We extend the Wigner-Weyl-Moyal phase-space formulation of quantum mechanics to general curved configuration spaces. The underlying phase space is based on the chosen coordinates of the manifold and their canonically conjugate momenta. The resulting Wigner function displays the axioms of a quasiprobability distribution, and any Weyl-ordered operator gets associated with the corresponding phase-space function, even in the absence of continuous symmetries. The corresponding quantum Liouville equation reduces to the classical curved space Liouville equation in the semiclassical limit. We demonstrate the formalism for a point particle moving on two-dimensional manifolds, such as a paraboloid or the surface of a sphere. The latter clarifies the treatment of compact coordinate spaces, as well as the relation of the presented phase-space representation to symmetry groups of the configuration space.