Faculty of Biology

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Prof. Dr. Markus Kaiser

Fakultät Biologie, ZMB, Chemische Biologie

Address
Universitätsstr 2
45117 Essen
Room
S03 S02 A55
Phone
+49 201 183 4980
Fax
+49 201 183 4982
E-Mail
markus.kaiser@uni-due.de
Website
https://www.uni-due.de/zmb/chemical-biology/

Functions

  • Vorsitzender, Promotionsausschuss Fakultät Biologie

  • Professor/in, Chemische Biologie

The following publications are listed in the online university bibliography of the University of Duisburg-Essen. Further information may also be found on the person's personal web pages.

    Journal articles

  • Sewald, Leonard; Molke, Niko; Tabak, Werner W. A.; Haak, Anette; Najdzion, Maja; Geiss-Friedlander, Ruth; Hellerschmied, Doris; Huber, Robert; Kaiser, Markus
    A Photocaged N-Phosphonopiperidinone as a Selective Photo-Cleavable DPP8/9 Inhibitor
    In: ChemBioChem, Vol. 26, 2025, Nr. 19, e202500558
    DOI (Open Access)
  • Reinders, Maike; Kravic, Bojana; Gahlot, Pinki; Koska, Sandra; van den Boom, Johannes; Schulze, Nina; Levantovsky, Sophie; Kleine, Stefan; Kaiser, Markus; Kulathu, Yogesh; Behrends, Christian; Meyer, Hemmo
    ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains
    In: The EMBO Journal, Vol. 44, 2025, Nr. 18, pp. 5086 – 5111
    DOI (Open Access)
  • Schmerling, Christian; Schroeder, Carsten; Zhou, Xiaoxiao; Bost, Jan; Waßmer, Bianca; Ninck, Sabrina; Busche, Tobias; Montero, Lidia; Kaschani, Farnusch; Schmitz, Oliver J.; Kalinowski, Jörn; Kaiser, Markus; Albers, Sonja-Verena; Bräsen, Christopher; Siebers, Bettina
    An unusual glycerol-3-phosphate dehydrogenase in Sulfolobus acidocaldarius elucidates the diversity of glycerol metabolism across Archaea
    In: Communications Biology, Vol. 8, 2025, Nr. 1, 539
    DOI (Open Access)
  • Sanguankiattichai, Nattapong; Chandrasekar, Balakumaran; Sheng, Yuewen; Hardenbrook, Nathan; Tabak, Werner W.A.; Drapal, Margit; Kaschani, Farnusch; Grünwald-Gruber, Clemens; Krahn, Daniel; Buscaill, Pierre; Yamamoto, Suzuka; Kato, Atsushi; Nash, Robert; Fleet, George; Strasser, Richard; Fraser, Paul D.; Kaiser, Markus; Zhang, Peijun; Preston, Gail M.; van der Hoorn, Renier A.L.
    Bacterial pathogen deploys the iminosugar glycosyrin to manipulate plant glycobiology
    In: Science, Vol. 388, 2025, Nr. 6744, pp. 297 – 303
    DOI
  • Brenner, Joel Cyrille; Zirden, Linda; Almeida-Hernandez, Yasser; Kaschani, Farnusch; Kaiser, Markus; Sanchez-Garcia, Elsa; Poepsel, Simon; Hellerschmied-Jelinek, Doris
    Conformational plasticity of a BiP-GRP94 chaperone complex
    In: Nature Structural & Molecular Biology, Vol. 32, 2025, Nr. 10, pp. 1947 – 1958
    DOI (Open Access)
  • Langer, Mona-May; Guckenbiehl, Sabrina; Bauschen, Alina; Stadler, Helena; Kaschani, Farnusch; Kaiser, Markus; Walkenfort, Bernd; Wedemeyer, Heiner; Lange, Christian M.
    Extracellular vesicles of patients with acute-on-chronic liver failure induce mitochondrial dysfunction in T cells
    In: Frontiers in Immunology, Vol. 16, 2025, 1656692
    DOI (Open Access)
  • Sowislok, Andrea; Gruber, Gerrit; Kaschani, Farnusch; Kaiser, Markus; Papaeleftheriou, Eleftherios; Jäger, Marcus
    Intraoperative Biologization of β-TCP and PCL-TCP by Autologous Proteins
    In: Journal of Functional Biomaterials, Vol. 16, 2025, Nr. 9, 340
    DOI, Online Full Text (Open Access)
  • Salguero-Linares, Jose; Armengot, Laia; Ayet, Joel; Ruiz-Solaní, Nerea; Saile, Svenja C; Salas-Gómez, Marta; Fernandez, Esperanza; Denolf, Lode; Navarrete, Fernando; Krumbach, Jenna; Kaiser, Markus; Stael, Simon; Van Breusegem, Frank; Gevaert, Kris; Kaschani, Farnusch; Petersen, Morten; El Kasmi, Farid; Valls, Marc; Coll, Núria S
    Lack of AtMC1 catalytic activity triggers autoimmunity dependent on NLR stability
    In: EMBO Reports, Vol. 26, 2025, Nr. 9, pp. 2378 – 2412
    DOI (Open Access)
  • Katz, Liora S.; Visser, Emira J.; Plitzko, Kathrin F.; Pennings, Marloes A. M.; Cossar, Peter J.; Tse, Isabelle L.; Kaiser, Markus; Brunsveld, Luc; Ottmann, Christian; Scott, Donald K.
    Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity
    In: Nature Communications, Vol. 16, 2025, Nr. 1, 2110
    DOI (Open Access)
  • Führer, Siska; Gallant, Kai; Kaschani, Farnusch; Kaiser, Markus; Janning, Petra; Waldmann, Herbert; Gersch, Malte
    Small Molecule-Induced Alterations of Protein Polyubiquitination Revealed by Mass-Spectrometric Ubiquitome Analysis
    In: Angewandte Chemie International Edition, Vol. 64, 2025, Nr. 32, e202508916
    DOI (Open Access)
  • Sewald, Leonard; Tabak, Werner W. A.; Fehr, Lorenz; Zolg, Samuel; Najdzion, Maja; Verhoef, Carlo J. A.; Podlesainski, David; Geiss-Friedlander, Ruth; Lammens, Alfred; Kaschani, Farnusch; Hellerschmied, Doris; Huber, Robert; Kaiser, Markus
    Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors
    In: Nature Communications, Vol. 16, 2025, Nr. 1, 3208
    DOI (Open Access)
  • Sternberg, Anna; Borger, Jennifer Lynne; Thies, Mathilda; Matena, Anja; Blüggel, Mike; Kamba, Bianca; Beuck, Christine; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter
    The Actin‐Binding Prolyl‐Isomerase Par17 Sustains Its Substrate Selectivity by Interdomain Allostery
    In: Proteins: Structure, Function and Genetics, Vol. 93, 2025, Nr. 9, pp. 1481 – 1497
    DOI (Open Access)
  • Zhang, Weiqi; Planas-Marquès, Marc; Liang, Moyan; Zhang, Qingshan; Vermeulen, Annemarie; Kaschani, Farnusch; Kaiser, Markus; Takken, Frank L W; Coll, Nuria S; Valls, Marc
    The CAPE1 peptide confers resistance against bacterial wilt in tomato
    In: Journal of Experimental Botany (JEB), Vol. 76, 2025, Nr. 15, pp. 4340 – 4358
    DOI (Open Access)
  • Hagemeier, Birte; Ripkens, Kamilla; Schulze, Nina; Bluemke, Anika; Strzala, Michal; Koci, Michelle; Kaschani, Farnusch; Kaiser, Markus; Erkelenz, Michael; Schluecker, Sebastian; Merdanovic, Melisa; Poepsel, Simon; Hellerschmied, Doris; Burston, Steven G.; Ehrmann, Michael
    The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations
    In: The Journal of Biological Chemistry (JBC), Vol. 301, 2025, Nr. 10, 110729
    DOI, Online Full Text (Open Access)
  • Huang, Jing; Jaekel, Andreas; van den Boom, Johannes; Podlesainski, David; Elnaggar, M.; Heuer-Jungemann, A.; Kaiser, Markus; Meyer, Hemmo; Saccà, Barbara
    A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathway
    In: Nature Nanotechnology, Vol. 19, 2024, Nr. 10, pp. 1521 – 1531
    DOI (Open Access)
  • Sueldo, Daniela J.; Godson, Alice; Kaschani, Farnusch; Krahn, Daniel; Kessenbrock, Till; Buscaill, Pierre; Schofield, Christopher J.; Kaiser, Markus; van der Hoorn, Renier A. L.
    Activity-based proteomics uncovers suppressed hydrolases and a neo-functionalised antibacterial enzyme at the plant–pathogen interface
    In: New Phytologist, Vol. 241, 2024, Nr. 1, pp. 394 – 408
    DOI (Open Access)
  • Präve, Leonard; Kuttenlochner, Wolfgang; Tabak, Werner W.A.; Langer, Chiara; Kaiser, Markus; Groll, Michael; Bode, Helge B.
    Bioengineering of syrbactin megasynthetases for immunoproteasome inhibitor production
    In: Chem, Vol. 10, 2024, Nr. 10, pp. 3212 – 3223
    DOI (Open Access)
  • Kaplieva-Dudek, I.; Samak, Nadia; Bormann, Jenny; Kaschani, Farnusch; Kaiser, Markus; Meckenstock, Rainer
    Characterization of 2-phenanthroate:CoA ligase from the sulfate-reducing, phenanthrene-degrading enrichment culture TRIP
    In: Applied and Environmental Microbiology, Vol. 90, 2024, Nr. 10, e0129624
    DOI (Open Access)
  • Sowislok, Andrea; Busch, André; Kaschani, Farnusch; Kaiser, Markus; Jäger, Marcus
    Differences in the Synovial Fluid Proteome of Septic and Aseptic Implant Failure
    In: Antibiotics, Vol. 13, 2024, Nr. 4, 346
    DOI, Online Full Text (Open Access)
  • Font-Farre, Maria; Brown, Daniel; Toth, Reka; Mahadevan, Chidambareswaren; Brazier-Hicks, Melissa; Morimoto, Kyoko; Kaschani, Farnusch; Sinclair, John; Dale, Richard; Hall, Samantha; Morris, Melloney; Kaiser, Markus; Wright, Aaron T.; Burton, Jonathan; van der Hoorn, Renier A. L.
    Discovery of active mouse, plant and fungal cytochrome P450s in endogenous proteomes and upon expression in planta
    In: Scientific Reports, Vol. 14, 2024, Nr. 1, 10091
    DOI (Open Access)
  • Ninck, Sabrina; Klaus, Thomas; Kochetkova, Tatiana V.; Esser, Sarah P.; Sewald, Leonard; Kaschani, Farnusch; Bräsen, Christopher; Probst, Alexander J.; Kublanov, Ilya V.; Siebers, Bettina; Kaiser, Markus
    Environmental activity-based protein profiling for function-driven enzyme discovery from natural communities
    In: Environmental Microbiomes, Vol. 19, 2024, Nr. 1, 36
    DOI, Online Full Text (Open Access)
  • Chen, Changlong; Buscaill, Pierre; Sanguankiattichai, Nattapong; Huang, Jie; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A. L.
    Extracellular plant subtilases dampen cold-shock peptide elicitor levels
    In: Nature Plants, Vol. 10, 2024, Nr. 11, pp. 1749 – 1760
    DOI (Open Access)
  • Parsons, Jack D.; Cocker, Clare R.; East, Alison K.; Wheatley, Rachel M.; Ramachandran, Vinoy K.; Kaschani, Farnusch; Kaiser, Markus; Poole, Philip S.
    Factors governing attachment of Rhizobium leguminosarum to legume roots at acid, neutral, and alkaline pHs
    In: mSystems, Vol. 9, 2024, Nr. 9, e0042224
    DOI (Open Access)
  • Font Farre, Maria; Brown, Daniel; König, Maurice; Killinger, Brian J.; Kaschani, Farnusch; Kaiser, Markus; Wright, Aaron T.; Burton, Jonathan; van der Hoorn, Renier A.L.
    Glutathione Transferase Photoaffinity Labeling Displays GST Induction by Safeners and Pathogen Infection
    In: Plant and Cell Physiology, Vol. 65, 2024, Nr. 1, pp. 128 – 141
