Faculty of Biology

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Dr. Manuela Wülling

Address
Universitätsstr 2
45117 Essen
Room
S05 V01 E46
Phone
+49 201 183 2297
E-Mail
manuela.wuelling@uni-due.de

Functions

  • Akademische/r Rätin/Rat, Entwicklungsbiologie

The following publications are listed in the online university bibliography of the University of Duisburg-Essen. Further information may also be found on the person's personal web pages.

    Journal articles

  • Neu, Christoph; Wülling, Manuela; Waterkamp, Christoph; Hoffmann, Daniel; Vortkamp, Andrea
    Bath : A Bayesian approach to analyze epigenetic transitions reveals a dual role of H3K27me3 in chondrogenesis
    In: Epigenetics and Chromatin, Vol. 18, 2025, Nr. 1, 38
    DOI (Open Access)
  • Wülling, Manuela; Neu, Christoph; Thiesen, Andrea M.; Kitanovski, Simo; Cao, Yingying; Lange, Anja; Westendorf, Astrid; Hoffmann, Daniel; Vortkamp, Andrea
    Epigenetic mechanisms mediating cell state transitions in chondrocytes
    In: Journal of Bone and Mineral Research (JBMR), Vol. 36, 2021, Nr. 5, pp. 968 – 985
    DOI, Online Full Text (Open Access)
  • Wülling, Manuela; Schneider, Sabine; Schröther, Verena A.; Waterkamp, Christoph; Hoffmann, Daniel; Vortkamp, Andrea
    Wnt5a is a transcriptional target of Gli3 and Trps1 at the onset of chondrocyte hypertrophy
    In: Developmental Biology, Vol. 457, 2020, Nr. 1, pp. 104 – 118
    DOI (Open Access)
  • Grüneboom, Anika; Hawwari, Ibrahim; Weidner, Daniela; Culemann, Stephan; Müller, Sylvia; Henneberg, Sophie; Brenzel, Alexandra; Merz, Simon; Bornemann, Lea; Zec, Kristina; Wülling, Manuela; Kling, Lasse; Hasenberg, Mike; Voortmann, Sylvia; Lang, Stefanie; Baum, Wolfgang; Ohs, Alexandra; Kraff, Oliver; Quick, Harald H.; Jäger, Marcus; Landgraeber, Stefan; Dudda, Marcel; Danuser, Renzo; Stein, Jens V.; Rohde, Manfred; Gelse, Kolja; Garbe, Annette I.; Adamczyk, Alexandra; Westendorf, Astrid; Hoffmann, Daniel; Christiansen, Silke; Engel, Daniel Robert; Vortkamp, Andrea; Krönke, Gerhard; Herrmann, Martin; Kamradt, Thomas; Schett, Georg; Hasenberg, Anja; Gunzer, Matthias
    A network of trans-cortical capillaries as mainstay for blood circulation in long bones
    In: Nature Metabolism, Vol. 1, 2019, Nr. 2, pp. 236 – 250
    DOI, Online Full Text (Open Access)
  • Wülling, Manuela; Vortkamp, Andrea
    A newly discovered stem cell that keeps bones growing
    In: Nature, Vol. 567, 2019, Nr. 7747, pp. 178 – 179
    DOI
  • Schröder, Nadine; Wülling, Manuela; Hoffmann, Daniel; Brand-Saberi, Beate; Vortkamp, Andrea
    Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones
    In: PLoS ONE, Vol. 14, 2019, Nr. 8, pp. e0218230
    DOI, Online Full Text (Open Access)
  • Piombo, Virginia; Jochmann, Katja; Hoffmann, Daniel; Wülling, Manuela; Vortkamp, Andrea
    Signaling systems affecting the severity of multiple osteochondromas
    In: Bone: Official Journal of the International Bone and Mineral Society (IBMS), Vol. 111, 2018, pp. 71 – 81
    DOI (Open Access)
  • Wülling, Manuela; Thiesen, Andrea M.; Vortkamp, Andrea
    Epigenetic regulation of chondrocyte differentiation
    18th International Congress of Developmental Biology, 18-22 June, Singapore,
    In: Mechanisms of Development, Vol. 145, 2017, Nr. Supplement: 18th International Congress of Developmental Biology 18-22 June, University Cultural Centre, National University of Singapore, pp. S141
    DOI
  • Kipkeew, Friederike; Kirsch, Manuela; Klein, Diana; Wülling, Manuela; Winterhager, Elke; Gellhaus, Alexandra
    CCN1 (CYR61) and CCN3 (NOV) signaling drives human trophoblast cells into senescence and stimulates migration properties
    In: Cell Adhesion & Migration, Vol. 10, 2016, Nr. 1-2, pp. 163 – 178
    DOI, Online Full Text (Open Access)
  • Kirsch, Michael; Kipkeew, Friederike; Klein, Diana; Wülling, Manuela; Winterhager, Elke; Gellhaus, Alexandra
    CCN3 signaling is dysregulated in the pregnancy disorder preeclampsia
    In: Journal of Reproductive Immunology, Vol. 115, 2016, pp. 71 – 71
    DOI
  • Mattheij, Nadine J. A.; Kunzelmann, Karl; Vortkamp, Andrea; Schreiber, Rainer; Köhler, Ralf; Wülling, Manuela; Nieswandt, Bernhard; Pircher, Joachim; Castoldi, Elisabetta; van Kruchten, Roger; Braun, Attila
    Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage
    In: The FASEB Journal, Vol. 30, 2016, Nr. 2, pp. 727 – 737
    DOI
  • Ousingsawat, Jiraporn; Wanitchakool, Podchanart; Schreiber, Rainer; Wülling, Manuela; Vortkamp, Andrea; Kunzelmann, Karl
    Anoctamin-6 Controls Bone Mineralization by Activating the Calcium Transporter NCX1
