Faculty of Biology

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Biologie / ZMB / AG Bioinformatik

Address
Universitätsstr. 2-5
45141 Essen
Room
S03 S03 A44

Functions

  • Doktorand/in, Bioinformatik and Computational Biophysics

Current lectures

No current lectures.

Past lectures (max. 10)

No past lectures.

The following publications are listed in the online university bibliography of the University of Duisburg-Essen. Further information may also be found on the person's personal web pages.

    Journal articles

  • Berg, Victoria; Lollies, Anna; Schneider, Markus; Johansson, Patricia; Weniger, Marc A.; Albertini, Emma; Facchetti, Fabio; Ascani, Stefano; Moawia, Abubakar; Bens, Susanne; Fischer, Anja; Siebert, Reiner; Klapper, Wolfram; Lorenzi, Luisa; Tiacci, Enrico; Hartmann, Sylvia; Budeus, Bettina; Hansmann, Martin-Leo; Küppers, Ralf
    Common origin and somatic mutation patterns of composite lymphomas and leukemias
    In: Leukemia, Vol. 39, 2025, Nr. 8, pp. 1960 – 1971
  • Berg, F.; Köper, E.; Limberg, A.S.; Mattonet, K.; Budeus, Bettina; Kumsta, R.; Hummel, E.M.; Moser, D.A.
    Development and validation of a novel cell type estimation method for targeted bisulfite sequencing data
    In: Epigenomics, Vol. 17, 2025, Nr. 6, pp. 389 – 396
  • Rajcsanyi, Luisa; Oral, Simge; Borgardt, Julia; Vondran, Florian; Beetz, Oliver; Sambou, Joanne; Ugurel, Selma; Peters, Triinu; Flohe, Stefanie; Kindler-Röhrborn, Andrea; Budeus, Bettina; Oezcelik, Arzu; Hinney, Anke
    Distinct liver sections exhibit sex-specific gene expression patterns in Lewis rats
    In: Scientific Reports, Vol. 15, 2025, Nr. 1, 32143
  • Stasch, Lisa Marie; Buchholzki, Maja; Ketheeswaranathan, Vaanilaa; Sevindik, Zehra; Jendrossek, Verena; Budeus, Bettina; Klein, Diana
    Generating Free-floating Normal Human Epithelial-Fibroblast Spheroid Co-Cultures
    In: JoVE, Vol. 2025, 2025, Nr. 221, e68440
  • Dubler, Simon; Etringer, Michael; Lichtenstern, Christoph; Brenner, Thorsten; Zimmermann, Stefan; Schnitzler, Paul; Budeus, Bettina; Rengier, Fabian; Kalinowska, Paulina; Hoo, Yuan Lih; Weigand, Markus A.
    Implications for the diagnosis of aspiration and aspergillosis in critically ill patients with detection of galactomannan in broncho-alveolar lavage fluids
    In: Scientific Reports, Vol. 15, 2025, Nr. 1, 1997
  • Rajcsanyi, Luisa; Kesselmeier, Miriam; Schröder, Christopher; Schmelting, Carolin; Peters, Triinu; Föcker, Manuel; Kraft, Isabelle; Beygo, Jasmin; Leitão, Elsa; Zeschnigk, Michael; Giuranna, Johanna; Herpertz-Dahlmann, Beate; Seitz, Jochen; de Zwaan, Martina; Herzog, Wolfgang; Ehrlich, Stefan; Zipfel, Stephan; Giel, Katrin; Egberts, Karin; Burghardt, Roland; Budeus, Bettina; Hebebrand, Johannes; Horsthemke, Bernhard; Hinney, Anke
    No indications of weight gain associated DNA methylation changes in patients with anorexia nervosa
    In: Scientific Reports, Vol. 15, 2025, Nr. 1, 28870
  • Dampmann, Maria; Kibler, Artur; von Tresckow, Julia; Reinhardt, Hans Christian; Küppers, Ralf; Budeus, Bettina
    Single-cell analysis of a bi-clonal chronic lymphocytic leukemia reveals two clones with distinct gene expression pattern
    In: Leukemia and Lymphoma, Vol. 66, 2025, Nr. 4, pp. 744 – 752
  • Berg, Victoria; Ross, J. Alexander; Dampmann, Maria; Küppers, Ralf; Budeus, Bettina
    Substantial loss of T cells upon lymphocyte isolation from heparin-anticoagulated peripheral blood
    In: Frontiers in Immunology, Vol. 16, 2025, 1665686
  • Szlachetko, Jagoda Agnieszka; Hofmann-Vega, Francisca; Budeus, Bettina; Schröder, Lara-Jasmin; Dumitru, Claudia Alexandra; Schmidt, Mathias; Deuss, Eric; Vollmer, Sebastian; Hanschmann, Eva-Maria; Busch, Maike; Kehrmann, Jan; Lang, Stephan; Dünker, Nicole; Hussain, Timon; Brandau, Sven
