Transporter expression and TH action in the brain

Prof. Dr. med. Ingo Bechmann  &  Prof. Dr. Heike Biebermann

MCT8 is a specific TH transporter in the brain. In this project, spatiotemporal expression of MCT8 from early weeks of gestation to adult healthy and diseased human brains will be examined. In a complementary approach, we will develop MCT8 reporter stem cell models to monitor MCT8 expression during cerebral organoid differentiation and development and to enable enrichment of MCT8-expressing neuronal cell types for transcriptome analyses.

Project Team Members

Name Position Phone Email
Jonas Rotter MD candidate (Team Bechmann)   Mail
Heidrun Kurz Lab Technician (Team Bechmann)     
Angela Merkwitz Lab Technician (Team Bechmann)    
Cigdem Cetindag  Lab Technician (Team Biebermann)    

Further Information

Homepage Team Bechmann

 

Selected Publications

What is the blood-brain barrier (not)?
Bechmann I, Galea I, Perry VH.
2007. Trends Immunol 28:5-11. doi: 10.1016/j.it.2006.11.007

Different segments of the cerebral vasculature reveal specific endothelial specifications, while tight junction proteins appear equally distributed.
Hanske S, Dyrn F, Bechmann I, Krueger M.
2017. Brain Struct Funct 222:1179-1192. doi: 10.1007/s00429-016-1267-0

CNS pericytes: concepts, misconceptions, and a way out.
Krueger M, Bechmann I.
2010. Glia 58:1-10. doi: 10.1002/glia.20898

Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid.
Schläger C, Körner H, Krueger M, Vidoli S, Haberl M, Mielke D, Brylla E, Issekutz T, Cabañas C, Nelson PJ, Ziemssen T, Rohde V, Bechmann I, Lodygin D, Odoardi F, Flügel A.
2016. Nature 530:349-53. doi: 10.1038/nature16939

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.
Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Müller L, Angelis MD, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sánchez-Garrido MA, Liu P, Tuckermann J, Malehmir M, Healy ME, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm KW, Biebermann H, Döring Y, Weber C, Habegger KM, Keuper M, Gelfanov V, Liu F, Köhrle J, Rozman J, Fuchs H, Gailus-Durner V, de Angelis MH, Hofmann SM, Yang B, Tschöp MH, DiMarchi R, Müller TD.
2016. Cell 167: 843-857. doi: 10.1016/j.cell.2016.09.014

Treatment of congenital thyroid dysfunction: Achievements and challenges.
Krude H, Kühnen P, Biebermann H.
2015. Best Pract Res Clin Endocrinol Metab 29:399-413. doi: 10.1016/j.beem.2015.04.004

Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation.
Friesema EC, Grueters A, Biebermann H, Krude H, von Moers A, Reeser M, Barrett TG, Mancilla EE, Svensson J, Kester MH, Kuiper GG, Balkassmi S, Uitterlinden AG, Koehrle J, Rodien P, Halestrap AP, Visser TJ.
2004. Lancet 364:1435-7. doi: 10.1016/S0140-6736(04)17226-7

Extended clinical phenotype, endocrine investigations and functional studies of a loss-of-function mutation A150V in the thyroid hormone specific transporter MCT8.
Biebermann H, Ambrugger P, Tarnow P, von Moers A, Schweizer U, Grueters A.
2005. Eur J Endocrinol 153:359-66. doi: 10.1530/eje.1.01980

Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level.
Fischer J, Kleinau G, Rutz C, Zwanziger D, Khajavi N, Müller A, Rehders M, Brix K, Worth CL, Führer D, Krude H, Wiesner B, Schülein R, Biebermann H.
2018. Cell Mol Life Sci 75:2227-2239. doi: 10.1007/s00018-017-2728-1