    In: The Journal of Biological Chemistry (JBC), Vol. 290, 2015, Nr. 10, pp. 6270 – 6280
    DOI (Open Access)
  • Kipkeew, Friederike; Klein, Diana; Wülling, Manuela; Whitley, Guy; Köninger, Angela; Winterhager, Elke; Gellhaus, Alexandra
    CCN3 (NOV) : A key player in trophoblast differentiation promoting cell cycle exit and migration of extravillous trophoblast cells and its role in preeclampsia
    In: Placenta, Vol. 35, 2014, Nr. 9, pp. A108
    DOI
  • Dittmann, Kai; Wülling, Manuela; Uhmann, Anja; Dullin, Christian; Hahn, Heidi; Schweyer, Stefan; Vortkamp, Andrea; Wienands, Jürgen
    Inactivation of Patched1 in murine chondrocytes causes spinal fusion without inflammation
    In: Arthritis & Rheumatology, Vol. 66, 2014, Nr. 4, pp. 831 – 840
    DOI
  • Ehlen, Harald W. A.; Chinenkova, Milana; Moser, Markus; Munter, Hans-Markus; Krause, Yvonne Stefanie; Gross, Stefanie; Brachvogel, Bent; Wülling, Manuela; Kornak, Uwe; Vortkamp, Andrea
    Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues
    In: Journal of Bone and Mineral Research (JBMR), Vol. 28, 2013, Nr. 2, pp. 246 – 259
    DOI
  • Wülling, Manuela; Pasdziernik, Markus; Moll, Carina; Thiesen, Andrea; Schneider, Sabine; Johannes, Christian; Vortkamp, Andrea
    The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosis
    In: Cell Cycle, Vol. 12, 2013, Nr. 14, pp. 2219 – 2232
    DOI
  • Gross, Stefanie; Krause, Yvonne Stefanie; Wülling, Manuela; Vortkamp, Andrea
    Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice
    In: PLoS ONE, Vol. 7, 2012, Nr. 8, pp. e43553
    DOI, Online Full Text (Open Access)
  • Galli, Giorgio Giacomo; Honnens de Lichtenberg, Kristian; Carrara, Matteo; Hans, Wolfgang; Wülling, Manuela; Mentz, Bettina; Multhaupt, Hinke Arnolda; Fog, Cathrine Kolster; Jensen, Klaus Thorleif; Rappsilber, Juri; Vortkamp, Andrea; Coulton, Les; Fuchs, Helmut; Gailus-Durner, Valérie; Hrabě de Angelis, Martin; Calogero, Raffaele Adolfo; Couchman, John Robert; Lund, Anders Henrik
    Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing Bone
    In: PLoS Genetics, Vol. 8, 2012, Nr. 5, pp. e1002711
    DOI (Open Access)
  • Friedrichs, Melanie; Wirsdöerfer, Florian; Flohe, Stefanie; Schneider, Sabine; Wülling, Manuela; Vortkamp, Andrea
    BMP signaling balances proliferation and differentiation of muscle satellite cell descendants.
    In: BMC Cell Biology, Vol. 12, 2011, 26
    DOI, Online Full Text (Open Access)
  • Detsch, Rainer; Hagmeyer, Daniel; Neumann, Markus C; Schaefer, Susannne; Vortkamp, Andrea; Wülling, Manuela; Ziegler, Günter; Epple, Matthias
    The resorption of nanocrystalline calcium phosphates by osteoclast-like cells
    In: Acta Biomaterialia, Vol. 6, 2010, Nr. 8, pp. 3223 – 3233
    DOI
  • Wülling, Manuela; Vortkamp, Andrea
    Transcriptional networks controlling chondrocyte proliferation and differentiation during endochondral ossification.
    In: Pediatric Nephrology, Vol. 25, 2010, Nr. 4, pp. 625 – 631
    DOI
  • Wülling, Manuela; Kaiser, Frank J.; Buelens, Laetitia; Braunholz, Diana; Shivdasani, Ramesh A.; Depping, Reinhard; Vortkamp, Andrea
    Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3
    In: Developmental Biology, Vol. 328, 2009, Nr. 1, pp. 40 – 53
    DOI
  • Kantaputra, P.; Miletich, I.; Lüdecke, Hermann-Josef; Suzuki, E. Y.; Praphanphoj, V.; Shivdasani, R.; Wülling, Manuela; Vortkamp, Andrea; Napierala, D.; Sharpe, P. T.
    Tricho-rhino-phalangeal syndrome with supernumerary teeth
    In: Journal of Dental Research: JDR Online, Vol. 87, 2008, Nr. 11, pp. 1027 – 1031
    DOI
  • Tagariello, A.; Luther, J.; Streiter, M.; Didt-Koziel, L.; Wülling, Manuela; Surmann-Schmitt, C.; Stock, M.; Adam, N.; Vortkamp, Andrea; Winterpacht, A.
    Ucma - A novel secreted factor represents a highly specific marker for distal chondrocytes
    In: Matrix Biology, Vol. 27, 2008, Nr. 1, pp. 3 – 11
    DOI
  • Didt-Koziel, L.; Wülling, Manuela; Vortkamp, Andrea
    The role of growth factors in chondrogenesis and osteogenesis
    In: Current Opinion in Orthopaedics, Vol. 17, 2006, pp. 405 – 411
    DOI
  • Didt-Koziel, L.; Wülling, Manuela; Schneider, Sabine; Vortkamp, Andrea
    Gli3 has repressing and activating functions downstream of Ihh in regulating two distinct steps of chondrocyte differentiation
    In: Development / Company of Biologists, Vol. 132, 2005, Nr. 23, pp. 5249 – 5260
    DOI
  • Wülling, Manuela; Vortkamp, Andrea
    Model systems for human muscoskeletal diseases
    In: Drug Discovery Today: Disease Models, Vol. 1, 2004, Nr. 3, pp. 359 – 364
    DOI

