Faculty of Biology
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The person's links lead to the central register of persons of the UDE, refering to the data of LSF. Personal data can be edited in LSF (Login with Uni-ID is required).
Address
Universitätsstr. 1-5
45141 Essen
45141 Essen
Room
S03 S01 A35
Phone
Fax
E-Mail
Website
Office hours
Termine im Sekretariat erhältlich
Functions
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Vorsitzender, Prüfungsausschuss B.Sc./M.Sc.-Studiengänge Biologie mit Lehramtsoption
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Universitätsprofessor/in, Strukturelle und Medizinische Biochemie
Current lectures
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WiSe 2025
- Allgemeine Methoden Praktikum (Bachelor Bio); Priorität für G1 oder G2
- Biophysikalische Chemie
- Struktur und Funktion der Zelle (LA Ba)
- MedBio Lab Rotation
- Physik für Biologen (Bio B.Sc. und Aquatische Bio B.Sc., Molekularbiologie)
- Analytikmethoden zur Struktur von Molekülen
- Allgemeine Methoden (Bachelor Bio)
- Grundlagen der Biotechnologie (LA Ba); Platzvergabe: 3 Präferenzen angeben
- ZJA40120 und ZJA40121 - Physik für Biologen - Bio BA
- "ZJA71009/ ZJA71017" - Struktur und Funktion - Bio BA
- Vertiefungsarbeit LA alte LPO und Ba LA
- ZJA40148 - " Struktur und Funktion "
- PA-Sitzung
- VO Struktur und Funktion von Biopolymeren
Past lectures (max. 10)
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SoSe 2025
- Bausteine des Lebens: Einführung in die Biochemie für Hauptstudium LA Chemie, Biotechnik und BSc Chemie Vorlesung/Klausur
- Physiologie für aquatische Biologen
- Vertiefungsarbeit LA alte LPO und Ba LA
- PA-Sitzung
- ZIA71044 Klausur Struktur/Funktion der Zelle
- Struktur und Funktion
- Klausur
- Struktur und Funktion (LA Ba) - Anmeldung mit mehreren Prioritäten
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WiSe 2024
The following publications are listed in the online university bibliography of the University of Duisburg-Essen. Further information may also be found on the person's personal web pages.
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Highly Preorganized Calixarene Tweezers for Protein Recognition.In: Biomacromolecules, Vol. 26, 2025, Nr. 8, pp. 5310 – 5319
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Molecular Tweezers Block the Functional Pore of a Protein MachineIn: Journal of the American Chemical Society: JACS, Vol. 147, 2025, Nr. 20, pp. 16836 – 16849DOI (Open Access)
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Molecular Tweezers with Built-in Photoswitches Modulate Protein ActivityIn: RSC Chemical Biology, 2025, in pressDOI (Open Access)
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Photoresponsive molecular tweezers modulate Taspase 1 activityIn: RSC Chemical Biology, 2025, in pressDOI (Open Access)
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Synthesis and characterization of dodecylamine-capped ultrasmall metallic palladium nanoparticles (2 nm)In: Nanoscale Advances, 2025, in pressDOI (Open Access)
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Synthesis and characterization of ultrasmall rhenium nanoparticles (1.5 nm)In: Journal of Nanoparticle Research, Vol. 27, 2025, Nr. 8, 218DOI (Open Access)
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Temperature‐Resolved Fluorescence Quenching on Ultrasmall Gold Nanoparticles Conjugated with Dye‐Labeled PeptidesIn: Nano Select, 2025, in pressDOI (Open Access)
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The Actin‐Binding Prolyl‐Isomerase Par17 Sustains Its Substrate Selectivity by Interdomain AllosteryIn: Proteins: Structure, Function and Genetics, Vol. 93, 2025, Nr. 9, pp. 1481 – 1497DOI (Open Access)
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Ultrasmall Gold Nanoparticles (2 nm) Decorated with a High Density of Photochemically Switchable LigandsIn: Chemistry - A European Journal, 2025DOI (Open Access)
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Functional Linkers Support Targeting of Multivalent Tweezers to Taspase1In: Chemistry - A European Journal, Vol. 30, 2024, Nr. 56, e202401542DOI (Open Access)
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Increased Cytotoxicity of Bimetallic Ultrasmall Silver–Platinum Nanoparticles (2 nm) on Cells and Bacteria in Comparison to Silver Nanoparticles of the Same SizeIn: Materials, Vol. 17, 2024, Nr. 15, 3702DOI (Open Access)
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The Molecular Footprint of Peptides on the Surface of Ultrasmall Gold Nanoparticles (2 nm) Is Governed by Steric DemandIn: Journal of Physical Chemistry B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical Chemistry, Vol. 128, 2024, Nr. 17, pp. 4266 – 4281
