Faculty of Biology
Register of People
The person's links lead to the central register of persons of the UDE, refering to the data of LSF. Personal data can be edited in LSF (Login with Uni-ID is required).
Address
Universitätsstr. 1-5
45141 Essen
45141 Essen
Room
S03 S01 A35
Phone
Fax
E-Mail
Website
Office hours
Termine im Sekretariat erhältlich
Functions
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Vorsitzender, Prüfungsausschuss B.Sc./M.Sc.-Studiengänge Biologie mit Lehramtsoption
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Universitätsprofessor/in, Strukturelle und Medizinische Biochemie
Current lectures
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2024 SS
- Struktur und Funktion (LA Ba) - Anmeldung mit mehreren Prioritäten
- Biophysik-Praktikum
- Physiologie für aquatische Biologen
- Bausteine des Lebens: Einführung in die Biochemie für Hauptstudium LA Chemie, Biotechnik und BSc Chemie Vorlesung/Klausur
- Struktur und Funktion
- Vertiefungsarbeit LA alte LPO und Ba LA
- ZJA40120 Physik für Biologen
- ZIA71044 Klausur Struktur/Funktion der Zelle
Past lectures (max. 10)
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2023 WS
- Vertiefungsarbeit LA alte LPO und Ba LA
- Allgemeine Methoden Praktikum (Bachelor Bio); Priorität für G1 oder G2
- Biochemistry: Structure and function of biomolecules
- Struktur und Funktion der Zelle (LA Ba)
- MedBio Lab Rotation
- Physik für Biologen (Bio B.Sc. und Aquatische Bio B.Sc., Molekularbiologie)
- Allgemeine Methoden (Bachelor Bio)
- Struktur und Funktion
- ZIA71054; ZIA71055 Klausur Biochemie (Bausteine des Lebens: Einführung in die Biochemie)
- ZIA71044 Klausur Struktur/Funktion der Zelle
The following publications are listed in the online university bibliography of the University of Duisburg-Essen. Further information may also be found on the person's personal web pages.
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Multivalent Molecular Tweezers Disrupt the Essential NDC80 Interaction with MicrotubulesIn: Journal of the American Chemical Society: JACS Vol. 145 (2023) Nr. 28, pp. 15251 - 15264Online Full Text: dx.doi.org/
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Potentiating Tweezer Affinity to a Protein Interface with Sequence-Defined Macromolecules on NanoparticlesIn: Biomacromolecules Vol. 24 (2023) Nr. 8, pp. 3666 - 3679Online Full Text: dx.doi.org/
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The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPaseIn: Nature Communications Vol. 14 (2023) Nr. 1, 3258Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Ultrastructure and Surface Composition of Glutathione-Terminated Ultrasmall Silver, Gold, Platinum, and Alloyed Silver-Platinum Nanoparticles (2 nm)In: Inorganic Chemistry Vol. 62 (2023) Nr. 42, pp. 17470 - 17485Online Full Text: dx.doi.org/
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Binding Methylarginines and Methyllysines as Free Amino Acids : A Comparative Study of Multiple Host ClassesIn: ChemBioChem Vol. 23 (2022) Nr. 2, e202100502Online Full Text: dx.doi.org/ (Open Access)
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Dual activity inhibition of threonine aspartase 1 by a single bisphosphate ligandIn: RSC Advances Vol. 12 (2022) Nr. 53, pp. 34176 - 34184Online Full Text: dx.doi.org/ (Open Access)
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Recognition of a Flexible Protein Loop in Taspase 1 by Multivalent Supramolecular TweezersIn: Biomacromolecules Vol. 23 (2022) Nr. 11, pp. 4504 - 4518Online Full Text: dx.doi.org/
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Water-Based Synthesis of Ultrasmall Nanoparticles of Platinum Group Metal Oxides (1.8 nm)In: Inorganic Chemistry Vol. 61 (2022) Nr. 12, pp. 5133 - 5147Online Full Text: dx.doi.org/
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Metal-Ligand Interface and Internal Structure of Ultrasmall Silver Nanoparticles (2 nm)In: Journal of Physical Chemistry B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical Chemistry Vol. 125 (2021) Nr. 21, pp. 5645 - 5659Online Full Text: dx.doi.org/
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New tools to probe the protein surface : Ultrasmall gold nanoparticles carry amino acid bindersIn: Journal of Physical Chemistry B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical Chemistry Vol. 125 (2021) Nr. 1, pp. 115 - 127Online Full Text: dx.doi.org/ (Open Access)