    • Abstracts

  • Wülling, Manuela; Neu, Christoph; Kitanovski, Simo; Cao, Ying Ying; Lange, Anja; Johnstone, B.; Hoffmann, Daniel; Vortkamp, Andrea
    Epigenetic profiling of articular chondrocytes
    OARSI World Congress on Osteoarthritis, 29.04.-01.05.2021, Virtual,
    In: Osteoarthritis and Cartilage. Amsterdam: Elsevier, Vol. 29, 2021, Nr. Suppl. 1: Abstracts from the Virtual 2021 OARSI World Congress on Osteoarthritis, pp. 309
    DOI (Open Access)
  • Kipkeew, Friederike; Winterhager, Elke; Whitley, Guy; Klein, Diana; Wülling, Manuela; Gellhaus, Alexandra
    Matricellular CCN1 and CCN3 proteins are key regulators at the fetal-maternal interface by promoting cell cycle exit and migration of extravillous trophoblast cells
    In: Placenta. Amsterdam: Elsevier, Vol. 34, 2013, pp. A87
    DOI
  • Galli, G. G.; de Lichtenberg, K. H.; Wülling, Manuela; Calogero, R.; Lund, A. H.
    The transcription factor PRDM5 is involved in endochondral bone formation by regulating collagen I in vivo
    In: Bone: Official Journal of the International Bone and Mineral Society (IBMS). Amsterdam; Amsterdam: Elsevier, Vol. 48, 2011, Nr. Suppl. 2, pp. S110
    DOI

    • Book articles / Proceedings papers

  • Wülling, Manuela; Vortkamp, Andrea
    Murine Limb Explant Cultures to Assess Cartilage Development
    In: Skeletal Development and Repair: Methods and Protocols / Hilton, Matthew J. (Eds.). Berlin: Springer Nature, 2021, pp. 139 – 149
    DOI
  • Wülling, Manuela; Vortkamp, Andrea
    Molecular control of cartilage differentiation
    In: Cartilage: Volume 1: Physiology and Development / Grässel, Susanne; Aszódi, Attila (Eds.). Cham: Springer International Publishing, 2016, pp. 191 – 213
    DOI
  • Wülling, Manuela; Vortkamp, Andrea
    Cartilage explant cultures
    In: Skeletal Development and Repair: Methods and Protocols. Totowa, NJ: Humana Press, 2014, pp. 89 – 97
    DOI
  • Wülling, Manuela; Vortkamp, Andrea
    Chondrocyte proliferation and differentiation
    In: Cartilage and bone development and its disorders: 3 Tables / Camacho-Hübner, Cecilia; Nilsson, Ola G.; Sävendahl, Lars; 4th ESPE Advanced Seminar in Developmental Endocrinology, Stockholm, June 30 - July 1, 2010. Basel [u.a.]: S. Karger AG, 2011, pp. 1 – 11