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Multivalent Molecular Tweezers Disrupt the Essential NDC80 Interaction with MicrotubulesIn: Journal of the American Chemical Society: JACS, Vol. 145, 2023, Nr. 28, pp. 15251 – 15264
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Potentiating Tweezer Affinity to a Protein Interface with Sequence-Defined Macromolecules on NanoparticlesIn: Biomacromolecules, Vol. 24, 2023, Nr. 8, pp. 3666 – 3679
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The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPaseIn: Nature Communications, Vol. 14, 2023, Nr. 1, 3258DOI, Online Full Text (Open Access)
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Ultrastructure and Surface Composition of Glutathione-Terminated Ultrasmall Silver, Gold, Platinum, and Alloyed Silver-Platinum Nanoparticles (2 nm)In: Inorganic Chemistry, Vol. 62, 2023, Nr. 42, pp. 17470 – 17485
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Binding Methylarginines and Methyllysines as Free Amino Acids : A Comparative Study of Multiple Host ClassesIn: ChemBioChem, Vol. 23, 2022, Nr. 2, e202100502DOI (Open Access)
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Dual activity inhibition of threonine aspartase 1 by a single bisphosphate ligandIn: RSC Advances, Vol. 12, 2022, Nr. 53, pp. 34176 – 34184DOI (Open Access)
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Recognition of a Flexible Protein Loop in Taspase 1 by Multivalent Supramolecular TweezersIn: Biomacromolecules, Vol. 23, 2022, Nr. 11, pp. 4504 – 4518
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Water-Based Synthesis of Ultrasmall Nanoparticles of Platinum Group Metal Oxides (1.8 nm)In: Inorganic Chemistry, Vol. 61, 2022, Nr. 12, pp. 5133 – 5147
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Metal-Ligand Interface and Internal Structure of Ultrasmall Silver Nanoparticles (2 nm)In: Journal of Physical Chemistry B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical Chemistry, Vol. 125, 2021, Nr. 21, pp. 5645 – 5659
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New tools to probe the protein surface : Ultrasmall gold nanoparticles carry amino acid bindersIn: Journal of Physical Chemistry B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical Chemistry, Vol. 125, 2021, Nr. 1, pp. 115 – 127DOI (Open Access)
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Peptide-Conjugated Ultrasmall Gold Nanoparticles (2 nm) for Selective Protein TargetingIn: ACS Applied Bio Materials, Vol. 4, 2021, Nr. 1, pp. 945 – 965DOI (Open Access)
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Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezersIn: Nature Communications, Vol. 12, 2021, Nr. 1, pp. 1505DOI, Online Full Text (Open Access)
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Targeting the Surface of the Protein 14-3-3 by Ultrasmall (1.5 nm) Gold Nanoparticles Carrying the Specific Peptide CRafIn: ChemBioChem, Vol. 22, 2021, Nr. 8, pp. 1456 – 1463DOI (Open Access)
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Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeastIn: The EMBO Journal, Vol. 39, 2020, Nr. 14, pp. e102938DOI, Online Full Text (Open Access)
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Functional Disruption of the Cancer-Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole LigandIn: Angewandte Chemie International Edition, Vol. 59, 2020, Nr. 14, pp. 5567 – 5571DOI (Open Access)
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NMR Spectroscopy of supramolecular chemistry on protein surfacesIn: Beilstein Journal of Organic Chemistry, Vol. 16, 2020, pp. 2505 – 2522DOI (Open Access)
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Targeting of parvulin interactors by diazirine mediated cross-linking discloses a cellular role of human Par14/17 in actin polymerizationIn: Biological Chemistry, Vol. 401, 2020, Nr. 8, pp. 955 – 968DOI (Open Access)
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The other side of the corona : Nanoparticles inhibit the protease taspase1 in a size-dependent mannerIn: Nanoscale, Vol. 12, 2020, Nr. 37, pp. 19093 – 19103
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Backbone and side-chain chemical shift assignments of full-length, apo, human Pin1, a phosphoprotein regulator with interdomain allosteryIn: Biomolecular NMR Assignments, Vol. 13, 2019, Nr. 1, pp. 85 – 89DOI, Online Full Text (Open Access)
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Click chemistry on the surface of ultrasmall gold nanoparticles (2 nm) for covalent ligand attachment followed by nmr spectroscopyIn: Langmuir, Vol. 35, 2019, Nr. 22, pp. 7191 – 7204
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Multivalent Ligands with Tailor-Made Anion Binding Motif as Stabilizers of Protein–Protein InteractionsIn: ChemBioChem, Vol. 20, 2019, Nr. 23, pp. 2921 – 2926