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Peptide-Conjugated Ultrasmall Gold Nanoparticles (2 nm) for Selective Protein TargetingIn: ACS Applied Bio Materials Vol. 4 (2021) Nr. 1, pp. 945 - 965Online Full Text: dx.doi.org/ (Open Access)
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Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezersIn: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1505Online Full Text: dx.doi.org/ (Open Access)
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Targeting the Surface of the Protein 14-3-3 by Ultrasmall (1.5 nm) Gold Nanoparticles Carrying the Specific Peptide CRafIn: ChemBioChem Vol. 22 (2021) Nr. 8, pp. 1456 - 1463Online Full Text: dx.doi.org/ (Open Access)
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Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeastIn: The EMBO Journal Vol. 39 (2020) Nr. 14, pp. e102938Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Functional Disruption of the Cancer-Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole LigandIn: Angewandte Chemie International Edition Vol. 59 (2020) Nr. 14, pp. 5567 - 5571Online Full Text: dx.doi.org/ (Open Access)
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NMR Spectroscopy of supramolecular chemistry on protein surfacesIn: Beilstein Journal of Organic Chemistry Vol. 16 (2020) pp. 2505 - 2522Online Full Text: dx.doi.org/ (Open Access)
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Targeting of parvulin interactors by diazirine mediated cross-linking discloses a cellular role of human Par14/17 in actin polymerizationIn: Biological Chemistry Vol. 401 (2020) Nr. 8, pp. 955 - 968Online Full Text: dx.doi.org/ (Open Access)
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The other side of the corona : Nanoparticles inhibit the protease taspase1 in a size-dependent mannerIn: Nanoscale Vol. 12 (2020) Nr. 37, pp. 19093 - 19103Online Full Text: dx.doi.org/
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Backbone and side-chain chemical shift assignments of full-length, apo, human Pin1, a phosphoprotein regulator with interdomain allosteryIn: Biomolecular NMR Assignments Vol. 13 (2019) Nr. 1, pp. 85 - 89Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Click chemistry on the surface of ultrasmall gold nanoparticles (2 nm) for covalent ligand attachment followed by nmr spectroscopyIn: Langmuir Vol. 35 (2019) Nr. 22, pp. 7191 - 7204Online Full Text: dx.doi.org/
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Multivalent Ligands with Tailor-Made Anion Binding Motif as Stabilizers of Protein–Protein InteractionsIn: ChemBioChem Vol. 20 (2019) Nr. 23, pp. 2921 - 2926Online Full Text: dx.doi.org/
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Solution NMR Spectroscopy with Isotope-Labeled Cysteine (¹³C and ¹⁵N) Reveals the Surface Structure of l -Cysteine-Coated Ultrasmall Gold Nanoparticles (1.8 nm)In: Langmuir Vol. 35 (2019) Nr. 3, pp. 767 - 778Online Full Text: dx.doi.org/
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Structural Analysis of the 42 kDa Parvulin of Trypanosoma bruceiIn: Biomolecules Vol. 9 (2019) Nr. 3, 93Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Structure of the PUB Domain from Ubiquitin Regulatory X Domain Protein 1 (UBXD1) and Its Interaction with the p97 AAA+ ATPaseIn: Biomolecules Vol. 9 (2019) Nr. 12, 876Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Cell entry of a host-targeting protein of oomycetes requires gp96In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 2347Online Full Text: dx.doi.org/ (Open Access)
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Structure and function of the human parvulins Pin1 and Par14/17In: Biological Chemistry Vol. 399 (2018) Nr. 2, pp. 101 - 125Online Full Text: dx.doi.org/ (Open Access)
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The RxLR motif of the host targeting effector AVR3a of phytophthora infestans is cleaved before secretionIn: The Plant Cell Vol. 29 (2017) Nr. 6, pp. 1184 - 1195Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Determinants of tyrosylprotein sulfation coding and substrate specificity of tyrosylprotein sulfotransferases in metazoansIn: Chemico-Biological Interactions Vol. 259 (2016) Nr. Part A, pp. 17 - 22Online Full Text: dx.doi.org/