    DOI (Open Access)
  • Schillinger, Jasmin; Koci, Michelle; Bravo-Rodriguez, Kenny; Heilmann, Geronimo; Kaschani, Farnusch; Kaiser, Markus; Beuck, Christine; Luecke, Hartmut; Huber, Robert; Hellerschmied-Jelinek, Doris; Burston, Steven G.; Ehrmann, Michael
    High resolution analysis of proteolytic substrate processing
    In: The Journal of Biological Chemistry (JBC), Vol. 300, 2024, Nr. 11, 107812
    DOI, Online Full Text (Open Access)
  • Pol, Savina Abraham; Liljenberg, Sara; Barr, Jack; Simon, Gina; Wong-Dilworth, Luis; Paterson, Danielle L.; Berishvili, Vladimir P.; Bottanelli, Francesca; Kaschani, Farnusch; Kaiser, Markus; Pettersson, Mariell; Hellerschmied, Doris
    Induced degradation of SNAP-fusion proteins
    In: RSC Chemical Biology, Vol. 5, 2024, Nr. 12, pp. 1232 – 1247
    DOI (Open Access)
  • Pleuger, Richard; Cozma, Christian; Hohoff, Simone; Denkhaus, Christian; Dudziak, Alexander; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Vetter, Ingrid R.; Westermann, Stefan
    Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor
    In: Current Biology, Vol. 34, 2024, Nr. 11, pp. 2279 – 2293.e6
    DOI (Open Access)
  • Beaufort, Nathalie; Ingendahl, Linda; Merdanovic, Melisa; Schmidt, Andree; Podlesainski, David; Richter, Tim; Neumann, Thorben; Kuszner, Michael; Vetter, Ingrid R.; Stege, Patricia; Burston, Steven G.; Filipovic, Anto; Ruiz-Blanco, Yasser B.; Bravo Rodriguez, Kenny; Mieres-Perez, Joel; Beuck, Christine; Uebel, Stephan; Zobawa, Monika; Schillinger, Jasmin; Malik, Rainer; Todorov-Völgyi, Katalin; Rey, Juliana; Roberti, Annabell; Hagemeier, Birte; Wefers, Benedikt; Müller, Stephan A.; Wurst, Wolfgang; Sanchez-Garcia, Elsa; Zimmermann, Alexander; Hu, Xiao-Yu; Clausen, Tim; Huber, Robert; Lichtenthaler, Stefan F.; Schmuck, Carsten; Giese, Michael; Kaiser, Markus; Ehrmann, Michael; Dichgans, Martin
    Rational correction of pathogenic conformational defects in HTRA1
    In: Nature Communications, Vol. 15, 2024, Nr. 1, 5944
    DOI (Open Access)
  • Shen, Lu; Peraglie, Carmen; Podlesainski, David; Stracke, Christina; Ojha, Ravi Shankar; Caliebe, Frauke; Kaiser, Markus; Forchhammer, Karl; Hagemann, Martin; Gutekunst, Kirstin; Snoep, Jacky L.; Bräsen, Christopher; Siebers, Bettina
    Structure function analysis of ADP-dependent cyanobacterial phosphofructokinase reveals new phylogenetic grouping in the PFK-A family
    In: The Journal of Biological Chemistry (JBC), Vol. 300, 2024, Nr. 11, 107868
    DOI, Online Full Text (Open Access)
  • Buscaill, Pierre; Sanguankiattichai, Nattapong; Kaschani, Farnusch; Huang, Jie; Mooney, Brian C.; Li, Yuge; Lyu, Joy; Sueldo, Daniela; Kaiser, Markus; van der Hoorn, Renier A. L.
    Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast
    In: Nature Communications, Vol. 15, 2024, Nr. 1, 10431
    DOI (Open Access)
  • Podlesainski, David; Adeniyi, Emmanuel T.; Gröner, Yvonne; Schulz, Florian; Krisilia, Violetta; Rehberg, Nidja; Richter, Tim; Sehr, Daria; Xie, Huzhuyue; Simons, Viktor E.; Kiffe-Delf, Anna-Lene; Kaschani, Farnusch; Ioerger, Thomas R.; Kaiser, Markus; Kalscheuer, Rainer
    The anti-tubercular callyaerins target the Mycobacterium tuberculosis-specific non-essential membrane protein Rv2113
    In: Cell Chemical Biology, Vol. 31, 2024, Nr. 10, pp. 1755 – 1771.e73
    DOI (Open Access)
  • Zheng, Kaijie; Lyu, Joy C.; Thomas, Emma L.; Schuster, Mariana; Sanguankiattichai, Nattapong; Ninck, Sabrina; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A. L.
    The proteome of Nicotiana benthamiana is shaped by extensive protein processing
    In: New Phytologist, Vol. 243, 2024, Nr. 3, pp. 1034 – 1049
    DOI (Open Access)
  • Day, Matthew; Tetik, Bilal; Parlak, Milena; Almeida-Hernández, Yasser; Räschle, Markus; Kaschani, Farnusch; Siegert, Heike; Marko, Anika; Sanchez-Garcia, Elsa; Kaiser, Markus; Barker, Isabel A.; Pearl, Laurence H.; Oliver, Antony W.; Boos, Dominik
    TopBP1 utilises a bipartite GINS binding mode to support genome replication
    In: Nature Communications, Vol. 15, 2024, Nr. 1, 1797
    DOI, Online Full Text (Open Access)
  • Merle, David A.; Sen, Merve; Armento, Angela; Stanton, Chloe M.; Thee, Eric F.; Meester-Smoor, Magda A.; Kaiser, Markus; Clark, Simon J.; Klaver, Caroline C.W.; Keane, Pearse A.; Wright, Alan F.; Ehrmann, Michael; Ueffing, Marius
    10q26 – The enigma in age-related macular degeneration
    In: Progress in Retinal and Eye Research, Vol. 96, 2023, 101154
    DOI (Open Access)
  • Ninck, Sabrina; Halder, Vivek; Krahn, Jan; Beisser, Daniela; Resch, Sarah; Dodds, Isobel; Scholtysik, René; Bormann, Jenny; Sewald, Leonard; Gupta, Mainak D.; Heilmann, Geronimo; Bhandari, Deepak D.; Morimoto, Kyoko; Buscaill, Pierre; Hause, Bettina; van der Hoorn, Renier A. L.; Kaschani, Farnusch; Kaiser, Markus
    Chemoproteomics Reveals the Pan-HER Kinase Inhibitor Neratinib To Target an Arabidopsis Epoxide Hydrolase Related to Phytohormone Signaling
    In: ACS Chemical Biology, Vol. 18, 2023, Nr. 5, pp. 1076 – 1088
    DOI
  • Hoi, David M.; Junker, Sabryna; Junk, Lukas; Schwechel, Kristin; Fischel, Katharina; Podlesainski, David; Hawkins, Paige M.E.; van Geelen, Lasse; Kaschani, Farnusch; Leodolter, Julia; Morreale, Francesca Ester; Kleine, Stefan; Guha, Somraj; Rumpel, Klaus; Schmiedel, Volker M.; Weinstabl, Harald; Meinhart, Anton; Payne, Richard J.; Kaiser, Markus; Hartl, Markus; Boehmelt, Guido; Kazmaier, Uli; Kalscheuer, Rainer; Clausen, Tim
    Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival
    In: Cell, Vol. 186, 2023, Nr. 10, pp. 2176 – 2192.e22
    DOI (Open Access)
  • Schuster, Mariana; Eisele, Sophie; Armas-Egas, Liz; Kessenbrock, Till; Kourelis, Jiorgos; Kaiser, Markus; van der Hoorn, Renier A. L.
    Enhanced late blight resistance by engineering an EpiC2B-insensitive immune protease
    In: Plant Biotechnology Journal, Vol. 22, 2023, Nr. 2, pp. 284 – 286
    DOI (Open Access)
  • Fehr, Lorenz; Sewald, Leonard; Huber, Robert; Kaiser, Markus
    Facile Multicomponent Synthesis of Oxazolidinones from Primary Amines and Cesium (Hydrogen)Carbonate
    In: European Journal of Organic Chemistry, Vol. 26, 2023, Nr. 27, e202300135
    DOI (Open Access)
  • Andlovic, Blaž; Heilmann, Geronimo; Ninck, Sabrina; Andrei, Sebastian A.; Centorrino, Federica; Higuchi, Yusuke; Kato, Nobuo; Brunsveld, Luc; Arkin, Michelle; Menninger, Sascha; Choidas, Axel; Wolf, Alexander; Klebl, Bert; Kaschani, Farnusch; Kaiser, Markus; Eickhoff, Jan; Ottmann, Christian
    IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization
    In: Cell Chemical Biology, Vol. 30, 2023, Nr. 6, pp. 573 – 590.e6
    DOI, Online Full Text (Open Access)
  • Blüggel, Mike; Kröning, Alexander; Kracht, Matthias; van den Boom, Johannes; Dabisch, Matthias; Göhring, Anna; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter; Meyer, Hemmo; Beuck, Christine
    The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase
    In: Nature Communications, Vol. 14, 2023, Nr. 1, 3258
    DOI, Online Full Text (Open Access)
  • Kiselev, Andrei; Camborde, Laurent; Carballo, Laura Ossorio; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A. L.; Gaulin, Elodie
    The root pathogen Aphanomyces euteiches secretes modular proteases in pea apoplast during host infection
    In: Frontiers in Plant Science (FPLS), Vol. 14, 2023, 1140101
    DOI (Open Access)
  • Klaus, Thomas; Ninck, Sabrina; Albersmeier, Andreas; Busche, Tobias; Wibberg, Daniel; Jiang, Jianbing; Elcheninov, Alexander G.; Zayulina, Kseniya S.; Kaschani, Farnusch; Bräsen, Christopher; Overkleeft, Herman S.; Kalinowski, Jörn; Kublanov, Ilya V.; Kaiser, Markus; Siebers, Bettina
    Activity-Based Protein Profiling for the Identification of Novel Carbohydrate-Active Enzymes Involved in Xylan Degradation in the Hyperthermophilic Euryarchaeon Thermococcus sp. Strain 2319x1E
    In: Frontiers in Microbiology, Vol. 12, 2022, 734039
    DOI, Online Full Text (Open Access)
  • Morreale, Francesca E.; Kleine, Stefan; Leodolter, Julia; Junker, Sabryna; Hoi, David M.; Ovchinnikov, Stepan; Okun, Anastasia; Kley, Juliane; Kurzbauer, Robert; Junk, Lukas; Guha, Somraj; Podlesainski, David; Kazmaier, Uli; Boehmelt, Guido; Weinstabl, Harald; Rumpel, Klaus; Schmiedel, Volker M.; Hartl, Markus; Haselbach, David; Meinhart, Anton; Kaiser, Markus; Clausen, Tim
    BacPROTACs mediate targeted protein degradation in bacteria
    In: Cell, Vol. 185, 2022, Nr. 13, pp. 2338 – 2353.e18
    DOI (Open Access)
  • Carvalho, Luís A. R.; Ross, Breyan; Fehr, Lorenz; Bolgi, Oguz; Wöhrle, Svenja; Lum, Kenneth M.; Podlesainski, David; Vieira, Andreia C.; Kiefersauer, Reiner; Félix, Rita; Rodrigues, Tiago; Lucas, Susana D.; Groß, Olaf; Geiss‐Friedlander, Ruth; Cravatt, Benjamin F.; Huber, Robert; Kaiser, Markus; Moreira, Rui
    Chemoproteomics‐Enabled Identification of 4‐Oxo‐β‐Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9
    In: Angewandte Chemie International Edition, Vol. 61, 2022, Nr. 47, e202210498
    DOI (Open Access)
  • Schmerling, Christian; Sewald, Leonard; Heilmann, Geronimo; Witfeld, Frederick; Begerow, Dominik; Jensen, Kenneth; Bräsen, Christopher; Kaschani, Farnusch; Overkleeft, Herman S.; Siebers, Bettina; Kaiser, Markus
    Erratum: Author Correction: Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling (Communications biology (2022) 5 1 (1254))
    In: Communications Biology, Vol. 5, 2022, Nr. 1, pp. 1319
    DOI (Open Access)
  • Schmerling, Christian; Sewald, Leonard; Heilmann, Geronimo; Witfeld, Frederick; Begerow, Dominik; Jensen, Kenneth; Bräsen, Christopher; Kaschani, Farnusch; Overkleeft, Herman S.; Siebers, Bettina; Kaiser, Markus
    Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling
    In: Communications Biology, Vol. 5, 2022, Nr. 1, 1254
    DOI, Online Full Text (Open Access)
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander
    Persister state-directed transitioning and vulnerability in melanoma
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Nature Communications, Vol. 13, 2022, Nr. 1, pp. 35 – 36
    DOI, Online Full Text (Open Access)
  • Abreha, Kibrom B.; Alexandersson, Erik; Resjö, Svante; Lankinen, Åsa; Sueldo, Daniela; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A. L.; Levander, Fredrik; Andreasson, Erik
    Article leaf apoplast of field-grown potato analyzed by quantitative proteomics and activity-based protein profiling
    In: International Journal of Molecular Sciences (IJMS), Vol. 22, 2021, Nr. 21, 12033
    DOI (Open Access)
  • van Geelen, Lasse; Kaschani, Farnusch; Sazzadeh, Shabnam S.; Adeniyi, Emmanuel T.; Meier, Dieter; Proksch, Peter; Pfeffer, Klaus; Kaiser, Markus; Ioerger, Thomas R.; Kalscheuer, Rainer
    Correction to : Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteria
    In: Applied Microbiology and Biotechnology, Vol. 105, 2021, Nr. 14-15, pp. 6119 – 6119
    DOI (Open Access)
  • Dorsch, Madeleine; Kowalczyk, Manuela; Planque, Mélanie; Heilmann, Geronimo; Urban, Sebastian; Dujardin, Philip; Forster, Jan; Ueffing, Kristina; Nothdurft, Silke; Oeck, Sebastian; Paul, Annika; Liffers, Sven T.; Kaschani, Farnusch; Kaiser, Markus; Schramm, Alexander; Siveke, Jens T.; Winslow, Monte M.; Fendt, Sarah-Maria; Nalbant, Perihan; Grüner, Barbara M.
    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
    In: Cell Reports, Vol. 37, 2021, Nr. 8, 110056
    DOI, Online Full Text (Open Access)
  • van den Boom, Johannes; Kück, Anja; Kravic, Bojana; Müschenborn, Helen; Giesing, Maike; Pan, Dongqing; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Meyer, Hemmo
    Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly
    In: Nature Structural & Molecular Biology, Vol. 28, 2021, Nr. 12, pp. 964 – 971
    DOI
  • van der Woude, Lennard; Piotrowski, Markus; Klaasse, Gruson; Paulus, Judith K.; Krahn, Daniel; Ninck, Sabrina; Kaschani, Farnusch; Kaiser, Markus; Novák, Ondřej; Ljung, Karin; Bulder, Suzanne; van Verk, Marcel; Snoek, Basten L.; Fiers, Martijn; Martin, Nathaniel I.; van der Hoorn, Renier A. L.; Robert, Stéphanie; Smeekens, Sjef; van Zanten, Martijn
    The chemical compound ‘Heatin’ stimulates hypocotyl elongation and interferes with the Arabidopsis NIT1-subfamily of nitrilases
    In: The Plant Journal, Vol. 106, 2021, Nr. 6, pp. 1523 – 1540
    DOI (Open Access)
  • Smolin, Daniel; Tötsch, Niklas; Grad, Jean-Noël; Linders, Jürgen; Kaschani, Farnusch; Kaiser, Markus; Kirsch, Michael; Hoffmann, Daniel; Schrader, Thomas
    Accelerated trypsin autolysis by affinity polymer templates
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  • Smolin, Daniel; Tötsch, Niklas; Grad, Jean-Noël; Linders, Jürgen; Kaschani, Farnusch; Kaiser, Markus; Kirsch, Michael; Hoffmann, Daniel; Schrader, Thomas
    Accelerated trypsin autolysis by affinity polymer templates
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  • Merdanovic, Melisa; Burston, Steven G.; Schmitz, Anna Laura; Köcher, Steffen; Knapp, Stefan; Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Activation by substoichiometric inhibition
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  • Bach-Pages, Marcel; Homma, Felix; Kourelis, Jiorgos; Kaschani, Farnusch; Mohammed, Shabaz; Kaiser, Markus; van der Hoorn, Renier A. L.; Castello, Alfredo; Preston, Gail M.
    Discovering the RNA-binding proteome of plant leaves with an improved RNA interactome capture method
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  • Köcher, Steffen; Resch, Sarah; Kessenbrock, Till; Schrapp, Lukas; Ehrmann, Michael; Kaiser, Markus
    From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins : the chemical biology of Ahp-cyclodepsipeptides
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  • van Geelen, Lasse; Kaschani, Farnusch; Sazzadeh, Shabnam S.; Adeniyi, Emmanuel T.; Meier, Dieter; Proksch, Peter; Pfeffer, Klaus; Kaiser, Markus; Ioerger, Thomas R.; Kalscheuer, Rainer
    Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteria
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  • Kracht, Matthias; van den Boom, Johannes; Seiler, Jonas; Kröning, Alexander; Kaschani, Farnusch; Kaiser, Markus; Meyer, Hemmo
    Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain Adapters
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  • Sijbesma, Eline; Visser, Emira; Plitzko, Kathrin; Thiel, Philipp; Milroy, Lech-Gustav; Kaiser, Markus; Brunsveld, Luc; Ottmann, Christian
    Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions
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  • Göhring, Anna; Michin, Irina; Gerdes, Tina; Schulze, Nina; Blüggel, Mike; Rehic, Edisa; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter
    Targeting of parvulin interactors by diazirine mediated cross-linking discloses a cellular role of human Par14/17 in actin polymerization
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  • Azizan, Asma; Kaschani, Farnusch; Barinas, Hellen; Blaskowski, Svenja; Kaiser, Markus; Denecke, Martin
    Using proteomics for an insight into the performance of activated sludge in a lab-scale WWTP
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  • Krahn, Daniel; Heilmann, Geronimo; Vogel, Felix C. E.; Papadopoulos, Chrisovalantis; Zweerink, Susanne; Kaschani, Farnusch; Meyer, Hemmo; Rösch, Alexander; Kaiser, Markus
    Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family
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  • Kourelis, Jiorgos; Kaschani, Farnusch; Grosse-Holz, Friederike M.; Homma, Felix; Kaiser, Markus; van der Hoorn, Renier A. L.
    A homology-guided, genome-based proteome for improved proteomics in the alloploid Nicotiana benthamiana
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  • Jutras, Philippe V.; Grosse-Holz, Friederike; Kaschani, Farnusch; Kaiser, Markus; Michaud, Dominique; Hoorn, Renier A. L. van der
    Activity-based proteomics reveals nine target proteases for the recombinant protein-stabilizing inhibitor S/CYS8 in Nicotiana benthamiana
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  • Weiss-Sadan, Tommy; Itzhak, Gal; Kaschani, Farnusch; Yu, Zhanru; Mahameed, Mohamed; Anaki, Adi; Ben-Nun, Yael; Merquiol, Emmanuelle; Tirosh, Boaz; Kessler, Benedikt; Kaiser, Markus; Blum, Galia
    Cathepsin L regulates metabolic networks controlling rapid cell growth and proliferation
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  • Weiss-Sadan, Tommy; Maimoun, David; Oelschlagel, Diana; Kaschani, Farnusch; Misiak, Danny; Gaikwad, Hanmant; Ben-Nun, Yael; Merquiol, Emmanuelle; Anaki, Adi; Tsvirkun, Darya; Kaiser, Markus; Michl, Patrick; Gotsman, Israel; Blum, Galia
    Cathepsins Drive Anti-Inflammatory Activity by Regulating Autophagy and Mitochondrial Dynamics in Macrophage Foam Cells
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  • Bongard, Jens; Schmitz, Anna Laura; Wolf, Alex; Zischinsky, Gunther; Pieren, Michel; Schellhorn, Birgit; Bravo-Rodriguez, Kenny; Schillinger, Jasmin; Koch, Uwe; Nussbaumer, Peter; Klebl, Bert; Steinmann, Jörg; Buer, Jan; Sánchez-García, Elsa; Ehrmann, Michael; Kaiser, Markus
    Chemical Validation of DegS As a Target for the Development of Antibiotics with a Novel Mode of Action
    In: ChemMedChem, Vol. 14, 2019, Nr. 11, pp. 1074 – 1078
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  • Viñegra de la Torre, Natanael; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A L; Soppe, Wim J J; Misas Villamil, Johana C.
    Dynamic hydrolase labelling as a marker for seed quality in Arabidopsis seeds
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  • Buscaill, Pierre; Chandrasekar, Balakumaran; Sanguankiattichai, Nattapong; Kourelis, Jiorgos; Kaschani, Farnusch; Thomas, Emma L.; Morimoto, Kyoko; Kaiser, Markus; Preston, Gail M.; Ichinose, Yuki; Van Der Hoorn, Renier A.L.
    Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptides
    In: Science, Vol. 364, 2019, Nr. 6436, eaav0748
    DOI, Online Full Text (Open Access)
  • Kraiselburd, Ivana; Brüls, Thomas; Heilmann, Geronimo; Kaschani, Farnusch; Kaiser, Markus; Meckenstock, Rainer
    Metabolic reconstruction of the genome of candidate Desulfatiglans TRIP_1 and identification of key candidate enzymes for anaerobic phenanthrene degradation
    In: Environmental Microbiology, Vol. 21, 2019, Nr. 4, pp. 1267 – 1286
    DOI (Open Access)
  • Halder, Vivek; Suliman, Mohamed N S; Kaschani, Farnusch; Kaiser, Markus
    Plant chemical genetics reveals colistin sulphate as a SA and NPR1-independent PR1 inducer functioning via a p38-like kinase pathway
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  • Schulze Hüynck, Jan; Kaschani, Farnusch; van der Linde, Karina; Ziemann, Sebastian; Müller, André N.; Colby, Thomas; Kaiser, Markus; Misas Villamil, Johana C.; Doehlemann, Gunther
    Proteases underground : Analysis of the maize root apoplast identifies organ specific papain-like cysteine protease activity
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  • Morimoto, Kyoko; Cole, Kyle S.; Kourelis, Jiorgos; Witt, Collin H.; Brown, Daniel; Krahn, Daniel; Stegmann, Monika; Kaschani, Farnusch; Kaiser, Markus; Burton, Jonathan; Mohammed, Shabaz; Yamaguchi-Shinozaki, Kazuko; Weerapana, Eranthie; van der Hoorn, Renier A. L.
    Triazine probes target ascorbate peroxidases in plants
