Faculty of Biology
Register of People
The person's links lead to the central register of persons of the UDE, refering to the data of LSF. Personal data can be edited in LSF (Login with Uni-ID is required).
Biologie
Address
Universitätsstr. 5
D-45141 Essen
D-45141 Essen
Room
S05 R01 H75
Phone
Fax
E-Mail
Functions
-
Gruppe der Professorinnen und Professoren, Fakultätsrat Biologie
-
Vorsitzender, Promotionsausschuss Fakultät Biologie
-
Professor/in, Molekulare Genetik I
Current lectures
-
2024 SS
- Struktur und Funktion (LA Ba) - Anmeldung mit mehreren Prioritäten
- Anleitungen zum wissenschaftlichen Arbeiten
- Applied Molecular Biology
- Molekularbiologie der Chromosomen und genetische Stabilität (Spezielle Genetik)
- Group Meeting
- Begleitmodul zur Masterarbeit: Professionelles Handeln wissenschaftsbasiert weiterentwickeln aus der Perspektive des Unterrichtsfachs Biologie (LA Master)
Past lectures (max. 10)
-
2023 WS
- Molekulare Genetik f. Molbio (VO u. PR)
- Anleitung zum wissenschaftlichen Arbeiten
- Seminar zur Genetik
- Grundlagen der Biotechnologie (LA Ba); Platzvergabe: 3 Präferenzen angeben
- Modern Biomedicine/Beispiele biologischer Forschung (Teil 1)
- Einführung in die Genetik
- Begleitmodul zur Masterarbeit: Professionelles Handeln wissenschaftsbasiert weiterentwickeln aus der Perspektive des Unterrichtsfachs Biologie (LA Master)
- Molekulare Genetik
- Allgemeine Methoden in der Molekularbiologie
- Group Meeting
The following publications are listed in the online university bibliography of the University of Duisburg-Essen. Further information may also be found on the person's personal web pages.
-
Multivalent Molecular Tweezers Disrupt the Essential NDC80 Interaction with MicrotubulesIn: Journal of the American Chemical Society: JACS Vol. 145 (2023) Nr. 28, pp. 15251 - 15264Online Full Text: dx.doi.org/
-
Systematic analysis of microtubule plus-end networks defines EB-cargo complexes critical for mitosis in budding yeastIn: Molecular Biology of the Cell Vol. 34 (2023) Nr. 5, ar37Online Full Text: dx.doi.org/ Online Full Text (Open Access)
-
Cdc4 phospho-degrons allow differential regulation of ame1ceⁿp⁻u protein stability across the cell cycleIn: eLife Vol. 10 (2021) e67390Online Full Text: dx.doi.org/ (Open Access)
-
Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochoreIn: The EMBO Journal Vol. 40 (2021) Nr. 18, e108004Online Full Text: dx.doi.org/ (Open Access)
-
Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeastIn: The EMBO Journal Vol. 39 (2020) Nr. 14, pp. e102938Online Full Text: dx.doi.org/ Online Full Text (Open Access)
-
The EB1-Kinesin-14 complex is required for efficient metaphase spindle assembly and kinetochore bi-orientationIn: The Journal of Cell Biology (JCB) Vol. 219 (2020) Nr. 12, 202003072Online Full Text: dx.doi.org/ (Open Access)
-
Molecular basis for inner kinetochore configuration through RWD domain–peptide interactionsIn: The EMBO Journal Vol. 36 (2017) Nr. 23, pp. 3458 - 3482Online Full Text: dx.doi.org/ (Open Access)
-
Structural differences between yeast and mammalian microtubules revealed by cryo-EMIn: The Journal of Cell Biology (JCB) Vol. 216 (2017) Nr. 9, pp. 2669 - 2677Online Full Text: dx.doi.org/ (Open Access)
-
TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2In: The Journal of Cell Biology (JCB) Vol. 216 (2017) Nr. 11, pp. 3471 - 3484Online Full Text: dx.doi.org/ (Open Access)
-
A Force-Induced Directional Switch of a Molecular Motor Enables Parallel Microtubule Bundle FormationIn: Cell Vol. 167 (2016) Nr. 2, pp. 539 - 552.e14Online Full Text: dx.doi.org/ Online Full Text (Open Access)
-
BiGBac enables rapid gene assembly for the expression of large multisubunit protein complexesIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 113 (2016) Nr. 19, pp. E2564 - E2569Online Full Text: dx.doi.org/ (Open Access)
-
CCAN Assembly Configures Composite Binding Interfaces to Promote Cross-Linking of Ndc80 Complexes at the KinetochoreIn: Current Biology Vol. 26 (2016) Nr. 17, pp. 2370 - 2378Online Full Text: dx.doi.org/ Online Full Text (Open Access)
-
Non-catalytic motor domains enable processive movement and functional diversification of the kinesin-14 Kar3In: eLife Vol. 4 (2015) pp. e04489Online Full Text: dx.doi.org/ (Open Access)