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Molecular tweezers target a protein-protein interface and thereby modulate complex formationIn: Chemical Communications: ChemComm Vol. 52 (2016) Nr. 98, pp. 14141 - 14144Online Full Text: dx.doi.org/ (Open Access)
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NmPin from the marine thaumarchaeote Nitrosopumilus maritimus is an active membrane associated prolyl isomeraseIn: BMC Biology (incorporating Journal of Biology) Vol. 14 (2016) Nr. 1, pp. 53Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Structural Characterization of the Loop at the Alpha-Subunit C-Terminus of the Mixed Lineage Leukemia Protein Activating Protease Taspase1In: PLoS ONE Vol. 11 (2016) Nr. 3, pp. e0151431Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Heterodimers of Tyrosylprotein Sulfotransferases Suggest Existence of a Higher Organization Level of Transferases in the Membrane of the trans-Golgi ApparatusIn: Journal of Molecular Biology (JMB) Vol. 427 (2015) Nr. Issue 6, Part B, pp. 1404 - 1412Online Full Text: dx.doi.org/
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Human DNA-binding peptidyl-prolyl cis/trans isomerase Par14 is cell cycle dependently expressed and associates with chromatin in vivoIn: BMC Biochemistry Vol. 16 (2015) Nr. 1,Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Structural model of the bilitranslocase transmembrane domain supported by NMR and FRET dataIn: PLoS ONE Vol. 10 (2015) Nr. 8, pp. e0135455Online Full Text: dx.doi.org/ (Open Access)
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The N-terminal region of the ubiquitin regulatory X (UBX) domain-containing protein 1 (UBXD1) modulates interdomain communication within the valosin-containing protein p97In: The Journal of Biological Chemistry (JBC) Vol. 290 (2015) Nr. 49, pp. 29414 - 29427Online Full Text: dx.doi.org/ (Open Access)
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Peptidyl succinimidyl peptides as taspase 1 inhibitorsIn: ChemBioChem Vol. 15 (2014) Nr. 15, pp. 2233 - 2237Online Full Text: dx.doi.org/
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Design of a Modular Protein-Based MRI Contrast Agent for Targeted ApplicationIn: PLoS ONE Vol. 8 (2013) Nr. 6, pp. e65346Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Identification and characterization of peptides that bind the PPIase domain of Parvulin17In: Journal of Peptide Science Vol. 19 (2013) Nr. 6, pp. 362 - 369Online Full Text: dx.doi.org/
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Transient domain interactions enhance the affinity of the mitotic regulator pin1 toward phosphorylated peptide ligandsIn: Structure Vol. 21 (2013) Nr. 10, pp. 1769 - 1777Online Full Text: dx.doi.org/ (Open Access)
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Document Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasmIn: PLoS ONE Vol. 7 (2012) Nr. 1, pp. e29559Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Host-targeting protein 1 (SpHtp1) from the oomycete Saprolegnia parasitica translocates specifically into fish cells in a tyrosine-O-sulphate-dependent mannerIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 109 (2012) Nr. 6, pp. 2096 - 2101Online Full Text: dx.doi.org/
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Structure of the corrinoid : coenzyme M methyltransferase MtaA from Methanosarcina mazeiIn: Acta Crystallographica Section D: Biological Crystallography Vol. 68 (2012) Nr. 11, pp. 1549 - 1557Online Full Text: dx.doi.org/
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A potential transcriptional regulator is out-of-frame translated from the metallothionein 2A messenger RNAIn: Analytical Biochemistry Vol. 409 (2011) Nr. 1, pp. 159 - 161Online Full Text: dx.doi.org/
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Crystallographic Proof for an Extended Hydrogen Bonding Network in Small Prolyl IsomerasesIn: Journal of the American Chemical Society: JACS Vol. 133 (2011) Nr. 50, pp. 20096 - 20099Online Full Text: dx.doi.org/ Online Full Text
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Single-Domain Parvulins Constitute a Specific Marker for Recently Proposed Deep-Branching Archaeal SubgroupsIn: Evolutionary Bioinformatics Vol. 7 (2011) pp. 135 - 148Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Structure and Dynamics of the First Archaeal Parvulin Reveal a New Functionally Important Loop in Parvulin-type Prolyl IsomerasesIn: The Journal of Biological Chemistry (JBC) Vol. 286 (2011) pp. 6554 - 6565Online Full Text: dx.doi.org/ (Open Access)