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  • Pöhler, Robert; Krahn, Jan; van den Boom, Johannes; Dobrynin, Grzegorz; Kaschani, Farnusch; Eggenweiler, Hans-Michael; Zenke, Frank T.; Kaiser, Markus; Meyer, Hemmo
    A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases
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  • Ziemann, Sebastian; Van Der Linde, Karina; Lahrmann, Urs; Acar, Beyda; Kaschani, Farnusch; Colby, Tom; Kaiser, Markus; Ding, Yezhang; Schmelz, Eric; Huffaker, Alisa; Holton, Nicholas; Zipfel, Cyril; Doehlemann, Gunther
    An apoplastic peptide activates salicylic acid signalling in maize
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    DOI, Online Full Text (Open Access)
  • Dong, Xiyang; Greening, Chris; Brüls, Thomas; Conrad, Ralf; Guo, Kun; Blaskowski, Svenja; Kaschani, Farnusch; Kaiser, Markus; Abu Laban, Nidal; Meckenstock, Rainer
    Fermentative Spirochaetes mediate necromass recycling in anoxic hydrocarbon-contaminated habitats
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  • Schillinger, Jasmin; Severin, Katharina; Kaschani, Farnusch; Kaiser, Markus; Ehrmann, Michael
    HTRA1-Dependent Cell Cycle Proteomics
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  • Bongard, Jens; Lorenz, Marian; Vetter, Ingrid R.; Stege, Patricia; Porfetye, Arthur T.; Schmitz, Anna Laura; Kaschani, Farnusch; Wolf, Alex; Koch, Uwe; Nussbaumer, Peter; Klebl, Bert; Kaiser, Markus; Ehrmann, Michael
    Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent Probes
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  • Halder, Vivek; Oeljeklaus, Julian; Heilmann, Geronimo; Krahn, Jan; Liu, Yanlin; Xiong, Yan; Schlicht, Markus; Schillinger, Jasmin; Kracher, Barbara; Ehrmann, Michael; Kombrink, Erich; Kaschani, Farnusch; Kaiser, Markus
    Identification of the Natural Product RotihibinA as a TOR Kinase Signaling Inhibitor by Unbiased Transcriptional Profiling
    In: Chemistry - A European Journal, Vol. 24, 2018, Nr. 48, pp. 12500 – 12504
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  • Santos, Rita B.; Chandrasekar, Balakumaran; Mandal, Manoj K.; Kaschani, Farnusch; Kaiser, Markus; Both, Leonard; van der Hoorn, Renier A. L.; Schiermeyer, Andreas; Abranches, Rita
    Low Protease Content in Medicago truncatula Cell Cultures Facilitates Recombinant Protein Production
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  • Yilmaz, Elvan; Bier, David; Guillory, Xavier; Briels, Jeroen; Ruiz-Blanco, Yasser B.; Sánchez-García, Elsa; Ottmann, Christian; Kaiser, Markus
    Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular “Lysine Wrapping” of Oligoethylene Glycol (OEG) Moieties in Proteins
    In: Chemistry - A European Journal, 2018
    DOI, Online Full Text (Open Access)
  • Husaini, Amjad M; Morimoto, Kyoko; Chandrasekar, Balakumaran; Kelly, Steven; Kaschani, Farnusch; Palmero, Daniel; Jiang, Jianbing; Kaiser, Markus; Ahrazem, Oussama; Overkleeft, Hermen S; van der Hoorn, Renier A L
    Multiplex Fluorescent, Activity-Based Protein Profiling Identifies Active α-Glycosidases and Other Hydrolases in Plants
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    DOI, Online Full Text (Open Access)
  • Planas-Marquès, Marc; Bernardo-Faura, Martí; Paulus, Judith; Kaschani, Farnusch; Kaiser, Markus; Valls, Marc; Van Der Hoorn, Renier A. L.; Coll, Núria S.
    Protease Activities Triggered by Ralstonia solanacearum Infection in Susceptible and Tolerant Tomato Lines
    In: Molecular and Cellular Proteomics (MCP), Vol. 17, 2018, Nr. 6, pp. 1112 – 1125
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  • Grosse-Holz, Friederike; Kelly, Steven; Blaskowski, Svenja; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A.L.
    The transcriptome, extracellular proteome and active secretome of agroinfiltrated Nicotiana benthamiana uncover a large, diverse protease repertoire
    In: Plant Biotechnology Journal, Vol. 16, 2018, Nr. 5, pp. 1068 – 1084
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  • Grosse-Holz, Friederike; Madeira, Luisa; Zahid, Muhammad Awais; Songer, Molly; Kourelis, Jiorgos; Fesenko, Mary; Ninck, Sabrina; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A.L.
    Three unrelated protease inhibitors enhance accumulation of pharmaceutical recombinant proteins in Nicotiana benthamiana
    In: Plant Biotechnology Journal, Vol. 16, 2018, Nr. 10, pp. 1797 – 1810
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  • Weith, Matthias; Seiler, Jonas; van den Boom, Johannes; Kracht, Matthias; Hülsmann, Julia; Primorac, Ivana; Del Pino Garcia, Javier; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Bollen, Mathieu; Meyer, Hemmo
    Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation
    In: Molecular Cell, Vol. 72, 2018, Nr. 4, pp. 766 – 777
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  • Bravo-Rodriguez, Kenny; Hagemeier, Birte; Drescher, Lea; Lorenz, Marian; Rey, Juliana; Meltzer, Michael; Kaschani, Farnusch; Kaiser, Markus; Ehrmann, Michael
    Utilities for Mass Spectrometry Analysis of Proteins (UMSAP) : Fast post-processing of mass spectrometry data
    In: Rapid Communications in Mass Spectrometry, Vol. 32, 2018, Nr. 19, pp. 1659 – 1667
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  • Zweerink, Susanne; Kallnik, Verena; Ninck, Sabrina; Nickel, Sabrina; Verheyen, Julia; Blum, Marcel; Wagner, Alexander; Feldmann, Ingo; Sickmann, Albert; Albers, Sonja-Verena; Bräsen, Christopher; Kaschani, Farnusch; Siebers, Bettina; Kaiser, Markus
    Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic Archaea
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  • Klein, Diana; Steens, Jennifer; Wiesemann, Alina; Schulz, Florian; Kaschani, Farnusch; Röck, Katharina; Yamaguchi, Masahiro; Wirsdörfer, Florian; Kaiser, Markus; Fischer, Jens W.; Stuschke, Martin; Jendrossek, Verena
    Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expression
    In: Antioxidants and Redox Signaling, Vol. 26, 2017, Nr. 11, pp. 563 – 582
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  • Kovács, Judit; Poór, Péter; Kaschani, Farnusch; Chandrasekar, Balakumaran; Hong, Tram N.; Misas-Villamil, Johana C.; Xin, Bo T.; Kaiser, Markus; Overkleeft, Herman S.; Tari, Irma; van der Hoorn, Renier A. L.
    Proteasome activity profiling uncovers alteration of catalytic β2 and β5 subunits of the stress-induced proteasome during salinity stress in tomato roots
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  • Beisser, Daniela; Kaschani, Farnusch; Graupner, Nadine; Großmann, Lars; Jensen, Manfred; Ninck, Sabrina; Schulz, Florian; Rahmann, Sven; Boenigk, Jens; Kaiser, Markus
    Quantitative proteomics reveals ecophysiological effects of light and silver stress on the mixotrophic protist Poterioochromonas malhamensis
    In: PLoS ONE, Vol. 12, 2017, Nr. 1, pp. e0168183
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  • Ehrmann, Michael; Kaiser, Markus
    Small Molecules from Deep within the Gut
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  • Misas-Villamil, Johana C.; van der Burgh, Aranka M.; Grosse-Holz, Friederike; Bach-Pages, Marcel; Kovács, Judit; Kaschani, Farnusch; Schilasky, Sören; Emon, Asif E.K.; Ruben, Mark; Kaiser, Markus; Overkleeft, Hermen S.; van der Hoorn, Renier A.L.
    Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections
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  • Köcher, Steffen; Rey, Juliana; Bongard, Jens; Tiaden, André N.; Meltzer, Michael; Richards, Peter J.; Ehrmann, Michael; Kaiser, Markus
    Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease Inhibitors
    In: Angewandte Chemie International Edition, Vol. 56, 2017, Nr. 29, Special Issue: 100th Anniversary of the Royal Australian Chemical Institute, pp. 8555 – 8558
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  • De Montaigu, Amaury; Oeljeklaus, Julian; Krahn, Jan; Suliman, Mohamed N.S.; Halder, Vivek; De Ansorena, Elisa; Nickel, Sabrina; Schlicht, Markus; Plíhal, Ondřej; Kubiasová, Karolina; Radová, Lenka; Kracher, Barbara; Tóth, Réka; Kaschani, Farnusch; Coupland, George; Kombrink, Erich; Kaiser, Markus
    The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock
    In: ACS Chemical Biology, Vol. 12, 2017, Nr. 6, pp. 1466 – 1471
    DOI (Open Access)
  • Krahn, Jan; Kaschani, Farnusch; Kaiser, Markus
    Turning-ON Proteasomes
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  • Shaulov-Rotem, Yulia; Merquiol, Emmanuelle; Weiss-Sadan, Tommy; Moshel, Ofra; Salpeter, Seth; Shabat, Doron; Kaschani, Farnusch; Kaiser, Markus; Blum, Galia
    A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosis
    In: Chemical Science, Vol. 7, 2016, pp. 1322 – 1337
    DOI (Open Access)
  • Kaschani, Farnusch; Wei, Quing; Dingemans, Jozef; van der Hoorn, Renier A.L.; Cornelis, Pierre; Kaiser, Markus
    Capture of endogenously biotinylated proteins from Pseudomonas aeruginosa displays unexpected downregulation of LiuD upon iron nutrition
    In: Bioorganic and Medicinal Chemistry, Vol. 24, 2016, Nr. 15, pp. 3330 – 3335
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  • van den Boom, Johannes; Wolf, Markus; Weimann, Lena; Schulze, Nina; Li, Fanghua; Kaschani, Farnusch; Riemer, Anne; Zierhut, Christian; Kaiser, Markus; Iliakis, George; Funabiki, Hironori; Meyer, Hemmo
    VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair
    In: Molecular Cell, Vol. 64, 2016, Nr. 1, pp. 189 – 198
    DOI (Open Access)
  • Ehrmann, Michael; Kaschani, Farnusch; Kaiser, Markus
    Chemical proteomics versus Leishmaniasis
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    DOI (Open Access)