    Tumor cells that resist neutrophil anticancer cytotoxicity acquire a prometastatic and innate immune escape phenotype
    In: Cellular & Molecular Immunology, Vol. 22, 2025, Nr. 5, pp. 527 – 540
  • Budeus, Bettina; Álvaro-Benito, Miguel; Crivello, Pietro
    HLA-DM and HLA-DO interplay for the peptide editing of HLA class II in healthy tissues and leukemia
    In: Best Practice & Research Clinical Haematology, Vol. 37, 2024, Nr. 2, 101561
  • Alefeld, Emily; Haase, André; Van Meenen, Dario; Budeus, Bettina; Dräger, Oliver; Miroschnikov, Natalia; Ting, Saskia; Kanber, Deniz; Biewald, Eva; Bechrakis, Nikolaos; Dünker, Nicole; Busch, Maike
    In vitro model of retinoblastoma derived tumor and stromal cells for tumor microenvironment (TME) studies
    In: Cell Death and Disease, Vol. 15, 2024, Nr. 12, 905
  • Budeus, Bettina; Kroepel, Chiara; Stasch, Lisa Marie; Klein, Diana
    Matrix-free human lung organoids derived from induced pluripotent stem cells to model lung injury
    In: Stem Cell Research & Therapy, Vol. 15, 2024, Nr. 1, 468
  • Sentek, Hanna; Braun, Annika; Budeus, Bettina; Klein, Diana
    Non-small cell lung cancer cells and concomitant cancer therapy induce a resistance-promoting phenotype of tumor-associated mesenchymal stem cells
    In: Frontiers in Oncology, Vol. 14, 2024, 1406268
  • Kibler, Artur; Seifert, Marc; Budeus, Bettina
    Age-related changes of the human splenic marginal zone B cell compartment
    In: Immunology Letters, Vol. 256-257, 2023, pp. 59 – 65
  • Küppers, Ralf; Budeus, Bettina; Hartmann, Sylvia; Hansmann, Martin-Leo
    Clonal composition and differentiation stage of human CD30⁺ B cells in reactive lymph nodes
    In: Frontiers in Immunology, Vol. 14, 2023, 1208610
  • Budeus, Bettina; Unger, Kristian; Hess, Julia; Sentek, Hanna; Klein, Diana
    Comparative computational analysis to distinguish mesenchymal stem cells from fibroblasts
    In: Frontiers in Immunology, Vol. 14, 2023, 1270493
  • Zec, Kristina; Thiebes, Stephanie; Bottek, Jenny; Siemes, Devon; Spangenberg, Philippa; Trieu, Duc Viet; Kirstein, Nils; Subramaniam, Nirojah; Christ, Robin; Klein, Diana; Jendrossek, Verena; Loose, Maria; Wagenlehner, Florian; Jablonska, Jadwiga; Bracht, Thilo; Sitek, Barbara; Budeus, Bettina; Klein-Hitpaß, Ludger; Theegarten, Dirk; Shevchuk, Olga; Engel, Daniel Robert
    Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infection
    In: Frontiers in Immunology, Vol. 14, 2023, 1227191
  • Kronimus, Yannick; Albus, Alexandra; Hasenberg, Mike; Walkenfort, Bernd; Seifert, Marc; Budeus, Bettina; Gronewold, Janine; Hermann, Dirk M.; Ross, J. Alexander; Lochnit, Günter; Galuska, Sebastian P.; Marcus, Katrin; Sitek, Barbara; Klotsche, Jens; Mengel, David; Neumann, Sascha; Dodel, Richard
    Fc N-glycosylation of autoreactive Aβ antibodies as a blood-based biomarker for Alzheimer's disease
    In: Alzheimer's & Dementia, Vol. 19, 2023, Nr. 12, pp. 5563 – 5572
  • Budeus, Bettina; Kibler, Artur; Küppers, Ralf
    Human IgM–expressing memory B cells
    In: Frontiers in Immunology, Vol. 14, 2023, 1308378
  • Dubler, Simon; Etringer, Michael; Weigand, Markus A.; Brenner, Thorsten; Zimmermann, Stefan; Schnitzler, Paul; Budeus, Bettina; Rengier, Fabian; Kalinowska, Paulina; Hoo, Yuan Lih; Lichtenstern, Christoph
    Impact of Invasive Pulmonary Aspergillosis in Critically Ill Surgical Patients with or without Solid Organ Transplantation
    In: Journal of Clinical Medicine (JCM), Vol. 12, 2023, Nr. 9, 3282
  • Röder, Bettina; Fahnenstiel, Hannah; Schäfer, Simon; Budeus, Bettina; Dampmann, Maria; Eichhorn, Melanie; Angermüller, Sieglinde; Brost, Claudia; Winkler, Thomas H; Seifert, Marc; Nitschke, Lars
    The inhibitory receptor Siglec-G controls the severity of chronic lymphocytic leukemia
    In: EMBO Reports, Vol. 24, 2023, Nr. 8, e56420