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The solution structure of pGolemi, a high affinity Mena EVH1 binding miniature protein, suggests explanations for paralog-specific binding to Ena/VASP homology (EVH) 1 domainsIn: Biological Chemistry Vol. 390 (2009) Nr. 5-6, pp. 417 - 426Online Full Text: dx.doi.org/
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Wie Proteine sich erkennen ... : ... und man ihnen dabei zusehen kann!In: Unikate: Berichte aus Forschung und Lehre (2009) Nr. 36: Naturwissenschaften/Medizin : Kernmagnetische Resonanz, pp. 28 - 35Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Small family with key contacts : par14 and par17 parvulin proteins, relatives of pin1, now emerge in biomedical researchIn: Perspectives in Medicinal Chemistry Vol. 2 (2008) pp. 11 - 20Online Full Text: dx.doi.org/ (Open Access)
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15N magnetic relaxation study of backbone dynamics of the ribosomeassociated cold shock response protein Yfia of Escherichia coliIn: Acta Biochimica Polonica Vol. 54 (2007) Nr. 4, pp. 769 - 775(Open Access)
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The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae.In: BMC Biology (incorporating Journal of Biology) Vol. 5 (2007) pp. 37Online Full Text: dx.doi.org/
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Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation.In: BMC Molecular Biology Vol. 7 (2006) pp. 9
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GTP-Ras disrupts the intramolecular complex of C1 and RA domains of Nore1.In: Structure Vol. 14 (2006) pp. 881 - 888Online Full Text: dx.doi.org/ (Open Access)
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Human TPST1 Transmembrane Domain Triggers Enzyme Dimerisation and Localisation to the Golgi CompartmentIn: Journal of Molecular Biology (JMB) Vol. 361 (2006) Nr. 3, pp. 436 - 449Online Full Text: dx.doi.org/
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Isotopic labelling of recombinant proteins expressed in the protozoan host Leishmania tarentolae.In: Protein Expression & Purification Vol. 48 (2006) pp. 167 - 172
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Specification of SUMO1- and SUMO2-interacting motifsIn: The Journal of Biological Chemistry (JBC) Vol. 281 (2006) Nr. 23, pp. 16117 - 16127Online Full Text: dx.doi.org/ (Open Access)
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Identification of hPin1 inhibitors that induce apoptosis in a mammalian Ras transformed cell lineIn: Chemical Communications: ChemComm Vol. 4 (2005) pp. 516 - 518Online Full Text: dx.doi.org/
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The crystal structure of human PAPS synthetase 1 reveals asymmetry in substrate bindingIn: Journal of Molecular Biology (JMB) Vol. 347 (2005) Nr. 3, pp. 623 - 635Online Full Text: dx.doi.org/
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Expression, purification and crystallization of human 3′- phosphoadenosine-5′-phosphosulfate synthetase 1In: Acta Crystallographica Section D: Structural Biology Vol. 60 (2004) Nr. 2, pp. 350 - 352Online Full Text: dx.doi.org/
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Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescensIn: Proceedings of the National Academy of Sciences of the United States of America Vol. 101 (2004) Nr. 47, pp. 16431 - 16436Online Full Text: dx.doi.org/ (Open Access)
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Die Vorliebe für Physik und die StrukturbiologieIn: Nachrichten aus der Chemie Vol. 51 (2003) Nr. 9, pp. 917 - 917Online Full Text: dx.doi.org/
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Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14In: Journal of Molecular Biology (JMB) Vol. 330 (2003) Nr. 5, pp. 955 - 966Online Full Text: dx.doi.org/
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Structural analysis of the mitotic regulator hPin1 in solution : insights into domain architecture and substrate bindingIn: The Journal of Biological Chemistry (JBC) Vol. 278 (2003) Nr. 28, pp. 26183 - 26193Online Full Text: dx.doi.org/ (Open Access)
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Induction of tyrosylprotein sulfotransferase isoform shift in human endothelial cellsIn: Circulation Vol. 106 (2002) Nr. Suppl. 2, pp. 287