  • Nickel, Sabrina; Serwa, Remigiusz A.; Kaschani, Farnusch; Ninck, Sabrina; Zweerink, Susanne; Tate, Edward W.; Kaiser, Markus
    Chemoproteomic Evaluation of the Polyacetylene Callyspongynic Acid
    In: Chemistry - A European Journal, Vol. 21, 2015, Nr. 30, pp. 10721 – 10728
    DOI (Open Access)
  • Poepsel, Simon; Sprengel, Andreas; Sacca, Barbara; Kaschani, Farnusch; Kaiser, Markus; Gatsogiannis, Christos; Raunser, Stefan; Clausen, Tim; Ehrmann, Michael
    Determinants of amyloid fibril degradation by the PDZ protease HTRA1
    In: Nature Chemical Biology, Vol. 11, 2015, Nr. 11, pp. 862 – 869
    DOI, Online Full Text (Open Access)
  • Ilyas, Muhammad; Hörger, Anja C.; Bozkurt, Tolga O.; Burg, Harrold A. van den; Kaschani, Farnusch; Kaiser, Markus; Belhaj, Khaoula; Smoker, Matthew; Joosten, Matthieu H. A. J.; Kamoun, Sophien; Hoorn, Renier A. L. van der
    Functional divergence of two secreted immune proteases of tomato
    In: Current Biology, Vol. 25, 2015, Nr. 17, pp. 2300 – 2306
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  • Kellermann, Guillaume; Kaiser, Markus; Dingli, Florent; Lahuna, Olivier; Naud-Martin, Delphine; Mahuteau-Betzer, Florence; Loew, Damarys; Ségal-Bendirdjian, Évelyne; Teulade-Fichou, Marie-Paule; Bombard, Sophie
    Identification of human telomerase assembly inhibitors enabled by a novel method to produce hTERT
    In: Nucleic Acids Research, Vol. 43, 2015, Nr. 15, art. no. e99
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  • Lu, Haibin; Chandrasekar, Balakumaran; Oeljeklaus, Julian; Misas-Villamil, Johana C.; Wang, Zheming; Shindo, Takayuki; Bogyo, Matthew; Kaiser, Markus; van der Hoorn, Renier A. L.
    Subfamily-specific fluorescent probes for cysteine proteases display dynamic protease activities during seed germination
    In: Plant Physiology, Vol. 168, 2015, Nr. 4, pp. 1462 – 1475
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  • Nickel, Sabrina; Nickel, Philipp; Hellmert, Marco; Ernst, Silvia; Jewell, Robert; Pearce, Christopher A.; Jones, Geraint; Hamza, Daniel; Kaiser, Markus
    Synthesis of a hexahydropyrrolo indole (HPI) compound library
    In: Bioorganic and Medicinal Chemistry, Vol. 23, 2015, Nr. 11, pp. 2636 – 2645
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  • Meesters, Christian; Mönig, Timon; Oeljeklaus, Julian; Krahn, Daniel; Westfall, Corey S.; Hause, Bettina; Jez, Joseph M; Kaiser, Markus; Kombrink, Erich
    A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana
    In: Nature Chemical Biology, Vol. 10, 2014, Nr. 10, pp. 830 – 836
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  • Köhn, Maja; Meijler, Michael M.; Kaiser, Markus
    Building up a chemical proteomics network in Europe and beyond
    In: ACS Chemical Biology, Vol. 9, 2014, Nr. 8, pp. 1647 – 1648
    DOI
  • van den Boom, Johannes; Mamic, Marija; Baccelliere, Daniele; Zweerink, Susanne; Kaschani, Farnusch; Knauer, Shirley; Bayer, Peter; Kaiser, Markus
    Peptidyl succinimidyl peptides as taspase 1 inhibitors
    In: ChemBioChem, Vol. 15, 2014, Nr. 15, pp. 2233 – 2237
    DOI
  • Bruss, Hanna; Schuster, Hannah; Martinez, Rémi; Kaiser, Markus; Antonchick, Andrey P.; Waldmann, Herbert
    Synthesis of the B-seco limonoid core scaffold
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    DOI (Open Access)
  • Lu, Haibin; Wang, Zheming; Shabab, Mohammed; Oeljeklaus, Julian; Verhelst, Steven H.; Kaschani, Farnusch; Kaiser, Markus; Bogyo, Matthew; Hoorn, Renier A. L. van der
    A substrate-inspired probe monitors translocation, activation, and subcellular targeting of bacterial type III effector protease AvrPphB
    In: Chemistry and Biology, Vol. 20, 2013, Nr. 2, pp. 168 – 176
    DOI
  • Stolze, Sara C.; Meltzer, Michael; Ehrmann, Michael; Kaiser, Markus
    Ahp cyclodepsipeptides: The impact of the ahp residue on the "Canonical Inhibition" of S1 serine proteases
    In: ChemBioChem, Vol. 14, 2013, Nr. 11, pp. 1301 – 1308
    DOI
  • Stolze, Sara C.; Kaiser, Markus
    Case studies of the synthesis of bioactive cyclodepsipeptide natural products
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    DOI (Open Access)
  • Gu, Christian; Shannon, D. Alexander; Colby, Tom; Wang, Zheming; Shabab, Mohammed; Kumari, Selva; Villamor, Joji Grace; McLaughlin, Christopher J.; Weerapana, Eranthie; Kaiser, Markus; Cravatt, Benjamin F.; Van Der Hoorn, Renier A.L.
    Chemical proteomics with sulfonyl fluoride probes reveals selective labeling of functional tyrosines in glutathione transferases
    In: Chemistry and Biology, Vol. 20, 2013, Nr. 4, pp. 541 – 548
    DOI (Open Access)
  • Merdanovic, Melisa; Mönig, Timon; Ehrmann, Michael; Kaiser, Markus
    Diversity of allosteric regulation in proteases
    In: ACS Chemical Biology, Vol. 8, 2013, Nr. 1, pp. 19 – 26
    DOI
  • Villamor, Joji Grace; Kaschani, Farnusch; Colby, Tom; Oeljeklaus, Julian; Zhao, David; Kaiser, Markus; Patricelli, Matthew P.; Van Der Hoorn, Renier A. L.
    Profiling protein kinases and other ATP binding proteins in arabidopsis using acyl-ATP probes
    In: Molecular and Cellular Proteomics (MCP), Vol. 12, 2013, Nr. 9, pp. 2481 – 2496
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  • Misas-Villamil, Johana C.; Kolodziejek, Izabella; Crabill, Emerson; Kaschani, Farnusch; Niessen, Sherry; Shindo, Takayuki; Kaiser, Markus; Alfano, James R.; van der Hoorn, Renier A. L.
    Pseudomonas syringae pv. syringae Uses Proteasome Inhibitor Syringolin A to Colonize from Wound Infection Sites
    In: PLoS Pathogens, Vol. 9, 2013, Nr. 3, pp. e1003281
    DOI (Open Access)
  • Oeljeklaus, Julian; Kaschani, Farnusch; Kaiser, Markus
    Streamlining chemical probe discovery : libraries of "fully functionalized" small molecules for phenotypic screening
    In: Angewandte Chemie International Edition, Vol. 52, 2013, Nr. 5, pp. 1368 – 1370
    DOI
  • Nickel, Sabrina; Kaschani, Farnusch; Colby, Tom; Van Der Hoorn, Renier A.L.; Kaiser, Markus
    A para-nitrophenol phosphonate probe labels distinct serine hydrolases of Arabidopsis
    In: Bioorganic and Medicinal Chemistry, Vol. 20, 2012, Nr. 2, pp. 601 – 606
    DOI
  • Archer, Crystal R; Groll, Michael; Stein, Martin L; Schellenberg, Barbara; Clerc, Jérôme; Kaiser, Markus; Kondratyuk, Tamara P; Pezzuto, John M; Dudler, Robert; Bachmann, André S.
    Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells
    In: Biochemistry, Vol. 51, 2012, Nr. 34, pp. 6880 – 6888
    DOI
  • Bier, Carolin; Knauer, Shirley; Wünsch, Désirée; Kunst, Lena; Scheiding, Sabine; Kaiser, Markus; Ottmann, Christian; Krämer, Oliver H.; Stauber, Roland H.
    Allosteric inhibition of Taspase1's pathobiological activity by enforced dimerization in vivo
    In: The FASEB Journal, Vol. 26, 2012, Nr. 8, pp. 3421 – 3429
    DOI
  • Stolze, Sara C.; Kaiser, Markus
    Challenges in the syntheses of peptidic natural products
    In: Synthesis: Journal of Synthetic Organic Chemistry, Vol. 44, 2012, Nr. 12, pp. 1755 – 1777
    DOI
  • Weski, Juliane; Meltzer, Michael; Spaan, Lina; Mönig, Timon; Oeljeklaus, Julian; Hauske, Patrick; Vouilleme, Lars; Volkmer, Rudolf; Boisguerin, Prisca; Boyd, Dana; Huber, Robert; Kaiser, Markus; Ehrmann, Michael
    Chemical Biology Approaches Reveal Conserved Features of a C-Terminal Processing PDZ Protease
    In: ChemBioChem, Vol. 13, 2012, Nr. 3, pp. 402 – 408
    DOI
  • Stolze, Sara Christina; Meltzer, Michael; Ehrmann, Michael; Kaiser, Markus
    Development of a Solid-Phase Approach to the Natural Product Class of Ahp-Containing Cyclodepsipeptides
    In: European Journal of Organic Chemistry, 2012, Nr. 8, pp. 1616 – 1625
    DOI
  • Van Der Linden, Wouter A.; Willems, Lianne I.; Shabaneh, Tamer B.; Li, Nan; Ruben, Mark; Florea, Bogdan I.; Van Der Marel, Gijs A.; Kaiser, Markus; Kisselev, Alexei F.; Overkleeft, Herman S.
    Discovery of a potent and highly β1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones
    In: Organic and Biomolecular Chemistry, Vol. 10, 2012, Nr. 1, pp. 181 – 194
    DOI
  • Lütticke, Christiane; Hauske, Patrick; Lewandrowski, Urs; Sickmann, Albert; Kaiser, Markus; Ehrmann, Michael
    E. coli LoiP (YggG), a metalloprotease hydrolyzing Phe–Phe bonds
    In: Molecular BioSystems, Vol. 8, 2012, Nr. 6, pp. 1775 – 1782
    DOI, Online Full Text
  • Tennstaedt, Annette; Pöpsel, Simon; Trübestein, Linda; Hauske, Patrick; Brockmann, Anke; Schmidt, Nina; Irle, Inga; Sacca, Barbara; Niemeyer, Christof M.; Brandt, Roland; Ksiezak-Reding, Hanna; Tirniceriu, Anca Laura; Egensperger, Rupert; Baldi, Alfonso; Dehmelt, Leif; Kaiser, Markus; Huber, Robert; Clausen, Tim; Ehrmann, Michael
    Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates
    In: The Journal of Biological Chemistry (JBC), Vol. 287, 2012, Nr. 25, pp. 20931 – 20941
    DOI
  • Kaschani, Farnusch; Clerc, Jérôme; Krahn, Daniel; Bier, David; Hong, Tram Ngoc; Ottmann, Christian; Niessen, Sherry; Colby, Tom; Van Der Hoorn, Renier A. L.; Kaiser, Markus; van der Hoorn, Renier A. L.
    Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenases
    In: Angewandte Chemie International Edition, Vol. 51, 2012, Nr. 21, pp. 5230 – 5233
    DOI
  • Kaiser, Markus; Ottmann, Christian
    In Silico Identification of an Interferon Inhibitor
    In: ChemMedChem, Vol. 7, 2012, Nr. 4, pp. 555 – 557
    DOI
  • Stein, Martin L.; Beck, Philipp; Kaiser, Markus; Dudler, Robert; Becker, Christian F. W.; Groll, Michael
    One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 109, 2012, Nr. 45, pp. 18367 – 18371
    DOI
  • van der Hoorn, Renier A. L.; Kaiser, Markus