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Solution NMR Spectroscopy with Isotope-Labeled Cysteine (¹³C and ¹⁵N) Reveals the Surface Structure of l -Cysteine-Coated Ultrasmall Gold Nanoparticles (1.8 nm)In: Langmuir, Vol. 35, 2019, Nr. 3, pp. 767 – 778
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Structural Analysis of the 42 kDa Parvulin of Trypanosoma bruceiIn: Biomolecules, Vol. 9, 2019, Nr. 3, 93DOI, Online Full Text (Open Access)
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Structure of the PUB Domain from Ubiquitin Regulatory X Domain Protein 1 (UBXD1) and Its Interaction with the p97 AAA+ ATPaseIn: Biomolecules, Vol. 9, 2019, Nr. 12, 876DOI, Online Full Text (Open Access)
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Cell entry of a host-targeting protein of oomycetes requires gp96In: Nature Communications, Vol. 9, 2018, Nr. 1, pp. 2347DOI (Open Access)
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Structure and function of the human parvulins Pin1 and Par14/17In: Biological Chemistry, Vol. 399, 2018, Nr. 2, pp. 101 – 125DOI (Open Access)
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The RxLR motif of the host targeting effector AVR3a of phytophthora infestans is cleaved before secretionIn: The Plant Cell, Vol. 29, 2017, Nr. 6, pp. 1184 – 1195DOI, Online Full Text (Open Access)
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Determinants of tyrosylprotein sulfation coding and substrate specificity of tyrosylprotein sulfotransferases in metazoansIn: Chemico-Biological Interactions, Vol. 259, 2016, Nr. Part A, pp. 17 – 22
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Molecular tweezers target a protein-protein interface and thereby modulate complex formationIn: Chemical Communications: ChemComm, Vol. 52, 2016, Nr. 98, pp. 14141 – 14144DOI (Open Access)
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NmPin from the marine thaumarchaeote Nitrosopumilus maritimus is an active membrane associated prolyl isomeraseIn: BMC Biology (incorporating Journal of Biology), Vol. 14, 2016, Nr. 1, pp. 53DOI, Online Full Text (Open Access)
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Structural Characterization of the Loop at the Alpha-Subunit C-Terminus of the Mixed Lineage Leukemia Protein Activating Protease Taspase1In: PLoS ONE, Vol. 11, 2016, Nr. 3, pp. e0151431DOI, Online Full Text (Open Access)
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Heterodimers of Tyrosylprotein Sulfotransferases Suggest Existence of a Higher Organization Level of Transferases in the Membrane of the trans-Golgi ApparatusIn: Journal of Molecular Biology (JMB), Vol. 427, 2015, Nr. Issue 6, Part B, pp. 1404 – 1412
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Human DNA-binding peptidyl-prolyl cis/trans isomerase Par14 is cell cycle dependently expressed and associates with chromatin in vivoIn: BMC Biochemistry, Vol. 16, 2015, Nr. 1DOI, Online Full Text (Open Access)
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Structural model of the bilitranslocase transmembrane domain supported by NMR and FRET dataIn: PLoS ONE, Vol. 10, 2015, Nr. 8, pp. e0135455DOI (Open Access)
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The N-terminal region of the ubiquitin regulatory X (UBX) domain-containing protein 1 (UBXD1) modulates interdomain communication within the valosin-containing protein p97In: The Journal of Biological Chemistry (JBC), Vol. 290, 2015, Nr. 49, pp. 29414 – 29427DOI (Open Access)
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Peptidyl succinimidyl peptides as taspase 1 inhibitorsIn: ChemBioChem, Vol. 15, 2014, Nr. 15, pp. 2233 – 2237
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Design of a Modular Protein-Based MRI Contrast Agent for Targeted ApplicationIn: PLoS ONE, Vol. 8, 2013, Nr. 6, pp. e65346DOI, Online Full Text (Open Access)
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Identification and characterization of peptides that bind the PPIase domain of Parvulin17In: Journal of Peptide Science, Vol. 19, 2013, Nr. 6, pp. 362 – 369
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Transient domain interactions enhance the affinity of the mitotic regulator pin1 toward phosphorylated peptide ligandsIn: Structure, Vol. 21, 2013, Nr. 10, pp. 1769 – 1777DOI (Open Access)
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Document Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasmIn: PLoS ONE, Vol. 7, 2012, Nr. 1, pp. e29559DOI, Online Full Text (Open Access)
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Host-targeting protein 1 (SpHtp1) from the oomycete Saprolegnia parasitica translocates specifically into fish cells in a tyrosine-O-sulphate-dependent mannerIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 109, 2012, Nr. 6, pp. 2096 – 2101
