Faculty of Biology

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Linda Kubat

Translationale Hautkrebsforschung DKTK - Klinik für Dermatologie

Address
Universitätsstraße 2
45141 Essen
Room
S05 T05 B19
Phone
+49 201 183 6946
E-Mail
linda.kubat@uni-due.de

Functions

  • Wissenschaftliche/r Mitarbeiter/in, Experimentelle Immunologie und Bildgebung

Current lectures

No current lectures.

Past lectures (max. 10)

The following publications are listed in the online university bibliography of the University of Duisburg-Essen. Further information may also be found on the person's personal web pages.

    Journal articles

  • Srinivas, Nalini; Peiffer, Lukas; Horny, Kai; Lei, Kuan Cheok; Buus, Terkild B.; Kubat, Linda; Luo, Meng; Yin, Menghong; Spassova, Ivelina; Sucker, Antje; Farahpour, Farnoush; Kehrmann, Jan; Ugurel, Selma; Livingstone, Elisabeth; Gambichler, Thilo; Ødum, Niels; Becker, Jürgen C.
    Single-cell RNA and T-cell receptor sequencing unveil mycosis fungoides heterogeneity and a possible gene signature
    In: Frontiers in Oncology, Vol. 14, 2024, 1408614
    DOI (Open Access)
  • Schaper-Gerhardt, Katrin; Gutzmer, Ralf; Angela, Yenny; Zimmer, Lisa; Livingstone, Elisabeth; Schadendorf, Dirk; Hassel, Jessica C.; Weishaupt, Carsten; Remes, Bernhard; Kubat, Linda; Spassova, Ivelina; Becker, Jürgen
    The RANKL inhibitor denosumab in combination with dual checkpoint inhibition is associated with increased CXCL-13 serum concentrations
    In: European Journal of Cancer (EJC), Vol. 202, 2024, 113984
    DOI (Open Access)
  • Fan, Kaiji; Srinivas, Nalini; Kubat, Linda; Gravemeyer, Jan; Sucker, Antje; Schadendorf, Dirk; Gambichler, Thilo; Becker, Jürgen
    B-cell lymphoma extra-large (Bcl-xL) is a promising drug target in Merkel cell carcinoma
    In: British Journal of Dermatology: BJD, 2023
    DOI
  • Peiffer, Lukas; Gambichler, Thilo; Buus, Terkild B.; Horny, Kai; Gravemeyer, Jan; Furtmann, Frauke; Spassova, Ivelina; Kubat, Linda; Susok, Laura; Stranzenbach, René; Srinivas, Nalini; Ødum, Niels; Becker, Jürgen
    Phenotypic plasticity of malignant T cells in blood and skin of a Sézary syndrome patient revealed by single cell transcriptomics
    In: Frontiers in Oncology, Vol. 13, 2023, 1090592
    DOI (Open Access)
  • Spassova, Ivelina; Ugurel, Selma; Kubat, Linda; Zimmer, Lisa; Terheyden, Patrick; Mohr, Annalena; Björn Andtback, Hannah; Villabona, Lisa; Leiter, Ulrike; Eigentler, Thomas; Loquai, Carmen; Hassel, Jessica C.; Gambichler, Thilo; Haferkamp, Sebastian; Mohr, Peter; Pfoehler, Claudia; Heinzerling, Lucie; Gutzmer, Ralf; Utikal, Jochen S.; Horny, Kai; Schildhaus, Hans-Ulrich; Habermann, Daniel; Hoffmann, Daniel; Schadendorf, Dirk; Becker, Jürgen
    Clinical and molecular characteristics associated with response to therapeutic PD-1/PD-L1 inhibition in advanced Merkel cell carcinoma
    In: Journal for ImmunoTherapy of Cancer, Vol. 10, 2022, Nr. 1, e003198
    DOI, Online Full Text (Open Access)
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander
    Persister state-directed transitioning and vulnerability in melanoma
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Nature Communications, Vol. 13, 2022, Nr. 1, pp. 35 – 36
    DOI, Online Full Text (Open Access)
  • Pfeiffer, Lukas; Farahpour, Farnoush; Sriram, Ashwin; Spassova, Ivelina; Hoffmann, Daniel; Kubat, Linda; Stoitzner, Patrizia; Gambichler, Thilo; Sucker, Antje; Ugurel, Selma; Schadendorf, Dirk; Becker, Jürgen C.
    BRAF and MEK inhibition in melanoma patients enables reprogramming of tumor infiltrating lymphocytes
    In: Cancer Immunology, Immunotherapy, Vol. 70, 2021, Nr. 6, pp. 1635 – 1647
    DOI (Open Access)