    Probes for activity-based profiling of plant proteases
    In: Physiologia Plantarum, Vol. 145, 2012, Nr. 1, Special Issue: Plant Proteases, pp. 18 – 27
    DOI
  • Kaschani, Farnusch; Nickel, Sabrina; Pandey, Bikram; Cravatt, Benjamin F.; Kaiser, Markus; Van Der Hoorn, Renier A.L.
    Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP
    In: Bioorganic and Medicinal Chemistry, Vol. 20, 2012, Nr. 2, pp. 597 – 600
    DOI, Online Full Text (Open Access)
  • Thiel, Philipp; Kaiser, Markus; Ottmann, Christian
    Small-molecule stabilization of protein-protein interactions : An underestimated concept in drug discovery?
    In: Angewandte Chemie International Edition, Vol. 51, 2012, Nr. 9, pp. 2012 – 2018
    DOI
  • Shannon, D. Alexander; Gu, Christian; Mclaughlin, Christopher J.; Kaiser, Markus; van der Hoorn, Renier A. L.; Weerapana, Eranthie
    Sulfonyl Fluoride Analogues as Activity-Based Probes for Serine Proteases
    In: ChemBioChem, Vol. 13, 2012, Nr. 16, pp. 2327 – 2330
    DOI
  • Stolze, Sara Christina; Deu, Edgar; Kaschani, Farnusch; Li, Nan; Florea, Bogdan I.; Richau, Kerstin H.; Colby, Tom; Van Der Hoorn, Renier A.L.; Overkleeft, Hermen S.; Bogyo, Matthew; Kaiser, Markus
    The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains
    In: Chemistry and Biology, Vol. 19, 2012, Nr. 12, pp. 1546 – 1555
    DOI
  • Ottmann, Christian; Van Der Hoorn, Renier A. L.; Kaiser, Markus
    The impact of plant-pathogen studies on medicinal drug discovery
    In: Chemical Society Reviews, Vol. 41, 2012, Nr. 8, pp. 3168 – 3178
    DOI
  • Wuest, William M.; Krahn, Daniel; Kaiser, Markus; Walsh, Christopher T.
    Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesis
    In: Organic Letters, Vol. 13, 2011, Nr. 17, pp. 4518 – 4521
    DOI
  • Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    HTRA proteases : regulated proteolysis in protein quality control
    In: Nature Reviews Molecular Cell Biology, Vol. 12, 2011, Nr. 3, pp. 152 – 162
    DOI
  • Krahn, D.; Ottmann, C.; Kaiser, Markus
    Macrocyclic Proteasome Inhibitors
    In: Current Medicinal Chemistry, Vol. 18, 2011, Nr. 33, pp. 5052 – 5060
    DOI
  • Van der Hoorn, Renier A.L.; Colby, Tom; Nickel, Sabrina; Richau, Kerstin H.; Schmidt, Jürgen; Kaiser, Markus
    Mining the active proteome of Arabidopsis Thaliana
    In: Frontiers in Plant Science (FPLS), Vol. 2, 2011, 89
    DOI (Open Access)
  • Kolodziejek, Izabella; Misas-Villamil, Johana C.; Kaschani, Farnusch; Clerc, Jérôme; Gu, Christian; Krahn, Daniel; Niessen, Sherry; Verdoes, Martijn; Willems, Lianne I.; Overkleeft, Hermen S.; Kaiser, Markus; van der Hoorn, Renier A. L.
    Proteasome activity imaging and profiling characterizes bacterial effector Syringolin A
    In: Plant Physiology, Vol. 155, 2011, Nr. 1, pp. 477 – 489
    DOI, Online Full Text (Open Access)
  • Merdanovic, Melisa; Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Protein quality control in the bacterial periplasm
    In: Annual Review of Microbiology, Vol. 65, 2011, pp. 149 – 168
    DOI
  • Trübestein, Linda; Tennstaedt, Annette; Mönig, Timon; Krojer, Tobias; Canellas, Flavia; Kaiser, Markus; Clausen, Tim; Ehrmann, Michael
    Substrate induced remodeling of the active site regulates human HtrA1 activity
    In: Nature Structural & Molecular Biology, Vol. 18, 2011, pp. 386 – 388
    DOI
  • Schuster, Hannah; Martinez, Rémi; Bruss, Hanna; Antonchick, Andrey P.; Kaiser, Markus; Schürmann, Markus; Waldmann, Herbert
    Synthesis of the B-seco limonoid scaffold
    In: Chemical Communications: ChemComm, Vol. 47, 2011, Nr. 23, pp. 6545 – 6547
    DOI
  • Krahn, Daniel; Ottmann, Christian; Kaiser, Markus
    The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins)
    In: Natural Product Reports, Vol. 28, 2011, Nr. 11, pp. 1854 – 1867
    DOI
  • Clerc, Jérôme; Li, Nan; Krahn, Daniel; Groll, Michael; Bachmann, André S; Florea, Bogdan I; Overkleeft, Herman S; Kaiser, Markus
    The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity.
    In: Chemical Communications: ChemComm, Vol. 47, 2011, Nr. 1, pp. 385 – 387
    DOI
  • Cottier, Stéphanie; Mönig, Timon; Wang, Zheming; Svoboda, Jiří; Boland, Wilhelm; Kaiser, Markus; Kombrink, Erich
    The yeast three-hybrid system as an experimental platform to identify proteins interacting with small signaling molecules in plant cells : Potential and limitations
    In: Frontiers in Plant Science (FPLS), Vol. 2, 2011, Nr. DEC, 101
    DOI (Open Access)
  • Wetzel, Stefan; Wilk, Wolfram; Chammaa, Samy; Sperl, Bianca; Roth, Anke G.; Yektaoglu, Aybike; Renner, Steffen; Berg, Thorsten; Arenz, Christoph; Giannis, Athanassios; Oprea, Tudor I.; Rauh, Daniel; Kaiser, Markus; Waldmann, Herbert
    A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones
    In: Angewandte Chemie International Edition, Vol. 49, 2010, Nr. 21, pp. 3666 – 3670
    DOI
  • Ottmann, Christian; Hauske, Patrick; Kaiser, Markus
    Activation Instead of Inhibition : Targeting Proenzymes for Small-Molecule Intervention
    In: ChemBioChem, Vol. 11, 2010, Nr. 5, pp. 637 – 639
    DOI, Online Full Text
  • Clerc, Jérôme; Schellenberg, Barbara; Groll, Michael; Bachmann, André S.; Huber, Robert; Dudler, Robert; Kaiser, Markus
    Convergent synthesis and biological evaluation of syringolin a and derivatives as eukaryotic 20S proteasome inhibitors
    In: European Journal of Organic Chemistry, 2010, Nr. 21, pp. 3991 – 4003
    DOI
  • Hasenbein, Sonja; Meltzer, Michael; Hauske, Patrick; Kaiser, Markus; Huber, Robert; Clausen, Tim; Ehrmann, Michael
    Conversion of a regulatory into a degradative protease
    In: Journal of Molecular Biology (JMB), Vol. 397, 2010, Nr. 4, pp. 957 – 966
    DOI
  • Merdanovic, Melisa; Mamant, Nicolette; Meltzer, Michael; Poepsel, Simon; Auckenthaler, Alexandra; Melgaard, Rie; Hauske, Patrick; Nagel-Steger, Luitgard; Clarke, Anthony R.; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Determinants of structural and functional plasticity of a widely conserved protease chaperone complex
    In: Nature Structural & Molecular Biology, Vol. 17, 2010, Nr. 7, pp. 837 – 843
    DOI
  • Molzan, Manuela; Schumacher, Benjamin; Ottmann, Corinna; Baljuls, Angela; Polzien, Lisa; Weyand, Michael; Thiel, Philipp; Rose, Rolf; Rose, Micheline; Kuhenne, Philipp; Kaiser, Markus; Rapp, Ulf R.; Kuhlmann, Jürgen; Ottmann, Christian
    Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling
    In: Molecular and Cellular Biology (MCB), Vol. 30, 2010, Nr. 19, pp. 4698 – 4711
    DOI
  • Kim, Sung Soo; Grienenberger, Etienne; Lallemand, Benjamin; Colpitts, Che C.; Kim, Sun Young; de Azevedo Souza, Clarice; Geoffroy, Pierrette; Heintz, Dimitri; Krahn, Daniel; Kaiser, Markus; Kombrink, Erich; Heitz, Thierry; Suh, Dae-Yeon; Legrand, Michel; Douglas, Carl J.
    LAP6/POLYKETIDE SYNTHASE A and LAP5/POLYKETIDE SYNTHASE B encode hydroxyalkyl α-pyrone synthases required for pollen development and sporopollenin biosynthesis in Arabidopsis thaliana
    In: The Plant Cell, Vol. 22, 2010, Nr. 12, pp. 4045 – 4066
    DOI (Open Access)
  • Imker, Heidi J.; Krahn, Daniel; Clerc, Jérôme; Kaiser, Markus; Walsh, Christopher T.
    N-Acylation during glidobactin biosynthesis by the tridomain nonribosomal peptide synthetase module GlbF
    In: Chemistry and Biology, Vol. 17, 2010, Nr. 10, pp. 1077 – 1083
    DOI, Online Full Text (Open Access)
  • Wilk, Wolfram; Zimmermann, Tobias J.; Kaiser, Markus; Waldmann, Herbert
    Principles, implementation, and application of biology-oriented synthesis (BIOS).
    In: Biological Chemistry, Vol. 391, 2010, Nr. 5, pp. 491 – 497
    Online Full Text
  • Stolze, Sara Christina; Meltzer, Michael; Ehrmann, Michael; Kaiser, Markus
    Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A
    In: Chemical Communications: ChemComm, 2010, Nr. 46, pp. 8857 – 8859
    DOI
  • Archer, Crystal R.; Koomoa, Dana-Lynn T.; Mitsunaga, Erin M.; Clerc, Jérôme; Shimizu, Mariko; Kaiser, Markus; Schellenberg, Barbara; Dudler, Robert; Bachmann, André S.
    Syrbactin class proteasome inhibitor-induced apoptosis and autophagy occurs in association with p53 accumulation and Akt/PKB activation in neuroblastoma
    In: Biochemical Pharmacology, Vol. 80, 2010, Nr. 2, pp. 170 – 178
    DOI
  • Kaiser, Markus; Ottmann, Christian
    The first small-molecule inhibitor of 14-3-3s : Modulating the master regulator
    In: ChemBioChem, Vol. 11, 2010, Nr. 15, pp. 2085 – 2087
    DOI
  • Wilk, Wolfram; Nören-Müller, Andrea; Kaiser, Markus; Waldmann, Herbert
    Biology-Oriented Combined Solid- and Solution-Phase Synthesis of a Macroline-Like Compound Collection
    In: Chemistry - A European Journal, Vol. 15, 2009, Nr. 44, pp. 11976 – 11984
    DOI
  • Kaschani, Farnusch; Verhelst, Steven H. L.; van Swieten, Paul F.; Verdoes, Martijn; Wong, Chung-Sing; Wang, Zheming; Kaiser, Markus; Overkleeft, Herman S.; Bogyo, Matthew; van der Hoorn, Renier A.L.
    Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using ‘click chemistry’.
    In: The Plant Journal, Vol. 57, 2009, Nr. 2, pp. 373 – 385
    Online Full Text
  • Hauske, Patrick; Mamant, Nicolette; Hasenbein, Sonja; Nickel, Sabrina; Ottmann, Christian; Clausen, Tim; Ehrmann, Michael; Kaiser, Markus
    Peptidic small molecule activators of the stress sensor DegS
    In: Molecular BioSystems, Vol. 5, 2009, Nr. 9, pp. 980 – 985
    DOI
  • Rose, Rolf; Huttenlocher, Franziska; Cedzich, Anna; Kaiser, Markus; Schaller, Andreas; Ottmann, Christian
    Purification, crystallization and preliminary X-ray diffraction analysis of a plant subtilase.
    In: Acta crystallographica, Section F, Structural biology and crystallization communications online, Vol. 65, 2009, Nr. 5, pp. 522 – 525