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Structure of the corrinoid : coenzyme M methyltransferase MtaA from Methanosarcina mazeiIn: Acta Crystallographica Section D: Biological Crystallography, Vol. 68, 2012, Nr. 11, pp. 1549 – 1557
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A potential transcriptional regulator is out-of-frame translated from the metallothionein 2A messenger RNAIn: Analytical Biochemistry, Vol. 409, 2011, Nr. 1, pp. 159 – 161
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Crystallographic Proof for an Extended Hydrogen Bonding Network in Small Prolyl IsomerasesIn: Journal of the American Chemical Society: JACS, Vol. 133, 2011, Nr. 50, pp. 20096 – 20099
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Single-Domain Parvulins Constitute a Specific Marker for Recently Proposed Deep-Branching Archaeal SubgroupsIn: Evolutionary Bioinformatics, Vol. 7, 2011, pp. 135 – 148DOI, Online Full Text (Open Access)
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Structure and Dynamics of the First Archaeal Parvulin Reveal a New Functionally Important Loop in Parvulin-type Prolyl IsomerasesIn: The Journal of Biological Chemistry (JBC), Vol. 286, 2011, pp. 6554 – 6565DOI (Open Access)
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The solution structure of pGolemi, a high affinity Mena EVH1 binding miniature protein, suggests explanations for paralog-specific binding to Ena/VASP homology (EVH) 1 domainsIn: Biological Chemistry, Vol. 390, 2009, Nr. 5-6, pp. 417 – 426
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Wie Proteine sich erkennen ... : ... und man ihnen dabei zusehen kann!In: Unikate: Berichte aus Forschung und Lehre, 2009, Nr. 36: Naturwissenschaften/Medizin : Kernmagnetische Resonanz, pp. 28 – 35DOI, Online Full Text (Open Access)
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Small family with key contacts : par14 and par17 parvulin proteins, relatives of pin1, now emerge in biomedical researchIn: Perspectives in Medicinal Chemistry, Vol. 2, 2008, pp. 11 – 20DOI (Open Access)
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15N magnetic relaxation study of backbone dynamics of the ribosomeassociated cold shock response protein Yfia of Escherichia coliIn: Acta Biochimica Polonica, Vol. 54, 2007, Nr. 4, pp. 769 – 775(Open Access)
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The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in HominidaeIn: BMC Biology (incorporating Journal of Biology), Vol. 5, 2007, 37
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Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiationIn: BMC Molecular Biology, Vol. 7, 2006, 9
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GTP-Ras disrupts the intramolecular complex of C1 and RA domains of Nore1.In: Structure, Vol. 14, 2006, pp. 881 – 888DOI (Open Access)
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Human TPST1 Transmembrane Domain Triggers Enzyme Dimerisation and Localisation to the Golgi CompartmentIn: Journal of Molecular Biology (JMB), Vol. 361, 2006, Nr. 3, pp. 436 – 449
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Isotopic labelling of recombinant proteins expressed in the protozoan host Leishmania tarentolae.In: Protein Expression & Purification, Vol. 48, 2006, pp. 167 – 172
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Specification of SUMO1- and SUMO2-interacting motifsIn: The Journal of Biological Chemistry (JBC), Vol. 281, 2006, Nr. 23, pp. 16117 – 16127DOI (Open Access)
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Identification of hPin1 inhibitors that induce apoptosis in a mammalian Ras transformed cell lineIn: Chemical Communications: ChemComm, Vol. 4, 2005, pp. 516 – 518
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The crystal structure of human PAPS synthetase 1 reveals asymmetry in substrate bindingIn: Journal of Molecular Biology (JMB), Vol. 347, 2005, Nr. 3, pp. 623 – 635
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Expression, purification and crystallization of human 3′- phosphoadenosine-5′-phosphosulfate synthetase 1In: Acta Crystallographica Section D: Structural Biology, Vol. 60, 2004, Nr. 2, pp. 350 – 352
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Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescensIn: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, 2004, Nr. 47, pp. 16431 – 16436DOI (Open Access)
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Die Vorliebe für Physik und die StrukturbiologieIn: Nachrichten aus der Chemie, Vol. 51, 2003, Nr. 9, pp. 917 – 917
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Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14In: Journal of Molecular Biology (JMB), Vol. 330, 2003, Nr. 5, pp. 955 – 966