  • Spassova, Ivelina; Ugurel, Selma; Terheyden, Patrick; Sucker, Antje; Hassel, Jessica C.; Ritter, Cathrin; Kubat, Linda; Habermann, Daniel; Farahpour, Farnoush; Saeedghalati, Mohammadkarim; Peiffer, Lukas; Kumar, Rajiv; Schrama, David; Hoffmann, Daniel; Schadendorf, Dirk; Becker, Jürgen C.
    Predominance of Central Memory T Cells with High T-Cell Receptor Repertoire Diversity is Associated with Response to PD-1/PD-L1 Inhibition in Merkel Cell Carcinoma
    In: Clinical Cancer Research, Vol. 26, 2020, Nr. 9, pp. 2257 – 2267
    DOI (Open Access)
  • Farah, Maya; Reuben, Alexandre; Spassova, Ivelina; Yang, Richard K.; Kubat, Linda; Nagarajan, Priyadharsini; Ning, Jing; Li, Wen; Aung, Phyu P.; Curry, Jonathan L.; Torres-Cabala, Carlos A.; Hudgens, Courtney W.; Ugurel, Selma; Schadendorf, Dirk; Gumbs, Curtis; Little, Latasha D.; Futreal, Andrew; Wistuba, Ignacio I.; Prieto, Victor G.; Wang, Linghua; Wong, Michael K.; Wargo, Jennifer A.; Becker, Jürgen; Tetzlaff, Michael T.
    T-Cell Repertoire in Combination with T-Cell Density Predicts Clinical Outcomes in Patients with Merkel Cell Carcinoma
    In: Journal of Investigative Dermatology, Vol. 140, 2020, Nr. 11, pp. 2146 – 2156.e4
    DOI (Open Access)
  • Chen, I-Peng; Bender, Marc; Spassova, Ivelina; Henning, Stefan; Kubat, Linda; Fan, Kaiji; Degenhardt, Sarah; Mhamdi-Ghodbani, Mouna; Sriram, Ashwin; Volkmer, Beate; Boukamp, Petra; Becker, Jürgen; Greinert, Rüdiger
    UV-type specific alteration of miRNA expression and its association with tumor progression and metastasis in SCC cell lines
    In: Journal of Cancer Research and Clinical Oncology, Vol. 146, 2020, Nr. 12, pp. 3215 – 3231
    DOI
  • Lindahl, Lise M.; Willerslev-Olsen, Andreas; Gjerdrum, Lise M.R.; Nielsen, Pia R.; Blümel, Edda; Rittig, Anne H.; Celis, Pamela; Herpers, Bjorn; Becker, Jürgen; Stausbøl-Grøn, Birgitte; Wasik, Mariusz A.; Gluud, Maria; Fredholm, Simon; Buus, Terkild B.; Johansen, Claus; Nastasi, Claudia; Peiffer, Lukas; Kubat, Linda; Bzorek, Michael; Eriksen, Jens O.; Krejsgaard, Thorbjørn; Bonefeld, Charlotte M.; Geisler, Carsten; Mustelin, Tomas; Langhoff, Erik; Givskov, Michael; Woetmann, Anders; Kilian, Mogens; Litman, Thomas; Iversen, Lars; Odum, Niels
    Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma
    In: Blood, Vol. 134, 2019, Nr. 13, pp. 1072 – 1083
    DOI (Open Access)
  • Harold, Alexis; Amako, Yutaka; Hachisuka, Junichi; Bai, Yulong; Li, Meng Yen; Kubat, Linda; Gravemeyer, Jan; Franks, Jonathan; Gibbs, Julia R.; Park, Hyun Jung; Ezhkova, Elena; Becker, Jürgen; Shuda, Masahiro
    Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 116, 2019, Nr. 40, pp. 20104 – 20114
    DOI (Open Access)
  • Westmeier, Dana; Solouk-Saran, Djamschid; Vallet, Cecilia; Siemer, Svenja; Docter, Dominic; Götz, Hermann; Männ, Linda; Hasenberg, Anja; Hahlbrock, Angelina; Erler, Kathrin; Reinhardt, Christoph; Schilling, Oliver; Becker, Sven; Gunzer, Matthias; Hasenberg, Mike; Knauer, Shirley; Stauber, Roland H.
    Nanoparticle decoration impacts airborne fungal pathobiology
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 115, 2018, Nr. 27, pp. 7087 – 7092
    DOI (Open Access)
  • Holland, Tristan; Wohlleber, Dirk; Marx, Samira; Kreutzberg, Thomas; Vento-Asturias, Salvador; Schmitt-Mbamunyo, Christine; Welz, Meike; Janas, Marianne; Komander, Karl; Eickhoff, Sarah; Brewitz, Anna; Hasenberg, Mike; Männ, Linda; Gunzer, Matthias; Wilhelm, Christoph; Kastenmüller, Wolfgang; Knolle, Percy; Abdullah, Zeinab; Kurts, Christian; Garbi, Natalio
    Rescue of T-cell function during persistent pulmonary adenoviral infection by Toll-like receptor 9 activation
    In: The Journal of Allergy and Clinical Immunology, Vol. 141, 2018, Nr. 1, pp. 416 – 419.e10