    Online Full Text
  • Hauske, Patrick; Meltzer, Michael; Ottmann, Christian; Krojer, Tobias; Clausen, Tim; Ehrmann, Michael; Kaiser, Markus
    Selectivity profiling of DegP substrates and inhibitors
    In: Bioorganic and Medicinal Chemistry, Vol. 17, 2009, Nr. 7, pp. 2920 – 2924
    DOI
  • Ottmann, Christian; Rose, Rolf; Huttenlocher, Franziska; Cedzich, Anna; Hauske, Patrick; Kaiser, Markus; Huber, Robert; Schaller, Andreas
    Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 106, 2009, Nr. 40, pp. 17223 – 17228
    DOI
  • Meltzer, Michael; Hasenbein, Sonja; Mamant, Nicolette; Merdanovic, Melisa; Poepsel, Simon; Hauske, Patrick; Kaiser, Markus; Huber, Robert; Krojer, Tobias; Clausen, Tim; Ehrmann, Michael
    Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli
    In: Research in Microbiology, Vol. 160, 2009, Nr. 9, pp. 660 – 666
    DOI
  • Clerc, Jérôme; Groll, Michael; Illich, Damir J.; Bachmann, André S.; Huber, Robert; Schellenberg, Barbara; Dudler, Robert; Kaiser, Markus
    Synthetic and structural studies on Syringolin A and B reveal critical determinants for selectivity and potency of proteasome inhibition
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 106, 2009, Nr. 16, pp. 6507 – 6512
    Online Full Text
  • Clerc, Jérôme; Florea, Bogdan I.; Kraus, Marianne; Groll, Michael; Huber, Robert; Bachmann, André S.; Dudler, Robert; Driessen, Christoph; Overkleeft, Herman S.; Kaiser, Markus
    Syringolin A selectively labels the 20S proteasome in murine EL4 and wildtype and bortezomib adapted leukemic cell lines
    In: ChemBioChem, Vol. 10, 2009, Nr. 16, pp. 2638 – 2643
    DOI, Online Full Text
  • Knoth, Tanja; Warburg, Karin; Katzka, Catherine; Rai, Amrita; Wolf, Alexander; Brockmeyer, Andreas; Janning, Petra; Reubold, Thomas F.; Eschenburg, Susanne; Manstein, Dietmar J.; Hübel, Katja; Kaiser, Markus; Waldmann, Herbert; Manstein, Dietmar J.
    The ras pathway modulator melophlin a targets dynamins
    In: Angewandte Chemie International Edition, Vol. 48, 2009, Nr. 39, pp. 7240 – 7245
    DOI
  • Yoshida, Masahito; Hedberg, Christian; Kaiser, Markus; Waldmann, Herbert
    Traceless solid phase synthesis of natural product inspired cis-1,2-dehydrodecalins
    In: Chemical Communications: ChemComm, 2009, Nr. 20, pp. 2923 – 2925
    DOI
  • Wilk, Wolfram; Waldmann, Herbert; Kaiser, Markus
    γ-Pyrone natural products – a privileged compound class provided by nature.
    In: Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, Vol. 17, 2009, Nr. 6, pp. 2304 – 2309
  • Groll, Michael; Schellenberg, Barbara; Bachmann, André S.; Archer, Crystal R.; Huber, Robert; Powell, Tracy K.; Lindow, Steven; Kaiser, Markus; Dudler, Robert
    A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
    In: Nature, Vol. 452, 2008, pp. 755 – 758
    Online Full Text
  • Meltzer, Michael; Hasenbein, Sonja; Hauske, Patrick; Kucz, Nicolette; Merdanovic, Melisa; Grau, Sandra; Beil, Alexandra; Jones, Dafydd; Krojer, Tobias; Clausen, Tim; Ehrmann, Michael; Kaiser, Markus
    Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control
    In: Angewandte Chemie International Edition, Vol. 47, 2008, Nr. 7, pp. 1332 – 1334
    DOI
  • Hauske, Patrick; Otmann, Christian; Meltzer, Michael; Ehrmann, Michael; Kaiser, Markus
    Allosteric regulation of proteases
    In: ChemBioChem, Vol. 9, 2008, Nr. 18, pp. 2920 – 2928
    DOI, Online Full Text
  • Kaiser, Markus; Wetzel, Stefan; Kumar, K.; Waldmann, Herbert
    Biology-inspired synthesis of compound libraries
    In: Cellular and Molecular Life Sciences - CMLS, Vol. 65, 2008, Nr. 7/8, pp. 1186 – 1201
    Online Full Text
  • Nören-Müller, Andrea; Wilk, Wolfram; Krishna, Saxena; Schwalbe, Harald; Kaiser, Markus; Waldmann, Herbert
    Discovery of a New Class of Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B by Biology-Oriented Synthesis
    In: Angewandte Chemie International Edition, Vol. 47, 2008, Nr. 32, pp. 5973 – 5977
    DOI
  • Bachmann, André S.; Archer, Crystal R.; Schellenberg, Barbara; Kaiser, Markus; Groll, Michael; Dudler, Robert
    Identification and characterization of a novel proteasome inhibitor with apoptotic properties in neuroblastoma.
    In: Proceedings : annual meeting of the American Association for Cancer Research., Vol. 49, 2008, pp. 773
  • Amrane, Samir; De Cian, Anne; Rosu, Frédéric; Kaiser, Markus; De Pauw, Edwin; Teulade-Fichou, Marie-Paule; Mergny, Jean-Louis
    Identification of CNG trinucleotide repeat ligands with a FRET melting assay
    In: ChemBioChem, Vol. 9, 2008, Nr. 8, pp. 1229 – 1234
    DOI, Online Full Text
  • Schneider, Katja; Wang, Zheming; Kaiser, Markus; Kombrink, Erich
    On the molecular mechanism of hormone action: Hunting the jasmonate target(s)
    In: Current topics in phytochemistry, Vol. 9, 2008, pp. 1 – 16
  • Wang, Zheming; Gu, Christian; Colby, Tom; Shindo, Takayuki; Balamurugan, Rengarajan; Waldmann, Herbert; Kaiser, Markus; van der Hoorn, Renier A.L.
    β-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.
    In: Nature Chemical Biology, Vol. 4, 2008, Nr. 9, pp. 557 – 563
    Online Full Text
  • De Cian, Anne; Guittat, Lionel; Kaiser, Markus; Sacca, Barbara; Amrane, Samir; Bourdoncle, Anne; Alberti, Patrizia; Teulade-Fichou, Marie-Paule; Lacroix, Laurent; Mergny, Jean-Louis
    Fluorescence-based melting assays for studying quadruplex ligands
    In: Methods: A Companion to Methods in Enzymology, Vol. 42, 2007, Nr. 2, pp. 183 – 195
    DOI
  • Corrêa, Ivan R.; Nören-Müller, Andrea; Ambrosi, Horst-Dieter; Jakupovic, Sven; Saxena, Krishna; Schwalbe, Harald; Kaiser, Markus; Waldmann, Herbert
    Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS).
    In: Chemistry: An Asian Journal, Vol. 2, 2007, Nr. 9, pp. 1109 – 1126
    Online Full Text
  • Kaiser, Markus; Sainlos, Matthieu; Lehn, Jean-Marie; Bombard, Sophie; Teulade-Fichou, Marie-Paule
    Aminoglycoside-quinacridine conjugates : Towards recognition of the P6.1 element of Telomerase RNA.
    In: ChemBioChem, Vol. 7, 2006, Nr. 2, pp. 321 – 329
    DOI, Online Full Text
  • Kaiser, Markus; De Cian, Anne; Sainlos, Matthieu; Renner, Christian; Mergny, Jean-Louis; Teulade-Fichou, Marie-Paule
    Neomycin-capped aromatic platforms : Quadruplex DNA recognition and telomerase inhibition
    In: Organic and Biomolecular Chemistry, Vol. 4, 2006, Nr. 6, pp. 1049 – 1057
    DOI
  • Groll, Michael; Götz, Marion; Kaiser, Markus; Weyher, Elisabeth; Moroder, Luis
    TMC-95-Based Inhibitor Design Provides Evidence for the Catalytic Versatility of the Proteasome
    In: Chemistry and Biology, Vol. 13, 2006, Nr. 6, pp. 607 – 614
    Online Full Text
  • Musiol, Hans-Jürgen; Dong, Shouliang; Kaiser, Markus; Bausinger, Ralf; Zumbusch, Andreas; Bertsch, Uwe; Moroder, Luis
    Toward Semisynthetic Lipoproteins by Convergent Strategies Based on Click and Ligation Chemistry
    In: ChemBioChem, Vol. 6, 2005, Nr. 4, pp. 625 – 628
    DOI, Online Full Text
  • Kaiser, Markus; Groll, Michael; Siciliano, Carlo; Assfalg-Machleidt, Irmgard; Weyher, Elisabeth; Kohno, Jun; Milbradt, Alexander G.; Renner, Christian; Huber, Robert; Moroder, Luis
    Binding mode of TMC-95A analogues to eukaryotic 20S proteasome
    In: ChemBioChem, Vol. 5, 2004, Nr. 9, pp. 1256 – 1266
    DOI
  • Kaiser, Markus; Milbradt, Alexander G.; Sicilianoa, Carlo; Assfalg-Machleidt, Irmgard; Machleidt, Werner; Groll, Michael; Renner, Christian; Moroder, Luis
    TMC-95A analogues with endocyclic biphenyl ether group as proteasome inhibitors.
    In: Chemistry & biodiversity : CB ; an official journal of the Center for the Study of Biological Complexity, Vol. 1, 2004, Nr. 1, pp. 161 – 173
    Online Full Text
  • Kaiser, Markus; Siciliano, Carlo; Assfalg-Machleidt, Irmgard; Groll, Michael; Milbradt, Alexander G.; Moroder, Luis
    Synthesis of a TMC-95A ketomethylene analogue by cyclization via intramolecular Suzuki coupling.
    In: Organic Letters, Vol. 5, 2003, Nr. 19, pp. 3435 – 3437
    Online Full Text
  • Kim, Jeong-Sun; Groll, Michael; Musiol, Hans-Jürgen; Behrendt, Raymond; Kaiser, Markus; Moroder, Luis; Huber, Robert; Brandstetter, Hans
    Navigation inside a protease: Substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum
    In: Journal of Molecular Biology (JMB), Vol. 324, 2002, Nr. 5, pp. 1041 – 1050
    DOI
  • Ashcroft, Alison E.; Brinker, Achim; Coyle, Joseph E.; Weber, Frank; Kaiser, Markus; Moroder, Luis; Parsons, Mark R.; Jager, Joachim; Hartl, Ulrich F.; Hayer-Hartl, Manajit; Radford, Sheena E.
    Structural plasticity and non-covalent substrate binding in the GroEL apical domain: A study using electrospray ionisation mass spectrometry and fluorescence binding studies
    In: The Journal of Biological Chemistry (JBC), Vol. 277, 2002, Nr. 36, pp. 33115 – 33126
    Online Full Text
  • Kaiser, Markus; Milbradt, Alexander G.; Moroder, Luis
    Structure-based prediction of cyclization propensities of linear precursors
    In: International Journal of Peptide Research and Therapeutics, Vol. 9, 2002, Nr. 2/3, pp. 65 – 70
    Online Full Text
  • Kaiser, Markus; Milbradt, Alexander G.; Moroder, Luis
    Synthesis of TMC-95A analogues. Structure-based prediction of cyclization propensities of linear precursors
    In: Letters in Peptide Science, Vol. 9, 2002, Nr. 2-3, pp. 65 – 70
    DOI
  • Kaiser, Markus; Groll, Michael; Renner, Christian; Huber, Robert; Moroder, Luis
    The Core Structure of TMC-95A Is a Promising Lead for Reversible Proteasome Inhibition
    In: Angewandte Chemie International Edition, Vol. 41, 2002, Nr. 5, pp. 780 – 783
    DOI