  • Miroschnikov, Natalia; Dräger, Oliver; Van Meenen, Dario; Metz, Klaus; Budeus, Bettina; Dünker, Nicole; Busch, Maike
    Tumor Suppressor Role of INPP4B in Chemoresistant Retinoblastoma
    In: Journal of Oncology, 2023, 2270097
  • Antoni, Anne-Charlotte; Pylaeva, Ekaterina; Budeus, Bettina; Jablonska, Jadwiga; Klein-Hitpaß, Ludger; Dudda, Marcel; Flohé, Stefanie B.
    TLR2-induced CD8⁺ T-cell deactivation shapes dendritic cell differentiation in the bone marrow during sepsis
    In: Frontiers in Immunology, Vol. 13, 2022, 945409
  • Kibler, Artur; Budeus, Bettina; Küppers, Ralf; Seifert, Marc
    The Splenic Marginal Zone in Children Is Characterized by a Subpopulation of CD27-Negative, Lowly IGHV-Mutated B Cells
    In: Frontiers in Immunology, Vol. 13, 2022, 825619
  • Weiß, Annika L.; Meijer, Mandy; Budeus, Bettina; Pauper, Marc; Hakobjan, Marina; Groothuismink, Johanne; Shi, Yan; Neveling, Kornelia; Buitelaar, Jan K.; Hoogman, Martine; Franke, Barbara; Klein, Marieke
    DNA methylation associated with persistent ADHD suggests TARBP1 as novel candidate
    In: Neuropharmacology, Vol. 184, 2021, pp. 108370
  • Budeus, Bettina; Kibler, Artur; Brauser, Martina; Homp, Ekaterina; Bronischewski, Kevin; Ross, J. Alexander; Görgens, Andre; Weniger, Marc; Dunst, Josefine; Kreslavsky, Taras; da Conceição Castro, Symone Vitoriano; Murke, Florian; Oakes, Christopher C.; Rusch, Peter; Andrikos, Dimitrios; Kern, Peter; Köninger, Angela; Lindemann, Monika; Johansson, Patricia; Hansen, Wiebke; Lundell, Anna-Carin; Rudin, Anna; Dürig, Jan; Giebel, Bernd; Hoffmann, Daniel; Küppers, Ralf; Seifert, Marc
    Human cord blood b cells differ from the adult counterpart by conserved ig repertoires and accelerated response dynamics
    In: The Journal of Immunology (JI), Vol. 206, 2021, Nr. 12, pp. 2839 – 2851
  • Kibler, Artur; Budeus, Bettina; Homp, Ekaterina; Bronischewski, Kevin; Berg, Victoria; Sellmann, Ludger; Murke, Florian; Heinold, Andreas; Heinemann, Falko M.; Lindemann, Monika; Bekeredjian-Ding, Isabelle; Horn, Peter; Kirschning, Carsten Jürgen; Küppers, Ralf; Seifert, Marc
    Systematic memory B cell archiving and random display shape the human splenic marginal zone throughout life
    In: Journal of Experimental Medicine (JEM), Vol. 218, 2021, Nr. 4, pp. e20201952
  • Johansson, Patricia; Klein-Hitpaß, Ludger; Budeus, Bettina; Kuhn, Matthias; Lauber, Chris; Seifert, Michael; Roeder, Ingo; Pförtner, Roman; Stuschke, Martin; Dührsen, Ulrich; Eckstein, Anja; Dürig, Jan; Küppers, Ralf
    Identifying genetic lesions in ocular adnexal extranodal marginal zone lymphomas of the malt subtype by whole genome, whole exome and targeted sequencing
    In: Cancers, Vol. 12, 2020, Nr. 4, 986
  • Karimzadeh, Hadi; Kiraithe, Muthamia M.; Oberhardt, Valerie; Salimi Alizei, Elahe; Bockmann, Jan; Schulze zur Wiesch, Julian; Budeus, Bettina; Hoffmann, Daniel; Wedemeyer, Heiner; Cornberg, Markus; Krawczyk, Adalbert; Rashidi-Alavijeh, Jassin; Rodríguez-Frías, Francisco; Casillas, Rosario; Buti, Maria; Smedile, Antonina; Alavian, Seyed Moayed; Heinold, Andreas; Emmerich, Florian; Panning, Marcus; Gostick, Emma; Price, David A.; Timm, Jörg; Hofmann, Maike; Raziorrouh, Bijan; Thimme, Robert; Protzer, Ulrike; Roggendorf, Michael; Neumann-Haefelin, Christoph
    Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8⁺ T Cells and Evolve at the Population Level
    In: Gastroenterology, Vol. 156, 2019, Nr. 6, pp. 1820 – 1833
  • Alavian, Seyed Moayed; Price, David A.; Panning, Marcus; Neumann-Haefelin, Christoph; Bockmann, Jan; Wiesch, Julian Schulze zur; Wedemeyer, Heiner; Heinold, Andreas; Alizei, Elahe Salimi; Timm, Jörg; Casillas, Rosario; Protzer, Ulrike; Raziorrouh, Bijan; Smedile, Antonina; Rodríguez-Frías, Francisco; Hoffmann, Daniel; Oberhardt, Valerie; Buti, Maria; Thimme, Robert; Roggendorf, Michael; Hofmann, Maike; Gostick, Emma; Budeus, Bettina; Emmerich, Florian; Kiraithe, Muthamia M.; Karimzadeh, Hadi
