Faculty of Biology

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Prof. Dr. Malte Gersch

Faculty of Biology and Research Center One Health Ruhr

Address
Universitätstraße 2
45141 Essen
Room
S03 S02 A50
E-Mail
malte.gersch@uni-due.de
Website
https://www.uni-due.de/zmb/members/malte-gersch.php

Functions

  • Professor/in, One Health Ruhr - Cell Biology and Human Disease

  • Professor/in, Zellbiologie und menschliche Krankheiten

Current lectures

No current lectures.

Past lectures (max. 10)

No past lectures.

The following publications are listed in the online university bibliography of the University of Duisburg-Essen. Further information may also be found on the person's personal web pages.

    Journal articles

  • Klink, Nikolas; Urban, Sebastian; Seier, Johanna A.; Adhikari, Bikash; Schwalm, Martin P.; Müller, Juliane; Dorsch, Madeleine; Steinbach, Philine; Jung, Jennifer; Vogt, Markus; Kaschani, Farnusch; Koch, Johannes; Führer, Siska; Kaiser, Markus; Schulze, Nina; Knapp, Stefan; Wolf, Elmar; Paschen, Annette; Grüner, Barbara M.; Gersch, Malte
    Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors
    In: Nature Communications, Vol. 17, 2026, Nr. 1, 4331
    DOI (Open Access)
  • Kazi, Nafizul Haque; Klink, Nikolas; Gallant, Kai; Kipka, Gian-Marvin; Gersch, Malte
    Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30
    In: Nature Structural & Molecular Biology, Vol. 32, 2025, Nr. 9, pp. 1776 – 1786
    DOI (Open Access)
  • Wendrich, Kim; Gallant, Kai; Recknagel, Sarah; Petroulia, Stavroula; Kazi, Nafizul Haque; Hane, Jan André; Führer, Siska; Bezstarosti, Karel; O’Dea, Rachel; Demmers, Jeroen; Gersch, Malte
    Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53
    In: Nature Chemical Biology, Vol. 21, 2025, Nr. 5, pp. 746 – 757
    DOI (Open Access)
  • Banerjee, Sudakshina; Cakil, Zeyneb Vildan; Gallant, Kai; van den Boom, Johannes; Palei, Shubhendu; Meyer, Hemmo; Gersch, Malte; Summerer, Daniel
    Light-Activatable Ubiquitin for Studying Linkage-Specific Ubiquitin Chain Formation Kinetics
    In: Advanced Science, Vol. 12, 2025, Nr. 6, 2406570
    DOI (Open Access)
  • Führer, Siska; Gallant, Kai; Kaschani, Farnusch; Kaiser, Markus; Janning, Petra; Waldmann, Herbert; Gersch, Malte
    Small Molecule-Induced Alterations of Protein Polyubiquitination Revealed by Mass-Spectrometric Ubiquitome Analysis
    In: Angewandte Chemie International Edition, Vol. 64, 2025, Nr. 32, e202508916
    DOI (Open Access)
  • Schmidt, Mirko; Grethe, Christian; Recknagel, Sarah; Kipka, Gian-Marvin; Klink, Nikolas; Gersch, Malte
    N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1
    In: Angewandte Chemie International Edition, Vol. 63, 2024, Nr. 12, e202318849
    DOI (Open Access)
  • O’Dea, Rachel; Kazi, Nafizul; Hoffmann-Benito, Alicia; Zhao, Zhou; Recknagel, Sarah; Wendrich, Kim; Janning, Petra; Gersch, Malte
    Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36
    In: Nature Chemical Biology, Vol. 19, 2023, Nr. 11, pp. 1394 – 1405
    DOI (Open Access)
  • Zhao, Zhou; O’Dea, Rachel; Wendrich, Kim; Kazi, Nafizul; Gersch, Malte
    Native Semisynthesis of Isopeptide-Linked Substrates for Specificity Analysis of Deubiquitinases and Ubl Proteases
    In: Journal of the American Chemical Society: JACS, Vol. 145, 2023, Nr. 38, pp. 20801 – 20812
    DOI (Open Access)
  • Grethe, Christian; Schmidt, Mirko; Kipka, Gian-Marvin; O’Dea, Rachel; Gallant, Kai; Janning, Petra; Gersch, Malte
    Structural basis for specific inhibition of the deubiquitinase UCHL1
    In: Nature Communications, Vol. 13, 2022, Nr. 1, 5950
    DOI (Open Access)

    • Preprints

  • Klink, Nikolas; Urban, Sebastian; Seier, Johanna A.; Adhikari, Bikash; Schwalm, Martin P.; Müller, Juliane; Dorsch, Madeleine; Kaschani, Farnusch; Koch, Johannes; Führer, Siska; Kaiser, Markus; Schulze, Nina; Knapp, Stefan; Wolf, Elmar; Paschen, Annette; Grüner, Barbara M.; Gersch, Malte
    Targeted degradation of USP7 in solid cancer cells reveals disparate effects of deubiquitinase inhibition vs. acute protein depletion
    2025
    DOI, Online Full Text (Open Access)