Impact of TH transport on seizure generation

Dr. Steffen Mayerl

Human MCT8 patients demonstrate a pronounced seizure susceptibility of yet unknown etiology. Here, we will analyse how TH transport defects in different neuronal populations contribute to this phenotype. To this end, we will compare Mct8/Oatp1c1 DKO mice to mice lacking both TH transporters in inhibitory or excitatory neurons only. We will further unravel changes in the TH transporter deficient brain following seizure induction and their role in the transition to epilepsy.

 

Project Team Members

Name Position Phone Email
Andrea Alcaide Martín PhD candidate +49 201 723 5677 Mail
Natalie Sadowski Lab Technician +49 201 723 5677  

 

Further Information

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Selected Publications

Establishing an adult mouse brain hippocampal organotypic slice systme that allows for tracing and pharmacological manipulation of ex vivo neurogenesis.
Mayerl S, Ffrench-Constant C.
2021. Bio Protoc 11(1):23869. doi: 10.21769/BioProtoc.3869

Hippocampal neurogenesis requires cell-autonomous thyroid hormone signaling.
Mayerl S, Heuer H, Ffrench-Constant C.
2020. Stem Cell Reports 14:845-860. doi: 10.1016/j.stemcr.2020.03.014

Thyroid hormone transporters Mct8 and Oatp1c1 control skeletal muscle regeneration.
Mayerl S, Schmidt M, Doycheva D, Darras VM, Hüttner SS, Boelen A, Visser TJ, Kaether C, Heuer H*, von Maltzahn J*. *equal contribution.
2018. Stem Cell Reports 10:1959-1974. doi: 10.1016/j.stemcr.2018.03.021

The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific Sulforhodamine 101-labeling of hippocampal astrocytes.
Schnell C, Shahmoradi A, Wichert SP, Mayerl S, Hagos Y, Heuer H, Rossner MJ, Hülsmann S.
2015. Brain Struct Funct 220(1):193-203. doi: 10.1007/s00429-013-0645-0

Absence of TRH receptor 1 in male mice affects gastric ghrelin production.
Mayerl S, Liebsch C, Visser TJ, Heuer H.
2015. Endocrinology 156;755-767. doi: 10.1210/en.2014-1395

Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, and Heuer H.
2014. J Clin Invest 124:1987-1999. doi: 10.1172/JCI70324

Hypothyroidism compromises hypothalamic leptin signaling in mice.
Groba C, Mayerl S, van Mullem AA, Visser TJ, Darras VM, Habenicht AJ, Heuer H.
2013. Mol Endocrinol 27:586-597; doi: 10.1210/me.2012-1311

Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain.
Mayerl S, Visser TJ, Darras VM, Horn S, Heuer H.
2012. Endocrinology 153(3):1528-1537. doi: 10.1210/en.2011-1633