    Viral escape contributes to the failure of hepatitis D virus-specific CD8+ T-cells and drives evolution of HDV
    In: Journal of Hepatology, Vol. 70, 2019, Nr. Suppl. 1, pp. e21
  • Karimzadeh, Hadi; Kiraithe, Muthamia M.; Kosinska, Anna D.; Glaser, Manuel; Fiedler, Melanie; Oberhardt, Valerie; Alizei, Elahe Salimi; Hofmann, Maike; Mok, Juk Yee; Nguyen, Melanie; van Esch, Wim J.E.; Budeus, Bettina; Grabowski, Jan; Homs, Maria; Olivero, Antonella; Keyvani, Hossein; Rodríguez-Frías, Francisco; Tabernero, David; Buti, Maria; Heinold, Andreas; Alavian, Seyed Moayed; Bauer, Tanja; Wiesch, Julian Schulze zur; Raziorrouh, Bijan; Hoffmann, Daniel; Smedile, Antonina; Rizzetto, Mario; Wedemeyer, Heiner; Timm, Jörg; Antes, Iris; Neumann-Haefelin, Christoph; Protzer, Ulrike; Roggendorf, Michael
    Amino acid substitutions within HLA-B*27- restricted T cell epitopes prevent recognition by hepatitis delta virus-specific CD8⁺ T cells
    In: Journal of Virology, Vol. 92, 2018, Nr. 13, e01891-17
  • Saeedghalati, Mohammadkarim; Farahpour, Farnoush; Budeus, Bettina; Lange, Anja; Westendorf, Astrid; Seifert, Marc; Küppers, Ralf; Hoffmann, Daniel
    Quantitative Comparison of Abundance Structures of Generalized Communities : from B-Cell Receptor Repertoires to Microbiomes
    In: PLoS Computational Biology, Vol. 13, 2017, Nr. 1, e1005362
  • Riemenschneider, Mona; Heider, Dominik; Gorry, Paul R.; Kaiser, Rolf; Bayanolhagh, Saeed; Shirvani-Dastgerdi, Elham; Sierra, Saleta; Budeus, Bettina; Cash, Kieran Y.
    Genotypic Prediction of Co-receptor Tropism of HIV-1 Subtypes A and C
    In: Scientific Reports, Vol. 6, 2016, pp. 24883
  • Budeus, Bettina; Timm, Jörg; Hoffmann, Daniel
    SeqFeatR for the Discovery of Feature-Sequence Associations
    In: PLoS ONE, Vol. 11, 2016, Nr. 1, pp. e0146409
  • Kefalakes, Helenie; Budeus, Bettina; Walker, Andreas; Jochum, Christoph; Hilgard, Gudrun; Heinold, Andreas; Heinemann, Falko M.; Gerken, Guido; Hoffmann, Daniel; Timm, Jörg
    Adaptation of the Hepatitis B Virus Core Protein to CD8+ T-Cell Selection Pressure
    In: Hepatology, Vol. 62, 2015, Nr. 1, pp. 47 – 56
  • Lange, Anja; Jost, Steffen Oliver; Heider, Dominik; Bock, Christina; Budeus, Bettina; Schilling, Elmar; Strittmatter, Axel; Boenigk, Jens; Hoffmann, Daniel
    AmpliconDuo : a split-sample filtering protocol for high-throughput amplicon sequencing of microbial communities
    In: PLoS ONE, Vol. 10, 2015, Nr. 11, pp. e0141590
  • Budeus, Bettina; De Reynoso, Stefanie Schweigle; Przekopowitz, Martina; Hoffmann, Daniel; Seifert, Marc; Küppers, Ralf
    Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centers
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 112, 2015, Nr. 38, pp. E5281 – E5289
  • Dang, S.; Wang, Yan; Budeus, Bettina; Verheyen, Jens; Yang, R.; Hoffmann, Daniel
    Differential selection in HIV-1 gp120 between subtype B and East Asian variant B'
    In: Virologica Sinica, Vol. 29, 2014, Nr. 1, pp. 40 – 47
  • Skibbe, K.; Budeus, Bettina; Heinemann, Falko M.; Timmer, L.; Horn, Peter; van Esch, W.; Hoffmann, Daniel; Siemann, H.; Scherbaum, Norbert; Timm, Jörg
    HLA-B*27 is protective against HCV genotype 1 and 3 and associated with targeting of distinct genotype-specific CD8(+) cell epitopes
    In: Journal of Hepatology, Vol. 60, 2014, Nr. Suppl. 1, pp. 140
  • Qin, Bo; Budeus, Bettina; Cao, Liang; Wu, Chunchen; Wang, Yun; Zhang, Xiaoyong; Rayner, Simon; Hoffmann, Daniel; Lu, Mengji; Chen, Xinwen
    The amino acid substitutions rtP177G and rtF249A in the reverse transcriptase domain of hepatitis B virus polymerase reduce the susceptibility to tenofovir
    In: Antiviral Research, Vol. 97, 2013, Nr. 2, pp. 93 – 100
  • Abstracts