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Structural analysis of the mitotic regulator hPin1 in solution : insights into domain architecture and substrate bindingIn: The Journal of Biological Chemistry (JBC), Vol. 278, 2003, Nr. 28, pp. 26183 – 26193DOI (Open Access)
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Induction of tyrosylprotein sulfotransferase isoform shift in human endothelial cellsIn: Circulation, Vol. 106, 2002, Nr. Suppl. 2, pp. 287
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Letter to the Editor: ¹H, ¹³C and ¹⁵N resonance assignments of the ribosome-associated cold shock response protein Yfia of Escherichia coliIn: Journal of Biomolecular NMR, Vol. 23, 2002, Nr. 4, pp. 335 – 336
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Shear stress mediates tyrosylprotein sulfotransferase isoform shift in human endothelial cellsIn: Biochemical and Biophysical Research Communications (BBRC), Vol. 294, 2002, Nr. 3, pp. 541 – 546
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Solution structure of the ribosome-associated cold shock response protein Yfia of Escherichia coliIn: Biochemical and Biophysical Research Communications (BBRC), Vol. 299, 2002, Nr. 5, pp. 710 – 714
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Structural attributes in the conjugation of Ubiquitin, RUB and SUMO to protein substrates.In: Frontiers in Bioscience, Vol. 7, 2002, pp. 148 – 162
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The N-terminal basic domain of human parvulin h Par14 is responsible for the entry to the nucleus and high-affinity DNA-bindingIn: Journal of Molecular Biology (JMB), Vol. 321, 2002, Nr. 2, pp. 235 – 247
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Increased backbone flexibility in threonineIn: Biochemistry, Vol. 40, 2001, Nr. 27, pp. 7957 – 7963
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Structure prediction of protein complexes by an NMR-based protein docking algorithmIn: Journal of Biomolecular NMR, Vol. 20, 2001, Nr. 1, pp. 15 – 21
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NMR solution structure of hPar14 reveals similarity to the peptidyl prolyl cis/trans isomerase domain of the mitotic regulator hPin1 but indicates a different functionality of the proteinIn: Journal of Molecular Biology (JMB), Vol. 301, 2000, Nr. 4, pp. 1003 – 1017
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Nuclear magnetic resonance methods to study RNA-protein complexesIn: Methods in Enzymology, Vol. 317: RNA - Ligand Interactions, Part A, 2000, pp. 198 – 220
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Solution structures of human parathyroid hormone fragments hPTH(1-34) and hPTH(1-39) and bovine parathyroid hormone fragment bPTH(1-37)In: Biochemical and Biophysical Research Communications (BBRC), Vol. 267, 2000, Nr. 1, pp. 213 – 220
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Book Review: Protein Structure: Determination, Analysis, and Applications for Drug Discovery. Edited by Daniel I. ChasmanIn: ChemBioChem. Weinheim: Wiley-VCH, Vol. 5, 2004, Nr. 4, pp. 547 – 548
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A molecular handshakeIn: Trends in Biochemical Sciences: Elsevier, Vol. 27, 2002, Nr. 10, pp. 502 – 503
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ATP, a trigger for pain-signalingIn: Trends in Biochemical Sciences: Elsevier, Vol. 26, 2001, Nr. 1, pp. 12
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Delta: a mitogenic regulator of human hematopoesisIn: Trends in Biochemical Sciences: Elsevier, Vol. 26, 2001, Nr. 5, pp. 281
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Living in the cytosolIn: Trends in Biochemical Sciences: Elsevier, Vol. 26, 2001, Nr. 12, pp. 702
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TonB – a mediator of iron uptake in bacteriaIn: Trends in Biochemical Sciences: Elsevier, Vol. 26, 2001, Nr. 8, pp. 472
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Super-resolution microscopy reveals the submitochondrial localization of human Par17In: FEBS Open Bio. Hoboken: Wiley, Vol. 15, 2025, Nr. S2, Special Issue: Bridging Continents to Advance Life Science, 49th FEBS Congress, 5–9 July 2025, Istanbul, TürkiyeDOI (Open Access)
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A NMR-spectra based scoring function for protein dockingIn: Proceedings of the Fifth Annual International Conference on Computational Biology / RECOMB01: The Fifth Annual International Conference on Computational Molecular Biology, Montreal, Quebec, Canada, April 22 - 25, 2001 / Lengauer, Thomas (Eds.). New York: ACM, 2001, pp. 184 – 192
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HumanbiologieStuttgart: Ulmer, 2014
(UTB ; 4130) -
Rationally designed DNA-origami hosts for protein guest
Nantech2019, Nucleic Acid Nanotechnology: from algorithmic design to biochemical applications, Aalto University, Espoo, Finland May 27-29, 2019,2019