-
A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-AIn: The Journal of Cell Biology (JCB) Vol. 206 (2014) Nr. 4, pp. 506 - 524Online Full Text: dx.doi.org/ (Open Access)
-
“Uno, nessuno e centomila” : the different faces of the budding yeast kinetochoreIn: Chromosoma Vol. 123 (2014) Nr. 5, pp. 447 - 457Online Full Text: dx.doi.org/
-
A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptorsIn: The EMBO Journal Vol. 32 (2013) Nr. 3, pp. 409 - 423Online Full Text: dx.doi.org/
-
Esperanto for histones : CENP-A, not CenH3, is the centromeric histone H3 variantIn: Chromosome Research Vol. 21 (2013) Nr. 2, pp. 101 - 106Online Full Text: dx.doi.org/
-
Molecular requirements for the formation of a kinetochore–microtubule interface by Dam1 and Ndc80 complexesIn: The Journal of Cell Biology (JCB) Vol. 200 (2013) Nr. 1, pp. 21 - 30Online Full Text: dx.doi.org/
-
CENP-T proteins are conserved centromere receptors of the Ndc80 complexIn: Nature Cell Biology Vol. 14 (2012) Nr. 6, pp. 604 - 613Online Full Text: dx.doi.org/
-
Family matters: structural and functional conservation of centromere-associated proteins from yeast to humansIn: Trends in Cell Biology Vol. 23 (2012) Nr. 6, pp. 260 - 269Online Full Text: dx.doi.org/
-
Spatiotemporal regulation of Ipl1/Aurora activity by direct Cdk1 phosphorylationIn: Current Biology Vol. 22 (2012) Nr. 9, pp. 787 - 793Online Full Text: dx.doi.org/
-
A blueprint for kinetochores - new insights into the molecular mechanics of cell divisionIn: Nature reviews. Molecular cell biology Vol. 12 (2011) Nr. 7, pp. 407 - 412Online Full Text: dx.doi.org/
-
Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complexIn: Journal of Molecular Biology (JMB) Vol. 405 (2011) Nr. 2, pp. 548 - 559Online Full Text: dx.doi.org/ Online Full Text (Open Access)
-
The Dam1 complex confers microtubule plus end–tracking activity to the Ndc80 kinetochore complexIn: The Journal of Cell Biology (JCB) Vol. 189 (2010) Nr. 4, pp. 641 - 649Online Full Text: dx.doi.org/
-
A Dam1-based artificial kinetochore is sufficient to promote chromosome segregation in budding yeastIn: Nature Cell Biology Vol. 11 (2009) Nr. 9, pp. 1109 - 1115Online Full Text: dx.doi.org/
-
Phosphoregulation of the budding yeast EB1 homologue Bim1p by Aurora/Ipl1pIn: The Journal of Cell Biology (JCB) Vol. 186 (2009) Nr. 3, pp. 379 - 391Online Full Text: dx.doi.org/
-
Architecture and flexibility of the yeast Ndc80 kinetochore complexIn: Journal of Molecular Biology (JMB) Vol. 383 (2008) Nr. 4, pp. 894 - 903Online Full Text: dx.doi.org/ Online Full Text (Open Access)
-
Different assemblies of the DAM1 complex follow shortening microtubules by distinct mechanismsIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 105 (2008) Nr. 19, pp. 6918 - 6923Online Full Text: dx.doi.org/
-
The Dam1 ring binds microtubules strongly enough to be a processive as well as energy-efficient coupler for chromosome motionIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 105 (2008) Nr. 40, pp. 15423 - 15428Online Full Text: dx.doi.org/
-
A protein interaction map of the mitotic spindleIn: Molecular Biology of the Cell (MBoC) Vol. 18 (2007) Nr. 10, pp. 3800 - 3809Online Full Text: dx.doi.org/
-
Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanismsIn: Nature Structural & Molecular Biology Vol. 14 (2007) Nr. 8, pp. 721 - 726Online Full Text: dx.doi.org/
-
Structures and functions of yeast kinetochore complexesIn: Annual Review of Biochemistry Vol. 76 (2007) pp. 563 - 591Online Full Text: dx.doi.org/
-
The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule endsIn: Nature Vol. 440 (2006) Nr. 7083, pp. 565 - 569Online Full Text: dx.doi.org/
-
Formation of a dynamic kinetochore-microtubule interface through assembly of the Dam1 ring complexIn: Molecular Cell Vol. 17 (2005) Nr. 2, pp. 277 - 290Online Full Text: dx.doi.org/
-
Architecture of the budding yeast kinetochore reveals a conserved molecular coreIn: The Journal of Cell Biology (JCB) Vol. 163 (2003) Nr. 2, pp. 215 - 222Online Full Text: dx.doi.org/
-
Ipl1-controlled attachment maturation regulates Mps1 association with its kinetochore receptor(2023) 43 SeitenOnline Full Text: dx.doi.org/ (Open Access)