  • Fitzgerald, Donnacha; Roider, Tobias; Baertsch, Marc-A.; Vöhringer, Harald; Knoll, Mareike; Budeus, Bettina; Kibler, Artur; Mathioudaki, Anna; Caillé, Léandra; Li, Linsha; Mammen, Johannes; Seifert, Marc; Huber, Wolfgang; Dietrich, Sascha
    Single-Cell Multi-Omic and Spatial Analysis of Nodal B Cell Non-Hodgkin Lymphomas Reveals Plasticity in B Cell Maturation As a Driver of Intratumor Heterogeneity
    In: Blood. Washington; New York, NY [u.a.]; Philadelphia, Pa.: American Society of Hematology, Vol. 140, 2022, Nr. Supplement 1: 64th ASH Annual Meeting and Exposition, 10-13 December 2022, New Orleans, pp. 752 – 753
  • Karimzadeh, H.; Budeus, Bettina; Kosinska, A.; Bauer, T.; Heinold, Andreas; Hoffmann, D.; Protzer, U.; Roggendorf, Michael
    Correlation of Mutations within HDV-Protein with HLA Backgrounds of Patients Leads to Identification of Novel CD8 T Cell Epitopes
    In: Journal of Hepatology. Amsterdam; Copenhagen; Oxford: Elsevier, Vol. 64, 2016, Nr. 2, Suppl., pp. S361
  • Seifert, Marc; Przekopowitz, Martina; Schweigle, Stefanie; Budeus, Bettina; Taudien, Sarah; Lollies, Anna; Ronge, Viola; Sellmann, Ludger; Hillen, Uwe; Engler, Harald; Schedlowski, Manfred; Singer, Bernhard B.; Hoffmann, Daniel; Küppers, Ralf
    Functional Characterization and Clonal Composition of Human Post-germinal Center Memory B Cells
    In: Scandinavian Journal of Immunology: Wiley-Blackwell, Vol. 80, 2014, Nr. 3: The 18th germinal centre conferenceUddevalla, SwedenSeptember 11–14, 2014, Abstracts, pp. 233
  • Book articles / Proceedings papers