    DOI (Open Access)
  • Klingberg, Anika; Hasenberg, Anja; Ludwig-Portugall, Isis; Medyukhina, Anna; Männ, Linda; Brenzel, Alexandra; Engel, Daniel Robert; Figge, Marc Thilo; Kurts, Christian; Gunzer, Matthias
    Fully automated evaluation of total glomerular number and capillary tuft size in nephritic kidneys using lightsheet microscopy
    In: Journal of the American Society of Nephrology (JASN), Vol. 28, 2017, Nr. 2, pp. 452 – 459
    DOI
  • Männ, Linda; Klingberg, Anika; Gunzer, Matthias; Hasenberg, Mike
    Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy
    In: JoVE, 2017, Nr. 123, e55450
    DOI, Online Full Text (Open Access)
  • Männ, Linda; Kochupurakkal, Nora; Martin, Christian; Verjans, Eva; Klingberg, Anika; Sody, Simon; Kraus, Andreas; Dalimot, Jill; Bergmüller, Eileen; Jung, Steffen; Voortman, Sylvia; Winterhager, Elke; Brandau, Sven; Garbi, Natalio; Kurrer, Michael; Eriksson, Urs; Gunzer, Matthias; Hasenberg, Mike
    CD11c.DTR mice develop a fatal fulminant myocarditis after local or systemic treatment with diphtheria toxin
    In: European Journal of Immunology, Vol. 46, 2016, Nr. 8, pp. 2028 – 2042
    DOI (Open Access)
  • Rolle, Anna-Maria; Hasenberg, Mike; Thornton, Christopher R.; Solouk-Saran, Djamschid; Männ, Linda; Weski, Juliane; Maurer, Andreas; Fischer, Eliane; Spycher, Philipp R.; Schibli, Roger; Boschetti, Frederic; Stegemann-Koniszewski, Sabine; Bruder, Dunja; Severin, Gregory W.; Autenrieth, Stella E.; Krappmann, Sven; Davies, Genna; Pichler, Bernd J.; Gunzer, Matthias; Wiehr, Stefan
    ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 113, 2016, Nr. 8, pp. E1026 – E1033
    DOI (Open Access)
  • Moses, Katrin; Klein, Johanna C; Männ, Linda; Klingberg, Anika; Gunzer, Matthias; Brandau, Sven
    Survival of residual neutrophils and accelerated myelopoiesis limit the efficacy of antibody-mediated depletion of Ly-6G+ cells in tumor-bearing mice
    In: Journal of Leukocyte Biology (JLB), Vol. 99, 2016, Nr. 6, pp. 811 – 823
    DOI
  • Hasenberg, Anja; Hasenberg, Mike; Männ, Linda; Neumann, Franziska; Borkenstein, Lars; Stecher, Manuel; Kraus, Andreas; Engel, Daniel Robert; Klingberg, Anika; Seddigh, Pegah; Abdullah, Zeinab; Klebow, Sabrina; Engelmann, Swen; Reinhold, Annegret; Brandau, Sven; Seeling, Michaela; Waisman, Ari; Schraven, Burkhart; Göthert, Joachim Rudolf; Nimmerjahn, Falk; Gunzer, Matthias
    Catchup : a mouse model for imaging-based tracking and modulation of neutrophil granulocytes
    In: Nature Methods, Vol. 12, 2015, Nr. 5, pp. 445 – 452
    DOI
  • Neumann, Jens; Riek-Burchardt, Monika; Herz, Josephine; Döppner, Thorsten R.; König, Rebecca; Hütten, Heiko; Etemire, Eloho; Männ, Linda; Klingberg, Anika; Fischer, Thomas; Görtler, Michael W; Heinze, Hans-Jochen; Reichardt, Peter; Schraven, Burkhart; Hermann, Dirk M.; Reymann, Klaus G; Gunzer, Matthias
    Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke
    In: Acta Neuropathologica, Vol. 129, 2015, Nr. 2, pp. 259 – 277
    DOI
  • Köhler, A.; De Filippo, K.; Hasenberg, Mike; van den Brandt, C.; Nye, E.; Hosking, M. P.; Lane, T. E.; Männ, Linda; Ransohoff, R. M.; Hauser, A. E.; Winter, O.; Schraven, B.; Geiger, H.; Hogg, Nancy; Gunzer, Matthias
    G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands
    In: Blood, Vol. 117, 2011, Nr. 16, pp. 4349 – 4357
    DOI
  • Hasenberg, Mike; Köhler, A.; Bonifatius, S.; Borucki, K.; Riek-Burchardt, M.; Achilles, J.; Männ, Linda; Baumgart, K.; Schraven, B.; Gunzer, Matthias
    Rapid Immunomagnetic Negative Enrichment of Neutrophil Granulocytes from Murine Bone Marrow for Functional Studies In Vitro and In Vivo
    In: PLoS ONE, Vol. 6, 2011, Nr. 2, pp. e17314
    DOI (Open Access)