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Letter to the Editor: ¹H, ¹³C and ¹⁵N resonance assignments of the ribosome-associated cold shock response protein Yfia of Escherichia coliIn: Journal of Biomolecular NMR Vol. 23 (2002) Nr. 4, pp. 335 - 336Online Full Text: dx.doi.org/
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Shear stress mediates tyrosylprotein sulfotransferase isoform shift in human endothelial cellsIn: Biochemical and Biophysical Research Communications (BBRC) Vol. 294 (2002) Nr. 3, pp. 541 - 546Online Full Text: dx.doi.org/
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Solution structure of the ribosome-associated cold shock response protein Yfia of Escherichia coliIn: Biochemical and Biophysical Research Communications (BBRC) Vol. 299 (2002) Nr. 5, pp. 710 - 714Online Full Text: dx.doi.org/
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Structural attributes in the conjugation of Ubiquitin, RUB and SUMO to protein substrates.In: Frontiers in Bioscience Vol. 7 (2002) pp. 148 - 162
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The N-terminal basic domain of human parvulin h Par14 is responsible for the entry to the nucleus and high-affinity DNA-bindingIn: Journal of Molecular Biology (JMB) Vol. 321 (2002) Nr. 2, pp. 235 - 247Online Full Text: dx.doi.org/
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Increased backbone flexibility in threonineIn: Biochemistry Vol. 40 (2001) Nr. 27, pp. 7957 - 7963Online Full Text: dx.doi.org/
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Structure prediction of protein complexes by an NMR-based protein docking algorithmIn: Journal of Biomolecular NMR Vol. 20 (2001) Nr. 1, pp. 15 - 21Online Full Text: dx.doi.org/
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NMR solution structure of hPar14 reveals similarity to the peptidyl prolyl cis/trans isomerase domain of the mitotic regulator hPin1 but indicates a different functionality of the proteinIn: Journal of Molecular Biology (JMB) Vol. 301 (2000) Nr. 4, pp. 1003 - 1017Online Full Text: dx.doi.org/
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Nuclear magnetic resonance methods to study RNA-protein complexesIn: Methods in Enzymology Vol. 317: RNA - Ligand Interactions, Part A (2000) pp. 198 - 220Online Full Text: dx.doi.org/
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Solution structures of human parathyroid hormone fragments hPTH(1-34) and hPTH(1-39) and bovine parathyroid hormone fragment bPTH(1-37)In: Biochemical and Biophysical Research Communications (BBRC) Vol. 267 (2000) Nr. 1, pp. 213 - 220Online Full Text: dx.doi.org/
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Book Review: Protein Structure: Determination, Analysis, and Applications for Drug Discovery. Edited by Daniel I. ChasmanIn: ChemBioChem Vol. 5 (2004) Nr. 4, pp. 547 - 548Online Full Text: dx.doi.org/
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A molecular handshakeIn: Trends in Biochemical Sciences Vol. 27 (2002) Nr. 10, pp. 502 - 503Online Full Text: dx.doi.org/
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ATP, a trigger for pain-signalingIn: Trends in Biochemical Sciences Vol. 26 (2001) Nr. 1, pp. 12Online Full Text: dx.doi.org/
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Delta: a mitogenic regulator of human hematopoesisIn: Trends in Biochemical Sciences Vol. 26 (2001) Nr. 5, pp. 281Online Full Text: dx.doi.org/
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Living in the cytosolIn: Trends in Biochemical Sciences Vol. 26 (2001) Nr. 12, pp. 702Online Full Text: dx.doi.org/
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TonB – a mediator of iron uptake in bacteriaIn: Trends in Biochemical Sciences Vol. 26 (2001) Nr. 8, pp. 472Online Full Text: dx.doi.org/
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A NMR-spectra based scoring function for protein dockingIn: Proceedings of the Fifth Annual International Conference on Computational Biology / RECOMB01: The Fifth Annual International Conference on Computational Molecular Biology, Montreal, Quebec, Canada, April 22 - 25, 2001 / Lengauer, Thomas (Eds.) 2001, pp. 184 - 192Online Full Text: dx.doi.org/
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HumanbiologieStuttgart (2014) 446 Seiten
(UTB ; 4130)