  • Schnormeier, Ann-Kathrin; Budeus, Bettina
    Single Cell VDJ Sequencing of Normal and Malignant B and T Cells
    In: Lymphoma: Methods and Protocols / Küppers, Ralf (Eds.). New York: Humana, 2025, pp. 295 – 346
  • Thesis

  • Budeus, Bettina
    Statistical analysis of sequence populations in virology and immunology
    Duisburg, Essen, 2017
  • Posters / Proceedings posters

  • Jehn, L; Berg, V; Kibler, Artur; Boerner, E; Wälscher, J; Budeus, Bettina; Seifert, M; Taube, Christian; Bonella, Francesco
    Die durchflusszytometrische Untersuchung von T-Lymphozytensubpopulationen in der Ganzlungen-Lavage (GLL) bei der pulmonalen Alveolarproteinose : eine Pilot-Studie
    64. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin, 20.–23.03.2024, Mannheim, Germany,
    In: Pneumologie. Stuttgart: Thieme, Vol. 78, 2024, Nr. Suppl. 1, pp. S11 – S12
  • Jehn, Lutz-Bernhard; Berg, Victoria; Kibler, Artur; Boerner, Eda; Waelscher, Julia; Budeus, Bettina; Seifert, Marc; Taube, Christian; Bonella, Francesco
    Flow cytometric evaluation of whole lung lavage (WLL) fluid from patients with pulmonary alveolar proteinosis (PAP) : preliminary findings
    International Congress of the European Respiratory Society (ERS) 2023 ; 9 - 13 September 2023, Milan, Italy,
    In: European Respiratory Journal (ERJ). Sheffield: European Respiratory Society, Vol. 62, 2023, Nr. Supplement 67: ERS International Congress 2023 abstracts, PA3946