Rzepecki P, Hochdörffer K, Schaller T, Zienau J, Harms K, Ochsenfeld C, Xie X, Schrader T. Hierarchical Self-Assembly of Nanorosettes in Water. J. Am. Chem. Soc. 2008, 130:586-591.

Stolz C, Hess G, Hähnel PS, Grabellus F, Hoffarth S, Schmid KW, Schuler M. Targeting Bcl-2 family proteins modulates the sensitivity of B-cell lymphoma to Rituximab-induced apoptosis. Blood. 2008, 112:3312-3321.

Bargou R, Leo E, Zugmaier G, Klinger M, Goebeler M, Knop S, Noppeney R, Viardot A, Hess G, Schuler M, Einsele H, Brandl C, Wolf A, Kirchinger P, Klappers P, Schmidt M, Riethmüller G, Reinhardt C, Baeuerle PA, Kufer P. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science. 2008, 321:974-977.

Marques CA, Hähnel PS, Wölfel C, Thaler S, Huber C, Theobald M, Schuler M. An immune escape screen reveals Cdc42 as regulator of cancer susceptibility to lymphocyte-mediated tumor suppression. Blood. 2008, 111:1413-1419.

Dhar, S, Liu Z, Thomale J, Dai H, Lippard SJ. Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device. J Am Chem Soc. 2008, 130:11467-76.

Veldhoen M, Hirota K, Westendorf AM, Buer J, Dumoutier L, Renauld JC, Stockinger B. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature. 2008 May 1;453(7191):106-9. Epub 2008 Mar 23.

Krojer T, Sawa J, Schäfer E, Saibil HR, Ehrmann M, Clausen T. Structural basis for the regulated protease and chaperone function of DegP. Nature. 2008 Jun 12;453(7197):885-90. Epub 2008 May 21.

Selected publications 2007

Lang PA, Schenck M, Nicolay JP, Becker JU, Kempe DS, Lupescu A, Koka S, Eisele K, Klarl BA, Rübben H, Schmid KW, Mann K, Hildenbrand S, Hefter H, Huber SM, Wieder T, Erhardt A, Häussinger D, Gulbins E, Lang F. Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide. Nat Med. 2007 ;13(2):164-70.

Hasselblatt H, Kurzbauer R, Wilken C, Krojer T, Sawa, J, Kurt, J, Kirk R, Hasenbein S, Ehrmann M, Clausen T. Regulation of the sigmaE stress response by DegS: How the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress. Genes Dev. 2007 ;21(20):2659-70.

Birkenfeld J, Nalbant P, Bohl BP, Pertz O, Hahn KM, Bokoch GM. GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev Cell. 2007 ;12(5):699-712

Hasenbein S, Merdanovic M, Ehrmann M. Determinants of regulated proteolysis in signal transduction. Genes Dev. 2007 ;21(1):6-10.

Hahn U, Wermter J, Blasczyk R, Horn PA. Text mining: powering the database revolution. Nature. 2007; 448(7150): 130.

Kessler D, Papatheodorou P, Stratmann T, Dian EA, Hartmann-Fatu C, Rassow J, Bayer P, Mueller JW. The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae. BMC Biol 2007 ;5:37.

Ukena SN, Singh A, Dringenberg U, Engelhardt R, Seidler U, Hansen W, Bleich A, Bruder D, Franzke A, Rogler G, Suerbaum S, Buer J, Gunzer F, Westendorf AM. Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity. PLoS ONE. 2007 ;2(12):e1308.