    • Abstracts

  • Schaper-Gerhardt, K.; Gutzmer, R.; Angela, Y.; Zimmer, Lisa; Schadendorf, Dirk; Hassel, J. C.; Weishaupt, C.; Remes, B.; Kubat, Linda; Becker, Jürgen C.
    A low interventional trial addressing the immunological effects of the RANKL-inhibitor Denosumab in combination with dual checkpoint blockade in melanoma patients with bone involvement reveals upregulation of CXCL-13
    33. Deutscher Hautkrebskongress (ADO-Jahrestagung) ; 06.–09. September 2023, Hamburg, Germany,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG). Hoboken: Wiley-Blackwell - STM, Vol. 21, 2023, Nr. S4, Special Issue: Abstractband anlässlich des 33. Deutschen Hautkrebskongresses (ADO‐Jahrestagung) 06.–09. September 2023 Hamburg, pp. 17
    DOI (Open Access)
  • Peiffer, Likas; Lindahl, Lise M.; Kubat, Linda; Spassova, Ivelina; Gravemeyer, Jan; Litman, Thomas; Willserslev-Olsen, A.; Woetmann, A.; Iversen, Line; Odum, Niels; Becker, Jürgen
    Das reaktive Infiltrat beim kutanen T-Zell-Lymphom ist höchst unbeständig und zeigt keine der typischen Merkmale von Antigenspezifität
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG). Hoboken: Wiley-Blackwell - STM, Vol. 18, 2020, Nr. Suppl. 2: Special Issue: Abstractband anlässlich des 30. Deutschen Hautkrebskongresses (ADO‐Jahrestagung) 09.–12. September 2020, pp. FV10
    DOI (Open Access)
  • Lindahl, Lise M.; Willerslev-Olsen, Andreas; Gjerdrum, Lise M.R.; Nielsen, Pia R.; Blümel, Edda; Rittig, Anne H.; Celis, Pamela; Herpers, Bjorn; Becker, Jürgen; Stausbøl-Grøn, Birgitte; Wasik, Mariusz A.; Gluud, Maria; Fredholm, Simon; Buus, Terkild B.; Johansen, Claus; Nastasi, Claudia; Peiffer, Lukas; Kubat, Linda; Bzorek, Michael; Eriksen, Jens O.; Krejsgaard, Thorbjørn; Bonefeld, Charlotte M.; Geisler, Carsten; Mustelin, Tomas; Langhoff, Erik; Givskov, Michael; Woetmann, Anders; Kilian, Mogens; Litman, Thomas; Iversen, Lars; Odum, Niels
    Antibiotics inhibit tumor and disease activity in cutaneous T cell lymphoma
    EORTC-CLTF 2019 Meeting on Cutaneous Lymphoma: Insights in research and patient care, 26-28 September 2019, Athens, Greece,
    In: European Journal of Cancer (EJC). Amsterdam: Elsevier, Vol. 119, 2019, Nr. Suppl. 1, pp. S5
    DOI

    • Thesis

  • Männ, Linda
    Charakterisierung der Diphtherietoxin-vermittelten Mortalität im transgenen CD11cDTR Mausmodell
    Duisburg, Essen, 2015
    Online Full Text, Online Full Text