    • Prefaces/Postfaces

  • Kombrink, Erich; Kaiser, Markus
    Editorial : When chemistry meets biology – Generating innovative concepts, methods and tools for scientific discovery in the plant sciences
    In: Frontiers in Plant Science (FPLS). Lausanne: Frontiers Media, Vol. 7, 2016, Nr. February, 76
    DOI (Open Access)

    • Reviews

  • Kaiser, Markus
    Methods in Molecular Biology, Vol. 575: Chemogenomics: Methods and Applications Edited by Edgar Jacoby, Humana Press, Totowa 2009, VIII+315 pp., ISBN 978‐1‐60761‐273‐5
    In: ChemBioChem. Weinheim: Wiley-VCH, Vol. 11, 2010, Nr. 4, pp. 582 – 583
    DOI, Online Full Text

    • Preprints

  • Zaffar, Eman; Vieyto-Nuñez, Julio; Pravi, Katerina; Aslam, Mohammed Faidh; Almeida-Hernández, Yasser; Mieres-Pérez, Joel; Kaschani, Farnusch; Kaiser, Markus; Kroesen, Anika; Boos, Dominik; Sánchez-García, Elsa
    MTBP allosterically activates Cdk8-CycC kinase activity
    2025
    DOI (Open Access)
  • Klink, Nikolas; Urban, Sebastian; Seier, Johanna A.; Adhikari, Bikash; Schwalm, Martin P.; Müller, Juliane; Dorsch, Madeleine; Kaschani, Farnusch; Koch, Johannes; Führer, Siska; Kaiser, Markus; Schulze, Nina; Knapp, Stefan; Wolf, Elmar; Paschen, Annette; Grüner, Barbara M.; Gersch, Malte
    Targeted degradation of USP7 in solid cancer cells reveals disparate effects of deubiquitinase inhibition vs. acute protein depletion
    2025
    DOI, Online Full Text (Open Access)
  • Blümke, Anika; Hagemeier, Birte; Ripkens, Kamilla; Schulze, Nina; Strzala, Michal; Koci, Michelle; Kaschani, Farnusch; Kaiser, Markus; Erkelenz, Michael; Schlücker, Sebastian; Merdanovic, Melisa; Poepsel, Simon; Hellerschmied-Jelinek, Doris; Burston, Steve; Ehrmann, Michael
    A non-autonomous protein quality control mechanism targeting tau aggregate propagation
    2024
    DOI (Open Access)
  • Schmerling, Christian; Schroeder, Carsten; Zhou, Xiaoxiao; Busche, Tobias; Kalinowski, Jörn; Montero, Lidia; Schmitz, Oliver J.; Kaschani, Farnusch; Ninck, Sabrina; Kaiser, Markus; Bost, Jan; Waßmer, Bianca; Albers, Sonja; Siebers, Bettina; Bräsen, Christopher
    Glycerol degradation in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius involves an unusual glycerol-3-phosphate dehydrogenase
    2024
    DOI (Open Access)

    • Book articles / Proceedings papers

  • Zweerink, Susanne; Pollmann, Tanja; Ninck, Sabrina; Kaschani, Farnusch; Kaiser, Markus
    Activity-based protein profiling with natural product-derived chemical probes in human cell lysates
    In: Activity-Based Proteomics: Methods and Protocols / Overkleeft, Herman S.; Florea, Bogdan I. (Eds.). New York: Springer, 2017, pp. 23 – 46
    DOI
  • Huber, Robert; Kaiser, Markus; Ehrmann, Michael
    Proteases ☆
    In: Reference Module in Life Sciences: Elsevier, 2017
    DOI
  • Oeljeklaus, Julian; Kaiser, Markus
    The Identification of the Molecular Receptor of the Plant Hormone Abscisic Acid
    In: Concepts and Case Studies in Chemical Biology / Waldmann, Herbert; Aerts, Hans; Janning, Petra (Eds.). Weinheim [u.a.]: Wiley-VCH, 2014
  • Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Proteolysis
    In: Brenner's Encyclopedia of Genetics: Second Edition / Maloy, Stanley R.; Hughes, Kelly T.. Amsterdam: Elsevier, 2013, pp. 501 – 503
    DOI
  • Kombrink, Erich; Serrano, Mario; Wang, Zheming; Kaiser, Markus; Cottier, Stéphanie
    Small signaling molecules in the plant immune response : New tools for unraveling molecular mechanisms
    In: Biology of plant-microbe interactions: Volume 7 / 14th International Congress on Molecular Plant-Microbe Interactions, Quebec, Canada, July 19-23, 2009 / Antoun, Hani; Avis, Tyler; Brisson, Louise; Prévost, Danielle; Trepanier, Martin (Eds.). St. Paul: International Society for Plant-Microbe Interactions, 2010, pp. 1 – 8
  • Sacca, Barbara; Kaiser, Markus
    G-quadruplex ligands as tools for elucidating c-MYC transcriptional regulation
    In: Chemical Biology: learning through case studies / Waldmann, Herbert (Eds.). Weinheim [u.a.]: Wiley-VCH, 2009, pp. 247 – 259
  • Kaiser, Markus
    Targeted protein degradation in live cells
    In: Chemical Biology. Learning through Case Studies / Waldmann, Herbert (Eds.). Weinheim [u.a.]: Wiley-VCH, 2009, pp. 121 – 133
  • Teulade-Fichou, Marie-Paule; Kaiser, Markus; Sainlos, Matthieu; Bombard, Sophie; Monchaud, David; Jacquelin, Clémence; Hounsou, Candide; Lartia, Rémy
    Customized fused aromatics for structural recognition of nucleic acids.
    In: Chemistry of Nucleic acids components. o.A.: o.A., 2005, pp. 245 – 249
  • Kaiser, Markus; Groll, Michael; Siciliano, C.; Götz, M.; Assfalg-Machleidt, Irmgard; Kohno, J.; Milbradt, Alexander G.; Renner, Christian; Huber, R.; Moroder, Luis
    Inhibition of yeast 20S proteasome by biaryl- and biaryl ether cross-bridged tripeptide derivatives as TMC-95A analogs
    In: Peptides Biology and Chemistry / Liu, Ke-Liang; Tam, James P. (Eds.). o.A.: Commercial Pr Ltd, 2005
  • Musiol, Hans-Jürgen; Dong, Shouliang; Kaiser, Markus; Bausinger, Ralf; Zumbusch, Andrea; Moroder, Luis
    Click and ligation chemistry for the synthesis of GPI-anchored membrane proteins
    In: Peptides 2004 : bridges between disciplines ; proceedings of the Third International and Twenty-Eighth European Peptide Symposium, September 5 - 10, 2004, Prague, Czech Republic / Flegel, Martin (Eds.). Geneva, Switzerland: Kenes International, 2004, pp. 595 – 596
  • Kaiser, Markus; Groll, Michael; Götz, M.; Siciliano, C.; Assfalg-Machleidt, Irmgard; Weyer, E.; Kohno, J.; Milbradt, Alexander; Renner, Christian; Huber, Robert; Moroder, Luis
    Structural determinants for 20S proteasome inhibition by TMC-95A
    In: Peptides 2004 : bridges between disciplines ; proceedings of the Third International and Twenty-Eighth European Peptide Symposium, September 5 - 10, 2004, Prague, Czech Republic / Flegel, Martin (Eds.). Geneva, Switzerland: Kenes International, 2004, pp. 657 – 658
  • Kaiser, Markus; Milbradt, Alexander G.; Renner, Christian; Assfalg-Machleidt, Irmgard; Groll, Michael; Huber, R.; Moroder, Luis
    Cyclic biphenyl ether tripeptides as proteasome inhibitors
    In: Peptide revolution: genomics, proteomics & therapeutics: 18th American Peptide Symposium, July 19 - 23, 2003, Boston, Massachusetts ; program and abstracts : (Biopolymers ; 71,3) / Chorev, Michael (Eds.). Hoboken, NJ: Wiley, 2003, pp. 348 – 349

    • Research report

  • Kaiser, Markus; Clerc, Jérôme; Hauske, Patrick; Mönig, Timon; Krahn, Daniel
    Entwicklung chemischer Sonden zur Proteasenforschung
    2009(Max Planck Institute of Molecular Physiology: Forschungsbericht)
    Online Full Text